BEGIN:VCALENDAR VERSION:2.0 PRODID:-//wp-events-plugin.com//7.2.2.1//EN TZID:Asia/Jerusalem X-WR-TIMEZONE:Asia/Jerusalem BEGIN:VEVENT UID:1328@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20260629T130000 DTEND;TZID=Asia/Jerusalem:20260629T140000 DTSTAMP:20251029T121516Z URL:https://biology.technion.ac.il/en/seminars/faculty-seminar-prof-avraha m-yaron/ SUMMARY:Faculty Seminar- Prof. Avraham Yaron [No Categories] DESCRIPTION:Location: Faculty Of Biology Auditorium \n Affiliation: Weizma nn Institute of Science\n Host:Dr\, Maya Maor-Nof \n LOCATION:Faculty Of Biology Auditorium END:VEVENT BEGIN:VEVENT UID:1337@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20260624T123000 DTEND;TZID=Asia/Jerusalem:20260624T140000 DTSTAMP:20251202T065929Z URL:https://biology.technion.ac.il/en/seminars/bridge-to-industry-tbd-5/ SUMMARY:Bridge to Industry - TBD [No Categories] DESCRIPTION:Location: Faculty Of Biology Auditorium \n Affiliation: \n Hos t:Dr. Dror Melamed\n LOCATION:Faculty Of Biology Auditorium END:VEVENT BEGIN:VEVENT UID:1327@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20260615T130000 DTEND;TZID=Asia/Jerusalem:20260615T140000 DTSTAMP:20251029T121400Z URL:https://biology.technion.ac.il/en/seminars/faculty-seminar-dr-eyal-kar zbrun/ SUMMARY:Faculty Seminar- Dr. Eyal Karzbrun [No Categories] DESCRIPTION:Location: Faculty Of Biology Auditorium \n Affiliation: Weizma nn Institute of Science\n Host:Dr\, Maya Maor-Nof \n LOCATION:Faculty Of Biology Auditorium END:VEVENT BEGIN:VEVENT UID:1326@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20260608T130000 DTEND;TZID=Asia/Jerusalem:20260608T140000 DTSTAMP:20251029T121203Z URL:https://biology.technion.ac.il/en/seminars/faculty-seminar-dr-abed-man sour/ SUMMARY:Faculty Seminar- Dr. Abed Mansour [No Categories] DESCRIPTION:Location: Faculty Of Biology Auditorium \n Affiliation: The He brew University of Jerusalem\n Host:Dr\, Maya Maor-Nof \n LOCATION:Faculty Of Biology Auditorium END:VEVENT BEGIN:VEVENT UID:1325@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20260601T130000 DTEND;TZID=Asia/Jerusalem:20260601T140000 DTSTAMP:20251029T121100Z URL:https://biology.technion.ac.il/en/seminars/faculty-seminar-dr-shahar-a lon/ SUMMARY:Faculty Seminar- Dr. Shahar Alon [No Categories] DESCRIPTION:Location: Faculty Of Biology Auditorium \n Affiliation: Bar I lan University\n Host:Dr\, Maya Maor-Nof \n 13 LOCATION:Faculty Of Biology Auditorium END:VEVENT BEGIN:VEVENT UID:1336@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20260527T123000 DTEND;TZID=Asia/Jerusalem:20260527T140000 DTSTAMP:20251202T065904Z URL:https://biology.technion.ac.il/en/seminars/bridge-to-industry-tbd-4/ SUMMARY:Bridge to Industry - TBD [No Categories] DESCRIPTION:Location: Faculty Of Biology Auditorium \n Affiliation: \n Hos t:Dr. Dror Melamed\n LOCATION:Faculty Of Biology Auditorium END:VEVENT BEGIN:VEVENT UID:1324@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20260518T130000 DTEND;TZID=Asia/Jerusalem:20260518T140000 DTSTAMP:20251029T120923Z URL:https://biology.technion.ac.il/en/seminars/faculty-seminar-dr-inbal-be nhar/ SUMMARY:Faculty Seminar- Dr. Inbal Benhar [No Categories] DESCRIPTION:Location: Faculty Of Biology Auditorium \n Affiliation: The He brew University of Jerusalem\n Host:Dr\, Maya Maor-Nof \n LOCATION:Faculty Of Biology Auditorium END:VEVENT BEGIN:VEVENT UID:1323@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20260511T130000 DTEND;TZID=Asia/Jerusalem:20260511T140000 DTSTAMP:20251029T120819Z URL:https://biology.technion.ac.il/en/seminars/faculty-seminar-dr-aldema-s as-chen/ SUMMARY:Faculty Seminar- Dr. Aldema Sas-Chen [No Categories] DESCRIPTION:Location: Faculty Of Biology Auditorium \n Affiliation: Tel Av iv University\n Host:Dr\, Maya Maor-Nof \n LOCATION:Faculty Of Biology Auditorium END:VEVENT BEGIN:VEVENT UID:1322@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20260504T130000 DTEND;TZID=Asia/Jerusalem:20260504T140000 DTSTAMP:20251029T120703Z URL:https://biology.technion.ac.il/en/seminars/faculty-seminar-prof-ofer-y izhar/ SUMMARY:Faculty Seminar- Prof. Ofer Yizhar [No Categories] DESCRIPTION:Location: Faculty Of Biology Auditorium \n Affiliation: Weizma nn Institute of Science\n Host:Dr\, Maya Maor-Nof \n LOCATION:Faculty Of Biology Auditorium END:VEVENT BEGIN:VEVENT UID:1334@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20260429T123000 DTEND;TZID=Asia/Jerusalem:20260429T140000 DTSTAMP:20260319T145405Z URL:https://biology.technion.ac.il/en/seminars/bridge-to-industry-tbd-2/ SUMMARY:Bridge to Industry - Bioconvergence: Technologies\, Applications\, and Emerging Opportunities - Dr. Reut Guy [No Categories] DESCRIPTION:Location: Faculty Of Biology Auditorium \n Affiliation: \n Hos t:Dr. Dror Melamed\n Bioconvergence integrates biology with engineering\, computation\, materials science\, and physics\, enabling the development o f powerful platform technologies with applications across a wide range of domains\, including healthcare\, energy\, manufacturing\, environment\, an d agriculture.\n\nThis seminar will present the vision and rationale behin d Israel’s National Bioconvergence Program\, which aims to leverage Isra el’s multidisciplinary research strengths to advance this emerging field . As a concrete use case\, the seminar will draw on a recent study conduct ed by the Israel Innovation Authority that examined the potential of bioco nvergence technologies to address diverse climate challenges. The session will present the study’s methodology and key insights\, including a mapp ing of technologies to diverse application areas. Real-world applications will be showcased\, highlighting the role of academia in building a resili ent\, innovation-driven ecosystem. LOCATION:Faculty Of Biology Auditorium END:VEVENT BEGIN:VEVENT UID:1321@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20260427T130000 DTEND;TZID=Asia/Jerusalem:20260427T140000 DTSTAMP:20251029T120404Z URL:https://biology.technion.ac.il/en/seminars/faculty-seminar-prof-mike-f ainzilber/ SUMMARY:Faculty Seminar-Prof. Mike Fainzilber [No Categories] DESCRIPTION:Location: Faculty Of Biology Auditorium \n Affiliation: Weizma nn Institute of Science\n Host:Dr\, Maya Maor-Nof \n LOCATION:Faculty Of Biology Auditorium END:VEVENT BEGIN:VEVENT UID:1320@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20260420T130000 DTEND;TZID=Asia/Jerusalem:20260420T140000 DTSTAMP:20251029T120038Z URL:https://biology.technion.ac.il/en/seminars/faculty-seminar-prof-eran-m osherer/ SUMMARY:Faculty Seminar-Prof. Eran Mosherer [No Categories] DESCRIPTION:Location: Faculty Of Biology Auditorium \n Affiliation: The He brew University of Jerusalem\n Host:Dr\, Maya Maor-Nof \n 1 LOCATION:Faculty Of Biology Auditorium END:VEVENT BEGIN:VEVENT UID:1319@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20260413T130000 DTEND;TZID=Asia/Jerusalem:20260413T140000 DTSTAMP:20251029T115929Z URL:https://biology.technion.ac.il/en/seminars/faculty-seminar-dr-iris-dro r/ SUMMARY:Faculty Seminar- Dr. Iris Dror [No Categories] DESCRIPTION:Location: Faculty Of Biology Auditorium \n Affiliation: MIGAL - Galilee Research Institute\n Host:Dr\, Maya Maor-Nof \n LOCATION:Faculty Of Biology Auditorium END:VEVENT BEGIN:VEVENT UID:1362@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20260331T133000 DTEND;TZID=Asia/Jerusalem:20260331T140000 DTSTAMP:20260329T095409Z URL:https://biology.technion.ac.il/en/seminars/msc-graduate-seminar-nitzan -sioni/ SUMMARY:Msc Graduate Seminar-Nitzan Sioni [No Categories] DESCRIPTION:Location: Faculty Auditorium + Zoom https://technion.zoom.us/j /91848871351 Nitzan Sioni \n Affiliation: \n Host:Associate Prof. David M eiri\n The Effect of Metabolites from Psilocybin-Producing Fungi on the Gu t Microbiome\n\nThis research investigates the impact of PAN_CINC mushroom extract on the gut-brain axis\, specifically focusing on its role in modu lating the host's serotonin system. Our findings demonstrate that the extr act significantly increases the expression of TPH-1 and SERT in colonic ti ssue. Interestingly\, this effect is microbiome-dependent\, as the extract promotes the growth of key beneficial bacteria\, such as Roseburia and Ru minococcus. These bacteria ferment fibers to produce butyrate\, which acts as a signaling molecule to induce serotonin synthesis. Overall\, this stu dy highlights the potential of medicinal mushrooms to improve gut health a nd regulate serotonin through microbial mediation.\n\n \; LOCATION:Faculty Auditorium + Zoom https://technion.zoom.us/j/91848871351 END:VEVENT BEGIN:VEVENT UID:1361@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20260331T130000 DTEND;TZID=Asia/Jerusalem:20260331T133000 DTSTAMP:20260329T094809Z URL:https://biology.technion.ac.il/en/seminars/msc-graduate-seminar-shoval -ravitzky/ SUMMARY:Msc Graduate Seminar-Shoval Ravitzky [No Categories] DESCRIPTION:Location: Faculty Auditorium + Zoom https://technion.zoom.us/j /91848871351 Shoval Ravitzky \n Affiliation: Associate Prof. David Meiri\ n Host:\n In Vitro Screening of the Neuroplastic Effect of Psychoactive Mu shroom Extracts\n\nNeuroplasticity underlies learning\, memory\, and cogni tive flexibility\, and its impairment is a hallmark of neurological and ps ychiatric disorders. While psychedelic compounds are associated with plast icity-enhancing effects\, the neuroplastic potential of whole mushroom ext racts remains poorly characterized. Here\, we tested whether whole extract s from neuroactive fungi modulate structural plasticity using an in vitro neuronal model and a high-throughput neurite analysis system we developed. Psilocybin-producing mushrooms showed species-specific effects\, likely r eflecting differences in metabolic composition\, whereas Amanita muscaria showed no detectable structural or molecular effects. Together\, these fin dings demonstrate that whole mushroom extracts differentially affect neuro nal plasticity and established a platform for identifying novel modulators of neuronal growth.\n\n \; LOCATION:Faculty Auditorium + Zoom https://technion.zoom.us/j/91848871351 END:VEVENT BEGIN:VEVENT UID:1318@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20260330T130000 DTEND;TZID=Asia/Jerusalem:20260330T140000 DTSTAMP:20251029T115752Z URL:https://biology.technion.ac.il/en/seminars/faculty-seminar-assistant-p rofessor-itay-koren/ SUMMARY:Faculty Seminar-Assistant Prof. Itay Koren [No Categories] DESCRIPTION:Location: Faculty Of Biology Auditorium \n Affiliation: Bar Il an University\n Host:Dr\, Maya Maor-Nof \n LOCATION:Faculty Of Biology Auditorium END:VEVENT BEGIN:VEVENT UID:1356@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20260330T130000 DTEND;TZID=Asia/Jerusalem:20260330T140000 DTSTAMP:20260323T123518Z URL:https://biology.technion.ac.il/en/seminars/phd-graduate-seminar-jonath an-greenbaum/ SUMMARY:PhD Graduate Seminar-Jonathan Greenbaum [No Categories] DESCRIPTION:Location: Hybrid - in the Faculty Auditorium /ZOOM: https://tec hnion.zoom.us/j/94149580805 Jonathan Greenbaum\n Affiliation: \n Host:Pro f. Debbie Lindell \n Host availability effects on evolution of generalist and specialist cyanophages\n\nObligate parasites such as bacteriophages ar e dependent on the availability of a sensitive host to persist. Natural en vironments pose challenges for survival\, with periods of unavailability o f such a host and gradual loss of infectivity of phages. Despite the impor tance of host availability to bacteriophages in natural environments\, kno wledge regarding evolution of ecologically prevalent bacteriophages is lac king. Here\, we characterized the evolution of cyanobacteria-infecting bac teriophages (cyanophages) when propagating in the presence of a sensitive host. In addition\, we characterized cyanophage evolution in the presence of increasing amounts of distinct resistant strains to which they can atta ch\, while reducing the amount of sensitive host availability. Most cyanop hage populations adapted to better infect the sensitive host. No evidence for changes in host range was observed. Whole-genome sequencing revealed p atterns of convergent evolution\, host availability-specific mutations\, a nd genes associated with adaptation. Specifically\, we found a putative ho lin\, a common phage protein not previously characterized in marine cyanop hages\, that affects the length of the infection cycle. In addition\, we f ound a decrease in attachment to both sensitive and resistant strains\, su ggesting a balance between infection characteristics beneficial in some ho st availabilities\, and detrimental in others. In addition\, we found that cyanophage evolution can have an unexpected effect on the growth of cyano bacteria not involved in the process of evolution. Together\, these findin gs shed light on the complexity of cyanophage-cyanobacteria interactions i n natural environments\, highlighting some unexpected outcomes of these in teractions for cyanophage persistence strategies and evolution of infectio n characteristics. LOCATION:Hybrid - in the Faculty Auditorium /ZOOM: https://technion.zoom.us /j/94149580805 END:VEVENT BEGIN:VEVENT UID:1359@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20260324T133000 DTEND;TZID=Asia/Jerusalem:20260324T140000 DTSTAMP:20260323T123258Z URL:https://biology.technion.ac.il/en/seminars/msc-graduate-seminar-nada-s widan/ SUMMARY:Msc Graduate Seminar-Nada Swidan [No Categories] DESCRIPTION:Location: Hybrid - in the Faculty Auditorium /ZOOM: https://tec hnion.zoom.us/j/96483815055 Nada Swidan\n Affiliation: Associate Prof. Ay elet Lamm\n Host:\n Characterizing A-G Mismatch Signatures Associated with A-to-I RNA Editing and m6A in C. elegans\n\nRNA molecules can undergo che mical modifications that influence how they are processed and regulated. U sing Caenorhabditis elegans as a model system\, we analyze RNA sequencing datasets to investigate different types of RNA modifications. Focusing on A-to-I RNA editing\, we identify candidate editing sites in mature and pre cursor microRNAs and examine their expression dynamics during embryonic de velopment. RNA sequencing data frequently contain nucleotide mismatches re lative to the reference genome\; while some can be explained by A-to-I RNA editing\, many remain unexplained. We therefore analyze transcriptome-wid e data to explore whether characteristic mismatch patterns in mRNA reads m ay reflect signatures associated with m6A modification. Together\, these a nalyses provide insight into how RNA modifications shape RNA regulation an d suggest potential avoidance between different RNA modification pathways. athways. LOCATION:Hybrid - in the Faculty Auditorium /ZOOM: https://technion.zoom.us /j/96483815055 END:VEVENT BEGIN:VEVENT UID:1360@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20260324T130000 DTEND;TZID=Asia/Jerusalem:20260324T133000 DTSTAMP:20260323T123206Z URL:https://biology.technion.ac.il/en/seminars/msc-graduate-seminar-christ een-elmor/ SUMMARY:Msc Graduate Seminar- Christeen Elmor [No Categories] DESCRIPTION:Location: Christeen Elmor\n Affiliation: \n Host:Prof. Nabie h Ayoub\n RBM15B–DDX21 coordinates m6A writer assembly to regulate gene expression\n\nN6-methyladenosine (m6A) is the most abundant mRNA modificat ion in eukaryotes\, with established roles in DNA damage response and canc er. m6A is deposited co-transcriptionally by the METTL3-METTL14 methyltran sferase complex (MTC)\, yet the mechanisms governing MTC assembly and chro matin recruitment remain poorly defined. Here\, we identify RBM15B as a cr itical regulator of MTC integrity\, demonstrating that its RRM1 domain dir ectly mediates interaction with METTL3 and promotes efficient complex form ation. Interactome analysis further reveals that the RNA helicase DDX21 dr ives RBM15B chromatin association\, placing DDX21 upstream in the regulato ry cascade. Consistently\, RBM15B-dependent MTC chromatin recruitment faci litates RNA Pol II occupancy\, linking this axis to active transcription. Collectively\, our data establish a hierarchical pathway of DDX21-RBM15B- MTC that coordinates co-transcriptional m6A deposition\, uncovering a new layer of epitranscriptomic regulation with implications for cancer biology END:VEVENT BEGIN:VEVENT UID:1358@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20260323T130000 DTEND;TZID=Asia/Jerusalem:20260323T140000 DTSTAMP:20260311T090844Z URL:https://biology.technion.ac.il/en/seminars/phd-graduate-seminar-3/ SUMMARY:PhD Graduate Seminar- Ofir Levin-Piaeda [No Categories] DESCRIPTION:Location: Hybrid - in the Faculty Auditorium /ZOOM: https://tec hnion.zoom.us/j/5447024192 Ofir Levin-Piaeda \n Affiliation: \n Hos t:Prof. Reiter Yoram\n  \;\n\nBeyond Signal Strength: Combining biophy sical properties with co-stimulatory signals to design optimal TCRL-based CAR-T cells\n\n \;\n\nTo address the limited efficacy of CAR T-cell th erapy in solid tumors\, we systematically optimized the intracellular sign aling domains of TCR-Like (TCRL) CARs targeting melanoma. Our research ide ntifies the advanced 3rd-generation CAR and the dual-signal novel hybrid c onstructs as lead candidates\, demonstrating superior targeted cytotoxicit y across varying antigen densities without triggering immediate inhibitory overload. Crucially\, transcriptomic analysis reveals these engineered T- cells succeed by reprogramming their genetic profile toward "metabolic int elligence"—prioritizing long-term metabolic fitness over mere signal amp lification to prevent exhaustion and sustain anti-tumor activity. LOCATION:Hybrid - in the Faculty Auditorium /ZOOM: https://technion.zoom.us /j/5447024192 END:VEVENT BEGIN:VEVENT UID:1357@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20260316T130000 DTEND;TZID=Asia/Jerusalem:20260316T140000 DTSTAMP:20260311T081001Z URL:https://biology.technion.ac.il/en/seminars/phd-graduate-seminar-jonath an-greenbaum-2/ SUMMARY:PhD Graduate Seminar-Jonathan Greenbaum [No Categories] DESCRIPTION:Location: Hybrid - in the Faculty Auditorium /ZOOM: https://te chnion.zoom.us/j/94149580805 Jonathan Greenbaum\n Affiliation: \n Host:Pr of. Debbie Lindell \n “Host availability effects on evolution of general ist and specialist cyanophages”\n\nObligate parasites such as bacterioph ages are dependent on the availability of a sensitive host to persist. Nat ural environments pose challenges for survival\, with periods of unavailab ility of such a host and gradual loss of infectivity of phages. Despite th e importance of host availability to bacteriophages in natural environment s\, knowledge regarding evolution of ecologically prevalent bacteriophages is lacking. Here\, we characterized the evolution of cyanobacteria-infect ing bacteriophages (cyanophages) when propagating in the presence of a sen sitive host. In addition\, we characterized cyanophage evolution in the pr esence of increasing amounts of distinct resistant strains to which they c an attach\, while reducing the amount of sensitive host availability. Most cyanophage populations adapted to better infect the sensitive host. No ev idence for changes in host range was observed. Whole-genome sequencing rev ealed patterns of convergent evolution\, host availability-specific mutati ons\, and genes associated with adaptation. Specifically\, we found a puta tive holin\, a common phage protein not previously characterized in marine cyanophages\, that affects the lengtah of the infection cycle. In additio n\, we found a decrease in attachment to both \n\n \;\n\nsensitive and resistant strains\, suggesting a balance between infection characteristic s beneficial in some host availabilities\, and detrimental in others. In a ddition\, we found that cyanophage evolution can have an unexpected effect on the growth of cyanobacteria not involved in the process of evolution. Together\, these findings shed light on the complexity of cyanophage-cyano bacteria interactions in natural environments\, highlighting some unexpect ed outcomes of these interactions for cyanophage persistence strategies an d evolution of infection characteristics.\n\n \; LOCATION: Hybrid - in the Faculty Auditorium /ZOOM: https://technion.zoom.u s/j/94149580805 END:VEVENT BEGIN:VEVENT UID:1354@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20260311T130000 DTEND;TZID=Asia/Jerusalem:20260311T140000 DTSTAMP:20260302T135854Z URL:https://biology.technion.ac.il/en/seminars/phd-graduate-seminar-bader- rayan/ SUMMARY:PhD Graduate Seminar-Bader Rayan [No Categories] DESCRIPTION:Location: Hybrid - in the Faculty Auditorium /ZOOM: https://tec hnion.zoom.us/j/92075968631 Bader Rayan\n Affiliation: \n Host:Associate Prof. Meytal Landau \n Amyloids are functional assemblies whose structura l plasticity governs biological activity. We identified fibril-forming ant imicrobial peptides with reversible structural switching that modulates th eir function. Extending this concept to bacterial virulence\, we show that PSMα3 from Staphylococcus aureus forms a dynamically regulated cross-α amyloid that transitions between soluble\, condensate\, and fibrillar stat es. These environmentally tuned states differentially control antimicrobia l activity and host immunometabolic responses.