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UID:1079@biology.technion.ac.il

DTSTART;TZID=Asia/Jerusalem:20220523T130000

DTEND;TZID=Asia/Jerusalem:20220523T140000

DTSTAMP:20220713T072650Z

URL:https://biology.technion.ac.il/en/seminars/prof-luca-jovine-department
 -of-biosciences-and-nutrition-karolinska-institute-sweden/

SUMMARY:Prof. Luca Jovine\, Department of Biosciences and Nutrition\, Karol
 inska Institute\, Sweden [No Categories]
DESCRIPTION:Location:   \n Affiliation: \n Host:\n Title: From the Egg to 
 the Kidney… and BackAbstract:Whatconnects the union of gametes at fertil
 ization\, a fundamental processthat ensures the transmission of genetic ma
 terial through the generations\, tothe defense against pathogens causing u
 rinary tractinfection (UTI) — the most common type of non-epidemic bacte
 rial infection inhumans? In my talk\, I will describe how our work on repr
 oductive proteins ledus to visualize uromodulin\, the most abundant protei
 n in human urine\,as well as glycoprotein 2\, a related defense molecule a
 cting at the level ofour gastrointestinal tract. By integrating cryo-EM\, 
 X-ray crystallography andAlphaFold modeling\, these studies not only shed 
 light on the molecular basis ofUTI prevention\, but also revealed an addit
 ional layer of complexity invertebrate egg-sperm recognitionHost: Benjamin
  Podbilewicz 

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