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UID:1076@biology.technion.ac.il

DTSTART;TZID=Asia/Jerusalem:20220502T130000

DTEND;TZID=Asia/Jerusalem:20220502T140000

DTSTAMP:20220713T072650Z

URL:https://biology.technion.ac.il/en/seminars/prof-gali-prag-department-o
 f-biochemistry-and-molecular-biology-tel-aviv-university/

SUMMARY:Prof. Gali Prag\, Department of Biochemistry and Molecular Biology\
 , Tel Aviv University [No Categories]
DESCRIPTION:Location:   \n Affiliation: \n Host:\n Title: Decoding uniquiti
 n signalsAbstract:UbiquitinE3-ligases regulate most of the cellular pathwa
 ys and consequently are tightlyregulated themselves. Several allosteric me
 chanisms for regulation of HECTE3-ligases that were identified and charact
 erized in our lab will be presented.Deep structural insights combined with
  our unique E. coli-based toolsfacilitated the development of compounds th
 at affect these regulatorymechanisms and opened the door for pharmacologic
 al intervention. We willdemonstrate the downstream effect of these regulat
 ions with a spectrum ofsoluble to membrane proteins including the proteaso
 mal ubiquitin-receptorRpn10\, the endocytic machinery protein Rvs167 (amph
 iphysin in human)\, the RTKprotein EGFR1 and the heart/brain potassium cha
 nnel KCNQ1.Host: Sagi Levy 

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