\n\n13 LOCATION:Hybrid - in the Faculty Auditorium /ZOOM: https://technion.zoom.us /j/92075968631 END:VEVENT BEGIN:VEVENT UID:1355@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20260309T130000 DTEND;TZID=Asia/Jerusalem:20260309T140000 DTSTAMP:20260304T131508Z URL:https://biology.technion.ac.il/en/seminars/phd-graduate-seminar-almog- angel/ SUMMARY:PhD Graduate Seminar-Almog Angel [No Categories] DESCRIPTION:Location: Hybrid - in the Faculty Auditorium /ZOOM: https://te chnion.zoom.us/j/91997034360 \n Affiliation: Almog Angel\n Host:Dr. Dvir Aran\n Computational Characterization of the Tumor Microenvironment for Op timizing Immunotherapy Response\n\nImmunotherapy has transformed cancer tr eatment\, yet most patients do not achieve a durable benefit. A prevailing hypothesis is that differences in the tumor microenvironment (TME) influe nce therapeutic response\, highlighting the need for accurate tools to cha racterize tumor cellular composition. In the first part of my PhD\, I deve loped xCell 2.0\, an improved computational method for inferring cell type enrichment from bulk transcriptomic data. The framework introduces a flex ible training pipeline and automated handling of cell type dependencies\, enabling robust performance across diverse reference datasets. In extensiv e benchmarking across human and mouse datasets\, xCell 2.0 outperformed ex isting deconvolution methods and improved prediction of immunotherapy resp onse in pan-cancer analyses. In the second part\, I investigated how chemo therapy may reshape the TME to influence response to subsequent immunother apy. I derived a transcriptomic signature that identifies tumors likely to undergo favorable immune remodeling following chemotherapy. Notably\, thi s benefit is specific to patients receiving combined chemo-immunotherapy a nd not immunotherapy alone\, consistent with a model of chemotherapy-media ted immune priming. Together\, this work provides both a methodological ad vance for TME characterization and a mechanism-informed framework for iden tifying patients who may benefit from combined or sequential chemo-immunot herapy strategies.\n\n \; LOCATION: Hybrid - in the Faculty Auditorium /ZOOM: https://technion.zoom.u s/j/91997034360 END:VEVENT BEGIN:VEVENT UID:1353@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20260304T130000 DTEND;TZID=Asia/Jerusalem:20260304T133000 DTSTAMP:20260302T133316Z URL:https://biology.technion.ac.il/en/seminars/msc-graduate-seminar-daniel -katz/ SUMMARY:MSc Graduate Seminar-Daniel Katz [No Categories] DESCRIPTION:Location: ZOOM: https://technion.zoom.us/j/94121779426 Daniel Katz\n Affiliation: \n Host: Associate Prof. David Meiri \n  \;\n\nAn ti-epileptic effect of Amanita muscaria metabolites\n\nAffecting millions worldwide\, epilepsy is a prevalent neurological disorder characterized by recurrent seizures\, with many patients unresponsive to current medicatio ns. Our study sought to identify novel therapeutic agents for epilepsy by investigating the psychoactive fungus Amanita muscaria. Using a pentylenet etrazole (PTZ)-induced seizure model\, we found that the whole extract of A. muscaria displayed significant anti-epileptic activity in mice. By frac tionating the extract and subsequently refractionating it\, we identified a subfraction that retains this activity\, which was profiled via mass spe ctrometry\, revealing both known anti-epileptic metabolites and previously uncharacterized compounds. Together\, these findings identify A. muscaria as a promising source of novel anti-seizure compounds. LOCATION:ZOOM: https://technion.zoom.us/j/94121779426 END:VEVENT BEGIN:VEVENT UID:1352@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20260218T133000 DTEND;TZID=Asia/Jerusalem:20260218T140000 DTSTAMP:20260212T125659Z URL:https://biology.technion.ac.il/en/seminars/msc-graduate-seminar-amit-f elach/ SUMMARY:MSc Graduate Seminar-Amit Felach [No Categories] DESCRIPTION:Location: Hybrid - in the Faculty Auditorium /ZOOM: https://tec hnion.zoom.us/j/99663315043 Amit Felach\n Affiliation: \n Host:Dr. Assaf Bester \n Studying lncRNA Sequence–Function Relationships Using Minimall y Supervised Model\n\n \;\n\nLong non-coding RNAs (lncRNAs) constitute a major regulatory component of the human transcriptome\, yet their mecha nisms of action and functional organization remain poorly understood. Enab led by advances in RNA sequencing\, genomic resources\, and molecular inte raction assays\, this study integrates computational and experimental appr oaches to characterize lncRNA regulatory functions and subcellular localiz ation. We applied a Minimally Supervised Model bioinformatic framework to identify functional domains within lncRNA sequences and combined it with e xperimental validation\, revealing stimulus-dependent localization dynamic s. In parallel\, optimization of a biotinylated RNA pulldown assay uncover ed novel lncRNA–protein interactions\, including a previously uncharacte rized regulatory mechanism involving SNHG14 and the identification of LINC 01001 as a chromatin-associated lncRNA. Together\, these findings highligh t the power of combining language-inspired computational models with molec ular biology techniques to uncover hidden regulatory features of the non-c oding genome\n\n \; LOCATION:Hybrid - in the Faculty Auditorium /ZOOM: https://technion.zoom.us /j/99663315043 END:VEVENT BEGIN:VEVENT UID:1351@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20260218T130000 DTEND;TZID=Asia/Jerusalem:20260218T133000 DTSTAMP:20260212T123953Z URL:https://biology.technion.ac.il/en/seminars/msc-graduate-seminar-yuanpu -sun/ SUMMARY:MSc Graduate Seminar-Yuanpu Sun [No Categories] DESCRIPTION:Location: Hybrid - in the Faculty Auditorium /ZOOM: https://tec hnion.zoom.us/j/99663315043 Yuanpu Sun\n Affiliation: \n Host:Prof. Yael Mandel-Gutfreund \n RBM25 Acts as a dual chromatin- and RNA-binding regula tor in Human Embryonic Stem Cells1\n\n \n\n \;\n\nRNA-binding protein s are increasingly recognized to have chromatin-associated functions beyon d their canonical post-transcriptional roles. Here\, we show that RBM25 ex hibits dual RNA- and DNA-binding functions in human Embryonic Stem Cells. At the RNA level\, RBM25 acts as a splicing factor\, while\, at the DNA le vel\, it is required for the binding of the Transcription regulator CEBPZ to promoters of cell cycle–related genes. In contrast\, RBM25 and CEBPZ bind to introns of silenced neuronal genes independently. Together\, these findings identify a functional RBM25–CEBPZ interaction that supports st em cell identity and prevents premature neuronal differentiation. LOCATION:Hybrid - in the Faculty Auditorium /ZOOM: https://technion.zoom.us /j/99663315043 END:VEVENT BEGIN:VEVENT UID:1350@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20260217T130000 DTEND;TZID=Asia/Jerusalem:20260217T140000 DTSTAMP:20260212T122649Z URL:https://biology.technion.ac.il/en/seminars/msc-graduate-seminar-guy-be n-zvi/ SUMMARY:MSc Graduate Seminar-Guy Ben Zvi [No Categories] DESCRIPTION:Location: Faculty Of Biology Auditorium Guy Ben Zvi\n Affiliat ion: \n Host:Prof. Emeritus Gadi Schuster\, Prof. Sigal Savaldi-Goldstein \,Assoc. Prof. Sariel Hubner\n We propose a new theory of wheat domesticat ion where climatic stress triggered transposable element (TE) bursts\, gen erating vast phenotypic diversity. Unlike wild relatives where natural sel ection favored lower TE content\, we suggest human selection preserved all eles with increased TE content near domestication-related traits\, effecti vely fixing these TE-rich variations.1 LOCATION:Faculty Of Biology Auditorium END:VEVENT BEGIN:VEVENT UID:1349@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20260128T130000 DTEND;TZID=Asia/Jerusalem:20260128T133000 DTSTAMP:20260125T105305Z URL:https://biology.technion.ac.il/en/seminars/msc-graduate-seminar-yiftac h-navot/ SUMMARY:MSc Graduate Seminar-Yiftach Navot [No Categories] DESCRIPTION:Location: Hybrid - in the Faculty Auditorium /ZOOM: https://tec hnion.zoom.us/j/96634615452?pwd=NukW9ZIewsbU0bj811uSi7nN04A6sT.1 Yiftach Navot\n Affiliation: \n Host:Associate Professor Tom Shemesh\n The Hidden Energy of Membrane Heterogeneity\n\nIn this work we develop a microscopic- scale model of a mixed membrane system. We use our results to add a correc tion term to the Helfrich Hamiltonian\, the established cornerstone of bio physical membrane modeling. Our correction provides testable predictions a nd has immediate implications on protein sorting and membrane-mediated pro tein interactions.\n\n \; LOCATION:Hybrid - in the Faculty Auditorium /ZOOM: https://technion.zoom.us /j/96634615452?pwd=NukW9ZIewsbU0bj811uSi7nN04A6sT.1 END:VEVENT BEGIN:VEVENT UID:1317@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20260126T130000 DTEND;TZID=Asia/Jerusalem:20260126T140000 DTSTAMP:20251029T115559Z URL:https://biology.technion.ac.il/en/seminars/faculty-seminar-prof-yakub- hanna/ SUMMARY:Faculty Seminar- Prof. Yakub Hanna [No Categories] DESCRIPTION:Location: Faculty Of Biology Auditorium \n Affiliation: Weizm ann Institute of Science\n Host:Dr\, Maya Maor-Nof \n LOCATION:Faculty Of Biology Auditorium END:VEVENT BEGIN:VEVENT UID:1348@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20260119T130000 DTEND;TZID=Asia/Jerusalem:20260119T140000 DTSTAMP:20260115T064452Z URL:https://biology.technion.ac.il/en/seminars/faculty-seminar-papers-of-t he-month-winners-january-19/ SUMMARY:Faculty Seminar: Papers of the Month Winners-January 19 [No Categor ies] DESCRIPTION:Location: Faculty Of Biology Auditorium Almog Angel\, Dr. Lail a A. Bishara\, Dr. Nir Strugo \n Affiliation: \n Host:Dr\, Maya Maor-Nof \n Dear Faculty Members\, Students\, and Staff\,\n\nYou are cordially inv ited to a faculty seminar featuring the Papers of the Month winners\, whi ch will take place next week on Monday\, January 19 at 13:00 in the Facul ty of Biology Auditorium.\n\nDuring the seminar\, the following STAR of th e Month awardees will present their outstanding research:\n\n Almog Ange l – Aran Lab (September 2025)\nxCell 2.0: A robust algorithm for cell t ype proportion estimation that predicts response to immune checkpoint bloc kade\n Dr. Laila A. Bishara – Ayoub Lab (November 2025)\nC8orf33 dicta tes DNA double-strand break repair choice by modulating KAT8-mediated H4K1 6 acetylation\n Dr. Nir Strugo – Kaplan Lab (December 2025)\nIntrinsic ally disordered regions facilitate target search to drive promoter selecti vity by a yeast transcription factor\n\nAll members of the Faculty of Biol ogy are warmly invited to attend and participate in this special seminar.\ n\nBest regards\,\nMaya LOCATION:Faculty Of Biology Auditorium END:VEVENT BEGIN:VEVENT UID:1345@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20260115T120000 DTEND;TZID=Asia/Jerusalem:20260115T130000 DTSTAMP:20251228T100005Z URL:https://biology.technion.ac.il/en/seminars/faculty-seminar-prof-marc-l ecuit-host-listeria-crosstalk-a-tale-of-invasion-and-evasion/ SUMMARY:Faculty Seminar: Prof. Marc Lecuit-Host-Listeria crosstalk: a tale of invasion and evasion [No Categories] DESCRIPTION:Location: Lecture Hall No. 1\, Schulich Faculty of Chemistry P rof. Marc Lecuit\n Affiliation: institut Pasteur\, Paris\, France\n Host:P rof. Roy Kishony\n LOCATION:Lecture Hall No. 1\, Schulich Faculty of Chemistry END:VEVENT BEGIN:VEVENT UID:1344@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20260114T130000 DTEND;TZID=Asia/Jerusalem:20260114T140000 DTSTAMP:20251224T102012Z URL:https://biology.technion.ac.il/en/seminars/phd-graduate-seminar-malak- darawshe/ SUMMARY:PhD Graduate Seminar- Malak Darawshe [No Categories] DESCRIPTION:Location: Hybrid - in the Faculty Auditorium /ZOOM: https://tec hnion.zoom.us/j/96635422862 Malak Darawshe\n Affiliation: \n Host:Prof. N abieh Ayoub\n LSm4 protein forms RNA degradation hubs at DNA breaks to fac ilitate repair\n\nAccurate repair of DNA double-strand breaks (DSBs) is es sential for genomic stability\, especially in transcriptionally active reg ions. Persistent transcription at DSBs leads to the formation of RNA:DNA h ybrids (R-loops)\, which obstruct homologous recombination (HR). While R-l oop resolution is understood\, the mechanisms that remove pre-existing RNA transcripts in the vicinity of DSBs to limit R-loop formation remain poor ly understood. In my PhD\, I describe a mechanism by which cells locally d egrade RNA at DSBs to enable repair. I show that the RNA-binding protein L Sm4 is rapidly recruited to DSBs in active chromatin\, where it undergoes liquid-liquid phase separation (LLPS) to form biomolecular condensates. Th ese condensates function as processing hubs that promote RNA decapping and recruit the 5′→3′ exonuclease XRN2 to degrade nascent transcripts n ear the break. This LSm4–XRN2 axis suppresses pathological R-loop accumu lation\, facilitating RAD51 recruitment and accurate HR. Loss of LSm4 lead s to genomic instability and increased translocations. These findings esta blish phase-separated condensates as spatial organizers of RNA clearance a t DNA lesions\, revealing a new paradigm for coordinating local RNA turnov er with faithful DNA repair. LOCATION:Hybrid - in the Faculty Auditorium /ZOOM: https://technion.zoom.us /j/96635422862 END:VEVENT BEGIN:VEVENT UID:1347@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20260112T130000 DTEND;TZID=Asia/Jerusalem:20260112T140000 DTSTAMP:20260107T110652Z URL:https://biology.technion.ac.il/en/seminars/faculty-seminar-dr-uri-shey n-virginia-tech-usa/ SUMMARY:Faculty Seminar- Dr. Uri Sheyn (Virginia Tech\, USA) [No Categories ] DESCRIPTION:Location: Dr. Uri Sheyn\n Affiliation: Department of Biologic al Sciences Virginia Tech\, USA\n Host:Dr\, Maya Maor-Nof \n Dear Biology Students\, Postdocs\, and Faculty\,\n\n \;\n\nNext week for our Facult y Seminar Series at 1:00 p.m. on Monday\, January 12th\, we will have a ta lk by Dr. Uri Sheyn  of the Department of Biological Sciences Virginia Te ch\, USA. Dr. Uri Sheyn will present a talk titled "“From Virocells to O cean Patterns\, A Single-Cell View of Viral Infection".\n\n \;\n\n&nbs p\;\n\nTalk Abstract: \n\n \;\n\nViruses play a central role in shapi ng aquatic ecosystems\, yet their impacts are often\n\ninferred from popul ation averages that obscure underlying cellular heterogeneity. In this\n\n seminar\, I present a single-cell framework for understanding viral infect ion across\n\nphytoplankton systems\, from acute lytic infection to viral genome integration.\n\nUsing single-cell transcriptomics and mRNA imaging\ , I show that viral infection\n\nproceeds through discrete cellular progra ms that define distinct virocell states\, providing\n\na mechanistic frame work that links intracellular regulation to emergent biological\n\npattern s. These states rewire host physiology and help explain how infection infl uences\n\nbloom dynamics and vertical redistribution of bloom biomass in t he ocean. I further\n\ndemonstrate that integrated viral genomes in Chlamy domonas reinhardtii exhibit\n\nheterogeneous expression states at the sing le-cell level\, revealing viral strategies that\n\nare difficult to interp ret from bulk data alone.\n\nI conclude by outlining how these approaches can be extended within the Technion’s\n\ninterdisciplinary research envi ronment to resolve how viral infection reshapes\n\ninteractions among micr obes\, linking cellular infection states to community organization\n\nand ecosystem-scale patterns.\n\n \;\n\nLooking forward to seeing you!\nMa ya END:VEVENT BEGIN:VEVENT UID:1346@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20260105T130000 DTEND;TZID=Asia/Jerusalem:20260105T140000 DTSTAMP:20251231T071830Z URL:https://biology.technion.ac.il/en/seminars/faculty-seminar-dr-ron-hada s-caltech-ca-usa/ SUMMARY:Faculty Seminar -Dr. Ron Hadas (Caltech\, CA\, USA) [No Categories ] DESCRIPTION:Location: Dr. Ron Hadas \n Affiliation: Developmental and Sy nthetic Biology Division of Biology and Biological Engineering\, Caltech\, CA\, USA .\n Host:Dr\, Maya Maor-Nof \n Dear Biology Students\, Postdocs\ , and Faculty\,\n\n \;\n\nNext week for our Faculty Seminar Series at 1:00 p.m. on Monday\, January 5th\, we will have a talk by Dr. Ron Hadas  of the Developmental and Synthetic Biology Division of Biology and Biologi cal Engineering\, Caltech\, CA\, USA .  Dr. Ron Hadas will present a talk titled "How Do Extraembryonic Tissues Shape Development ?".\n\n \;\n\ n \;\n\nAbstract\n\nMammalian embryogenesis progresses through rapid a nd coordinated diversification of embryonic and extraembryonic lineages\, yet how progenitors emerge across time\, space\, and lineage remains unres olved. To address this\, we built a temporal single-cell model of early de velopment that delineates continuous differentiation trajectories in embry onic and extraembryonic compartments. Combined with targeted perturbations \, this framework revealed an early bifurcation between early placental pr ogenitors and a biphasic role for BMP4: an extraembryonic-derived signal e ssential for placental differentiation\, mesoendoderm bifurcation\, allant ois formation\, and germline specification\, followed by an embryo-derived BMP4 signal that restricts the primordial germ cell pool.\nYet\, transcri ptional trajectories alone cannot reveal the actual lineage paths that cel ls take\, or how spatial organization constrains these fate outcomes. To r esolve these lineage relationships\, we engineered MEMOIR\, a spatial line age-recording mouse model that integrates barcode editing\, sequential ima ging\, and Bayesian methods for phylogenetic reconstruction. By retrospect ively tracing lineage segregation events\, MEMOIR charted epiblast diversi fication into germ layers\, identified the origins of the primordial germl ine\, and linked spatial position to fate choices in placental progenitors .\n\nTogether\, these complementary approaches reveal how early developmen t unfolds through coordinated signaling\, spatial context\, and lineage hi story. Understanding how gene programs generate distinct cell types provid es a foundation for uncovering mechanisms of pregnancy failure and informi ng regenerative medicine strategies.\n\n \;\n\nLooking forward to seei ng you!\nMaya END:VEVENT BEGIN:VEVENT UID:1339@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20251231T130000 DTEND;TZID=Asia/Jerusalem:20251231T140000 DTSTAMP:20251204T100841Z URL:https://biology.technion.ac.il/en/seminars/phd-graduate-seminar-johann es-venezian/ SUMMARY:PhD Graduate Seminar-Johannes Venezian [No Categories] DESCRIPTION:Location: Hybrid- in the Faculty Auditorium/ZOOM:https://techni on.zoom.us/j/99903047740 Johannes Venezian\n Affiliation: \n Host:Dr. Aya la Shiber \n Evolution of Protein Folding and Assembly Pathways: Decipheri ng the Characteristics of Divergent Co-translational Assembly Pathways\n\n Protein-protein interactions are at the heart of all cellular processes\, with the ribosome emerging as a platform that orchestrates nascent-chain i nterplay dynamics. In this seminar\, I will present a multidisciplinary st udy combining in vivo and in silico approaches to capture snapshots of t he translation process through various methods\, such as selective ribosom e profiling\, all-atom molecular dynamics simulations\, and AlphaFold-base d predictions. These approaches elucidate the interplay of ribosome-associ ated factors that guide the folding and assembly pathways of emerging poly peptide chains. Focusing on the divergent folding and assembly pathways of the N-terminal acetyltransferase complex family to gain mechanistic insig ht—and expanding the analysis to the proteome scale—we discovered that assembly is driven by high-energy interface 'hotspots' that anchor mutual ly stabilizing subunits. We further demonstrate that these structural sign atures can accurately predict co-translational assembly across species and that disrupting these hotspots is linked to aggregation and neurodegenera tive disease. LOCATION:Hybrid- in the Faculty Auditorium/ZOOM:https://technion.zoom.us/j/ 99903047740 END:VEVENT BEGIN:VEVENT UID:1343@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20251229T130000 DTEND;TZID=Asia/Jerusalem:20251229T140000 DTSTAMP:20251223T082155Z URL:https://biology.technion.ac.il/en/seminars/faculty-seminar-dr-rachelly -normand/ SUMMARY:Faculty Seminar-Dr. Rachelly Normand [No Categories] DESCRIPTION:Location: Faculty Of Biology Auditorium Dr. Rachelly Normand \ n Affiliation: the Massachusetts General Hospital Harvard Medical School B road Institute of MIT and Harvad Cambridge\, Massachusetts\, USA. \n Host :Dr\, Maya Maor-Nof \n Dear Biology Students\, Postdocs\, and Faculty\,\n\ n \;\n\nNext week for our Faculty Seminar Series at 1:00 p.m. on Monda y\, December 29th\, we will have a talk by Dr. Rachelly Normand of the Ma ssachusetts General Hospital Harvard Medical School Broad Institute of MIT and Harvad Cambridge\, Massachusetts\, USA.  Dr. Rachelly Normand will p resent a talk titled "Advancing\n\nWomen's Health One Cell at a Time: From Autoimmunity to Pregnancy".\n\n\nTalk Abstract: \n\n \;\n\nWomen’s health has historically been marginalized in research\, and much of biome dical\n\nknowledge still defaults to male physiology. My goal is to build a women-centered\n\nresearch program focused on two complementary areas of research: autoimmunity\,\n\nwhich disproportionately affects women\, and pregnancy\, a critical and complex process\n\nthat shapes women’s health long after delivery. Autoimmunity and pregnancy share\n\nfundamental tole rance pathways\, making their joint study particularly powerful. In this\n \nseminar I will present my post-doctoral study on thyroid autoimmunity\, where we show\n\nthat Hashimoto’s thyroiditis and Graves’ disease - th ough clinically distinct - share many\n\nfeatures in the cellular ecosyste m of the thyroid gland. We identified epithelial-immune\n\ncellular niches that form in the gland during autoimmunity and may act as a tissue\n\ntol erance mechanism to help preserve organ function in the setting of chronic immune\n\nattack. I will then share results from the largest single cell placenta atlas profiled to date\,\n\nincluding five different pregnancy co mplications. This comprehensive atlas reveals\n\npreviously unrecognized p lacental cell subsets and uncovers distinct dynamics of fetal\n\nand mater nal cells across different complications. I will conclude by outlining my future\n\nresearch program\, which will move beyond cataloging individual cell types to\n\nsystematically defining the cellular niches that support tissue function and tissue\n\ntolerance in diverse contexts of women’s h ealth.\n\n \;\n\nLooking forward to seeing you!