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TZID:Asia/Jerusalem

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UID:1007@biology.technion.ac.il

DTSTART;TZID=Asia/Jerusalem:20211122T130000

DTEND;TZID=Asia/Jerusalem:20211122T140000

DTSTAMP:20211118T122724Z

URL:https://biology.technion.ac.il/en/seminars/prof-yoav-arava-faculty-of-
 biology-technion/

SUMMARY:Prof. Yoav Arava\, Faculty of Biology\, Technion [No Categories]
DESCRIPTION:Location:   \n Affiliation: \n Host:\n Title: Factors andmechan
 isms in mRNA localization and translationAbstract:The expression ofgenes i
 nto a functional unit is regulated at multiple steps\, from the initial RN
 Atranscription\, through its processing\, intracellular localization\, and
  finally proteintranslation and degradation. In my talk I will focus on tw
 o of these steps thatmy lab had been working on for several years: mRNA lo
 calization and translation.First\, I will describe work that we did on dec
 iphering the factors that areinvolved in localization of mRNA to the proxi
 mity of mitochondria and thefunctional consequences of this localization. 
 Through extensive work in yeastwe identified several protein factors that 
 coordinate localization and most recentlyuncovered an unexpected role for 
 localization in transport of mRNA alongneuronal axons. In the second part 
 of my talk\, I will focus on RNA binding factorsthat regulate mRNA transla
 tion. We recently discovered that a well-studiedfamily of tRNA binding pro
 teins can also bind mRNA. mRNA binding occurs atelement that mimic the cog
 nate tRNA binding sites and allows regulation oftarget mRNA translation. T
 hus\, binding two types of RNA (i.e. tRNA and mRNA) bythe same RNA binding
  protein allows coordination between tRNA charging and mRNAtranslation\, a
 nd may have significant implications to cellular physiology inhealth and d
 isease. Host: Sagi Levy 

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DTSTART:20211031T010000

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