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UID:1244@biology.technion.ac.il

DTSTART;TZID=Asia/Jerusalem:20240926T131500

DTEND;TZID=Asia/Jerusalem:20240926T141500

DTSTAMP:20240925T075322Z

URL:https://biology.technion.ac.il/en/seminars/phd-graduate-seminar-suchet
 a-chopra/

SUMMARY:PhD Graduate Seminar-Sucheta Chopra [No Categories]
DESCRIPTION:Location: https://technion.zoom.us/j/96220819823  Meeting ID: 9
 62 2081 9823   Sucheta Chopra\n Affiliation: \n Host:Dr. Fuchs Yaron and A
 ssociate Prof. Shalom-Feuerste Ruby\n Abstract:\n\nUnderstanding the intri
 cate mechanisms governing epidermal pattern formation\, particularly\n\nwi
 thin ectodermal appendages like hair follicles\, is a key pursuit in devel
 opmental biology.\n\nReciprocal interactions between mesenchymal and epith
 elial cells regulate hair follicle\n\ngrowth and development through vario
 us signaling pathways\, yet the underlying molecular\n\npathways remain el
 usive. Our investigation focuses on Thy1\, a cell surface protein tethered
 \n\nvia a glycosylphosphatidylinositol (GPI) anchor\, which plays a multif
 aceted role in cell-cell\n\nand cell-matrix adhesion. We found that Thy1 s
 ignificantly influences hair follicle\n\ndevelopment through the YAP (Yes-
 associated protein) mediated signaling pathway. In-vivo\n\ndeletion experi
 ments revealed a marked increase in hair follicle numbers upon Thy1\n\ndel
 etion\, attributable to the activation of the YAP/Integrin-β1/Src module.
  Additionally\,\n\nemploying ultrasound-guided lentiviral delivery and pha
 rmacological inhibition\, we elucidated\n\nthe pronounced regulatory role 
 of YAP in hair follicle morphogenesis\, further delineating the\n\nThy1-de
 pendent phenotypes. Our findings underscore the pivotal role of YAP activi
 ty in\n\nregulating hair follicle development\, shedding light on potentia
 l therapeutic implications for\n\nhair-related disorders and presenting ex
 citing prospects in the realm of regenerative\n\nmedicine applications. 
LOCATION:https://technion.zoom.us/j/96220819823  Meeting ID: 962 2081 9823

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