\nMaya LOCATION:Faculty Of Biology Auditorium END:VEVENT BEGIN:VEVENT UID:1332@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20251224T123000 DTEND;TZID=Asia/Jerusalem:20251224T140000 DTSTAMP:20251209T121815Z URL:https://biology.technion.ac.il/en/seminars/bridge-to-industry-dr-rami- skaliter-cellcure-neurosciences-ltd/ SUMMARY:Bridge to Industry - Dr. Rami Skaliter\, Cellcure Neurosciences Ltd [No Categories] DESCRIPTION:Location: Faculty Of Biology Auditorium Dr. Rami Skaliter\n Af filiation: Cellcure Neurosciences Ltd\n Host:Dr. Dror Melamed\n You are in vited to the Sixth lecture in the "Bridge to Industry" series:\n\n \;\ n\nInsights from Developing Novel Allogeneic Cell Therapies for Serious Ne urological and Ophthalmic Diseases\nSpeaker: Dr. Rami Skaliter\, CEO of Ce llucure Neurosciences Ltd\n\n \n\nDr. Skaliter has an extensive career in the life sciences and pharmaceutical industries\, specializing in drug de velopment. He holds a B.Sc. in Biology from Ben-Gurion University and an M .Sc. and Ph.D. in Biochemistry from the Weizmann Institute\, where he focu sed on DNA replication and mutagenesis. After completing a postdoctoral fe llowship at Stanford University\, he transitioned into the biotech industr y.\n\n \;\n\nHe currently serves as the CEO of Cell Cure Neurosciences \, an Israeli subsidiary of Lineage Cell Therapeutics\, dedicated to devel oping and manufacturing pluripotent stem cell–derived therapies for dege nerative eye diseases and other neurodegenerative conditions. Previously\, he spent more than 20 years in key roles at Quark Pharmaceuticals\, inclu ding a decade as Chief Operating Officer.\n\n \;\n\nAt CellCure\, he l eads the development of scalable GMP manufacturing processes for allogenei c cell therapies\, including RPE cells for Dry AMD (in collaboration with Genentech/Roche) and auditory neuron progenitors for Auditory Neuropathy ( in partnership with Demant)\, alongside additional therapeutic programs. H e has been a speaker at major industry conferences\, presenting on cell th erapy formulation\, immune rejection challenges\, and advancing stem cell –based therapies into clinical trials.\n\n \;\n\nDate: Wednesday\, D ecember 24\, at 13:00\nLocation: Biology Auditorium\n\nSchedule:\n12:30– 13:00 Coffee and light refreshments – Lobby outside the auditorium\n13:0 0–14:00 Seminar – Biology Auditorium\n14:00–14:30 Open discussion wi th the speaker on “Bridge to Industry” – Auditorium Lobby\n\n \; \n\nJoin us for a fascinating journey of discovery\, collaboration\, and i nnovation!\n\nClick here to register LOCATION:Faculty Of Biology Auditorium END:VEVENT BEGIN:VEVENT UID:1342@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20251222T130000 DTEND;TZID=Asia/Jerusalem:20251222T140000 DTSTAMP:20251216T065203Z URL:https://biology.technion.ac.il/en/seminars/faculty-seminar-dr-jonathan -gropp-university-of-california-berkeley-ca-usa/ SUMMARY:Faculty Seminar-Dr. Jonathan Gropp (University of California\, Be rkeley\, CA\, USA) [No Categories] DESCRIPTION:Location: Faculty Of Biology Auditorium Dr. Jonathan Gropp \ n Affiliation: University of California\, Berkeley\, CA\, USA\n Host:Dr\, Maya Maor-Nof \n Dear Biology Students\, Postdocs\, and Faculty\,\n\n  \;\n\nNext week for our Faculty Seminar Series at 1:00 p.m. on Monday\, De cember 22nd\, we will have a talk by Dr. Jonathan Gropp of the Departmen t of Earth and Planetary Science\, University of California\, Berkeley\, C A\, USA. Dr. Jonathan Gropp will present a talk titled "Decoding microbia l methane production: from genes to ecosystems".\n\n \;\n\nTalk Abstra ct: \n\n \;\n\nMethanogenic archaea (methanogens) have the unique cap ability to couple methane (CH4) production with growth and energy conserva tion\, and they play a key role in the global carbon biogeochemical cycle. Despite this\, significant gaps remain in our understanding of their phys iology\, metabolism\, and ecology. This talk presents a platform for bridg ing this gap by using stable isotopes as probes to decode microbial methan e production from the gene to the ecosystem level.\n\nIn my work\, I study microbial methane metabolism using the stable isotopic ratios of carbon a nd hydrogen (13C/12C and 2H/1H) in methane\, which are widely used to tra ce methanogenic activity in natural environments. We have recently found t hat isotopic signatures of methane produced in laboratory cultures are dis tinct from those in natural environments. We have proposed that growth und er energy-limiting conditions increases enzyme reversibility\, thereby ind ucing isotopic exchange and altering isotopic signatures. To test this  “reversibility hypothesis\,” we used a genetically tractable methanoge nic strain modified via CRISPR-Cas9 to control the expression of methyl– coenzyme M reductase (MCR)\, a key enzyme in the pathway. Our results demo nstrate that MCR down-regulation decreases growth rates and alters the iso topic signature of the methane\, confirming that enzyme reversibility sets isotopic signatures under non-optimal growth conditions. We further found that temperature variations produce similar effects\, indicating that enz yme reversibility is prevalent during methanogenic growth\, especially und er conditions found in natural environments. These findings demonstrate th e utility of novel genome-editing techniques and stable-isotope probing as powerful tracers of biochemical processes in microbial metabolism and phy siology.\n\nFinally\, I will discuss future directions for my work\, using experimental and theoretical approaches\, including\, for example\, devel oping novel metabolic and isotopic biomarkers to track nitrogen fixation by methanogens. Nitrogen fixation first emerged in methanogens\, but their role in the nitrogen cycle remains unclear. I aim to elucidate this enigm a\, linking the carbon and nitrogen biogeochemical cycles. Such studies es tablish mechanistic frameworks to understand the fundamentals of microbial physiology and ecology\, paving the way for targeted strategies to mitiga te climate change and enhance renewable energy production.\n\n \;\n\nL ooking forward to seeing you!\nMaya LOCATION:Faculty Of Biology Auditorium END:VEVENT BEGIN:VEVENT UID:1341@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20251217T130000 DTEND;TZID=Asia/Jerusalem:20251217T140000 DTSTAMP:20251215T125531Z URL:https://biology.technion.ac.il/en/seminars/faculty-seminar-jenia-binen baum-crispr-targeting-of-h3k4me3-reprograms-transcription-immunity-and-mei otic-recombination-in-plants/ SUMMARY:Faculty Seminar- Jenia Binenbaum "CRISPR targeting of H3K4me3 Repr ograms Transcription\, Immunity\, and Meiotic Recombination in Plants". [N o Categories] DESCRIPTION:Location: Faculty Of Biology Auditorium Jenia Binenbaum \n Aff iliation: University of Cambridge\, United Kingdom)\n Host:Dr\, Maya Maor- Nof \n CRISPR targeting of H3K4me3 Reprograms Transcription\, Immunity\, a nd Meiotic \nRecombination in Plants\nPlants can develop a form of molecul ar memory through repeated exposure to specific stresses\,\nallowing them to respond more effectively upon subsequent challenges\, a process known a s\npriming. Primed genes have an enhanced transcriptional responsiveness u pon repeated exposure\nto stress\, while returning to baseline levels of e xpression in the absence of stimuli. These genes\nare thought to remain in ‘primed’ or ‘poised’ state\, with an altered chromatin landscape that\nfacilitates hyper-induction upon a recurrent stress event. We aim to synthetically recreate the\npathogen-primed state in Arabidopsis thaliana by targeted deposition of H3K4me3. To achieve\nthis\, we employ the CRISP R-based SunTag system to recruit the catalytic domain of SDG2\, a key\nhis tone methyltransferase responsible for H3K4me3 deposition in plants\, to t argeted promoters.\nOur work shows that H3K4me3 deposition by SunTag-SDG2 is sufficient to transcriptionally\nactivate the epigenetically silenced g ene FWA\, establishing that H3K4me3 itself can act as a causal\nregulatory mark. Next we demonstrate that SunTag-SDG2 can be employed to increase pa thogen\nresistance by targeting the H3K4me3-regulated disease resistance g ene\, SNC1. Extending this\napproach to pathogen memory\, we show that Sun Tag-directed H3K4me3 deposition can\nsuccessfully prime a WRKY-family tran scription factor\, further enhancing pathogen resistance.\nBeyond transcri ptional regulation\, targeting SunTag-SDG2 to low recombining centromeric\ nregions significantly increases proximal crossover formation. Together\, these findings establish\nthat locus-specific H3K4me3 deposition is able t o modulate transcription\, immunity\, stress\nmemory and recombination\, h ighlighting the potential of chromatin engineering as a tool for\nprecise modulation of important agricultural traits LOCATION:Faculty Of Biology Auditorium END:VEVENT BEGIN:VEVENT UID:1340@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20251215T130000 DTEND;TZID=Asia/Jerusalem:20251215T140000 DTSTAMP:20251209T130655Z URL:https://biology.technion.ac.il/en/seminars/faculty-seminar-eman-khatib -massalha-university-of-cambridge-united-kingdom/ SUMMARY:Faculty Seminar -Eman Khatib-Massalha (University of Cambridge\, Un ited Kingdom) [No Categories] DESCRIPTION:Location: Faculty Of Biology Auditorium Eman Khatib-Massalha \ n Affiliation: University of Cambridge\, United Kingdom)\n Host:Dr\, Maya Maor-Nof \n Dear Biology Students\, Postdocs\, and Faculty\,\n\n \;\n\ nNext week for our Faculty Seminar Series at 1:00 p.m. on Monday\, Decembe r 15th\, we will have a talk by Dr. Eman Khatib-Massalha  of the Cambridg e Stem Cell Institute and Department of Hematology\, University of Cambrid ge\, United Kingdom. Dr. Khatib-Massalha will present a talk titled  "Fr om Defense to Dysregulation: Understanding Neutrophil Plasticity in Health and Disease".\n\n \;\n\n \;\n\nTalk Abstract: \n\nNeutrophils ar e essential for immune homeostasis and are normally cleared by bone\n\nmar row macrophages to prevent inflammation and tissue damage. In\n\nmyeloprol iferative neoplasms (MPNs)\, myeloid malignancies driven by mutations\n\ns uch as JAK2 V617F \, neutrophils become abnormally long-lived and proinfla mmatory.\n\nMy research shows that JAK2 V617F neutrophils evade macrophage clearance through\n\nupregulation of the “don’t-eat-me” signal CD24 \, leading to their accumulation and\n\npathological interactions with meg akaryocytes that drive thrombocytosis and\n\nmyelofibrosis. Importantly\, genetic deletion or antibody blockade of CD24 restores\n\nneutrophil clear ance\, ameliorates disease features\, and prevents myelofibrosis.\n\nThese findings reveal defective neutrophil clearance as a key link between\n\ni nflammation and MPN progression and identify CD24 as a promising therapeut ic\n\ntarget.\n\n \;\n\nLooking forward to seeing you!\nMaya LOCATION:Faculty Of Biology Auditorium END:VEVENT BEGIN:VEVENT UID:1330@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20251210T130000 DTEND;TZID=Asia/Jerusalem:20251210T133000 DTSTAMP:20251109T094744Z URL:https://biology.technion.ac.il/en/seminars/msc-graduate-seminar-netali -snof/ SUMMARY:MSc Graduate Seminar- Netali Snof [No Categories] DESCRIPTION:Location: Hybrid - in the Faculty Auditorium /ZOOM: https://te chnion.zoom.us/j/91065669587 Netali Snof\n Affiliation: \n Host:Associat e Prof. David Meiri \n Enhancement of Human CD8+ T Cell Cytotoxicity by e xtracts from Amanita muscaria and Psilocybin-Producing Fungi13\nPsychoacti ve fungi contain diverse metabolites with potential immunomodulatory prope rties. Here we investigated metabolites from two distinct pharmacological classes: serotonergic tryptamines from psilocybin-producing fungi and glut amatergic compounds from Amanita muscaria. In a screen of 38 mushroom ext racts\, we identified several that enhanced the function of Cytotoxic T L ymphocytes. The A. muscaria extract was superior to all others\, and sign ificantly effective in increasing the levels of the cytotoxic protein Gran zyme B. These findings highlight the potential of metabolites from psychoa ctive fungi as an underexplored source of novel immunomodulatory agents. LOCATION:Hybrid - in the Faculty Auditorium /ZOOM: https://technion.zoom.u s/j/91065669587 END:VEVENT BEGIN:VEVENT UID:1338@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20251208T130000 DTEND;TZID=Asia/Jerusalem:20251208T140000 DTSTAMP:20251202T110902Z URL:https://biology.technion.ac.il/en/seminars/faculty-seminar-series-dr-a mir-sapir-technion/ SUMMARY:Faculty Seminar Series – Dr. Amir Sapir (Technion) [No Categorie s] DESCRIPTION:Location: Dr. Amir Sapir\n Affiliation: Department of Biolog y and the Environment\, The University of Haifa- Oranim Campus\n Host:Dr\, Maya Maor-Nof \n Dear Biology Students\, Postdocs\, and Faculty\,\n\n&nbs p\;\n\nNext week for our Faculty Seminar Series at 1:00 p.m. on Monday\, D ecember 8th\, we will have a talk by Dr. Amir Sapir of the Department of Biology and the Environment\, The University of Haifa- Oranim Campus\, Hai fa\, Israel. Dr. Sapir will present a talk titled "Why do mosquitoes bite? cholesterol is a metabolic driver of blood feeding in mosquitoes".\n\n&nb sp\;\n\nTalk Abstract: \n\nMosquitoes experience a biphasic ecological\, dietary\, and metabolic life cycle\, yet the\n\nbiochemical principles gui ding these transitions remain poorly understood. Through dietary\n\nengine ering to establish sterol-defined larval and adult systems\, we studied th e possible role of\n\nsterol and steroid metabolism in the Asian tiger mos quito Aedes albopictus (A. albopictus). Here\n\nwe show that larval develo pment\, successful metamorphosis\, and adult emergence critically rely\n\n on the conversion of environmental plant and fungal sterols into cholester ol. In adults\, we\n\nengineered an artificial blood system that allowed c ontrolled manipulation of dietary sterols and\n\nrevealed that cholesterol is an essential metabolic driver of egg production. We further show that\ n\nfemales transfer substantial amounts of cholesterol to their eggs\, sup porting early larval\n\ndevelopment until the dietary conversion mechanism becomes transcriptionally activated. This\n\nactivation includes the expr ession of the dietary sterol-to-cholesterol conversion enzyme DHCR-\n\n24\ , which emerges as a key component of the regulatory transition from mater nal sterols to\n\nenvironmental sterols. Together\, these findings reveal a biphasic strategy in which larvae depend\n\non conversion of plant and f ungal sterols\, whereas adult females acquire cholesterol from blood\n\nfo r reproduction and for supplying eggs with cholesterol essential for early development\, a\n\nstrategy tightly linked to mosquito ecology. Our findi ngs highlight the central and stage-\n\nregulated role of sterol metabolis m in mosquito development\, reproduction\, and pathogenicity.\n\n \;\n \nSome details about his research and publications can be found at:\n\nhtt ps://asapirlab.weebly.com/\n\n \;\n\nLooking forward to seeing you!\nM aya END:VEVENT BEGIN:VEVENT UID:1316@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20251201T130000 DTEND;TZID=Asia/Jerusalem:20251201T140000 DTSTAMP:20251125T132728Z URL:https://biology.technion.ac.il/en/seminars/faculy-seminar-dr-ifat-sher -rosenthal/ SUMMARY:Faculy Seminar-Dr. Ifat Sher-Rosenthal-“From Bedside to Bench and Back - Personalized Drug Discovery for Retinal Degeneration" [No Categori es] DESCRIPTION:Location: Faculty Of Biology Auditorium Dr. Ifat Sher-Rosent hal \n Affiliation: Shiba Medical Center\n Host:Dr\, Maya Maor-Nof \n Dea r Biology Students\, Postdocs\, and Faculty\,\n\n \;\n\nNext week for our Faculty Seminar Series at 1:00 p.m. on Monday\, December 1st\, we will have a talk by Dr. Ifat Sher-Rosenthal of the Goldschleger Eye Institute \, Sheba Medical Center\, Tel Hashomer\, and Ophthalmology Department\, Gr ay Faculty of Medical and Health Sciences Tel-Aviv University\, Tel Aviv\,   Israel. Dr. Sher-Rosenthal will present a talk titled “From Bedside to Bench and Back - Personalized Drug Discovery for Retinal Degeneration". \n\n \;\n\nTalk Abstract: From Bedside to Bench and Back - Personalize d Drug Discovery for Retinal Degeneration\n\n \;\n\nThis seminar will present our laboratory’s integrative research on advanced\n\ndiagnostics and therapeutic strategies for retinal degenerative diseases. Our work\n\ nspans three core domains: (1) Patient-specific in vitro models: We employ stem\n\ncell technologies and tissue engineering to construct in vitro sy stems that replicate\n\ndisease pathology for mechanistic studies and drug screening. (2) Transgenic in\n\nvivo models: Rodent models are used to el ucidate disease mechanisms and\n\nassess the safety and efficacy of candid ate therapies\, facilitating clinical translation.\n\n(3) Non-invasive cli nical diagnostic platforms: We develop sensitive\n\ntechnologies for early detection of neurodegenerative conditions. By leveraging the\n\neye as a window for brain health\, we advance objective diagnostics for disorders\n \nsuch as Alzheimer’s disease\, as well as AI-driven ocular imaging that can predict\n\nblood counts.\n\nThe presentation will outline our transla tional pipeline: from model development and\n\ndrug delivery optimization to preclinical validation and clinical application. I will share\n\nexampl es demonstrating how these steps drive neuroprotective therapy\n\ndevelopm ent.\n\n \;\n\nSome details about her research and publications can be found at:\n\nhttps://ifaat3.wixsite.com/restorative-retinal\n\n \;\n\ n \;\n\nLooking forward to seeing you!\nMaya LOCATION:Faculty Of Biology Auditorium END:VEVENT BEGIN:VEVENT UID:1315@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20251124T130000 DTEND;TZID=Asia/Jerusalem:20251124T140000 DTSTAMP:20251119T081750Z URL:https://biology.technion.ac.il/en/seminars/faculty-seminar-prof-schrag i-shwartz/ SUMMARY:Faculty Seminar-Prof. Schragi Shwartz [No Categories] DESCRIPTION:Location: Faculty Of Biology Auditorium \n Affiliation: Weizma nn Institute of Science\n Host:Dr\, Maya Maor-Nof \n Dear Biology Students \, Postdocs\, and Faculty\,\n\n \;\n\nNext week for our Faculty Semina r Series at 1:00 p.m. on Monday\, November 24th\, we will have a talk by D r. Schragi Schwartz of the Weizmann Institute of Science. Dr. Schwartz w ill present a talk titled “Methyl Marks and Molecular Heat Shields: How RNA Modifications Shape Function and Adaptation” .\n\n \;\n\nTalk Ab stract: Methyl Marks and Molecular Heat Shields: How RNA Modifications Sha pe Function and Adaptation\n\n \;\n\n \;\n\nSimilar to DNA and pro teins\, RNA undergoes extensive post-synthetic modification. To\n\ndate\, more than 170 distinct modifications have been documented\, installed by a \n\ndiverse set of typically highly conserved enzymes\, many of which play essential roles in\n\nRNA structure and function and are implicated in hu man disease.\n\nIn the first part of my talk\, I will focus on N6-methylad enosine (m6A)\, the most\n\nprevalent internal modification on mRNA. Altho ugh m6A is found at hundreds of\n\nthousands of sites transcriptome-wide\, the rules governing its deposition remained\n\nunclear. I will describe o ur advances in deciphering this “m6A code\,” which provided key\n\nins ights into the determinants of specificity and the functional consequences of this\n\nmodification.\n\nIn the second part\, I will turn to ribosomal RNA (rRNA) modifications\, which we\n\ndissected using a newly developed genomic platform that enables systematic profiling\n\nof 16 distinct modif ications across dozens of samples in parallel. Applying this approach\n\nt o species spanning the tree of life—particularly unicellular extremophil es that thrive\n\nunder harsh physical\, chemical\, or biological conditio ns—we discovered striking\n\nevolutionary patterns. While dynamic rRNA m odifications are rare in mesophiles\, in\n\nextreme hyperthermophiles near ly half of all modifications proved to be dynamic.\n\nI will highlight one example: a conserved module of tandem m5C–ac4C modifications\,\n\nco-in duced at elevated temperatures by enzymes that are intrinsically temperatu re-\n\nresponsive and essential for growth under thermal stress. By integr ating genomic\,\n\nbiophysical\, and structural analyses\, we revealed a s ynergistic thermostabilizing\n\nfunction of this modification pair.\n\nTog ether\, these findings shed light on the critical contribution of rRNA mod ifications to\n\nribosome stability\, enabling ribosomes to preserve their structural integrity even at near-\n\nboiling temperatures that would oth erwise cause denaturation.\n\n \;\n\nSome details about his research a nd publications can be found at:\n\nhttps://www.weizmann.ac.il/molgen/schw artz/\n\n \;\n\n \;\n\nLooking forward to seeing you!\nMaya LOCATION:Faculty Of Biology Auditorium END:VEVENT BEGIN:VEVENT UID:1331@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20251119T123000 DTEND;TZID=Asia/Jerusalem:20251119T143000 DTSTAMP:20251112T115119Z URL:https://biology.technion.ac.il/en/seminars/bridge-to-industry-series-d r-yehezkel-hezi-sason-vp-rd-biolojic-design/ SUMMARY:"Bridge to Industry" Series: Dr. Yehezkel (Hezi) Sason\, VP R&D\, B iolojic Design [No Categories] DESCRIPTION:Location: Dr. Yehezkel (Hezi) Sason\n Affiliation: VP R&D\, B iolojic Design\n Host:\n You are invited to the fifth lecture in the "Brid ge to Industry" series:\n\nRedefining the Boundaries of Antibody Capabilit ies\nSpeaker: Dr. Yehezkel (Hezi) Sason\, VP R&\;D\, Biolojic Design\n\ nDr. Hezi Sason is a senior executive in the biotechnology industry and a scientist whose career has flourished at the intersection of biology\, inn ovation\, and drug development. Currently serving as Senior Vice President for Technological Research and Development at Biolojic Design\, Dr. Sason leads teams developing antibody-based therapeutics for severe diseases su ch as cancer and autoimmune disorders.\n\nCombining his academic backgroun d with extensive industrial experience\, Dr. Sason has led multiple resear ch programs that evolved from the lab to clinical trials. Some of these pr ograms were acquired by international pharmaceutical companies and are now in advanced stages of human testing.