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UID:1225@biology.technion.ac.il

DTSTART;TZID=Asia/Jerusalem:20240619T130000

DTEND;TZID=Asia/Jerusalem:20240619T140000

DTSTAMP:20240602T171057Z

URL:https://biology.technion.ac.il/en/seminars/phd-graduate-seminar-tal-re
 fael/

SUMMARY:PhD Graduate Seminar- Tal Refael [No Categories]
DESCRIPTION:Location: Hybrid- in the Faculty Auditorium/ZOOM: https://techn
 ion.zoom.us/j/94259170040  Tal Refael \n Affiliation: \n Host:Prof. Philip
 pa Melamed \n Novel enhancers in transcriptional regulation of the gonadot
 ropin genes\n\nThe pituitary gland luteinizing hormone (LH) and follicle s
 timulating hormone (FSH) control gonadal development and function\, their 
 levels changing dramatically at puberty\, during the estrous/menstrual cyc
 le and at menopause\, in response to complex hormonal signals. We hypothes
 ized that distal DNA elements regulate Lhb and Fshb expression to mediate 
 some of these effects. We identified a bi-directional enhancer and lncRNA 
 which play distinct and sex-specific roles in Lhb expression\, and found t
 hat both elements are regulated by non-canonical DNA structures. Far upstr
 eam of Fshb\, we detected a gonadotrope-specific “super-enhancer” whos
 e activity affects Fshb mRNA levels. Protein binding and transcription of 
 this region increased in response to activin\, and the transcription incre
 ased in a mouse model of menopause which is characterized by high levels o
 f activin activity. This indicates a role for the region in mediating the 
 elevation of FSH at menopause\, which underlies the onset of several age-r
 elated diseases. Our findings reveal novel mechanisms involved in control 
 of the reproductive axis\, and shed new light on transcriptional regulatio
 n via various distal non-coding genomic elements. 
LOCATION:Hybrid- in the Faculty Auditorium/ZOOM: https://technion.zoom.us/j
 /94259170040

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