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UID:1084@biology.technion.ac.il

DTSTART;TZID=Asia/Jerusalem:20220627T130000

DTEND;TZID=Asia/Jerusalem:20220627T140000

DTSTAMP:20220713T072650Z

URL:https://biology.technion.ac.il/en/seminars/prof-shalev-itzkovitz-depar
 tment-of-molecular-cell-biology-weizmann-institute-of-science/

SUMMARY:Prof. Shalev Itzkovitz\, Department of Molecular Cell Biology\, Wei
 zmann Institute of Science [No Categories]
DESCRIPTION:Location:   \n Affiliation: \n Host:\n Title: Spatial transcri
 ptomics ofmammalian tissuesAbstract: Mammaliantissues are composed of rep
 eating anatomical units that are polarized bymorphogens or directional blo
 od flow. As a result\, cells at different tissuecoordinates sub-specialize
  in distinct physiological functions\, a phenomenontermed ‘zonation’. 
 I will describe approaches based on single cell RNAsequencing\, single mol
 ecule transcript imaging and spatial transcriptomics tocharacterize zonati
 on in the key metabolic organs – the liver and intestine. Iwill discuss 
 emerging design principles that facilitate optimal organ functionthrough s
 patial division of labor. I will also describe the impact of zonationon di
 verse pathological states. Host: Sagi Levy 

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