\n\nHe played a key role in developin g Biolojic’s unique AI-driven antibody design platform\, which has signi ficantly accelerated the company’s ability to create novel therapeutics. Throughout his journey\, Dr. Sason has demonstrated a deep commitment to mentoring and inspiring the next generation of scientists\, believing that the greatest breakthroughs emerge when diverse minds collaborate across d isciplines.\n\nIn this talk\, he will share not only the science but also the story behind the journey — how biology\, technology\, and teamwork c an unite to save lives.\n\nDate: Wednesday\, November 19\, at 13:00\nLocat ion: Biology Auditorium\n\nSchedule:\n12:30–13:00 Coffee and light refre shments – Lobby outside the auditorium\n13:00–14:00 Seminar – Biolog y Auditorium\n14:00–14:30 Open discussion with the speaker on “Bridge to Industry” – Auditorium Lobby\n\nJoin us for a fascinating journey o f discovery\, collaboration\, and innovation!\n[Click here to register] END:VEVENT BEGIN:VEVENT UID:1314@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20251117T130000 DTEND;TZID=Asia/Jerusalem:20251117T140000 DTSTAMP:20251111T102721Z URL:https://biology.technion.ac.il/en/seminars/faculty-seminar-dr-dvir-ara n/ SUMMARY:Faculty Seminar- Dr. Dvir Aran-“Using Biomedical Data Science to Advance Precision Medicine and Digital Health” [No Categories] DESCRIPTION:Location: Faculty Of Biology Auditorium Dr. Dvir Aran\n Affili ation: \n Host:Dr\, Maya Maor-Nof \n Dear Faculty\,\n\n \;\n\nNext wee k\, we will have a lecture at 1:00 p.m. on Monday\, November 17\, with a talk by Dr. Dvir Aran of our faculty of Biology\, at the Biology Auditori um.  Dr. Aran will present a talk titled “Using Biomedical Data Science to Advance Precision Medicine and Digital Health”.\n\n \;\n\nTalk A bstract:\nIn the seminar I will present an overview of my research program and the guiding themes that shape my lab’s work at the intersection of biomedical data science and precision medicine. I will discuss how we use computational and statistical approaches to analyze multidimensional biolo gical data\, from single-cell and spatial transcriptomics to clinical and real-world datasets\, to address key questions in human health. The talk w ill be organized around three areas that define our current and future wor k: understanding cellular heterogeneity\, dissecting tumor–immune intera ctions\, and developing AI systems for clinical decision-making.\n\n \ ;\n\nSome details about Dr. Arans' research and publications can be found at:\n\nhttps://aran-lab.com/author/dvir-aran/\n\n \;\n\nLooking forwar d to seeing you!\nMaya LOCATION:Faculty Of Biology Auditorium END:VEVENT BEGIN:VEVENT UID:1329@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20251112T130000 DTEND;TZID=Asia/Jerusalem:20251112T140000 DTSTAMP:20251105T082510Z URL:https://biology.technion.ac.il/en/seminars/phd-graduate-seminar-dharan ibalan-kasiviswanathan/ SUMMARY:PhD Graduate Seminar-Dharanibalan Kasiviswanathan [No Categories] DESCRIPTION:Location: Faculty Of Biology Auditorium/ZOOMhttps://technion.zo om.us/j/99692061614 Dharanibalan Kasiviswanathan\n Affiliation: \n Host: Associate Prof. Shenhav Shemer\n  \;\n\nA controlled in vitro model o f disuse atrophy reveals that skeletal muscle drives its own wasting via e xtracellular vesicles \n\nWe established a controlled in vitro model of m uscle disuse using simulated microgravity\, eliminating systemic influence s. This model accurately recapitulates transcriptional and proteomic signa tures of inactive muscles in vivo. We discovered that extracellular vesicl es (EVs) secreted by unloaded myotubes induce catabolic signaling in recip ient muscle cells. Our findings reveal that skeletal muscle can drive its own disuse atrophy through EV-mediated communication. LOCATION:Faculty Of Biology Auditorium/ZOOMhttps://technion.zoom.us/j/99692 061614 END:VEVENT BEGIN:VEVENT UID:1313@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20251110T130000 DTEND;TZID=Asia/Jerusalem:20251110T140000 DTSTAMP:20251103T160826Z URL:https://biology.technion.ac.il/en/seminars/faculty-semninr-professor-g il-ast/ SUMMARY:Faculty Semninr: Professor Gil Ast- 3D Genome Organization Directs Alternative Splicing [No Categories] DESCRIPTION:Location: Faculty Of Biology Auditorium \n Affiliation: Tel Av iv University\n Host:Dr\, Maya Maor-Nof \n I am very happy to open this ye ar’s Faculty Seminar Series at 1:00 p.m. on Monday\, November 10\, with a talk by Prof. Gil Ast of Tel Aviv University. Prof. Ast will present a talk titled “3D Genome Organization Directs Alternative Splicing.”\n\n  \;\n\nYou’re invited to enjoy pizza at 12:30 p.m. on Monday\, Novem ber 10\, at the Biology Auditorium.\n\n \;\n\nTalk Abstract:\nAlternat ive splicing is a major contributor to the creation of human genomic compl exity. However\, this comes at a price: it also contributes dramatically t o higher levels of genetic disorders and cancer. Understanding how alterna tive splicing drives human complexity is one of the major questions we add ress in my lab. We were the first to show that chromatin organization and epigenetic markers regulate alternative splicing. We demonstrated that the y exert this regulation by modulating the elongation rate of RNA polymeras e II. We further discovered that the genome contains two distinct gene arc hitectures—one that primarily resides in the nuclear center and another in the nuclear periphery. Cancer-associated mutations in each of these arc hitectures lead to different outcomes on alternative splicing. Overall\, I will present how 3D genome organization directs alternative splicing.\n\n  \;\n\nSome details about his research and publications can be found a t:\nhttps://www.astlab.sites.tau.ac.il/\n\n \;\n\nLooking forward to s eeing you!\nMaya\n\n \; LOCATION:Faculty Of Biology Auditorium END:VEVENT BEGIN:VEVENT UID:1312@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20251021T130000 DTEND;TZID=Asia/Jerusalem:20251021T140000 DTSTAMP:20251015T082649Z URL:https://biology.technion.ac.il/en/seminars/phd-graduate-seminar-berta- eliad/ SUMMARY:PhD Graduate Seminar-Berta Eliad [No Categories] DESCRIPTION:Location: Hybrid - in the Faculty Auditorium /ZOOM: https://tec hnion.zoom.us/j/99589054205 Berta Eliad\n Affiliation: \n Host : Associate Prof. Ayelet Lamm \n “Game of Edits” - A-to-I RNA Editi ng: Thrones of Regulation\, Gametogenesis and Embryogenesis\n\n \;\n\n Adenosine-to-inosine (A-to-I) RNA editing\, catalyzed by ADARs\, is a wide spread and evolutionarily conserved modification needed to regulate innate immunity. Using C. elegans\, a powerful model for RNA editing research\, we reveal that ADAR subcellular localization affects its substrate prefere nces and function. We show that edited transcripts are maternally\, but no t paternally\, inherited\, and editing levels fluctuate during embryogenes is\, probably to control transcript expression.  LOCATION:Hybrid - in the Faculty Auditorium /ZOOM: https://technion.zoom.us /j/99589054205 END:VEVENT BEGIN:VEVENT UID:1310@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20250918T130000 DTEND;TZID=Asia/Jerusalem:20250918T133000 DTSTAMP:20250914T105138Z URL:https://biology.technion.ac.il/en/seminars/msc-graduate-seminar-barak- gutman/ SUMMARY:MSc Graduate Seminar-Barak Gutman [No Categories] DESCRIPTION:Location: Hybrid - in the Faculty Auditorium /ZOOM: https://tec hnion.zoom.us/j/95647741443 Barak Gutman\n Affiliation: \n Host:Dr. Dvir Aran\n  \;\n\nImmune Profiling in CD59 Deficiency: From Single-Patient scRNA-seq to Therapeutic Insights\n\nCD59 deficiency is a rare disorder i n which cells are vulnerable to uncontrolled complement-mediated immune at tacks. To investigate its mechanisms of action\, we applied single-cell RN A sequencing (scRNA-seq) to peripheral blood mononuclear cells (PBMCs). Be cause only one CD59-deficient patient sample was available\, we developed a pairwise differential expression pipeline that leverages multiple matche d controls and significantly reduces false-positive discoveries. Using thi s approach\, we uncovered a distinct exhausted immune profile marked by do wnregulation of NF-κB signaling and evidence of oxidative stress\, findin gs that illuminate the pathophysiology of CD59 deficiency and also suggest potential avenues for therapeutic intervention LOCATION:Hybrid - in the Faculty Auditorium /ZOOM: https://technion.zoom.us /j/95647741443 END:VEVENT BEGIN:VEVENT UID:1311@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20250916T133000 DTEND;TZID=Asia/Jerusalem:20250916T140000 DTSTAMP:20250914T110634Z URL:https://biology.technion.ac.il/en/seminars/msc-graduate-seminar-valeri a-tsvichenko/ SUMMARY:MSc Graduate Seminar- Valeria Tsvichenko [No Categories] DESCRIPTION:Location: Hybrid - in the Faculty Auditorium /ZOOM: https://tec hnion.zoom.us/j/95522568296 Valeria Tsvichenko\n Affiliation: \n Host:P rof. Debbie Lindell \n Phage Resistance in Synechococcus sp. WH8109 \n\n& nbsp\;\n\nPhage resistance plays a central role in shaping cyanobacterial population dynamics and their interactions with viruses in the ocean. The coexistence of resistant and susceptible cells is likely one of the proces ses enabling hosts and phages to persist together. Yet the patterns and ge netic basis of resistance are only partially resolved. Here\, I examined g enetically distinct populations of Synechococcus sp. WH8109 and found that resistance to the cyanophages Syn9 and S-TIP37 was consistently density-d ependent across host populations. Whole genome sequencing of Syn9-resistan t cyanobacteria revealed mutations in nine genes in the resistant strains. In a complementary approach\, I investigated two porin-like genes previou sly implicated in resistance to phages S-TIP37 and Syn5. However\, heterol ogous binding assays in E. coli did not conclusively establish their role in phage resistance. Together\, these studies integrate ecological and gen etic perspectives to advance understanding of the processes that govern ho st–phage coexistence in marine systems. LOCATION:Hybrid - in the Faculty Auditorium /ZOOM: https://technion.zoom.us /j/95522568296 END:VEVENT BEGIN:VEVENT UID:1308@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20250916T130000 DTEND;TZID=Asia/Jerusalem:20250916T133000 DTSTAMP:20250909T054729Z URL:https://biology.technion.ac.il/en/seminars/msc-graduate-seminar-dolev- shmaltz/ SUMMARY:MSc Graduate Seminar-Dolev Shmaltz-Ayal [No Categories] DESCRIPTION:Location: Hybrid - in the Faculty Auditorium /ZOOM: https://tec hnion.zoom.us/j/95522568296 Dolev Shmaltz\n Affiliation: \n Host:Prof. Yo ram Reiter \n Inside and Out: Antigen Type Shapes T-Cell Engager Performan ce Across Intracellular and Extracellular Targets\n\n \;\n\nBi-specifi c T-cell engagers (BiTEs) are engineered antibodies that redirect a patien t’s own T cells to attack tumors\, providing an “off-the-shelf” immu notherapy option alongside cell-based therapies like CAR T cells. Most BiT Es focus on surface proteins\, yet many of the most clinically relevant tu mor antigens reside inside the cell and are displayed only as peptide–MH C complexes. In this work\, we directly compared BiTEs targeting a convent ional melanoma surface antigen (MCSP) with BiTEs recognizing an intracellu lar peptide presented by HLA. Through analysis of T-cell activation\, cyto kine release\, and tumor cell killing across a range of antigen densities\ , we demonstrate that the route of antigen presentation decisively shapes therapeutic potency and functional outcomes. LOCATION:Hybrid - in the Faculty Auditorium /ZOOM: https://technion.zoom.us /j/95522568296 END:VEVENT BEGIN:VEVENT UID:1309@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20250915T130000 DTEND;TZID=Asia/Jerusalem:20250915T140000 DTSTAMP:20250911T115612Z URL:https://biology.technion.ac.il/en/seminars/phd-graduate-seminar-christ oph-velling/ SUMMARY:PhD Graduate Seminar-Christoph Velling [No Categories] DESCRIPTION:Location: Hybrid - in the Faculty Auditorium /ZOOM: https://tec hnion.zoom.us/j/91646006232?pwd=qONDv5ujifMHOeKsXdQ2W5zByVjAF2.1 Christop h Velling\n Affiliation: \n Host:Prof. Roy Kishony \n Spatio-temporal micr obial evolution dynamics\n\n In natural microbial communities\, antagonis tic interactions among bacterial species\, or between bacteria and phages\ , are important drivers of community evolution and ecological dynamics. Th ese natural environments often involve spatial structure\, which could be a key factor for evolutionary processes as well as for expansion dynamics into new spaces\, yet it is often neglected in microbial community experim entation and simulations. In this project\, we first studied evolution of antibiotic producers in microdroplets\, effectively forming small\, distin ct environments where direct competition with resistant bacteria is exclud ed and\, therefore\, selection for producers can occur. In the second part \, we modeled bacteria-phage interactions in an expanding bacterial wave i n space. We show how phage-resistant bacteria can protect sensitive bacter ia through an indirect slowdown of phage migration in a competition scenar io and how phages could potentially overcome this protection mechanism. To gether\, these studies help shed light on the complex spatio-temporal dyna mics of antagonistically interacting microbial species. LOCATION:Hybrid - in the Faculty Auditorium /ZOOM: https://technion.zoom.us /j/91646006232?pwd=qONDv5ujifMHOeKsXdQ2W5zByVjAF2.1 END:VEVENT BEGIN:VEVENT UID:1305@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20250909T133000 DTEND;TZID=Asia/Jerusalem:20250909T140000 DTSTAMP:20250904T132848Z URL:https://biology.technion.ac.il/en/seminars/msc-graduate-seminar-tylor- brent-de-leon/ SUMMARY:MSc Graduate Seminar-Tylor-Tyler Brent de Leon [No Categories] DESCRIPTION:Location: Hybrid - in the Faculty Auditorium /ZOOM: - https:// technion.zoom.us/j/4885283424 Tylor-Brent De-Leon\n Affiliation: \n Host: Prof. Yoav Arava \n Locally synthesized glycyl aminoacyl tRNA synthetase ( GARS1) is important for  local translation in neurons\n\nRegulation of ge ne expression is essential for neuronal development and function. A promin ent regulatory mechanism involves synthesis of proteins at their activity site. Such local protein synthesis enables neurons to respond rapidly and tightly to stimuli. Key components of the translation machinery\, includin g mRNA and ribosomes\, were identified in subcellular regions of neurons. Yet\, the role of tRNAs and their charging enzymes\, aminoacyl tRNA synthe tases (aaRS)\, in this process remains largely unclear. Here\, we demonstr ate that glycyl tRNA synthetase (GARS1) mRNA is abundant in neurites and u ndergoes local translation\, producing GARS1 protein. Localized GARS1 prot ein is in close proximity to tRNAGly\, and disrupting this interaction imp airs local protein synthesis in neurites. Notably\, in a neuropathy-causin g mutant variant of GARS1\, we observed enhanced proximity to tRNAGly\, in dicating that altered GARS1– tRNAGly interactions may contribute to dise ase pathogenesis. These findings establish the functional importance of GA RS1 and tRNAGly in neuritic translation and suggest a mechanism for periph eral neuropathies due to mutations in GARS1. LOCATION:Hybrid - in the Faculty Auditorium /ZOOM: - https://technion.zoom .us/j/4885283424 END:VEVENT BEGIN:VEVENT UID:1304@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20250909T130000 DTEND;TZID=Asia/Jerusalem:20250909T133000 DTSTAMP:20250904T114048Z URL:https://biology.technion.ac.il/en/seminars/msc-graduate-seminar-dina-a lexandrovich/ SUMMARY:MSc Graduate Seminar-Dina Alexandrovich [No Categories] DESCRIPTION:Location: Hybrid - in the Faculty Auditorium /ZOOM:- https://te chnion.zoom.us/j/4885283424 Dina Alexandrovich\n Affiliation: \n Host:P rof. Yael Mandel-Gutfreund \n Developing computational approaches for pred icting nucleic acid binding proteins and their targets\n\n \;\n\nNucle ic acid binding proteins\, and specifically DNA-binding proteins (DBPs) an d RNA-binding proteins (RBPs)\, play a central role in all steps of the ge ne expression pathway\, from RNA transcription via post-transcriptional re gulation to protein translation. Understanding the complexity of gene expr ession regulation requires the identification of RBPs and DBPs\, which are involved in these processes\, and to define their binding sites. To addre ss these challenges\, we developed BindUP-Alpha\, a machine learning-based algorithm for predicting nucleic acid-binding proteins based on protein s tructure models from AlphaFold.We also developed intRBP\, a deep learning model trained on high-throughput RNA-binding data\, which accurately predi cts the targets of RNA-binding proteins. LOCATION:Hybrid - in the Faculty Auditorium /ZOOM:- https://technion.zoom.u s/j/4885283424 END:VEVENT BEGIN:VEVENT UID:1307@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20250908T133000 DTEND;TZID=Asia/Jerusalem:20250908T140000 DTSTAMP:20250907T065924Z URL:https://biology.technion.ac.il/en/seminars/msc-graduate-seminar-netane l-amiel/ SUMMARY:MSc Graduate Seminar-Netanel Amiel [No Categories] DESCRIPTION:Location: Hybrid - in the Faculty Auditorium /ZOOM: https://tec hnion.zoom.us/j/95534105252 Netanel Amiel\n Affiliation: \n Host:Associat e Prof. David Meiri \n The cumulative effect of cannabinoids on the immun e system in IBD mouse models\n\n \;\n\nInflammatory bowel disease (IBD ) is a chronic\, relapsing inflammatory disorder of the gastrointestinal t ract\, and current therapies often rely on immunosuppression with limited long-term success. To explore alternative strategies\, we examined the pot ential of cannabinoids to modulate both adaptive and innate immune pathway s relevant to IBD. Previous work in our lab showed that cannabidiolic acid (CBDA) affected the adaptive immune system by reducing pro-inflammatory T cell responses\, while a combination of cannabidiol (CBD) and cannabidiva rin (CBDV) acted on innate immunity by limiting CXCR4-dependent recruitmen t of inflammatory cells to the gut. We hypothesized that combining these c ompounds might provide additive or synergistic benefits by targeting compl ementary arms of the immune system. Using both acute and chronic DSS-induc ed colitis models in mice\, we assessed disease severity under separate an d combined treatments. While each treatment effectively reduced disease se verity\, the combination did not yield additive effects\, pointing the nee d for further exploration of cannabinoids in gut inflammation LOCATION:Hybrid - in the Faculty Auditorium /ZOOM: https://technion.zoom.us /j/95534105252 END:VEVENT BEGIN:VEVENT UID:1306@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20250908T130000 DTEND;TZID=Asia/Jerusalem:20250908T133000 DTSTAMP:20250904T115224Z URL:https://biology.technion.ac.il/en/seminars/msc-graduate-seminar-hannah -eda-rand/ SUMMARY:MSc Graduate Seminar-Hannah Eda Rand [No Categories] DESCRIPTION:Location: Hybrid - in the Faculty Auditorium /ZOOM: https://tec hnion.zoom.us/j/95534105252 Hannah Eda Rand\n Affiliation: \n Host:Dr. Na dav Sharon \n Investigating MMP12⁺ Macrophages as Potential Modulators o f Islet Vulnerability in Type 1 Diabetes\n\nType 1 diabetes is an autoimmu ne disease that leads to the selective destruction of insulin-producing pa ncreatic beta cells in the islets of Langerhans. Notably\, MMP12-expressin g macrophages appear predominantly in non-attacked islets. In line with th eir reported anti-inflammatory function in cancer\, we hypothesize that MM P12⁺ macrophages may play a protective role in T1D. To test this\, I use RNAscope to validate the scRNAseq findings in Non-Obese Diabetic (NOD) mi ce\, spatial transcriptomics to confirm their presence in human tissue\, a nd am working to create a transgenic mouse model to manipulate the cells. LOCATION:Hybrid - in the Faculty Auditorium /ZOOM: https://technion.zoom.us /j/95534105252 END:VEVENT BEGIN:VEVENT UID:1303@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20250826T130000 DTEND;TZID=Asia/Jerusalem:20250826T140000 DTSTAMP:20250724T080246Z URL:https://biology.technion.ac.il/en/seminars/phd-graduate-seminar-jonath an-ram/ SUMMARY:PhD Graduate Seminar-Jonathan Ram [No Categories] DESCRIPTION:Location: Hybrid - in the Faculty Auditorium /ZOOM: https://tec hnion.zoom.us/j/93938772814 Jonathan Ram\n Affiliation: \n Host:Prof. Mic hael Glickman\n  \;\n\nNew players in mitochondrial protein import qua lity control13\n\nMitochondria import most of their proteins from the cyto sol via dedicated channels in the outer membrane. This process is complex\ , and import can occasionally stall when proteins get stuck in transit. Wh ile the role of the ubiquitin–proteasome system (UPS) in this context is well established in yeast\, it remains poorly understood in mammalian cel ls. We performed a proximity-based screen to identify UPS components near the mitochondrial import channel and uncovered novel interactors. Among th em\, we identified UBXD8 and investigated its role in the quality control of mitochondrial protein import. These findings not only expand our unders tanding of mitochondrial proteostasis in mammals\, but also reveal UBXD8 a s a potential regulator of import channel homeostasis. LOCATION:Hybrid - in the Faculty Auditorium /ZOOM: https://technion.zoom.us /j/93938772814 END:VEVENT BEGIN:VEVENT UID:1302@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20250819T130000 DTEND;TZID=Asia/Jerusalem:20250819T140000 DTSTAMP:20250722T113934Z URL:https://biology.technion.ac.il/en/seminars/phd-graduate-seminar-sunu-j oseph/ SUMMARY:PhD Graduate Seminar-Sunu Joseph [No Categories] DESCRIPTION:Location: Sunu Joseph\n Affiliation: \n Host:Associate Prof. Shenhav Shemer\n 13\n\nThe ubiquitin-proteasome system plays a crucial ro le in excessive muscle proteolysis during atrophy\, a condition triggered by inactivity\, starvation\, aging\, cancer\, and muscular dystrophies. Wh ile ubiquitin ligases (E3s) have been extensively studied in this process\ , the functions of E2 conjugating