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UID:1126@biology.technion.ac.il

DTSTART;TZID=Asia/Jerusalem:20221026T130000

DTEND;TZID=Asia/Jerusalem:20221026T140000

DTSTAMP:20221031T130053Z

URL:https://biology.technion.ac.il/en/seminars/phd-graduate-seminar/

SUMMARY:PhD Graduate Seminar-Matan Yampolsky [No Categories]
DESCRIPTION:Location: hybrid- in the Faculty Auditorium/ZOOM: https://techn
 ion.zoom.us/j/9849342142  Matan Yampolsky\n Affiliation: \n Host: Dr. Yaro
 n Fuchs and Associate Prof. Shalom-Feuerste Ruby \n Adult stem cells (SCs)
  are tissue-specific resident cells that serve to replenish and maintain t
 he tissue. Two significant SC populations co-exist in the hair follicle: h
 air follicle SCs (HFSCs) and melanocytes SCs (McSCs). These populations ar
 e localized to the lower part of the follicle during the resting phase. Up
 on hair cycle activation these SCs divide generating differentiated progen
 itors for hair construction and pigmentation. As long-lived cells\, SCs ar
 e exposed to environmental stress for long periods of time. Therefore\, th
 ey are equipped with pro-survival mechanisms which prevent their loss by c
 ell death processes\, primarily via apoptosis. While the anti-apoptotic na
 ture of HFSCs has been previously investigated\, very little is known rega
 rding apoptotic regulation in McSCs.\n\nWe found that chemical inhibition 
 of apoptotic related proteins in vivo result in the rapid elimination of M
 cSCs\, leading to irreversible coat-depigmentation (whitening). Interestin
 gly\, local damage to HFSCs niche by hair depilation acquire McSCs with re
 sistance to cell death. Furthermore\, we found that hair depilation induce
 s release of pro-survival factors that enhance McSC resistance to cell dea
 th. These findings pave the way for therapeutic approaches for pigmentatio
 n disorders that originate from McSC-pool depletion. 
LOCATION:hybrid- in the Faculty Auditorium/ZOOM: https://technion.zoom.us/j
 /9849342142

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