BEGIN:VCALENDAR

VERSION:2.0

PRODID:-//wp-events-plugin.com//7.2.2.1//EN

TZID:Asia/Jerusalem

X-WR-TIMEZONE:Asia/Jerusalem
BEGIN:VEVENT

UID:1187@biology.technion.ac.il

DTSTART;TZID=Asia/Jerusalem:20230716T120000

DTEND;TZID=Asia/Jerusalem:20230716T130000

DTSTAMP:20230709T141418Z

URL:https://biology.technion.ac.il/en/seminars/special-seminar-prof-cynthi
 a-wolberger-histone-h2b-ubiquitination-in-transcription-regulation/

SUMMARY:Special Seminar - Prof. Cynthia Wolberger-Histone H2B ubiquitinatio
 n in transcription regulation [No Categories]
DESCRIPTION:Location: Faculty Of Biology Auditorium  Prof. Cynthia Wolberge
 r \n Affiliation: \n Host:Prof. Michael Glickman and Prof. Ashraf Brik.\n 
 Histone H2B ubiquitination in transcription regulation\n\nAbstract \n\nPos
 t-translational modifications of histones play a central role in regulatin
 g all cellular processes requiring access to DNA. Cross-talk between histo
 ne modifications\, in which one histone modification regulates deposition 
 of a second\, provides an additional layer of regulation and specificity. 
 Monoubiquitinated histone H2B-K120 (humans\; K123 in yeast) is a hallmark 
 of actively transcribed genes that plays multiple roles in activating tran
 scription. Our structural studies have revealed how H2B is specifically ub
 iquitinated and deubiquitinated\, as well as the mechanism by which H2B ub
 iquitination stimulates the enzymes that methylate histone H3K4 and H3K79\
 , two other marks of actively-transcribed genes. H2B ubiquitination also r
 egulates access to the nucleosome acidic patch\, a hotspot for interaction
 s with other chromatin-modifying enzymes\, and our studies have provided i
 nsights into the underlying mechanism. We will also present work on identi
 fying novel inhibitors of USP22\, an H2B deubiquitinating enzyme subunit o
 f the SAGA coactivator.\n\n&nbsp\;\n\n&nbsp\; 
LOCATION:Faculty Of Biology Auditorium

END:VEVENT

BEGIN:VTIMEZONE

TZID:Asia/Jerusalem

X-LIC-LOCATION:Asia/Jerusalem

BEGIN:DAYLIGHT

DTSTART:20230324T030000

TZOFFSETFROM:+0200

TZOFFSETTO:+0300

TZNAME:IDT

END:DAYLIGHT

END:VTIMEZONE
END:VCALENDAR