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UID:1302@biology.technion.ac.il

DTSTART;TZID=Asia/Jerusalem:20250819T130000

DTEND;TZID=Asia/Jerusalem:20250819T140000

DTSTAMP:20250722T113934Z

URL:https://biology.technion.ac.il/en/seminars/phd-graduate-seminar-sunu-j
 oseph/

SUMMARY:PhD Graduate Seminar-Sunu Joseph [No Categories]
DESCRIPTION:Location:   Sunu Joseph\n Affiliation: \n Host:Associate Prof. 
  Shenhav Shemer\n 13\n\nThe ubiquitin-proteasome system plays a crucial ro
 le in excessive muscle proteolysis during atrophy\, a condition triggered 
 by inactivity\, starvation\, aging\, cancer\, and muscular dystrophies. Wh
 ile ubiquitin ligases (E3s) have been extensively studied in this process\
 , the functions of E2 conjugating enzymes\, which facilitate ubiquitin tra
 nsfer with E3s\, remain poorly understood. Ube2h is an E2 ubiquitin-conjug
 ating enzyme with less understood cellular functions compared to E3 ligase
 s. Ube2h is distinct in lacking a typical ubiquitin-binding surface and ha
 ving a unique disordered C-terminal region. Our data suggest that Ube2h pr
 omotes fasting-induced muscle atrophy by impairing insulin signaling via i
 ts C-terminal region. In addition\, Ube2h reduces desmin integrity by targ
 eting the heat shock protein Hspb1 for degradation\, facilitating desmin d
 epolymerization and the resulting loss of the contractile machinery.0:0011
  

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