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UID:1164@biology.technion.ac.il

DTSTART;TZID=Asia/Jerusalem:20230308T130000

DTEND;TZID=Asia/Jerusalem:20230308T140000

DTSTAMP:20230302T101734Z

URL:https://biology.technion.ac.il/en/seminars/phd-seminar-nimrod-krupnik/

SUMMARY:PhD. Seminar-Nimrod Krupnik [No Categories]
DESCRIPTION:Location: hybrid- in the Faculty Auditorium/ZOOM: https://techn
 ion.zoom.us/j/96415693766  Nimrod Krupnik\n Affiliation: \n Host:Associate
  Prof. Meiri David\n Anti-cancer compounds from East Mediterranean seaweed
 s\n\nThis project is aimed to study the anti-cancer effect of the East Med
 iterranean seaweeds to point out seaweeds of interest for future investiga
 tion and to highlight the importance of understanding their chemical compo
 sition for future drugs development. By Integrating statistical models\, w
 e aim to supply deep insight into potential seaweed-based compounds for fu
 rther research as anti-cancer agents. In this work frame\, we conducted a 
 thorough annual screening of 38 genera of East Mediterranean seaweeds for 
 anti-cancer activity against non-small cell lung carcinoma (NCSLC) A549\, 
 prostate cancer (PC3)\, and colon carcinoma (HT29) cell lines. Based on ou
 r results\, we focused on the red seaweeds Jania rubens and Asparagopsi
 s teaxiformies as potential candidates for the isolation of bioactive com
 pounds. We further analyze each extract with High-Resolution Mass Spectrom
 etry Ultra-High-Performance Liquid Chromatography (HRMS-UHPLC) and analyze
 d the metabolomic profile through GNPS workflow to visualize the Molecular
  Network of natural products. Combining of the biological and the spectral
  data allows us to apply statistical models such as PLS-DA and Spearman’
 s correlation to point out compounds of interest with biological effect. 
LOCATION:hybrid- in the Faculty Auditorium/ZOOM: https://technion.zoom.us/j
 /96415693766

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DTSTART:20221030T010000

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