enzymes\, which facilitate ubiquitin tra nsfer with E3s\, remain poorly understood. Ube2h is an E2 ubiquitin-conjug ating enzyme with less understood cellular functions compared to E3 ligase s. Ube2h is distinct in lacking a typical ubiquitin-binding surface and ha ving a unique disordered C-terminal region. Our data suggest that Ube2h pr omotes fasting-induced muscle atrophy by impairing insulin signaling via i ts C-terminal region. In addition\, Ube2h reduces desmin integrity by targ eting the heat shock protein Hspb1 for degradation\, facilitating desmin d epolymerization and the resulting loss of the contractile machinery.0:0011 END:VEVENT BEGIN:VEVENT UID:1301@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20250812T130000 DTEND;TZID=Asia/Jerusalem:20250812T133000 DTSTAMP:20250715T071927Z URL:https://biology.technion.ac.il/en/seminars/msc-graduate-seminar-shahar -lavid/ SUMMARY:MSc Graduate Seminar-Shahar Lavid [No Categories] DESCRIPTION:Location: Hybrid - in the Faculty Auditorium /ZOOM: https://tec hnion.zoom.us/j/96544365611 Shahar Lavid\n Affiliation: \n Host:Prof. Ben jamin Podbilewicz \n  Title: Structure Prediction and Sequence Phylogeny of Fusion Family (FF) Proteins Indicate a Common Ancestor in Nematodes and Horizontal Gene Transfer Origin in Non-Nematodes13\n\nThe fusexin superfa mily comprises proteins that mediate cell-cell fusion during viral infecti ons\, somatic development and sexual reproduction\, and have also been ide ntified in Archaea. Among them\, a subfamily of FF proteins\, first identi fied in the nematode C. elegans\, exhibits a striking structural similarit y to Class II viral fusogens. This similarity\, however\, is absent at the sequence level\, making their evolutionary origin difficult to pinpoint. By analyzing the phylogenetic relationships and structural predictions of FF candidate ectodomains\, we present a phylogenetic inquiry of FF protein s in both nematode and non-nematode species. Results show that nematodes h arbor two distinct FF subgroups\, which correspond to the C. elegans fusog ens EFF-1 and AFF-1 and align with nematode phylogeny. In contrast\, the g eneral phylogeny of FF in non-nematode species diverges from broader inver tebrate evolution. The results reveal the variable origins of FF proteins and suggest divergence in their structural properties as well\n\n \; LOCATION:Hybrid - in the Faculty Auditorium /ZOOM: https://technion.zoom.us /j/96544365611 END:VEVENT BEGIN:VEVENT UID:1299@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20250722T130000 DTEND;TZID=Asia/Jerusalem:20250722T140000 DTSTAMP:20250702T150957Z URL:https://biology.technion.ac.il/en/seminars/phd-graduate-seminar-joshua -hazan/ SUMMARY:PhD Graduate Seminar-Joshua Hazan [No Categories] DESCRIPTION:Location: Hybrid - in the Faculty Auditorium /ZOOM: https://tec hnion.zoom.us/j/94162344686 Joshua Hazan \n Affiliation: \n Host:Dr. Assa f Bester \n  \;\n\nA toolkit to decipher mechanistic insights of long non-coding RNAs based on guided CRISPR screens\n\nLong non-coding RNAs (ln cRNAs) are a large and diverse group of non-protein-coding genes whose fun ctions span a wide range of cellular processes in healthy cells and in the progression of various diseases. Despite their potential roles in many ma jor cellular processes\, the molecular function of the majority of lncRNAs remains unknown. To improve the strategy for lncRNA identification\, we d eveloped two strategies to discover novel functional lncRNAs and character ize their molecular mechanisms of action. First\, we developed a machine l earning called INFLAMeR to predict functional lncRNAs in a cell type-speci fic manner. INFLAMeR showed high predictive accuracy\, and we saw that the lncRNA SNHG6 affected haematopoiesis in leukaemia cells.Second\, we desig ned a compact CRISPRi-based screening strategy called SPPARCL to identify new lncRNAs that function in diverse cellular stresses. Through this\, we saw that LINC00680 affects tRNA expression and ribosome assembly. Together \, these tools offer important new ways to identify lncRNAs that function in health and disease. LOCATION:Hybrid - in the Faculty Auditorium /ZOOM: https://technion.zoom.us /j/94162344686 END:VEVENT BEGIN:VEVENT UID:1298@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20250721T130000 DTEND;TZID=Asia/Jerusalem:20250721T140000 DTSTAMP:20250702T145905Z URL:https://biology.technion.ac.il/en/seminars/phd-graduate-seminar-peleg- ragonis-bachar/ SUMMARY:PhD Graduate Seminar-Peleg Ragonis-Bachar [No Categories] DESCRIPTION:Location: Hybrid - in the Faculty Auditorium /ZOOM: https://tec hnion.zoom.us/j/98805522689 Peleg Ragonis-Bachar\n Affiliation: \n Host:A ssociate Prof. Meytal Landau\n Towards the Design of Targeted Therapeutics based on Microbial and Antimicrobial \n\n \;\n\nAmyloids\, long thou ght to be defined by their classic cross-β fibril structure\, have recent ly revealed a surprising new form: the cross-α architecture built from α -helices—shifting our fundamental understanding of protein self-assembly . Harnessing cutting-edge computational tools that combine secondary struc ture prediction with AI-driven biochemical analysis\, I discovered dozens of novel amyloid-forming peptides\, including unique structural variants w ith distinct antimicrobial functions. These findings expose the astonishin g structural and functional diversity hidden within amyloids\, challenging the traditional dogma that structure dictates pathology. Additionally\, u sing sequence-based AI model we were able to correlate between various bio chemical property of a sequence to the amyloid structure and function. Ult imately\, this work opens new frontiers for precisely targeting pathologic al amyloids or designing next-generation antimicrobial agents. LOCATION:Hybrid - in the Faculty Auditorium /ZOOM: https://technion.zoom.us /j/98805522689 END:VEVENT BEGIN:VEVENT UID:1297@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20250715T130000 DTEND;TZID=Asia/Jerusalem:20250715T133000 DTSTAMP:20250701T085506Z URL:https://biology.technion.ac.il/en/seminars/7604/ SUMMARY:Msc Graduate Seminar-Tamar Gil [No Categories] DESCRIPTION:Location: Place: Hybrid - in the Faculty Auditorium /ZOOM: http s://technion.zoom.us/j/97752400169 \n Affiliation: \n Host:Prof. Roy Kish ony\n High-throughput mapping of transposon-driven genomic rearrangements under antibiotic stress\n\n \;\n\nTransposons and insertion sequence ( IS elements) facilitate bacterial adaptation to antibiotics through two ma in mechanisms. In regular transposition (insertion)\, an IS is excised fro m the genome and inserted at a target site. In replicative transposition\, each side of the IS attaches to another genomic locus\, joining them toge ther as it duplicates. These transpositions generate genomic rearrangement s and repeats\, which cannot be resolved by short reads. To overcome this challenge\, we couple inverse PCR with paired-end sequencing\, to jointly capture both IS flanks. Joint sequencing is achieved by fragmenting genomi c DNA\, self-ligating the fragments\, and PCR with outward-facing primers to target the now-fused flanks of the IS. We apply this method to IS1 in E . coli populations exposed to antibiotics\, and identify over 100 insertio n sites\, and a variety of locus-joining events. Comparison with control p opulations suggest adaptive amplification events via homologous recombinat ion between ISs\, as well as replicative transpositions. LOCATION:Place: Hybrid - in the Faculty Auditorium /ZOOM: https://technion. zoom.us/j/97752400169 END:VEVENT BEGIN:VEVENT UID:1300@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20250708T130000 DTEND;TZID=Asia/Jerusalem:20250708T140000 DTSTAMP:20250707T065050Z URL:https://biology.technion.ac.il/en/seminars/special-seminar-prof-ting-c hen/ SUMMARY:Special Seminar - Prof. Ting Chen [No Categories] DESCRIPTION:Location: Biology auditorium Prof. Ting Chen \n Affiliation: T singua University\n Host:Dr. Dvir Aran\n Dear all\,\n\n \;\n\nOn Tuesd ay\, July 8th\, we are delighted to host Prof. Ting Chen of Tsingua Unive rsity for a special research seminar. Prof. Chen is a leading figure in co mputational biology and medical informatics.  After earning his Ph.D. at SUNY Stony Brook\, he lectured at Harvard and then spent sixteen years on the faculty of the University of Southern California\, before joining Tsin ghua University in 2016\, where he now directs the Center for Big Data Res earch in Medicine and Health. His work spans genome analysis\, machine-lea rning algorithms for biomedical data\, and large-scale health-data platfor ms\, and it has garnered more than 40\,000 citations.\n0:0013:00\nPlease m ake an effort to attend and pass this notice to others at the Technion who may be interested.\n\nPlace and time: Biology auditorium\, Tuesday July 8 th at 13:00.\n\nTitle: AI Models for Rare Disease Diagnosis\, Treatment\, and Intelligent Medical Inquiry\n\nSpeaker webpage: https://www.cs.tsinghu a.edu.cn/csen/info/1312/4385.htm\n\nGoogle scholar: https://scholar.google .com/citations?user=yE6LvhMAAAAJ\n\n \;\n\nLooking forward to seeing y ou all\,\n\nDvir\n\n \;\n\nDvir Aran\, PhD\nAssistant Professor\n\nFac ulty of Biology \\ Taub Faculty of Computer Science\n\nTechnion - Israel I nstitute of Technology\n\nhttps://aran-lab.com13:00 LOCATION:Biology auditorium END:VEVENT BEGIN:VEVENT UID:1286@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20250708T130000 DTEND;TZID=Asia/Jerusalem:20250708T140000 DTSTAMP:20250521T101431Z URL:https://biology.technion.ac.il/en/seminars/special-seminar-prof-ting-c hen-ai-models-for-rare-disease-diagnosis-treatment-and-intelligent-medical -inquiry/ SUMMARY:Special Seminar - Prof. Ting Chen-AI Models for Rare Disease Diagno sis\, Treatment\, and Intelligent Medical Inquiry [No Categories] DESCRIPTION:Location: Biology auditorium Prof. Ting Chen \n Affiliation: T singua University \n Host:Dr. Dvir Aran\n On Tuesday\, July 8th\, we are d elighted to host Prof. Ting Chen of Tsingua University for a special rese arch seminar. Prof. Chen is a leading figure in computational biology and medical informatics.  After earning his Ph.D. at SUNY Stony Brook\, he le ctured at Harvard and then spent sixteen years on the faculty of the Unive rsity of Southern California\, before joining Tsinghua University in 2016\ , where he now directs the Center for Big Data Research in Medicine and He alth. His work spans genome analysis\, machine-learning algorithms for bio medical data\, and large-scale health-data platforms\, and it has garnered more than 40\,000 citations.\n\nPlease make an effort to attend and pass this notice to others at the Technion who may be interested.\n\nPlace and time: Biology auditorium\, Tuesday July 8th at 13:00.\n\nTitle: AI Models for Rare Disease Diagnosis\, Treatment\, and Intelligent Medical Inquiry\n \nSpeaker webpage: https://www.cs.tsinghua.edu.cn/csen/info/1312/4385.htm\ n\nGoogle scholar: https://scholar.google.com/citations?user=yE6LvhMAAAAJ\ n\n \;\n\nLooking forward to seeing you all\, LOCATION:Biology auditorium END:VEVENT BEGIN:VEVENT UID:1295@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20250701T130000 DTEND;TZID=Asia/Jerusalem:20250701T133000 DTSTAMP:20250701T073443Z URL:https://biology.technion.ac.il/en/seminars/msc-graduate-seminar-ekatar ins-petrenko/ SUMMARY:MSc Graduate Seminar-Ekaterina Petrenko [No Categories] DESCRIPTION:Location: Hybrid- in the Faculty Auditorium/ZOOM:https://techni on.zoom.us/j/97497946716 Ekatarins Petrenko\n Affiliation: \n Host:Dr. Dv ir Aran\n  Age-dependent differences in neuroblastoma microenvironment: i ntegrative analysis of human and mouse single-cell RNA sequencing data\n\n  \;\n\nThis research investigates the molecular basis of age-dependent outcome disparities in neuroblastoma\, the most common extracranial solid tumor in children\, where patients under 18 months show dramatically bett er survival rates than older children. We developed CellMentor\, a novel s upervised non-negative matrix factorization method that leverages labeled reference datasets to learn biologically meaningful latent spaces for sing le-cell RNA sequencing analysis. Using both mouse models and human patient data\, we discovered age-specific differences in the tumor microenvironme nt\, particularly in neutrophil populations that may contribute to better outcomes in younger patients. This work provides new computational tools a nd biological insights that could inform age-tailored therapeutic approach es for pediatric neuroblastoma. LOCATION:Hybrid- in the Faculty Auditorium/ZOOM:https://technion.zoom.us/j/ 97497946716 END:VEVENT BEGIN:VEVENT UID:1296@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20250630T130000 DTEND;TZID=Asia/Jerusalem:20250630T140000 DTSTAMP:20250629T054551Z URL:https://biology.technion.ac.il/en/seminars/faculty-seminar-dr-ayala-sh iber-30-6-2025/ SUMMARY:Faculty seminar - Dr. Ayala Shiber 30.6.2025 [No Categories] DESCRIPTION:Location: Dr. Ayala Shiber\n Affiliation: \n Host:Dr. Shainer Inbal\n Dear all\,\n\n \;\n\nOur next seminar will be given by Dr. Ay ala Shiber from the Technion Faculty of Biology\n\n \;\n\nPlace and ti me: Biology auditorium\, Monday 30/6 at 13:00.\n\n \;\n\nTitle: Co-tra nslational protein folding\, assembly and quality control\, in health and disease\n\n \;\n\nDr. Shiber’s website: https://shiberlab.wixsite.c om/shiber\n\n \;\n\nLooking forward to seeing you all\,\n\nInbal\n\n&n bsp\;\n\nThe full list of this semester’s speakers can be found here: Fa culty Seminars Spring 2025\n\n \;\n\nFor inquiries regarding the cours e or to receive a Zoom link\, please contact Prof. Dedi Meiri <\;dmeir i@technion.ac.il>\; END:VEVENT BEGIN:VEVENT UID:1294@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20250625T130000 DTEND;TZID=Asia/Jerusalem:20250625T140000 DTSTAMP:20250624T061542Z URL:https://biology.technion.ac.il/en/seminars/phd-graduate-seminar-raz-be n-david/ SUMMARY:PhD Graduate Seminar- Raz Ben-David [No Categories] DESCRIPTION:Location: ZOOM: https://technion.zoom.us/j/95719561465 Raz Be n-David\n Affiliation: \n Host:Associate Prof. Shenhav Shemer\n Intermitte nt Fasting to Attenuate Age-Related Muscle Atrophy In Aging C57BL/6 Mice:\ n\nStudy of the Underlying Molecular Mechanisms\n\n \;\n\nSarcopenia\, the age-related loss of muscle mass and strength\, contributes to frailty \, impaired mobility\, and metabolic dysfunction. Traditional intervention s\, such as resistance training and increased protein intake\, are not alw ays feasible\, leading to investigation into alternative strategies. This study investigated whether intermittent fasting can attenuate age-related atrophy\, with particular focus on the preservation of the dystrophin-glyc oprotein complex (DGC) and its associated signaling hub involving plakoglo bin and the insulin receptor. Young (3-6 months)\, middle-aged (12-15 and 15-18 months)\, and old (18-21 months) male C57BL/6 mice underwent 12-week regimens of either time-restricted feeding (TRF\; 8-hour feeding/16-hour fasting)\, alternate-day fasting (ADF\; fasting every other day)\, or ad l ibitum (AL) feeding. Outcomes measured included body composition\, muscle mass and function\, glucose metabolism\, anabolic signaling\, muscle histo logy\, and fiber-type distribution. LOCATION:ZOOM: https://technion.zoom.us/j/95719561465 END:VEVENT BEGIN:VEVENT UID:1293@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20250624T130000 DTEND;TZID=Asia/Jerusalem:20250624T133000 DTSTAMP:20250622T110930Z URL:https://biology.technion.ac.il/en/seminars/msc-graduate-seminar-adva-k fir/ SUMMARY:MSc Graduate Seminar-Adva Kfir [No Categories] DESCRIPTION:Location: ZOOM: https://technion.zoom.us/j/98815143098 Adva Kf ir\n Affiliation: \n Host:Dr. Ayala Shiber\n  \;\n\n \;\n\nSplit-A DAR System to Detect in vivo Co-translational Cooperativity in Single-Mole cule Resolution\n\n \;\n\nProtein biogenesis is challenging in the cro wded cellular environment\, where off-pathway interactions can lead to pro tein aggregation - a hallmark of neurodegenerative diseases. To maintain p rotein homeostasis\, cells employ an intricate network of ribosome-associa ted factors that regulate folding\, localization\, and complex assembly co -translationally. Yet\, how these factors coordinate their dynamic binding to translating ribosomes remains poorly understood. Here\, we developed a single-molecule approach that combines Nanopore sequencing of full-length transcripts with mRNA proximity labelling using a split-ADAR system. We h ave provided a proof of concept for the robustness of this approach in det ecting even transient co-translational interactions at the ribosome. Using this system\, we have demonstrated evidence for co-translational cooperat ivity between the highly conserved ribosome-associated factors Map1 and Na tA along single transcripts. LOCATION:ZOOM: https://technion.zoom.us/j/98815143098 END:VEVENT BEGIN:VEVENT UID:1292@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20250617T130000 DTEND;TZID=Asia/Jerusalem:20250617T140000 DTSTAMP:20250615T064500Z URL:https://biology.technion.ac.il/en/seminars/phd-graduate-seminar-hanna- saleem/ SUMMARY:PhD Graduate Seminar-Hanna Saleem [No Categories] DESCRIPTION:Location: Hybrid - in the Faculty Auditorium /ZOOM: https://tec hnion.zoom.us/j/93897432505 \n Affiliation: \n Host:Prof. Emeritus Dina R on and Associate Professor Shenhav Shemer\n Unveiling a new human SEF (IL- 17RD) function in breast cancer prevention LOCATION:Hybrid - in the Faculty Auditorium /ZOOM: https://technion.zoom.us /j/93897432505 END:VEVENT BEGIN:VEVENT UID:1291@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20250616T130000 DTEND;TZID=Asia/Jerusalem:20250616T140000 DTSTAMP:20250612T060840Z URL:https://biology.technion.ac.il/en/seminars/faculty-seminar-dr-ifat-she r-16-6-2025/ SUMMARY:Faculty seminar - Dr. Ifat Sher 16.6.2025 [No Categories] DESCRIPTION:Location: Biology auditorium Dr. Ifat Sher\n Affiliation: She ba Medical Center and Tel-Aviv University\n Host:Dr. Shainer Inbal\n Dear all\,\n\n \;\n\nOur next seminar will be given by Dr. Ifat Sher from the Sheba Medical Center and Tel-Aviv University\n\n \;\n\nPlace and t ime: Biology auditorium\, Monday 16/6 at 13:00.\n\n \;\n\nTitle: From Bedside to Bench and Back: Personalized Drug Discovery for Retinal Degener ation Diseases\n\n \;\n\nDr. Sher’s website: https://ifaat3.wixsite .com/restorative-retinal\n\n \;\n\nLooking forward to seeing you all\, \n\nInbal\n\n \;\n\nThe full list of this semester’s speakers can be found here: Faculty Seminars Spring 2025\n\n \;\n\nFor inquiries rega rding the course or to receive a Zoom link\, please contact Prof. Dedi Me iri <\;dmeiri@technion.ac.il>\; LOCATION:Biology auditorium END:VEVENT BEGIN:VEVENT UID:1290@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20250609T130000 DTEND;TZID=Asia/Jerusalem:20250609T140000 DTSTAMP:20250603T102723Z URL:https://biology.technion.ac.il/en/seminars/faculty-seminar-dr-shay-ste rn-9-6-2025/ SUMMARY:Faculty seminar - Dr. Shay Stern 9.6.2025 [No Categories] DESCRIPTION:Location: Biology auditorium Dr. Shay Stern \n Affiliation: \n Host:Dr. Shainer Inbal\n Dear all\,\n\n \;\n\nOur next seminar will b e given by Dr. Shay Stern from the Technion’s Faculty of Biology.\n\n&nb sp\;\n\nPlace and time: Biology auditorium\, Monday 9/6 at 13:00.\n\n  \;\n\nTitle: Organization and regulation of developmental patterns of beha vior and individuality\n\n \;\n\nDr. Stern’s website: https://www.ss ternlab.com/\n\n \;\n\nLooking forward to seeing you all\,\n\nInbal\n\ n \;\n\nThe full list of this semester’s speakers can be found here: Faculty Seminars Spring 2025\n\n \;\n\nFor inquiries regarding the co urse or to receive a Zoom link\, please contact Prof. Dedi Meiri <\;dm eiri@technion.ac.il>\; LOCATION:Biology auditorium END:VEVENT BEGIN:VEVENT UID:1289@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20250603T130000 DTEND;TZID=Asia/Jerusalem:20250603T140000 DTSTAMP:20250528T134458Z URL:https://biology.technion.ac.il/en/seminars/msc-graduate-seminar-yahav- festinger/ SUMMARY:MSc Graduate Seminar-Yahav Festinger [No Categories] DESCRIPTION:Location: Hybrid - in the Faculty Auditorium /ZOOM: https://tec hnion.zoom.us/j/8522459764?omn=91894620721 \n Affiliation: \n Host:Associ ate Professor Ayelet Lamm\n  Identification of false discoveries in seque ncing data\n\n \;\n\nSequencing techniques are fundamental in almost a ll genetic research\, either by sequencing the entire genome or transcript ome\, by high-throughput sequencing\, or by sequencing a small segment of DNA using Sanger sequencing. The biggest challenge in all techniques is id entifying noise and false discovery versus real biological changes. There are not many tools available that can be used for data exploration and the identification of false discoveries. Here\, we developed an algorithm on RNA-seq data to track discrepancies between the data and the statistical m odel design that enables optimal data analysis. In addition\, we developed a Sanger sequencing analyzer that quantifies and determines if a SNP is s equencing noise. LOCATION:Hybrid - in the Faculty Auditorium /ZOOM: https://technion.zoom.us /j/8522459764?omn=91894620721 END:VEVENT BEGIN:VEVENT UID:1287@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20250527T130000 DTEND;TZID=Asia/Jerusalem:20250527T140000 DTSTAMP:20250521T103016Z URL:https://biology.technion.ac.il/en/seminars/phd-graduate-seminar-eshkar -nir/ SUMMARY:PhD Graduate Seminar-Eshkar Nir [No Categories] DESCRIPTION:Location: Hybrid- in the Faculty Auditorium/ZOOM:https://techni on.zoom.us/j/95717334601 Eshkar Nir\n Affiliation: \n Host:Dr. Stern Shay \n Studying developmental patterns of social interactions in C. elegans an d their effects on individuality\n\nIndividuals within the same population dynamically change their social interactions across development. Understa nding how these long-term inter-individual behavioral interactions are mod ified across different stages of development and the neuronal pathways inv olved remains unclear. We developed and utilized a novel imaging setup to study behavioral interactions of multiple pairs of C. elegans across devel opmental timescales. We found that wild-type animals show dynamic patterns of social interactions that increase in frequency and change in duration in a stage-specific manner. We further revealed that these long-term socia l patterns are shaped by specific sensory modalities\, in particular\, mec hanosensation and chemosensation. Moreover\, we found that the social cont ext also affected consistent individuality within the pairs during early d evelopmental stages. Our results highlight an active role for sensory path ways in organizing the developmental dynamics of social behavior and their effects on individual variation. LOCATION:Hybrid- in the Faculty Auditorium/ZOOM:https://technion.zoom.us/j/ 95717334601 END:VEVENT BEGIN:VEVENT UID:1288@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20250526T130000 DTEND;TZID=Asia/Jerusalem:20250526T140000 DTSTAMP:20250525T080931Z URL:https://biology.technion.ac.il/en/seminars/aculty-seminar-prof-amit-ze isel-26-5-2025-single-cell-approaches-to-studying-connectivity-and-neurona l-states-during-fear-learning/ SUMMARY:aculty seminar - Prof. Amit Zeisel  26.5.2025-Single-cell approac hes to studying connectivity and neuronal states during fear learning [No Categories] DESCRIPTION:Location: Biology auditorium Prof. Amit Zeisel \n Affiliation: Technion’s Faculty of Biotechnology and Food Engineering \n Host:Dr. Sh ainer Inbal\n Dear all\,\n\n \;\n\nOur next seminar will be given by P rof. Amit Zeisel from the Technion’s Faculty of Biotechnology and Food E ngineering\n\n \;\n\nPlace and time: Biology auditorium\, Monday 26/5 at 13:00.