BEGIN:VCALENDAR

VERSION:2.0

PRODID:-//wp-events-plugin.com//7.2.2.1//EN

TZID:Asia/Jerusalem

X-WR-TIMEZONE:Asia/Jerusalem
BEGIN:VEVENT

UID:855@biology.technion.ac.il

DTSTART;TZID=Asia/Jerusalem:20190625T130000

DTEND;TZID=Asia/Jerusalem:20190625T140000

DTSTAMP:20210802T125857Z

URL:https://biology.technion.ac.il/en/seminars/phd-graduate-seminar-sophia
 -zborowsky-2/

SUMMARY:PhD. Graduate Seminar-Sophia Zborowsky [No Categories]
DESCRIPTION:Location:   \n Affiliation: \n Host:\n Research Topic:Resistanc
 e in marinecyanobacteria against infection bygeneralist and specialist cya
 nophagesCyanobacteria of the genera Synechococcus and Prochloroccocus arei
 nfected by generalist and specialist phages. Coexistence between thecyanob
 acteria and the phages is thought to be facilitated by resistance. Whileex
 tracellular resistance is established\, it not known if intracellularresis
 tance exists in marine cyanobacteria. In order to investigate whetherintra
 cellular resistance exists in Prochlorococcus and Synechococcusandif resis
 tance differs against generalist and specialist cyanophages wechecked if i
 nfections of resistant strains are halted inside or outside thecell. Resis
 tance was extracellular in most interactions against specialist cyanophage
 s. Incontrast\, resistance was intracellular in practically all interactio
 ns againstgeneralist cyanophages.This unveils a heavy cost of promiscuous 
 entry of generalist phages intonon-host cells that is rarely paid by speci
 alists. Furthermore\, the stage ofintracellular arrest was interaction-spe
 cific\, halting at various stages of theinfection cycle. This indicates th
 e presence of potential differentintracellular mechanismsofresistance. Sea
 rching the genome of marine Synechococcus and Prochloroccocusstrains for g
 enes of known defense systems showed that complete systems arerare. Inacti
 vation of two known systems in SynechococcusWH5701did not result in sensit
 ivity. Finally\, we found that in SynechococcusWH5701the mechanism of resi
 stance was loss of transaction of tRNAgenesthat appear to be crucial for t
 ranslation of phages proteins. TheSeminar will be given in English.  

END:VEVENT

BEGIN:VTIMEZONE

TZID:Asia/Jerusalem

X-LIC-LOCATION:Asia/Jerusalem

BEGIN:DAYLIGHT

DTSTART:20190329T030000

TZOFFSETFROM:+0200

TZOFFSETTO:+0300

TZNAME:IDT

END:DAYLIGHT

END:VTIMEZONE
END:VCALENDAR