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UID:1099@biology.technion.ac.il

DTSTART;TZID=Asia/Jerusalem:20220517T130000

DTEND;TZID=Asia/Jerusalem:20220517T140000

DTSTAMP:20220713T072650Z

URL:https://biology.technion.ac.il/en/seminars/phd-graduate-seminar-yizhaq
 -engelberg/

SUMMARY:PhD Graduate Seminar-Yizhaq Engelberg [No Categories]
DESCRIPTION:Location:   \n Affiliation: \n Host:\n Time: Tuesday May 17\, 2
 022\, 13:00 PMPlace: Hybrid – The Faculty og Biology AuditoriumZOOM: htt
 ps://technion.zoom.us/j/91251316715Functional Super Molecular Structures o
 f Self-assembled ProteinsAntimicrobial peptides are secreted by the innate
  immune system of almost every organism on this planet. Surprisingly\, man
 y of them are capable to self-assemble into ordered supramolecular structu
 res. In this work\, we provided a high- resolution structure of the fibril
  form of a human derived antimicrobial peptide\, LL3717-29\, and supported
  the critical role of self-assembly via structure-guided mutational analys
 is. Based on the findings\, we engineered controllable antimicrobial activ
 ity via the formation of supramolecular structures sensitive to specific e
 nvironmental conditions. In a second collaborative project\, we fabricated
  supramolecular structures of a food derived protein\, to serve as intesti
 nal delivery system. This system controllably and gradually releases nutra
 ceuticals compounds.Overall\, we have revealed new properties\, morphologi
 es\, regulation\, and applications for self-assembled protein systems. 

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