\n\n \;\n\nTitle: Single-cell approaches to studying connecti vity and neuronal states during fear learning\n\n \;\n\nProf. Zeisel ’s website: https://zeisellab.org/\n\n \;\n\n \;\n\nLooking forw ard to seeing you all\,\n\nInbal\n\n \;\n\nThe full list of this semes ter’s speakers can be found here: Faculty Seminars Spring 2025 LOCATION:Biology auditorium END:VEVENT BEGIN:VEVENT UID:1285@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20250519T130000 DTEND;TZID=Asia/Jerusalem:20250519T140000 DTSTAMP:20250514T101940Z URL:https://biology.technion.ac.il/en/seminars/faculty-seminar-dr-einat-se gev-19-5-2025-in-person-bacterial-physiology-in-an-environmental-context/ SUMMARY:Faculty seminar - Dr. Einat Segev 19.5.2025 [In-person]-Bacterial Physiology in an Environmental Context [No Categories] DESCRIPTION:Location: Biology auditorium Dr. Einat Segev \n Affiliation: Weizmann Institute of Science \n Host:\n Dear all\,\n\n \;\n\nOur nex t seminar will be given by Dr. Einat Segev from the Weizmann Institute of Science\n\n \;\n\nPlace and time: Biology auditorium\, Monday 19/5 at 13:00.\n\n \;\n\nTitle: Bacterial Physiology in an Environmental Cont ext\n\n \;\n\nAbstract:\n\nMicroorganisms have evolved in the cold\, n utrient-poor oceans for millions of years\, yet laboratory studies often u se conditions that differ greatly from their natural habitats. To better u nderstand the physiology of marine bacteria\, our group investigates model systems that closely mimic real-world environments. This approach allows us to reveal novel behaviors of marine microbes.\n\nBeyond basic environme ntal factors like temperature and nutrient availability\, marine bacteria are also shaped by interactions with algal hosts. These interactions range from competition to cooperation\, and significantly influence bacteria\, algae\, and ecosystem processes such as nutrient cycling and food web stab ility.\n\nIn my talk\, I will present our recent findings on bacterial phy siology in the context of algal interactions\, with a focus on how bacteri a transition from starvation to active growth. I will highlight how algal cues can shorten the bacterial lag phase and trigger specific physiologica l responses\, illustrating how microbial interactions shape bacterial beha vior\, and ultimately\, marine ecosystems.\n\n \;\n\nProf. Segev’s w ebsite: https://www.weizmann.ac.il/plants/segev/\n\n \;\n\nLooking for ward to seeing you all\,\n\nInbal\n\n \;\n\nThe full list of this seme ster’s speakers can be found here: Faculty Seminars Spring 2025\n\n  \;\n\nFor inquiries regarding the course or to receive a Zoom link\, pleas e contact Prof. Dedi Meiri <\;dmeiri@technion.ac.il>\; LOCATION:Biology auditorium END:VEVENT BEGIN:VEVENT UID:1280@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20250513T130000 DTEND;TZID=Asia/Jerusalem:20250513T140000 DTSTAMP:20250427T083743Z URL:https://biology.technion.ac.il/en/seminars/phd-graduate-seminar-laila- bishara/ SUMMARY:PhD Graduate Seminar-Laila Bishara [No Categories] DESCRIPTION:Location: Biology auditorium\, https:https://technion.zoom.us/j /95485558065 Laila Bishara\n Affiliation: \n Host: Prof. Nabieh Ayoub\n C8orf33: A novel regulator of DNA double strand break repair choice\n\nLiv ing organisms are continuously exposed to exogenous and endogenous DNA-dam aging agents that form DNA lesions. One of the most cytotoxic types of DNA lesions is double strand break (DSB) and its defective repair triggers ge nomic instability and carcinogenesis. DSBs are repaired through two main r epair pathways: homologous recombination (HR) and non-homologous end joini ng (NHEJ). While HR ensures accurate repair\, NHEJ is a rapid but mostly m utagenic repair pathway. Maintaining the balance between HR and NHEJ is cr ucial for preserving genomic stability. Consequently\, there is increasing interest in elucidating the molecular mechanisms that govern DSB repair p athway selection. Here\, we identify the uncharacterized C8orf33 protein a s a novel regulator of DSB repair choice. Our data reveal that C8orf33 is a nuclear protein localized predominantly to the nucleolus and accumulates at DSB sites within both nuclear and nucleolar regions. We demonstrate th at C8orf33 promotes NHEJ and suppresses HR repair of DSBs. Mechanistically \, we show that C8orf33 alters the epigenetic mark histone 4 lysine 16 ace tylation (H4K16ac)\, which controls the recruitment of NHEJ and HR factors to DSB sites. Accordingly\, C8orf33 deficiency elevates HR repair which r esults in genomic instability\, as evidenced by the loss of nucleolar DNA content and increased cell lethality. Collectively\, our findings establi sh C8orf33 as a critical regulator of DSB repair pathway choice\, safeguar ding genomic integrity. LOCATION:Biology auditorium\, https:https://technion.zoom.us/j/95485558065 END:VEVENT BEGIN:VEVENT UID:1283@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20250512T130000 DTEND;TZID=Asia/Jerusalem:20250512T140000 DTSTAMP:20250506T055954Z URL:https://biology.technion.ac.il/en/seminars/special-faculty-seminar-pro f-naama-barkai-12-5-2025-in-person/ SUMMARY:Special Faculty seminar - Prof. Naama Barkai 12.5.2025 [In-person] [No Categories] DESCRIPTION:Location: Biology auditorium Prof. Naama Barkai \n Affiliation : Weizmann Institute of Science \n Host:Dr. Shainer Inbal\n  \;\n\nDe ar all\,\n\n \;\n\nOur next seminar will be given by Prof. Naama Barka i from the Weizmann Institute of Science\n\n \;\n\nPlace and time: Bio logy auditorium\, Monday 12/5 at 13:00.\n\n \;\n\nLooking forward to s eeing you all\,\n\nInbal\n\n \;\n\nThe full list of this semester’s speakers can be found here: Faculty Seminars Spring 2025\n\n \;\n\nFor inquiries regarding the course or to receive a Zoom link\, please contact  Prof. Dedi Meiri <\;dmeiri@technion.ac.il>\; LOCATION:Biology auditorium END:VEVENT BEGIN:VEVENT UID:1281@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20250506T130000 DTEND;TZID=Asia/Jerusalem:20250506T140000 DTSTAMP:20250428T060044Z URL:https://biology.technion.ac.il/en/seminars/phd-gradutae-seminar-maya-l inial/ SUMMARY:PhD Gradutae Seminar- Maya Linial [No Categories] DESCRIPTION:Location: Hybrid- in the Faculty Auditorium/ZOOM:https://techni on.zoom.us/j/8510874821 Maya Linial\n Affiliation: \n Host:Prof\, Reiter Yoram \n  \;\n\nExploring How Antigen Type Shapes CAR T Cell Sensitivi ty and Function\n\n \;\n\nCAR T cell therapy has revolutionized cancer treatment\, yet challenges remain in targeting solid tumors.\nThis resear ch directly compares CAR T cells targeting two different types of antigens : a surface protein and a peptide MHC complex\, using a fully controlled s ystem.\nThe study reveals how antigen type influences CAR T cell sensitivi ty and function\, offering new insights for improving next-generation canc er immunotherapies. LOCATION:Hybrid- in the Faculty Auditorium/ZOOM:https://technion.zoom.us/j/ 8510874821 END:VEVENT BEGIN:VEVENT UID:1282@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20250505T130000 DTEND;TZID=Asia/Jerusalem:20250505T140000 DTSTAMP:20250504T070353Z URL:https://biology.technion.ac.il/en/seminars/faculty-seminar-prof-alexan der-bershadsky-5-5-2025-in-person/ SUMMARY:Faculty seminar - Prof. Alexander Bershadsky 5.5.2025 [In-person] [No Categories] DESCRIPTION:Location: Biology auditorium Prof. Alexander Bershadsky \n Af filiation: Weizmann Institute of Science and The Mechanobiology Institute\ , National University of Singapore\n Host:Dr. Shainer Inbal\n Dear all\,\n \n \;\n\nOur next seminar will be given by Prof. Alexander Bershadsky from the Weizmann Institute of Science and The Mechanobiology Institute\, National University of Singapore\n\n \;\n\nPlace and time: Biology aud itorium\, Monday 5/5 at 13:00.\n\n \;\n\nTitle: Integrin-based Adhesio ns in a Crosstalk with Actomyosin Cytoskeleton and Microtubules\n\n \; \n\nLooking forward to seeing you all\,\n\nInbal\n\n \;\n\nThe full li st of this semester’s speakers can be found here: Faculty Seminars Sprin g 2025\n\n \;\n\nFor inquiries regarding the course or to receive a Zo om link\, please contact Prof. Dedi Meiri <\;dmeiri@technion.ac.il>\ ; LOCATION:Biology auditorium END:VEVENT BEGIN:VEVENT UID:1279@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20250428T130000 DTEND;TZID=Asia/Jerusalem:20250428T140000 DTSTAMP:20250427T070343Z URL:https://biology.technion.ac.il/en/seminars/faculty-seminar-prof-gali-p rag-28-4-2025-in-person/ SUMMARY:Faculty seminar - Prof. Gali Prag 28.4.2025 [In-person] [No Categor ies] DESCRIPTION:Location: Biology auditorium Prof. Gali Prag\n Affiliation: th e School of Neurobiology\, Biochemistry & Biophysics\, Tel-Aviv University .\n Host:Prof. Dedi Meiri \n Dear all\,\n\n \;\n\nOur next seminar wil l be given by Prof. Gali Prag from the School of Neurobiology\, Biochemis try &\; Biophysics\, Tel-Aviv University.\n\n \;\n\nPlace and time: Biology auditorium\, Monday 28/4 at 13:00.\n\n \;\n\nTitle: The Art o f Allostery: Inhibiting Pocketless Enzymes.\n\n \;\n\nLooking forward to seeing you all\,\n\nInbal\n\n \;\n\nThe full list of this semester ’s speakers can be found here: Faculty Seminars Spring 2025\n\n \;\n \nFor inquiries regarding the course or to receive a Zoom link\, please co ntact Prof. Dedi Meiri <\;dmeiri@technion.ac.il>\; LOCATION:Biology auditorium END:VEVENT BEGIN:VEVENT UID:1278@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20250423T130000 DTEND;TZID=Asia/Jerusalem:20250423T140000 DTSTAMP:20250421T112523Z URL:https://biology.technion.ac.il/en/seminars/special-faculty-seminar-dr- saurav-mallik-23-4-2025/ SUMMARY:Special Faculty seminar - Dr. Saurav Mallik 23.4.2025 [No Categorie s] DESCRIPTION:Location: Biology auditorium\, Dr. Saurav Mallik\n Affiliation : Department of Molecular Genetics\, Weizmann Institute of Science.\n Host :Dr. Shainer Inbal\n Dear all\,\n\n \;\n\nWe will have a special facul ty seminar given by Dr. Saurav Mallik from the Department of Molecular Gen etics\, Weizmann Institute of Science.\n\n \;\n\nPlace and time: Biolo gy auditorium\, Wednesday 23/4 at 13:00.\n\n \;\n\nTitle: Molecular Or igami and the Hidden Rules of Protein Complex Evolution.\n\n \;\n\nLoo king forward to seeing you all\,\n\nInbal LOCATION:Biology auditorium\, END:VEVENT BEGIN:VEVENT UID:1277@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20250422T130000 DTEND;TZID=Asia/Jerusalem:20250422T140000 DTSTAMP:20250407T135703Z URL:https://biology.technion.ac.il/en/seminars/phd-graduate-seminar-liron- sulimani/ SUMMARY:PhD Graduate Seminar-Liron Sulimani [No Categories] DESCRIPTION:Location: \n Affiliation: \n Host:\n Title:  Multi-Omics Pro filing of Endocannabinoid System Remodeling in Aging Alzheimer’s Disease Mice\n\nThe endocannabinoid system (ECS) plays a crucial role in regulati ng brain homeostasis\, inflammation\, and aging. In this seminar\, I will present new findings on how the ECS is altered in Alzheimer's disease usin g the 5xFAD mouse model across different ages. By combining targeted lipid omics of endocannabinoid ligands with quantitative proteomics\, we identif ied age- and genotype-dependent changes that point to dysregulation of neu roprotective pathways. Notably\, levels of the endocannabinoid-like molecu le PEA decreased in parallel with increased expression of its degrading en zyme NAAA in 5xFAD mice. These shifts may contribute to enhanced neuroinfl ammation and neurodegeneration. Our integrative approach sheds light on th e molecular interface between aging\, ECS imbalance\, and Alzheimer’s pa thology. These findings open new directions for therapeutic intervention t argeting the ECS in neurodegenerative disease END:VEVENT BEGIN:VEVENT UID:1274@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20250401T133000 DTEND;TZID=Asia/Jerusalem:20250401T140000 DTSTAMP:20250330T073904Z URL:https://biology.technion.ac.il/en/seminars/msc-graduate-seminar-rinat- indig/ SUMMARY:Msc Graduate Seminar-Rinat Indig [No Categories] DESCRIPTION:Location: Hybrid - in the Faculty Auditorium /ZOOM: https://tec hnion.zoom.us/j/93635760084 Rinat Indig\n Affiliation: \n Host:Associate Prof. Meytal Landau\n  \;\n\n Modulating Virulent Amyloids Via Nuclei c-Acid and Small Molecules\n\nProteins and peptides can aggregate into amy loid fibrils\, while their formation\, structure and function are influenc ed by environmental and biological factors. Amyloids have diverse roles in different organisms. In bacteria\, amyloids contribute to key characteris tics and processes\, such as virulence and biofilm formation\, that provid e a shield against immune responses and antibiotics. Two examples of such bacteria are Staphylococcus aureus and Pseudomonas aeruginosa which secret e the amyloid proteins PSMα and Fap\, respectively. Our work revealed sev eral compounds that selectively inhibit these amyloids. Moreover\, we foun d that RNA and DNA significantly accelerated Fap fibrillation and broadene d the fibrillation conditions. Our findings advance the understanding of a myloid involvement and interactions within the biofilm\, opening the way f or developing therapeutic strategies against biofilm-forming bacteria. LOCATION:Hybrid - in the Faculty Auditorium /ZOOM: https://technion.zoom.us /j/93635760084 END:VEVENT BEGIN:VEVENT UID:1275@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20250401T130000 DTEND;TZID=Asia/Jerusalem:20250401T133000 DTSTAMP:20250330T074129Z URL:https://biology.technion.ac.il/en/seminars/msc-graduate-seminar-carmel -beard/ SUMMARY:MSc Graduate Seminar-Carmel Beard [No Categories] DESCRIPTION:Location: Hybrid - in the Faculty Auditorium /ZOOM: https://te chnion.zoom.us/j/93635760084 Carmel Beard\n Affiliation: \n Host:Prof. Ga di Schuster \n CBR: A Novel High-Light Expressed Protein and its Potentia l for Carotenoid Binding\n\nChlorella ohadii\, a green desert microalga\, is notable for its ability to thrive under extreme high-light intensities\ , a trait attributed to its efficient photoprotection mechanisms that miti gate photoinhibition. A novel thylakoid membrane protein\, Carotenoid Bios ynthesis Related (CBR)\, has been identified in high-light-grown cells of this alga. This protein is suspected to be a carotenoid-binding protein an d\, therefore\, a crucial component of the alga's photoprotective response . This study reports on the successful overexpression of recombinant CBR p rotein in E. coli. The expressed protein was then subjected to renaturatio n and purification\, and subsequently reconstituted with native pigments. These procedures provide the necessary reagents for future in-depth struct ural and functional studies of CBR. LOCATION: Hybrid - in the Faculty Auditorium /ZOOM: https://technion.zoom.u s/j/93635760084 END:VEVENT BEGIN:VEVENT UID:1273@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20250326T130000 DTEND;TZID=Asia/Jerusalem:20250326T140000 DTSTAMP:20250323T103335Z URL:https://biology.technion.ac.il/en/seminars/phd-graduate-seminar-mona-k abha/ SUMMARY:PhD Graduate Seminar-Mona Kabha [No Categories] DESCRIPTION:Location: Hybrid- in the Faculty Auditorium/ZOOM:https://techni on.zoom.us/j/95404467857 Mona Kabha\n Affiliation: \n Host: Dr. Noga Ro n-Harel\n T Cell Dysfunction in Aging and Disease\n\nMy research focuses o n T cell immunity in two contexts of dysfunction: (1) Inborn errors of imm unity\, focusing on CARMIL2 deficiency\, where we identified defective met abolic reprogramming and partially restored T cell activation through meta bolic supplementation. (2) Age-related immune dysfunction. We used a Chime ric Antigen Receptor (CAR) T cell model in mice to investigate how aging a ffects immunotherapy. We found that aging reduces CAR T cell production\, shifts their phenotype toward effector memory CD4+ T cells\, and induces non-specific cytotoxicity driven by heightened granzyme B secretion. A sim ilar phenotype in young T cells transferred into aged hosts suggests these dysfunctions are driven by the aged microenvironment. LOCATION:Hybrid- in the Faculty Auditorium/ZOOM:https://technion.zoom.us/j/ 95404467857 END:VEVENT BEGIN:VEVENT UID:1271@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20250319T130000 DTEND;TZID=Asia/Jerusalem:20250319T140000 DTSTAMP:20250306T092540Z URL:https://biology.technion.ac.il/en/seminars/phd-graduate-seminar-haya-d ahamshy/ SUMMARY:PhD Graduate Seminar- Haya Dahamshy [No Categories] DESCRIPTION:Location: Hybrid- in the Faculty Auditorium/ZOOM:https://techni on.zoom.us/j/93244858609 Haya Dahamshy\n Affiliation: \n Host:Dr. Asaf B ester\n "Identification and characterization of DNA damage response lncRNA by spatial-temporal analysis”\nLong non-coding RNAs (lncRNAs) are emerg ing as key regulators of cellular function\, with their spatial and tempor al expression playing a crucial role in maintaining homeostasis. Among the m\, LINC00944 stands out for its dynamic response to DNA damage\, showing a striking increase in nuclear expression following the DNA damage respons e (DDR). This lncRNA actively shapes cellular fate by regulating the cell cycle through p21 and driving apoptosis via BCL2 and γ-H2AX. Beyond its r ole in DDR\, our findings reveal an unexpected and significant influence o f LINC00944 on inflammation and immune response pathways. This dual functi onality suggests that LINC00944 is not just a participant in DNA repair bu t also a key player in broader stress response networks. Unraveling its me chanisms could open new avenues for understanding how cells balance surviv al\, repair\, and immune activation in response to damage LOCATION:Hybrid- in the Faculty Auditorium/ZOOM:https://technion.zoom.us/j/ 93244858609 END:VEVENT BEGIN:VEVENT UID:1272@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20250317T130000 DTEND;TZID=Asia/Jerusalem:20250317T140000 DTSTAMP:20250310T095133Z URL:https://biology.technion.ac.il/en/seminars/phd-graduate-seminar-maya-s udman/ SUMMARY:PhD Graduate Seminar- Maya Sudman [No Categories] DESCRIPTION:Location: Biology auditorium and by ZOOM: https://technion.zoom .us/j/92240169966 Maya Sudman\n Affiliation: \n Host:Prof. PHILIPPA MELAM ED\n The effect of adrenarche on the reproductive axis\n\nAdrenarche is a developmental process almost unique to humans in which the adrenal glands produce high levels of dehydroepiandrosterone (DHEA) ~2-3 years before pub erty. Although the function of adrenarche is not known\, premature adrenar che often leads to early puberty and polycystic ovarian syndrome (PCOS). W e hypothesized that these DHEA effects involve epigenetic modification. We examined DNA methylation levels in proxy tissues from a large cohort of c hildren\, and found levels around several puberty and PCOS-related genes w ere linked to DHEA levels. We then used a novel animal model for adrenarch e\, the spiny mouse\, to investigate changes in gene expression in reprodu ctive tissues during their natural adrenarche-like state\, and after prepu bertal adrenalectomy (ADX) and DHEA rescue. Our findings provide new insig hts into how DHEA affects the reproductive axis maturation leading up to p uberty\, and at high levels may predispose to PCOS. LOCATION:Biology auditorium and by ZOOM: https://technion.zoom.us/j/9224016 9966 END:VEVENT BEGIN:VEVENT UID:1270@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20250312T130000 DTEND;TZID=Asia/Jerusalem:20250312T140000 DTSTAMP:20250304T083554Z URL:https://biology.technion.ac.il/en/seminars/phd-graduate-seminar-shai-f ainsod/ SUMMARY:PhD Graduate Seminar-Shai Fainsod [No Categories] DESCRIPTION:Location: Hybrid- in the Faculty Auditorium/ZOOM:https://techni on.zoom.us/j/8390283157?pwd=Zy2htiYbEt3feUXUbQQ8GedcbkR1qv.1&omn=962931784 11 Shai Fainsod\n Affiliation: \n Host:Prof. Oded Beja \n Exploring Lig ht Acclimation in Microalgae\n\nLight availability drives biochemical and molecular adaptations in aquatic algae. We studied eukaryotic algae in the red-shifted-light Hula Lake via spectral incubations and transcriptomic p rofiling. Photosystem-I adjustments (up-regulated LHCA1 and LHCA4) dominat ed under red and green-lights\, and darkness\, while cryptophyte phycobili proteins increased in red and green-lights. A key chlorophyll biosynthesis enzyme also showed enrichment\, highlighting acclimation to varying light conditions. This community-wide transcriptomic study reveals how algae re program their molecular machinery. Our findings advance understanding of l ight-driven ecological adaptations and potential impacts on aquatic ecosys tems.