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UID:1235@biology.technion.ac.il

DTSTART;TZID=Asia/Jerusalem:20240806T130000

DTEND;TZID=Asia/Jerusalem:20240806T140000

DTSTAMP:20240710T131243Z

URL:https://biology.technion.ac.il/en/seminars/phd-graduate-seminar-reut-s
 egal-erel/

SUMMARY:PhD Graduate Seminar- Reut Segal-Erel [No Categories]
DESCRIPTION:Location: Hybrid- in the Faculty Auditorium/ZOOM: https://techn
 ion.zoom.us/j/91650895147  Reut Segal-Erel\n Affiliation: \n Host:Prof. Sh
 lomi Tomer \n Overcoming Metabolic T-Cell Suppression in Cancer Immunother
 apy Using Metabolic Engineering\n\nCancer immunotherapy has shown remarkab
 le success in hematologic cancers but remains less effective against solid
  tumors due to metabolic suppression in the tumor microenvironment (TME). 
 The metabolic reprogramming of cancer cells limits nutrient availability\,
  leading to T-cell dysfunction.\n\nTo address this challenge\, we develope
 d a novel in vivo screening method to identify metabolic genes that enhanc
 e T-cell function through gene overexpression. Using this innovative strat
 egy\, we identified three candidate genes — SLC7A8\, G6PD\, and AKT1 —
 each showing substantial potential for improving T-cell function and are c
 urrently undergoing rigorous in vivo validation.\n\nOur approach to overco
 ming metabolic barriers in the TME could significantly enhance the efficac
 y of cancer immunotherapy\, paving the way for new and more effective trea
 tments for solid tumors.\n\n&nbsp\;\n\n&nbsp\; 
LOCATION:Hybrid- in the Faculty Auditorium/ZOOM: https://technion.zoom.us/j
 /91650895147

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