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UID:857@biology.technion.ac.il

DTSTART;TZID=Asia/Jerusalem:20190716T130000

DTEND;TZID=Asia/Jerusalem:20190716T140000

DTSTAMP:20210802T125857Z

URL:https://biology.technion.ac.il/en/seminars/phd-graduate-seminar-shlomi
 -dvir-2/

SUMMARY:PhD. Graduate Seminar-Shlomi Dvir [No Categories]
DESCRIPTION:Location:   \n Affiliation: \n Host:\n ResearchTopic:Decipherin
 g theRNA-bound proteome of human embryonic stem cellsRNA-binding proteins(
 RBPs) are essential regulators of post-transcriptional gene expression\,co
 ntrolling numerous aspects in the life of an RNA molecule. While remarkabl
 eprogress has been made in unveiling the transcriptional regulatory princi
 plesunderlying pluripotency\, relatively little is known about the role of
 post-transcriptional regulation in embryonic stem cells (ESCs). Here\, we
 present the first mRNA-binding proteome of human ESCs (hESCs).Using a prot
 eomic-based approach\, we identified 810 high-confidence RBPs\,including 1
 68 candidate dual DNA and RNA binding proteins (DRBPs). We show thatRBPs a
 re preferentially expressed in hESCs and dynamically regulated during exit
 from pluripotency. Notably\, we found that many RBPs are bound by the core
 transcriptional circuitry of ESCs\, consisting of OCT4\, SOX2 and NANOG.Kn
 ockdown of these three master regulators further indicated that RBPs arek
 ey players in the pluripotency network. Finally\, we determined the dualnu
 cleic-acid-binding activity of two pluripotency factors\, ESRP1 and STAT3.
 Taken together\, our findings reveal that RBPs have a far greater role in 
 theregulation of human pluripotency than previously appreciated. 

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DTSTART:20190329T030000

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