\n\n \;\n\nZoom link: https://technion.zoom.us/j/8390283157?pwd=Z y2htiYbEt3feUXUbQQ8GedcbkR1qv.1&\;omn=96293178411\n\nZoom passcode: 472 LOCATION:Hybrid- in the Faculty Auditorium/ZOOM:https://technion.zoom.us/j/ 8390283157?pwd=Zy2htiYbEt3feUXUbQQ8GedcbkR1qv.1&omn=96293178411 END:VEVENT BEGIN:VEVENT UID:1268@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20250305T130000 DTEND;TZID=Asia/Jerusalem:20250305T140000 DTSTAMP:20250220T130905Z URL:https://biology.technion.ac.il/en/seminars/phd-graduate-seminar-dor-sh alev/ SUMMARY:PhD Graduate Seminar-Dor Shalev [No Categories] DESCRIPTION:Location: Biology auditorium and by ZOOM:https://technion.zoom. us/j/94977953065 \n Affiliation: \n Host:Prof. PHILIPPA MELAMED\,Prof. YA EL MANDEL-GUTFREUND \n The roles and regulation of Mkrn3 in mouse hypotha lamic neurons\n\nMakorin Ring Finger Protein 3 (MKRN3) functions as a "pub ertal brake\," and loss-of-function mutations in MKRN3 are the most common genetic cause of central precocious puberty\, which sees activation of th e reproductive axis at an abnormally young age. MKRN3 expression in the br ain decreases significantly leading up to puberty\, suggesting a repressiv e role on the hypothalamic GnRH which comprises the master regulator of re production. However\, the factors driving this drop in MKRN3 levels\, as w ell as its downstream targets are not known. Through extensive computation al analysis of bulk and single cell RNA sequencing data from rodent brain samples across development\, combined with experimental studies in a mouse GnRH neuronal cell line\, we identified the developmentally upregulated r eceptor\, Acvr1c\, as a repressor of Mkrn3 expression though activation of Smad2/3 signaling. This repression involves the recruitment of the transc ription factor Kap1\, and the induction of repressive histone modification s at the Mkrn3 gene locus. Additionally\, we generated and integrated vari ous multi-omics data from GnRH-producing neurons: Mkrn3 protein and RNA in teractomes\, as well as proteome and transcriptome data following Mkrn3 ov erexpression. These analyses revealed a predominant role for Mkrn3 in regu lating a large number of proteins\, primarily via translation. Moreover\, we found that Mkrn3 binds Gnrh1 mRNA\, along with Igf2bp2 which interacts directly with Mkrn3\, providing novel insights into the mechanisms through which Mkrn3 affects pubertal timing. LOCATION:Biology auditorium and by ZOOM:https://technion.zoom.us/j/94977953 065 END:VEVENT BEGIN:VEVENT UID:1269@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20250303T130000 DTEND;TZID=Asia/Jerusalem:20250303T133000 DTSTAMP:20250226T142355Z URL:https://biology.technion.ac.il/en/seminars/m-sc-graduate-seminar-tal-i fargan-the-faculty-of-data-and-decision-sciences/ SUMMARY:M.Sc. Graduate Seminar-Tal Ifargan (The Faculty of Data and Decisio n Sciences) [No Categories] DESCRIPTION:Location: Hybrid- in the Faculty Auditorium/ZOOM:https://techni on.zoom.us/j/95712138406 Tal Ifargan\n Affiliation: \n Host:Prof. Kishony Roy \n AI-Driven Research and Trait Aware Representations of Medical Diag nostics\n\n \;\n\nAbstract\n\n \;\n\nThis seminar is devoted to tw o separate projects:\n\n \;\n\nAs AI promises to accelerate scientific discovery\, it remains unclear whether AI systems can perform fully auton omous research and whether they can do so while adhering to key scientific values\, such as transparency\, traceability and verifiability. Mimicking human scientific practices\, we built data-to-paper\, an automation platf orm that guides interacting LLM agents through a complete stepwise researc h process\, from annotated data to comprehensive research papers\, while p rogrammatically back-tracing information flow\, resulting in “data-chain ed” manuscripts. Testing the platform on diverse datasets\, it produced autonomously correct papers in 80%-90% of runs for simple datasets and res earch goals\, yet human interventions became critical for more complex tas ks. Our work demonstrates a potential for AI-driven acceleration of scient ific discovery in data-driven research and beyond\, while setting through “data-chaining” a new standard for verifiability and traceability for the coming era of AI-driven science.\n\n \;\n\nElectronic health recor ds offer significant potential for uncovering trait-specific patterns and advancing personalized medicine. Various methods\, mainly borrowed from na tural language processing\, have been proposed to represent International Classification of Diseases (ICD) codes\, yet these approaches often yield representations that are difficult to quantify and primarily serve predict ive tasks. Here\, we present TAR—a method for Trait-Aware Representation s of ICD codes implemented as a modified skip-gram model and demonstrate i ts ability to explore sex-specific differences in medical diagnostics\, a topic often overlooked in prior literature. In collaboration with Maccabi Healthcare Services\, we trained TAR on 25 years of data from 1.3 million patients\, revealing sex-dependent dynamics of aging. In addition\, the le arned embeddings encode the concept of sex as a distinct direction. Overal l\, TAR presents sex-specific diagnostic differences\, and is readily exte ndable to other phenotypic traits\, offering a versatile tool for broader biomedical discovery. LOCATION:Hybrid- in the Faculty Auditorium/ZOOM:https://technion.zoom.us/j/ 95712138406 END:VEVENT BEGIN:VEVENT UID:1267@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20250212T130000 DTEND;TZID=Asia/Jerusalem:20250212T140000 DTSTAMP:20250203T110712Z URL:https://biology.technion.ac.il/en/seminars/phd-graduate-seminar-david- ezuz/ SUMMARY:PhD Graduate Seminar- David Ezuz [No Categories] DESCRIPTION:Location: Biology auditorium and by ZOOM:https:https://technion .zoom.us/j/8372688367 David Ezuz\n Affiliation: \n Host:dr. Noga Ron-Har el\n Heme toxicity in the aged spleen impairs T-cell immunity through iron deprivation\n\n \;\n\nMechanisms of T cell aging involve cell-intrins ic alterations and interactions with other immune and stromal cells. Here\ , we investigated how the tissue microenvironment influences T-cell aging trajectories. Spleen-derived lymphocytes exhibited greater functional decl ine compared to those from lymph nodes\, with proteomic analysis revealing increased expression of heme detoxification and iron storage proteins in aged spleen-derived lymphocytes. Exposure to the aged spleen microenvironm ent or to heme induced multiple aging phenotypes in young lymphocytes\, in cluding reduced proliferation and upregulation of CD39. T cells survived t he hostile microenvironment of the aged spleen by restricting iron uptake and maintaining low labile iron pools. Nevertheless\, vaccination response s in aged mice were enhanced by timed iron infusions. Our findings undersc ore a trade-off between T cell survival and function in the aged host\, an d highlight the bidirectional relationship between T cells and their micro environment. Understanding these mechanisms will inform strategies to enha nce immune responses in the elderly. LOCATION:Biology auditorium and by ZOOM:https:https://technion.zoom.us/j/83 72688367 END:VEVENT BEGIN:VEVENT UID:1266@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20250205T130000 DTEND;TZID=Asia/Jerusalem:20250205T140000 DTSTAMP:20250202T134644Z URL:https://biology.technion.ac.il/en/seminars/phd-graduate-seminar-junyi- he/ SUMMARY:PhD Graduate Seminar-Junyi He [No Categories] DESCRIPTION:Location: Biology auditorium and by ZOOM:https://technion.zoom. us/j/9592170138?omn=99221930350 Junyi He\n Affiliation: \n Host:Dr. Ayal a Shiber \n Identification and characterization of novel quality control factors acting in a co-translational manner\n \;\n\nAt the critical ju nction of translation and protein folding\, the ribosome serves as a centr al hub\, orchestrating the actions of various factors that facilitate the maturation of emerging polypeptide-chains. However\, ribosome associated q uality control mechanisms\, safeguarding the cell from early misfolding\, remain largely obscure. Here we identify and characterize specific degrada tion and sequestration factors\, acting on the ribosome\, when co-translat ional protein complex assembly interactions are perturbed. Combing ribosom e profiling and ribosome-targeted proteomics approaches\, we discover a no vel quality-control pathway for complex subunits that fail to assemble int o functional complexes. LOCATION:Biology auditorium and by ZOOM:https://technion.zoom.us/j/95921701 38?omn=99221930350 END:VEVENT BEGIN:VEVENT UID:1254@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20250203T130000 DTEND;TZID=Asia/Jerusalem:20250203T140000 DTSTAMP:20241230T092536Z URL:https://biology.technion.ac.il/en/seminars/science-communication-works hop-how-to-present-your-research-effectively-2/ SUMMARY:Faculty Seminar -Dr. Avner Wallach: Science Communication Workshop for graduate students\, part 2 [No Categories] DESCRIPTION:Location: Faculty Of Biology Auditorium Dr. Avner Wallach\n Af filiation: \n Host: \n Science Communication Workshop:\n\nHow to present y our research effectively\n\n \;\n\n \;\n\nSecond meeting:3/2/2025\ , Four volunteers will give their presentation and will receive feedback f rom the audience (focusing on the presentation rather than the content). LOCATION:Faculty Of Biology Auditorium END:VEVENT BEGIN:VEVENT UID:1265@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20250129T130000 DTEND;TZID=Asia/Jerusalem:20250129T140000 DTSTAMP:20250120T122848Z URL:https://biology.technion.ac.il/en/seminars/phd-graduate-seminar-jonath an-cohen/ SUMMARY:PhD Graduate Seminar-Jonathan Cohen [No Categories] DESCRIPTION:Location: Biology auditorium and by ZOOM:https://technion.zoom. us/j/92510662307 Jonathan Cohen\n Affiliation: \n Host:Associate Prof. M eiri David \n Join us for a seminar exploring the metabolomic diversity of psilocybin-producing fungi and their effects on immune-related disorders. This research combines standardized extraction and analytical methods wit h metabolomic analysis and in vivo models to identify species-specific clu sters exhibiting anti-inflammatory properties. The findings shed light on the role of fungal metabolites\, beyond psilocybin\, in mediating the immu ne response. LOCATION:Biology auditorium and by ZOOM:https://technion.zoom.us/j/92510662 307 END:VEVENT BEGIN:VEVENT UID:1253@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20250127T130000 DTEND;TZID=Asia/Jerusalem:20250127T140000 DTSTAMP:20241230T092352Z URL:https://biology.technion.ac.il/en/seminars/science-communication-works hop-how-to-present-your-research-effectively/ SUMMARY:Dr. Avner Wallach : Science Communication Workshop for graduate stu dents\, part 1 [No Categories] DESCRIPTION:Location: Faculty Of Biology Auditorium/ZOOM:https://technion.z oom.us/j/91374645319 Dr. Avner Wallach\n Affiliation: \n Host:\n Our nex t seminar will be given by Dr. Avner Wallach from the Faculty of Biology\, Technion - Israel Institute of Technology\n\nPlace and time: Biology audi torium\, Monday 27/1 at 13:00.\n\nTitle: Science Communication Workshop fo r graduate students\, part 1\n\nHow to present your research effectively\n \nThe faculty offers a short workshop to help graduate students better pre sent their research in scientific meetings. The workshop will be given ahe ad of the Faculty’s yearly retreat\, which will take place in February\, in which graduate students are expected to present their research to the Faculty.\n\nThe workshop will include two meetings that will take place in stead of the weekly seminar (Mondays\, 1 pm).\n\n How do you tailor your presentation to the audience?\n How do you plan your presentation?\n Wha t is the role of presentation aids\, and what is the difference between th e two common formats – the slide-deck and the poster?\n\nAfter the meeti ng students will work on their presentations for the Faculty retreat\, imp lementing the principles discussed in class.\n\nSecond meeting:3/2/2025\, Four volunteers will give their presentation and will receive feedback fro m the audience (focusing on the presentation rather than the content). LOCATION:Faculty Of Biology Auditorium/ZOOM:https://technion.zoom.us/j/9137 4645319 END:VEVENT BEGIN:VEVENT UID:1264@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20250120T130000 DTEND;TZID=Asia/Jerusalem:20250120T140000 DTSTAMP:20250116T094442Z URL:https://biology.technion.ac.il/en/seminars/faculty-seminar-dr-daria-am iad-pavlov-20-1/ SUMMARY:Faculty seminar - Dr. Daria Amiad Pavlov 20.1 [No Categories] DESCRIPTION:Location: Biology auditorium and by ZOOM:https://technion.zoom. us/j/91374645319 Dr. Daria Amiad Pavlov \n Affiliation: \n Host:Dr. Inba l Shainer \n Dear all\,\n\n \;\n\nOur next seminar will be given by Dr . Daria Amiad Pavlov from the Perelman School of Medicine\, University of Pennsylvania.\n\n \;\n\nPlace and time: Biology auditorium\, Monday 20 /1/2025 at 13:00.\n\n \;\n\nTitle: Mechano-regulation of gene expressi on in striated muscle\n\n \;\n\nAbstract:\n\nIn recent years\, the cel l nucleus emerged as a dynamic mechanosensor capable of sensing and transd ucing mechanical signals into cellular responses to facilitate homeostasis and adaptation to changing environmental conditions. The constantly beati ng heart has a remarkable ability to adapt its structure and contractility in response to changes in mechanical load. I am introducing unique\, live \, and dynamic imaging approaches to investigate how nuclei in the mature heart can provide such mechano-regulation of the genome while also protect ing the genome from excessive forces. I will present a novel assay to coup le cytoskeletal to nuclear strain transfer in the beating cardiomyocyte\, and its further application to decipher mechanisms of nuclear damage in di lated cardiomyopathy caused by mutations in the LMNA gene (LMNA-DCM). Thi s work pinpoints localized microtubule-dependent forces\, but surprisingly not actomyosin contractility\, as drivers of nuclear damage in LMNA-DCM\, highlighting new therapeutic avenues. I will further discuss the role of mechanical signaling in spatial organization of the genome within the nucl eus\, to regulate transcriptionally active and repressed hubs\, and downst ream gene expression.\n\n \;\n\n \;\n\nLooking forward to seeing y ou all\,\n\nInbal\n\n \;\n\nZoom link: https://technion.zoom.us/j/913 74645319 LOCATION:Biology auditorium and by ZOOM:https://technion.zoom.us/j/91374645 319 END:VEVENT BEGIN:VEVENT UID:1260@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20250113T130000 DTEND;TZID=Asia/Jerusalem:20250113T140000 DTSTAMP:20241224T141316Z URL:https://biology.technion.ac.il/en/seminars/faculty-seminar-prof-oliver -hobert-13-1-2025/ SUMMARY:Faculty seminar - Prof. Oliver Hobert 13.1.2025 [No Categories] DESCRIPTION:Location: Faculty Of Biology Auditorium/ZOOM:https://technion.z oom.us/j/91374645319 Prof. Oliver Hobert\n Affiliation: Department of Bi ological Sciences\, Columbia University. \n Host:Dr. Shainer Inbal\n Dear all\,\n\n \;\n\nOn January 13th the faculty seminar will be given by Prof. Oliver Hobert from the Department of Biological Sciences\, Columbia University.\n\n \;\n\nPlace and time: Biology auditorium\, Monday 13/1 /2025 at 13:00.\n\n \;\n\nTitle: Homeobox genes and the specification of cell types in the brain\n\n \;\n\nAbstract:\n\nThe enormous diversi ty of cell types in any animal model system is defined by neuron type-spec ific gene batteries that endow distinct cells with distinct anatomical and functional properties. I will show that the diversity of neuronal cell ty pes in the nematode C. elegans can be reduced to a simpler descriptor\, t he combinatorial expression of a specific class of transcription factors\, encoded by homeobox genes. I propose that the preponderance of homeobox g enes in neuronal identity control reflects an evolutionary trajectory in w hich an ancestral neuron type was specified by an ancestral homeobox genes and that this functional linkage then duplicated and diversified to gener ate distinct cell types in an evolving nervous system.\n\n \;\n\nHober t lab website: https://www.hobertlab.org/\n\n \;\n\nLooking forward to seeing you all\,\n\nInbal\n\n \;\n\nZoom link: https://technion.zoom .us/j/91374645319\n\n \;\n\n \;\n\nFor inquiries regarding the cou rse\, please contact Prof. Dedi Meiri <\;dmeiri@technion.ac.il>\;\n\n  \; LOCATION:Faculty Of Biology Auditorium/ZOOM:https://technion.zoom.us/j/9137 4645319 END:VEVENT BEGIN:VEVENT UID:1263@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20250113T130000 DTEND;TZID=Asia/Jerusalem:20250113T140000 DTSTAMP:20250106T154747Z URL:https://biology.technion.ac.il/en/seminars/faculty-seminar-prof-oliver -hobert-13-1-2025-2/ SUMMARY:Faculty seminar - Prof. Oliver Hobert 13.1.2025 [No Categories] DESCRIPTION:Location: Biology auditorium and by ZOOM:https://technion.zoom. us/j/91374645319 Prof. Oliver Hobert \n Affiliation: Department of Biolo gical Sciences\, Columbia University. \n Host:Dr. Inbal Shainer \n Dear a ll\,\n\n \;\n\nOur next seminar will be given by Prof. Oliver Hobert from the Department of Biological Sciences\, Columbia University.\n\n  \;\n\nPlace and time: Biology auditorium\, Monday 13/1/2025 at 13:00.\n\n& nbsp\;\n\nTitle: Homeobox genes and the specification of cell types in the brain\n\n \;\n\nAbstract:\n\nThe enormous diversity of cell types in any animal model system is defined by neuron type-specific gene batteries that endow distinct cells with distinct anatomical and functional properti es. I will show that the diversity of neuronal cell types in the nematode C. elegans can be reduced to a simpler descriptor\, the combinatorial exp ression of a specific class of transcription factors\, encoded by homeobox genes. I propose that the preponderance of homeobox genes in neuronal ide ntity control reflects an evolutionary trajectory in which an ancestral ne uron type was specified by an ancestral homeobox genes and that this funct ional linkage then duplicated and diversified to generate distinct cell ty pes in an evolving nervous system.\n\n \;\n\nHobert lab website: https ://www.hobertlab.org/\n\n \;\n\nLooking forward to seeing you all\,\n\ nInbal\n\n \;\n\nZoom link: https://technion.zoom.us/j/91374645319\n\ n \;\n\n \;\n\nFor inquiries regarding the course\, please contact Prof. Dedi Meiri <\;dmeiri@technion.ac.il>\; LOCATION:Biology auditorium and by ZOOM:https://technion.zoom.us/j/91374645 319 END:VEVENT BEGIN:VEVENT UID:1262@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20250108T130000 DTEND;TZID=Asia/Jerusalem:20250108T140000 DTSTAMP:20250101T095815Z URL:https://biology.technion.ac.il/en/seminars/phd-graduate-seminar-adi-sh apira/ SUMMARY:PhD Graduate Seminar- Dr. Adi Shapira [No Categories] DESCRIPTION:Location: Biology auditorium and by ZOOM:https://technion.zoom. us/j/91700637178 Adi Shapira\n Affiliation: \n Host:Prof. Reiter Yoram\n  \;\n\nTCR-like Antibodies for B Cell Malignancies. Can They Overcome Resistance to Antibody-Based CAR T Cells?\n\nChimeric antigen receptor (CA R) T cells directed at the CD19 surface protein are an effective treatment for refractory B cell  leukemia and lymphoma.\n\nDespite high response r ates\, many patients will experience relapse with loss of CD19 at the time of relapse\n\nTCR-like (TCRL) antibodies are designed to bind a peptides presented in the context of an HLA molecule\, and therefore expand the tar get repertoire of tumor associated antigens to include intra-cellular prot eins. In this study we aimed to address the phenomenon of CD19 negative re lapse following CAR T cell therapy using the TCRL approach. We have succes sfully isolated TCRL antibodies with specific binding to a complex of HLA- A2 and CD19-derived peptides.  TCRL-based CARs were generated and exhibit ed effective killing of multiple B cell malignancies\, including cells wit h loss of surface CD19. This study provides proof-of- concept for the targ eting of HLA-peptide complex using TCRL based therapies as means to overco me resistance to conventional CAR T cell therapy. LOCATION:Biology auditorium and by ZOOM:https://technion.zoom.us/j/91700637 178 END:VEVENT BEGIN:VEVENT UID:1261@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20250106T130000 DTEND;TZID=Asia/Jerusalem:20250106T140000 DTSTAMP:20241231T113938Z URL:https://biology.technion.ac.il/en/seminars/faculty-seminar-dr-neta-gaz it-shimoni-6-1/ SUMMARY:Faculty seminar - Dr. Neta Gazit Shimoni 6/1 [No Categories] DESCRIPTION:Location: Biology auditorium and by ZOOM:https://technion.zoom. us/j/91374645319 Dr. Neta Gazit Shimoni\n Affiliation: Department of Neu roscience\, University of California at Berkeley\n Host:Dr. Inbal Shainer \n Dear all\,\n\n \;\n\nOur next seminar will be given by Dr. Neta Gaz it Shimoni from the Department of Neuroscience\, University of California at Berkeley.\n\n \;\n\nPlace and time: Biology auditorium\, Monday 6/1 /2025 at 13:00.\n\n \;\n\nTitle: Regulation of Brain Function and Dis ease by Neuropeptides\n\n \;\n\nLooking forward to seeing you all\,\n\ nInbal\n\n \;\n\nZoom link: https://technion.zoom.us/j/91374645319\n\ n \;\n\n \;\n\nFor inquiries regarding the course\, please contact Prof. Dedi Meiri <\;dmeiri@technion.ac.il>\;\n\n \; LOCATION:Biology auditorium and by ZOOM:https://technion.zoom.us/j/91374645 319 END:VEVENT BEGIN:VEVENT UID:1259@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20241223T130000 DTEND;TZID=Asia/Jerusalem:20241223T140000 DTSTAMP:20241217T072724Z URL:https://biology.technion.ac.il/en/seminars/faculty-seminar-dr-dor-russ -23-12-molecular-mechanisms-of-plant-microbiome-assembly-from-bacterial-ge nes-to-host-specificity/ SUMMARY:Faculty seminar - Dr. Dor Russ 23.12 -"Molecular Mechanisms of Plan t Microbiome Assembly: From Bacterial Genes to Host Specificity" [No Categ ories] DESCRIPTION:Location: Faculty Of Biology Auditorium/ZOOM:https://technion.z oom.us/j/91374645319 Dr. Dor Russ \n Affiliation: University of North Ca rolina at Chapel Hill\n Host:Dr. Shainer Inbal\n Dear all\,\n\n \;\n\n Our next seminar will be given by Dr. Dor Russ from the Department of Biol ogy\, University of North Carolina at Chapel Hill\n\n \;\n\nPlace and time: Biology auditorium\, Monday 23/12 at 13:00.