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UID:1112@biology.technion.ac.il

DTSTART;TZID=Asia/Jerusalem:20220823T130000

DTEND;TZID=Asia/Jerusalem:20220823T140000

DTSTAMP:20220818T114910Z

URL:https://biology.technion.ac.il/en/seminars/phd-graduate-seminar-roi-an
 kawa/

SUMMARY:PhD Graduate Seminar-Roi Ankawa [No Categories]
DESCRIPTION:Location:   \n Affiliation: \n Host:\n Apoptoticcells represent
  a dynamic stem cell niche governing proliferation and tissueregeneration\
 n\n \n\nSummery\n\nStem cells (SCs) play a key role inhomeostasis and rep
 air. While many studies have focused on SC self-renewal anddifferentiation
 \, little is known regarding the molecular mechanism regulatingSC eliminat
 ion and compensation upon loss. Here\, we report that Caspase-9deletion in
  hair follicle SCs (HFSCs) attenuates the apoptotic cascade\,resulting in 
 significant temporal delays. Surprisingly\, Casp9-deficient HFSCsaccumulat
 e high levels of cleaved caspase-3 and are improperly cleared due toan ess
 ential caspase-3/caspase-9 feedforward loop. These SCs are retained in ana
 poptotic-engaged state\, serving as mitogenic signaling centers by continu
 ouslyreleasing Wnt3 and instructing proliferation. Investigating the under
 lyingmechanism\, we reveal a caspase-3/Dusp8/p38 module responsible for Wn
 t3induction\, which operates in both normal and Casp9-deleted HFSCs. Notab
 ly\,Casp9-deleted mice display accelerated wound repair and de novo hair f
 ollicleregeneration. Taken together\, we demonstrate that apoptotic cells 
 represent adynamic SC niche\, from which emanating signals drive SC prolif
 eration andtissue regeneration. 

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