פוקס – פקולטה לביולוגיה Biology Faculty

Education/ Resume: Education/ Resume:

2020 – Present EMBO Young Investigator.

2017 – Present Faculty member at the German-Israeli Helmholtz Research School.

2016 – Present Guest Investigator at the Rockefeller University.

2015 – Present Faculty member of the Technion Integrated Cancer Center.

2015 – 2018 Deloro Career Advancement Chair in the Leaders of Science and Technology program.

2014 – Present Faculty member of the Technion Lokey Interdisciplinary Center for Life Sciences & Engineering.

2014 – 2016 Adjunct Faculty at the Rockefeller University.

2014 – Present Assistant Professor. Head, Laboratory of Stem Cell Biology and Regenerative Medicine. The Faculty of Biology. Technion-Israel Institute of Technology.

2010-2014 Post-Doc. Steller Laboratory of Apoptosis and Cancer Biology. Howard Hughes Medical Institute, the Rockefeller University.

2004- 2010 Direct Ph.D. Track for Outstanding Students. Technion-Israel Institute of Technology.

קרא עוד

Research Summary

The Fuchs laboratory branches out into several different directions of research. We seek to understand how stem cells use the apoptotic machinery for their elimination and the effect this has on different aspects of stem cell biology and stem cell–dependent processes. We have established a comprehensive in vivo system that enables us to investigate the function and regulation of key apoptotic proteins in distinct stem cell populations. By combining advanced multicolor lineage tracing with intravital imaging, we examine how the manipulation of apoptotic pathways affects not only stem cells but also their progeny during regeneration and tumor development.

We recently started to explore how the apoptotic machinery can be harnessed for various functions outside the realm of cell death. Intriguingly, we find that “apoptotic” proteins regulate cell proliferation, organ size, and tissue regeneration independently of their function in apoptosis.In addition, we seek to uncover novel stem cell populations and elucidate the role they play in tissue homeostasis, tissue repair, and tumor formation. We also have recently established novel organoid platforms and use them as models for understanding the behavior and contribution of different stem cells.

It is our hope that our research may be translated into novel stem cell and apoptosis-based approaches for regenerative medicine and tumor therapy.

קרא עוד

Selected Awards:

The Juludan Research Prize (2020).

European Molecular Biology Organization (EMBO) Young Investigator Award (2019; start 2020).

The Daniel Shiran Memorial Research Prize (2019).

The Wolf Foundation Krill Prize for Excellence in Scientific Research (2019).

The American Association for the Advancement of Science (AAAS) Science and Sartorius Grand Prize for Regenerative Medicine and Cell Therapy (2019).

The Council for Higher Education Alon Fellowship for New Investigator (2015).

The Deloro Career Advancement Chair in The Leader in Science and Technology Program. Technion-Israel Institute of Technology. Israel (2015).

Awarded the Postdoctoral Shuman Fellowship. The Rockefeller University, USA (2011-2013).

Vivian Konigsberg Award and Faculty award for Outstanding Teaching Assistant. Technion-Israel Institute of Technology. Israel (2009, 2010, 2010).

The Jacobs Award for Scientific Excellence. Technion-Israel Institute of Technology. Israel (2006).

קרא עוד

Key Publications:

oren E. and Fuchs Y.* (2021) Modes of Regulated Cell Death in Cancer. Cancer Discovery.
Fuchs Y.* (2019) Harnessing Stem Cell Death for Tissue Regeneration. Science 363, 6431 1050-1051.

Feldman A., Dzimitry M., Maor I., Sedov E., Koren E., Yosefzon Y, Shlomi T. and Fuchs Y.* (2019) Single Blimp1⁺ cells can generate sebaceous gland organoids in vitro. Nature Communications 10, 2348.
Yosefzon Y., Soteriou D., Feldman A., Kostic L., Koren E., Brown S., Ankawa R., Sedov E., Glaser F. and Fuchs Y.*, (2018). Caspase-3 Regulates YAP-dependent Organ Size and Skin Regeneration. Molecular Cell 70, 4, 573-58.
Soteriou D. and Fuchs Y.* (2018). A Matter of Life and Death: Stem Cell Survival in Tissue Regeneration and Tumour Formation. Nature Review Cancer, 8:187-201.
Ankawa R. and Fuchs Y.* (2018) More than one way to skin a wound. Cell Stem Cell 23, 636-638.Koren E., Yosefzon Y., Ankawa R., Soteriou D., Jacob A., Nevelsky A., Ben-Yosef R., Bar-Sela G., Fuchs Y.* (2018) ARTS Mediates Apoptosis and Regeneration of the Intestinal Stem Cell Niche. Nature Communications 9:4582
Fuchs Y.* and Steller H*. (2015): Live to die another way- Modes of programmed cell death and the signals emanating from dying cells. Nature Review Molecular Cell Biology. 16,6, 329-344.
Fuchs Y., Brown S., Gorenc T., Rodriguez J., Fuchs E. and Steller H., (2013): Sept4/ARTS regulates stem-cell apoptosis and skin regeneration. Science 341, 6143 286-289.
Fuchs Y. and Steller H. (2011): Programmed cell death in animal development and disease. Cell 147,4,742-58.

קרא עוד

Open Positions:

The lab always welcomes applications from outstanding students. The research environment is incredibly stimulating, but most importantly fun!

ירון פוקס