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UID:1101@biology.technion.ac.il

DTSTART;TZID=Asia/Jerusalem:20220628T130000

DTEND;TZID=Asia/Jerusalem:20220628T140000

DTSTAMP:20220713T072650Z

URL:https://biology.technion.ac.il/en/seminars/phd-graduate-seminar-sofia-
 khazan-kost/

SUMMARY:Phd Graduate Seminar-Sofia Khazan Kost [No Categories]
DESCRIPTION:Location:   \n Affiliation: \n Host:\n Time: Thursday  June 28t
 h  13:00Place: hybrid- in the Faculty Auditorium/ZOOMhttps://technion.zoom
 .us/j/97658538324The HLA Peptidome of Lung Cancer: Towards the Development
 of Personalized ImmunotherapyLung cancer is the leading cause of cancer-re
 lated death worldwide\, mainly due to late diagnosis\, metastases\, accumu
 lation of pleural effusions\, and resistance to chemotherapy. Immunotherap
 y is emerging as a new treatment modality revolutionizing cancer care. How
 ever\, much progress is still needed for its implementation for lung cance
 r. Identification of tumor-specific antigens among the HLA peptidome of lu
 ng cancer may facilitate the development of effective personalized immunot
 herapy. This research aimed to identify HLA peptides that can be used as t
 argets or biomarkers for lung cancer. To achieve these goals we analyzed t
 he HLA peptidome from pleural effusions of lung cancer patients as well as
  cell lines\, including chemotherapy-resistant cultures. Many of the ident
 ified putative HLA ligands derived from tumor-associated antigens and mult
 i-drug resistance proteins. Such peptides are candidate targets for person
 alized immunotherapy and biomarkers. Importantly\, the immunogenicity of s
 elected peptides was demonstrated with T cells of a healthy donor\, indica
 ting a potential value of this approach for future clinical implementation
 .  

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