BEGIN:VCALENDAR

VERSION:2.0

PRODID:-//wp-events-plugin.com//7.2.2.1//EN

TZID:Asia/Jerusalem

X-WR-TIMEZONE:Asia/Jerusalem
BEGIN:VEVENT

UID:1005@biology.technion.ac.il

DTSTART;TZID=Asia/Jerusalem:20211108T130000

DTEND;TZID=Asia/Jerusalem:20211108T140000

DTSTAMP:20211118T110055Z

URL:https://biology.technion.ac.il/en/seminars/prof-yuval-garini-faculty-o
 f-biomedical-engineering-technion-2/

SUMMARY:Prof. Yuval Garini\, Faculty of Biomedical Engineering\, Technion [
 No Categories]
DESCRIPTION:Location:   \n Affiliation: \n Host:\n The multi-scale structur
 e of chromatin in the nucleusYuval GariniBiomedical Engineering Faculty\,T
 echnionYuval.garini@technion.ac.il  \,  www.garini-lab.com/  The DNA in
  a human cell which is ~3 meters long is packed in a ~10 μmradius nucleus
 . The DNA is immersed in a condensed soup of proteins\, RNA andenzymes and
  it is highly dynamic while taking part in many nuclear processessuch as p
 rotein expression and cell division.Nevertheless\, it must stay organized 
 to prevent chromosomeentanglement and for genome expression control. Study
 ing this nanometer –micrometer scale structure is difficult\, as it requ
 ires to use both highspatial and temporal resolutions for studying its cha
 racteristics.Studying the nucleus organization is complex and we developed
  variousmethods\, including live-cell imaging\, time-resolved spectroscopy
 \, chromosomeconformation capture (3C)\, FISH\, spectral karyotyping and s
 ingle moleculemethods such as AFM. The results are followed by biophysical
  modeling and allowedus to identify that a single protein\, lamin A\, is t
 he most important player inthe chromatin organization mechanism. It forms 
 chromatin loops therebyrestricting the chromatin dynamics in the whole nuc
 leus volume. Other proteinshave a secondary effect.We conclude that the or
 ganization of the DNA in the nucleus is basedon a “chromatin network”\
 , a structure that we describe here for the first time.Host: Sagi Levy 

END:VEVENT

BEGIN:VTIMEZONE

TZID:Asia/Jerusalem

X-LIC-LOCATION:Asia/Jerusalem

BEGIN:STANDARD

DTSTART:20211031T010000

TZOFFSETFROM:+0300

TZOFFSETTO:+0200

TZNAME:IST

END:STANDARD

END:VTIMEZONE
END:VCALENDAR