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UID:1081@biology.technion.ac.il

DTSTART;TZID=Asia/Jerusalem:20220606T130000

DTEND;TZID=Asia/Jerusalem:20220606T140000

DTSTAMP:20220713T072650Z

URL:https://biology.technion.ac.il/en/seminars/prof-inna-slutsky-departmen
 t-of-physiology-and-pharmacology-school-of-medicine-tel-aviv-university/

SUMMARY:Prof. Inna Slutsky\, Department of Physiology and Pharmacology\, Sc
 hool of Medicine\, Tel Aviv University [No Categories]
DESCRIPTION:Location:   \n Affiliation: \n Host:\n Title:Activity Homeostas
 is in Neural Circuits: From Basic Principles to MalfunctionsAbstract:Maint
 aining averageactivity level within a set-point range constitutes a fund
 amentalproperty of central neural circuits. Accumulated evidence suggests
  that firingrate distributions and their means represent physiological var
 iables regulatedby homeostatic systems during sleep-wake cycle in central 
 neuralcircuits. While intracellular Ca2+ has long beenhypothesized as a
  feedback control signal\, the source of Ca2+ andthe molecular machinery
  enabling network-wide homeostatic responses remainlargely unknown. I will
  present our experimental framework onidentification of homeostatic regul
 ators in neural circuits. Next\, I willshow our new results on the molec
 ular machinery underlying regulation ofactivity set-points and feedback re
 sponses. Finally\, I will provide an evidenceof state-dependent dysregulat
 ion of activity set-points at the presymptomaticdisease stage in familial 
 Alzheimer’s models.Host: Sagi Levy 

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