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UID:945@biology.technion.ac.il

DTSTART;TZID=Asia/Jerusalem:20210217T130000

DTEND;TZID=Asia/Jerusalem:20210217T140000

DTSTAMP:20210802T125904Z

URL:https://biology.technion.ac.il/en/seminars/phd-graduate-seminar-yoav-p
 izem-2/

SUMMARY:PhD Graduate Seminar- Yoav Pizem [No Categories]
DESCRIPTION:Location:   \n Affiliation: \n Host:\n BiophysicalProperties th
 at Influence Optimal Functional Output of TCR Engineered T Cells Theencou
 nter of the TCR with its cognate peptide-MHC complex (pMHC) is a crucialst
 ep in T-cell activation. One of the most critical parameters\, among manyf
 actors that influence antigen specific T-cell activation\, is the biophysi
 calnature of the TCR-pMHC interaction defined by TCR affinity and avidity 
 and therelationship with antigen density. Current understanding of how the
 se factorsand the interrelationships between them affect functional avidit
 y remainsundefined. To answer this question\, we generated an experimental
  system inwhich all these main parameters of T cell stimulation are contro
 llable usingTCR engineered T cells with single specificity. This unique sy
 stem allowedunderstanding the interplay between TCR affinity\, avidity and
  antigen densityand their effect on T cell functionality (as measured by c
 ytokine production\, Tcell degranulation and cytotoxicity). We found that 
 TCRs with medium affinityand avidity are more functionality in in-vitro an
 d in-vivo experiments. We alsofound that affinity is related to high TCR d
 ownregulation and antigen trogocytosiswhich can affect T-cells functionali
 ty at high antigen density\, these newfinding can explain the deference in
  functionality between TCRs. The knowledgeobtained in my research could ha
 ve significant impact in understanding basicT-cell biology and decision ma
 king in choose TCR for therapy in response toantigen. 

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