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UID:1072@biology.technion.ac.il

DTSTART;TZID=Asia/Jerusalem:20220328T130000

DTEND;TZID=Asia/Jerusalem:20220328T140000

DTSTAMP:20220713T072649Z

URL:https://biology.technion.ac.il/en/seminars/prof-moran-shalev-benami-de
 partment-of-chemical-and-structural-biology-weizmann-institute-of-science/

SUMMARY:Dr. Moran Shalev-Benami\, Department of Chemical and Structural Bio
 logy\, Weizmann Institute of Science [No Categories]
DESCRIPTION:Location:   \n Affiliation: \n Host:\n The ‘Hunger Games’- 
 Structural Studies of the MC4 Receptor Reveal Mechanism for SatietyHost: S
 agi LevyAbstract: Obesity is aglobal epidemic causing increased morbidity
  and impaired quality of life. Themelanocortin receptor 4 (MC4R) is at the
  crux of appetite\, energy homeostasis\,and body-weight control in the cen
 tral nervous system and is a prime target foranti-obesity drugs. MC4R is a
  member of the GPCR superfamily and signalsprimarily through the heterotri
 meric G protein Gs. Throughcombination of structural-\, biochemical- and c
 ellular- studies we determinedthe cryo-EM structure of the human MC4R-Gs s
 ignaling complex\, andexplored the cellular conduits for signal transducti
 on in health and disease.The work reveals the mechanism of MC4R activation
 \, highlighting a molecularswitch that signals satiation. These results fi
 ll a major gap in understandingMC4R activation and guide the design of fut
 ure weight management drugs. 

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