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UID:1147@biology.technion.ac.il

DTSTART;TZID=Asia/Jerusalem:20221228T130000

DTEND;TZID=Asia/Jerusalem:20221228T140000

DTSTAMP:20221225T093632Z

URL:https://biology.technion.ac.il/en/seminars/phd-graduate-seminar-xiaohu
 i-li/

SUMMARY:PhD Graduate Seminar-Xiaohui Li [No Categories]
DESCRIPTION:Location: hybrid- in the Faculty Auditorium/ZOOM: https://techn
 ion.zoom.us/j/95603525366  Xiaohui Li \n Affiliation: \n Host:Prof. Benjam
 in Podbilewicz\n \nArchaeal origins of gamete fusion\n\nSexual reproductio
 n consists of genome reduction by meiosis and subsequent gamete fusion. Fu
 sexins\, are a superfamily of structurally conserved proteins (fusogens) t
 hat mediate three types of exoplasmic membrane fusion events: eukaryotic g
 amete fusion\, somatic cell-cell fusion\, and entry of enveloped viruses t
 o host cells. Here\, we unveil a fourth family of fusexins in genomes of A
 rchaea and metagenomes from different environments. We provide structural\
 , functional and evolutionary evidence indicating that these archaeal prot
 eins are cellular fusogens: First\, the crystal structure of a trimeric ar
 chaeal Fusexin1 reveals high similarity to eukaryotic fusexins and in part
 icular to gamete GCS1/HAP2 fusogens from plants and protists. Second\, ect
 opically expressed Fusexin1 can fuse mammalian cells\, and this process in
 volves the conserved fusion loop and the additional globular domain. Third
 \, genomic analyses indicate that archaeal fusexins are carried by integra
 ted mobile genetic elements\, suggesting potential roles in cell fusion an
 d gene exchange in archaea\, as well as different scenarios for the evolut
 ionary history of fusexins. We will also discuss work in progress to 
LOCATION:hybrid- in the Faculty Auditorium/ZOOM: https://technion.zoom.us/j
 /95603525366

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DTSTART:20221030T010000

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