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UID:1073@biology.technion.ac.il

DTSTART;TZID=Asia/Jerusalem:20220404T130000

DTEND;TZID=Asia/Jerusalem:20220404T140000

DTSTAMP:20220713T072649Z

URL:https://biology.technion.ac.il/en/seminars/prof-igor-ulitsky-departmen
 t-of-biological-regulation-weizmann-institute-of-science/

SUMMARY:Prof. Igor Ulitsky\, Department of Biological Regulation\, Weizmann
  Institute of Science [No Categories]
DESCRIPTION:Location:   \n Affiliation: \n Host:\n Title: Cis-acting gene r
 egulationby long noncoding RNAs.  Abstract:It is now clear that many inte
 rgenic regions in eukaryoticgenomes give rise to a range of processed and 
 regulated transcripts that do notappear to code for functional proteins. A
  subset of these are long (>200nt)\, capped\, and polyadenylated RNAs tran
 scribed by RNA polymerase II andcollectively called long noncoding RNAs (l
 ncRNAs). The recent estimates arethat the human genome may have >50\,000 d
 istinct lncRNA-producing loci\, manyof which show tissue-specific activity
  and dysregulation in human disease\,including cancer and neurodegeneratio
 n.  Giventhe growing number of lncRNAs implicated in human disease or req
 uired forproper development\, fundamental questions that need to be addres
 sed are: WhichlncRNAs are functional? How is functional information encode
 d in the lncRNAsequence? Is this information interpreted in the context of
  the mature or thenascent RNA? What are the identities and functional role
 s of specific sequencedomains within lncRNA genes? These are challenging 
 questions\, primarilybecause of the substantial heterogeneity in mechanism
 s utilized by lncRNAs andthe current paucity of lncRNAs with well-understo
 od mechanisms. We are tacklingthese questions by combination of experiment
 al methods with a focus on lncRNAfunctions in early cell fate decisions an
 d computational methods focused onlncRNA evolution. I will describe our ef
 forts to decode conserved combinationsof short functional sequence element
 s in lncRNAs\, with a particular focus onthe Chaserr/Chd2 and Silc1/Sox11 
 pathways.Host: Sagi Levy 

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