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TZID:Asia/Jerusalem

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UID:1133@biology.technion.ac.il

DTSTART;TZID=Asia/Jerusalem:20221114T130000

DTEND;TZID=Asia/Jerusalem:20221114T140000

DTSTAMP:20221106T085210Z

URL:https://biology.technion.ac.il/en/seminars/prof-itai-yanai-cell-state-
 dynamics-and-plasticity-in-tumorigenesis-and-drug-resistance/

SUMMARY:Prof. Itai Yanai - Cell state dynamics and plasticity in tumorigene
 sis and drug resistance [No Categories]
DESCRIPTION:Location: Auditorium\, Faculty of Biology  Itai Yanai\n Affilia
 tion: Institute for Systems Genetics & Biochemistry and Molecular Pharma
 cology\, New York University School of Medicine\n Host:Benny Podbilewicz\n
  Abstract:\n\nCellular plasticity is emerging as an important driving forc
 e underlying cancer progression and drug resistance. In this talk\, I will
  discuss the concept of cancer cell states present in the tumor prior to t
 reatment\, as well as those that accompany resistance to increasing drug d
 oses. In particular\, I will discuss work published in our recent manuscri
 pt 'Cancer cell states recur across tumor types and form specific interact
 ions with the tumor microenvironment' and recent developments in this proj
 ect. Second\, I will discuss our new work of 'Drug-induced adaptation alon
 g a resistance continuum in cancer cells'. In this work we provide evidenc
 e that the dose and treatment duration together drive the resistance of ov
 arian cancer cells to targeted therapy along a trajectory of cellular adap
 tation\, that we denote the ‘resistance continuum’. We report that gra
 dual dose exposure and prolonged treatment promote a continuous increase i
 n fitness\, and show that this process is mediated by evolving transcripti
 onal\, epigenetic and genetic changes that promote multiple cell state tra
 nsitions. The resistance continuum is underpinned by the assembly of gene 
 expression programs and epigenetically reinforced stress response regulati
 on. Using both in vivo and in vitro models\, we found that this process in
 volves widespread reprogramming of cell survival pathways\, including inte
 rferon response\, lineage reprogramming\, metabolic rewiring and oxidative
  stress regulation. Together\, the resistance continuum reveals the dynami
 c nature of cellular adaptation\, and carries implications for cancer ther
 apies\, as initial exposure to lower doses primes cells over time for incr
 eased resistance to higher doses. 
LOCATION:Auditorium\, Faculty of Biology

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