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UID:1074@biology.technion.ac.il

DTSTART;TZID=Asia/Jerusalem:20220411T130000

DTEND;TZID=Asia/Jerusalem:20220411T140000

DTSTAMP:20220713T072649Z

URL:https://biology.technion.ac.il/en/seminars/prof-naama-barkai-departmen
 t-of-molecular-genetics-weizmann-institute-of-science/

SUMMARY:Prof. Naama Barkai\, Department of Molecular Genetics\, Weizmann In
 stitute of Science [No Categories]
DESCRIPTION:Location:   \n Affiliation: \n Host:\n Title: Howtranscription 
 factors recognize binding sites in large genomes: the role ofintrinsically
  disordered regions.  Abstract:Transcription factors (TFs) regulate genee
 xpression by binding DNA sequences recognized by their DNA-binding domains
  (DBDs).DBD-recognized motifs are short and highly abundant in genomes. Th
 e ability ofTFs to bind a specific subset of motif-containing sites\, and 
 to do so rapidlyupon activation\, is fundamental for gene expression in al
 l eukaryotes. Despiteextensive interest\, our understanding of the TF-targ
 et search process isfragmented\; I will discuss our results which implicat
 e intrinsically disorderedregions (IDRs) in this process\, and the possibl
 e implications ofthe 'distributed specificity' paradigm implemented by th
 ese regions in explainingbinding specificity while reducing the TF-target 
 search time.  

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