Prof. Nissan Yissachar, The Mina and Everard Goodman Faculty of Life Sciences Bar-Ilan Institute of Nanotechnology and Advanced Materials The Gonda Multidisciplinary Brain Research Center Bar-Ilan University, Israel [No Categories]
2022-06-20 13:00 - 14:00 (Asia/Jerusalem)
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Title: Thinking outsidethe mouse: ex-vivo dissections of host-microbiome cross-talksKey points: · We developed a novel 3D gut organ culture system, as a uniquetool for studying host-microbiome interactions.· Enteric neuro-immune-microbiome cross-talks control regulatoryand effector T-cells development.· The gut organ culture system provides insights into thefunctional consequences of microbial dysbiosis in mice and humans. · Development of a novel ‘on-chip gut permeability assay’, for trackingreal-time changes in gut permeability.· Dysbiotic, chemotherapy-disrupted microbiome alters gutpermeability, suggesting that barrier-modulating microbes may promotechemotherapy-induced gastrointestinal inflammation. Host: Sagi Levy