\n\n \;\n\nTitle: Mol ecular Mechanisms of Plant Microbiome Assembly: From Bacterial Genes to Ho st Specificity\n\n \;\n\nAbstract:\n\nIn nature\, plants recruit a div erse microbial community\, the plant microbiome\, that is distinct from th e surrounding soil community. That microbial community is essential for  plant growth and health. To understand the forces that shape the plant mic robiome we need to characterize the microbial traits that contribute to pl ant colonization. We used barcoded mutant libraries to identify bacterial genes that contribute to the colonization of a monocot and a eudicot host. Our analysis revealed dozens of colonization genes\, with most showing un expected host and organ specificity\, suggesting fine-tuned adaptation to distinct plant niches. We characterized two key mechanisms governing plant -microbe interactions. First\, we identified an efflux pump system prevale nt across Pseudomonadota that specifically facilitates Arabidopsis thali ana shoot colonization. By exploiting natural variation across A. thaliana  accessions\, we demonstrated that this pump selectively detoxifies gluco sinolate breakdown products\, suggesting commensal bacteria have evolved p rotection against collateral damage from plant defense responses targeting herbivores and pathogens. Second\, we discovered a unique adaptation in S phingomonas species involving dual copies of the flagellin gene (FliC). Wh ile one highly conserved copy triggers plant immune responses and mediates attachment\, the second\, more divergent copy enables motility and evade  immune recognition. This result is consistent with evolutionary conflict driving epitope recognition by the host. Our findings provide fundamental insights into the molecular mechanisms shaping plant microbiome assembly providing a framework for understanding and engineering plant-microbe as sociations.\n\n \;\n\n \;\n\nLooking forward to seeing you all\,\n \nInbal\n\n \;\n\nZoom link: https://technion.zoom.us/j/91374645319\n \n \;\n\n \;\n\nFor inquiries regarding the course\, please contac t Prof. Dedi Meiri <\;dmeiri@technion.ac.il>\; LOCATION:Faculty Of Biology Auditorium/ZOOM:https://technion.zoom.us/j/9137 4645319 END:VEVENT BEGIN:VEVENT UID:1258@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20241216T130000 DTEND;TZID=Asia/Jerusalem:20241216T140000 DTSTAMP:20241210T071305Z URL:https://biology.technion.ac.il/en/seminars/faculty-seminar-dr-sahar-me lamed-small-rnas-orchestrate-bacterial-phage-dynamics/ SUMMARY:Faculty seminar - Dr. Sahar Melamed -"Small RNAs Orchestrate Bacter ial-Phage Dynamics" [No Categories] DESCRIPTION:Location: Dr. Sahar Melamed\n Affiliation: Department of Micr obiology and Molecular Genetics\, Faculty of Medicine\, The Hebrew Univers ity of Jerusalem\n Host:Dr. Shainer Inbal\n Dear all\,\n\n \;\n\nOur n ext seminar will be given by Dr. Sahar Melamed from the Department of Micr obiology and Molecular Genetics\, Faculty of Medicine\, The Hebrew Univers ity of Jerusalem.\n\n \;\n\nPlace and time: Biology auditorium\, Monda y 16/12 at 13:00.\n\n \;\n\nTitle: Small RNAs Orchestrate Bacterial-Ph age Dynamics\n\n \;\n\nMelamed lab website: https://melamed-rna-lab.hu ji.ac.il/\n\n \;\n\nLooking forward to seeing you all\,\n\nInbal\n\n&n bsp\;\n\n \;\n\nZoom link: https://technion.zoom.us/j/91374645319\n\n  \;\n\nFor inquiries regarding the course\, please contact Prof. Dedi Meiri <\;dmeiri@technion.ac.il>\; END:VEVENT BEGIN:VEVENT UID:1257@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20241211T133000 DTEND;TZID=Asia/Jerusalem:20241211T140000 DTSTAMP:20241204T133755Z URL:https://biology.technion.ac.il/en/seminars/msc-graduate-seminar-yuval- moshe-haizler/ SUMMARY:Msc Graduate Seminar- Yuval Moshe Haizler [No Categories] DESCRIPTION:Location: Hybrid- in the Faculty Auditorium/ZOOM: https://tech nion.zoom.us/j/99669094452 Yuval Moshe Haizler\n Affiliation: ool of B iochemistry\, Neurobiology & Biophysics\, the Faculty of Life Sciences\, T el-Aviv University.\n Host:Prof. Levenberg Shulamit \n Hydroxyapatite Depo sition for 3D Bioprinting of Vascular Bone\n \nAbstract\nThis study inves tigates hydroxyapatite deposition within a bio-ink composed of fibrin\, co llagen\, thrombin\, calcium\, and phosphate for the 3D bioprinting of vasc ularized bone tissue. A key objective was to examine the natural hydroxyap atite nucleation and growth on collagen fibers within the engineered tissu e during the printing and maturation processes. The bio-ink’s rheologica l properties were optimized to ensure precise printability and structural stability. Hydroxyapatite formation under physiological conditions was suc cessfully demonstrated\, mimicking natural bone mineralization. The findin gs showcase the bio-ink’s potential as a scalable and personalized solut ion for bone regeneration\, paving the way for future in vivo and clinical applications. LOCATION:Hybrid- in the Faculty Auditorium/ZOOM: https://technion.zoom.us/ j/99669094452 END:VEVENT BEGIN:VEVENT UID:1255@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20241211T130000 DTEND;TZID=Asia/Jerusalem:20241211T133000 DTSTAMP:20241201T104523Z URL:https://biology.technion.ac.il/en/seminars/msc-graduate-seminar-sharon -fitoussi/ SUMMARY:MSc Graduate Seminar- Sharon fitoussi [No Categories] DESCRIPTION:Location: Hybrid- in the Faculty Auditorium/ZOOM: https://tech nion.zoom.us/j/99669094452 Sharon Fitoussi\n Affiliation: \n Host: Prof . Podbilewicz Benjamin\n The understanding of pathological body wall muscl e cell fusion mediated by ectopic expression of the fusogen - EFF-1 in Cae norhabditis elegans.\n\n \;\n\nAbstract:\n\nIn vertebrates\, skeletal muscle develops through myoblast fusion\, forming a vast multinuclear stru cture\, while other muscles such as smooth muscles do not fuse. In Caeno rhabditis elegans\, body movement is coordinated through unfused body wall muscle (BWM) cells\, whereas other muscle tissues rely on cell fusion req uiring the fusion protein EFF-1. To study the role of cell fusion in muscl es\, we induced the ectopic expression of EFF-1 in BWMs. We found that thi s treatment induced cell merger and an uncoordinated dumpy morphology\, in dicating that cell fusion is detrimental for BWMs function. Using modified mosaic analysis\, we provide evidence that EFF-1 expression is required o n both fusing cells\, consistent with a bilateral and homotypic mechanism of fusion. These findings expand our knowledge of the consequences of path ological muscle fusion\, with potential implications in different diseases . LOCATION:Hybrid- in the Faculty Auditorium/ZOOM: https://technion.zoom.us/ j/99669094452 END:VEVENT BEGIN:VEVENT UID:1256@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20241209T130000 DTEND;TZID=Asia/Jerusalem:20241209T140000 DTSTAMP:20241204T070949Z URL:https://biology.technion.ac.il/en/seminars/faculty-seminar-prof-yoav-g othilf-9-12/ SUMMARY:Faculty seminar - Prof. Yoav Gothilf 9.12 [No Categories] DESCRIPTION:Location: Hybrid- in the Faculty Auditorium/ZOOM: https://tech nion.zoom.us/j/91374645319 Prof. Yoav Gothilf\n Affiliation: ool of Bio chemistry\, Neurobiology & Biophysics\, the Faculty of Life Sciences\, Tel -Aviv University.\n Host:Dr. Shainer Inbal\n Dear all\,\n\n \;\n\nOur next seminar will be given by Prof. Yoav Gothilf from the School of Bioche mistry\, Neurobiology &\; Biophysics\, the Faculty of Life Sciences\, T el-Aviv University.\n\n \;\n\nPlace and time: Biology auditorium\, Mon day 9/12 at 13:00.\n\n \;\n\nTitle: Genetic dissection of the biologic al clock using zebrafish as a model.\n\n \;\n\nAbstract:\n\nAnimal fit ness largely depends on its ability to perform certain behaviors and physi ological processes at particular times of the daily cycle. Such temporal r egulation is mainly the outcome of an internal timing mechanism known as t he circadian clock. In fish\, and other non-mammalian vertebrates\, the pi neal gland contains an intrinsic circadian oscillator that drives the circ adian rhythms of its hormonal signal (melatonin)\, and has been considered a key element in the circadian system.\n\nEmploying a dominant-negative s trategy we generated a transgenic zebrafish line in which the molecular cl ock is selectively blocked in the melatonin-producing cells of the pineal gland. As a result\, clock-controlled rhythms of melatonin production in t he adult pineal gland were disrupted and the rhythmic expression pattern o f the majority of clock-controlled genes in the adult pineal gland was abo lished. Importantly\, the amplitude of behavioral rhythms was substantiall y reduced\, but not completely eliminated. Thus\, the pineal clock plays a key role in modulating circadian rhythms of behavior\, but it is not the only regulatory component. To determine the role of other tissues in the c ircadian clock system and the hierarchal relationship among them\, we are currently employing the same dominant-negative transgenic approach to bloc k the clock at other tissues and cell types.\n\n \;\n\nGothilf lab web site: https://gothilflab.wixsite.com/gothilflab\n\n \;\n\nLooking forw ard to seeing you all\,\n\nInbal\n\n \;\n\nZoom link: https://technio n.zoom.us/j/91374645319\n\n \;\n\nFor inquiries regarding the course\, please contact Prof. Dedi Meiri <\;dmeiri@technion.ac.il>\;\n\n  \; LOCATION:Hybrid- in the Faculty Auditorium/ZOOM: https://technion.zoom.us/ j/91374645319 END:VEVENT BEGIN:VEVENT UID:1252@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20241202T130000 DTEND;TZID=Asia/Jerusalem:20241202T140000 DTSTAMP:20241127T070917Z URL:https://biology.technion.ac.il/en/seminars/faculty-seminar-paper-of-th e-month-winners-2-12-in-person/ SUMMARY:Faculty seminar - Paper of the month winners 2.12 [In-person] [No C ategories] DESCRIPTION:Location: Hybrid- in the Faculty Auditorium/ZOOM: https://tech nion.zoom.us/j/91374645319 \n Affiliation: \n Host:Dr. Shainer Inbal\n  \;\n\nBerta Eliad (Lamm Lab):\n\n"ADBP-1 regulates ADR-2 nuclear loc alization to control editing substrate selection"\, Nucleic Acids Research .\n\n \n\nFeras Machour (Ayoub Lab):\n\n"Harnessing DNA replication stres s to target RBM10 deficiency in lung adenocarcinoma"\, Nature Communicatio ns.\n\n \n\nJohannes Venezian (Shiber Lab):\n\n"Structural determinants o f co-translational protein complex assembly" cell- in press.\n\n \n\nGuy Levin (Schuster Lab):\n\n"Processes independent of nonphotochemical quench ing protect a high-light-tolerant desert alga from oxidative stress" Plant Physiology.\n\n \;\n\n \;\n\nPlace and time: Biology auditorium\, Monday 2/12 at 13:00.\n\n \;\n\nLooking forward to seeing you all\,\n \nInbal\n\n \;\n\nZoom link: https://technion.zoom.us/j/91374645319\n \n \;\n\nFor inquiries regarding the course\, please contact Prof. Ded i Meiri <\;dmeiri@technion.ac.il>\;\n\n \; LOCATION:Hybrid- in the Faculty Auditorium/ZOOM: https://technion.zoom.us/ j/91374645319 END:VEVENT BEGIN:VEVENT UID:1251@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20241125T130000 DTEND;TZID=Asia/Jerusalem:20241125T140000 DTSTAMP:20241118T143117Z URL:https://biology.technion.ac.il/en/seminars/faculty-seminar-dr-yaniv-el kouby-25-11-in-person/ SUMMARY:Faculty Seminar - Dr. Yaniv Elkouby- "Illuminating Unpredicted Cell ular Machineries in Germ Cell Production and Reproduction" [No Categories] DESCRIPTION:Location: Hybrid- in the Faculty Auditorium/ZOOM: https://techn ion.zoom.us/j/91374645319 Dr. Yaniv Elkouby\n Affiliation: Department of Developmental Biology and Cancer Research\, Faculty of Medicine\, The Hebr ew University of Jerusalem\n Host:Dr. Shainer Inbal\n Dear all\,\n\n \ ;\n\nOur next seminar will be given by Dr. Yaniv Elkouby from the Departme nt of Developmental Biology and Cancer Research\, Faculty of Medicine\, T he Hebrew University of Jerusalem.\n\n \;\n\nPlace and time: Biology a uditorium\, Monday 25/11 at 13:00.\n\n \;\n\nTitle: Illuminating Unpre dicted Cellular Machineries in Germ Cell Production and Reproduction\n\n&n bsp\;\n\nElkouby lab website: https://www.yanivelkoubylab.com/\n\n \;\ n\nLooking forward to seeing you all\,\n\nInbal\n\n \;\n\nZoom link:  https://technion.zoom.us/j/91374645319 Please note that this is the update d link for this year!\n\n \;\n\n \;\n\nFor inquiries regarding the course\, please contact Prof. Dedi Meiri <\;dmeiri@technion.ac.il>\; LOCATION:Hybrid- in the Faculty Auditorium/ZOOM: https://technion.zoom.us/j /91374645319 END:VEVENT BEGIN:VEVENT UID:1250@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20241120T133000 DTEND;TZID=Asia/Jerusalem:20241120T140000 DTSTAMP:20241114T134711Z URL:https://biology.technion.ac.il/en/seminars/msc-graduate-seminar-adi-sh aked-levy-lab/ SUMMARY:Msc Graduate Seminar- Adi Shaked (Levy Lab) [No Categories] DESCRIPTION:Location: Faculty Of Biology Auditorium/ZOOM:https://technion.z oom.us/j/96190093354 Adi Shaked\n Affiliation: \n Host:Dr. Levy Sagi\n Title: Uncovering Neuronal Plasticity Following Associative Memory in C. e legans\n\nAssociative learning enables animals to link a conditioned stimu lus\, like an odor\, with an unconditioned stimulus\, such as reward or pu nishment\, facilitating adaptive behavioral responses to changing environm ents. A central challenge in neuroscience is identifying specific neuronal sites where these associations are stored. To reveal learning-dependent n euronal changes\, we developed a setup to track neuronal plasticity in C. elegans following associative learning. Our microfluidic device is unique ly designed to enable imaging of neuronal responses to precise stimulation s across multiple animals simultaneously. Using this system\, we analyzed activity patterns of individual neurons as animals learned to associate an odor positively\, with food availability\, or negatively\, with starvatio n. We will present our findings on learning-dependent plastic changes in s ensory and premotor interneurons\, illuminating potential neural substrate s where associative memory may reside. LOCATION:Faculty Of Biology Auditorium/ZOOM:https://technion.zoom.us/j/9619 0093354 END:VEVENT BEGIN:VEVENT UID:1249@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20241120T130000 DTEND;TZID=Asia/Jerusalem:20241120T133000 DTSTAMP:20241114T134836Z URL:https://biology.technion.ac.il/en/seminars/msc-graduate-seminar-huichi -cheng-kapln-lab/ SUMMARY:Msc Graduate Seminar- Huichi Cheng (Kaplan Lab) [No Categories] DESCRIPTION:Location: Faculty Of Biology Auditorium/ZOOM:https://technion.z oom.us/j/96190093354 Huichi Cheng\n Affiliation: \n Host:Associate Prof . Kaplan Ariel \n Title: "Using various single-molecular assays to measure the passage of RNA polymerase along the DNA template in optical tweezers" \n\nAbstract:\n\nTranscription is the subsequent step in the gene expressi on process. that started with the binding of RNA polymerases (RNAP) a DNA template and transcribing it\, leading to the release of an RNA molecule f rom the DNA template. Traditional "bulk" approaches are challenging to det ect the dynamic nature of the transcription elongation in real-time. Optic al tweezers offer a unique ability to address this problem. In my project\ , I sought to detect and characterize the RNAP movement utilizing and opti mizing several approaches in optical tweezers based on the literatures and our experimental conditions. LOCATION:Faculty Of Biology Auditorium/ZOOM:https://technion.zoom.us/j/9619 0093354 END:VEVENT BEGIN:VEVENT UID:1248@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20241118T130000 DTEND;TZID=Asia/Jerusalem:20241118T140000 DTSTAMP:20241111T083846Z URL:https://biology.technion.ac.il/en/seminars/faculty-seminar-prof-yasmin e-meroz-plant-tropisms-as-a-window-on-plant-computational-processes/ SUMMARY:Faculty Seminar -Prof. Yasmine Meroz- "Plant Tropisms as a Window o n Plant Computational Processes" [No Categories] DESCRIPTION:Location: Faculty Of Biology Auditorium/ZOOM:https://technion.z oom.us/j/91374645319 Prof. Yasmine Meroz \n Affiliation: \n Host:Dr. Sha iner Inbal\n Dear all\,\n\n \;\n\nOur next seminar will be given by Pr of. Yasmine Meroz from the School of Plant Science and Food Security and t he Center for Physics and Chemistry of Living Systems at Tel Aviv Universi ty.\n\n \;\n\nPlace and time: Biology auditorium\, Monday 18/11 at 13: 00.\n\n \;\n\nTitle: Plant Tropisms as a Window on Plant Computational Processes\n\n \;\n\nAbstract: \n\nPlants generally move by growing t owards or away from directional environmental signals such as light or gra vity – processes called tropisms. While they are not motile\, they survi ve in a harsh and fluctuating environment\, optimizing their search for fl uctuating nutrients\, and predicting danger. They achieve this through com plex response processes\, such as decision-making\, based on memory\, or t he capability to accumulate and compare past stimuli. For example\, a plan t shoot accumulates sensory information from various fluctuating light sou rces\, decides which direction yields consistently most light for photosyn thesis\, and grows in that direction. Here we propose a reverse-engineerin g approach to investigating the underlying rules for the accumulation and integration of sensory inputs. Our theoretical model\, based on response t heory\, predicts that plants respond to the sum of stimuli at short timesc ales\, and to the difference in stimuli at longer timescales. We confirm t his experimentally and suggest that this process may be essential for navi gational problem-solving capabilities of plants.\n\n \;\n\nMeroz lab w ebsite: https://www.merozlab.com/\n\nFor inquiries regarding the course\, please contact Prof. Dedi Meiri <\;dmeiri@technion.ac.il>\;\n\n \ ;\n\n \; LOCATION:Faculty Of Biology Auditorium/ZOOM:https://technion.zoom.us/j/9137 4645319 END:VEVENT BEGIN:VEVENT UID:1247@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20241106T130000 DTEND;TZID=Asia/Jerusalem:20241106T140000 DTSTAMP:20241030T074957Z URL:https://biology.technion.ac.il/en/seminars/7147/ SUMMARY: [No Categories] DESCRIPTION:Location: Faculty Of Biology Auditorium/ZOOM:https://technion.z oom.us/j/6057731604 Sijie Li\n Affiliation: \n Host:Associate Prof. Henn Arnon\n Title: Mitochondria dynamic and its translocation during cellular stress conditions\n\n \;\n\nAbstract \n\nMitochondria dynamics\, moti lity\, and translocation to distinct cellular regions by cytoskeleton-bas ed machinery are essential for adapting to eukaryote cells' physiological demands. Within this broad mitochondrial motility machinery\, the special ized function of actin-based motors has begun to emerge. Precisely\, it is not understood how mitochondrial motility is coordinated and regulated a nd how it is coupled to cellular processes to perform its functions. Usin g interdisciplinary approaches\, we show that mitochondria mobility to th e cell's leading edge upon EGF stimulation is manifested by a fission even t that enables mitochondria to reach filopodia in A431. Mitochondria trans location to the leading edge and filopodia required MT-and actin-based mot ors\, Kif5b and Myo19\, respectively\, and critically\, their cooperativit y. Importantly\, we have found that local calcium buffering affects Kif5b -mitochondria association but has no significant impact on Myo19-mitochond ria association both in-vivo and in-vitro. Hence\, we suggest a switch-o ver mechanism between MT- and actin-based motors in cargo transport in-cel ls such as mitochondria. Our finding supports coordination for mitochondri a motility that requires bridging between actin and MT-base motors. Mitoc hondria dynamics\, motility\, and cell positioning are essential in develo pment and homeostasis. Failure to regulate these processes directly leads to broad pathogenesis and many cell types. A comprehensive mechanism to de scribe the complete processes is still at large. My PhD thesis dissertatio n shed light on such biochemical pathways. LOCATION:Faculty Of Biology Auditorium/ZOOM:https://technion.zoom.us/j/6057 731604 END:VEVENT BEGIN:VEVENT UID:1246@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20241103T093000 DTEND;TZID=Asia/Jerusalem:20241103T113000 DTSTAMP:20241014T114310Z URL:https://biology.technion.ac.il/en/seminars/2024-nobel-prize-insights-s ymposium/ SUMMARY:2024 Nobel Prize Insights Symposium [No Categories] DESCRIPTION:Location: \n Affiliation: \n Host:\n We invite you to join us for an engaging informal symposium where we will present and explain this year's Nobel Prize-winning breakthroughs in the fields of Physics\, Chemi stry\, and Medicine.\nEach talk will present the initial groundbreaking di scoveries\, the scientists behind them\, and their lasting impact on scien ce and society.\n\nNobel Prize in Physics\nNeural Network\, AI- John J. Ho pfield and Geoffrey E. Hinton\nPresented by Dvir Aran and Roy Kishony\n\nN obel Prize in Chemistry\nProtein structure- David Baker\, Demis Hassabis a nd John M. Jumper\nPresented by Fabian Glaser\n\nNobel Prize in Physiology and Medicine\nmicroRNA- Victor Ambros and Gary Ruvkun\nPresented by Ayele t Lamm\nWhen: November 3rd\, 2024\, 09:30\nZoom Link: https://technion.zo om.us/j/99423710438\n \;\n\nOrganized by Roy Kishony and Sivan Geisler -Edelbaum\n\n \; END:VEVENT BEGIN:VEVENT UID:1245@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20241029T130000 DTEND;TZID=Asia/Jerusalem:20241029T140000 DTSTAMP:20241008T124932Z URL:https://biology.technion.ac.il/en/seminars/phd-graduate-seminar-2/ SUMMARY:PhD Graduate Seminar- Nikita Sarvin [No Categories] DESCRIPTION:Location: Hybrid- in the Faculty Auditorium/ZOOM: https://techn ion.zoom.us/j/2475665720?omn=93736958191 Nikita Sarvin\n Affiliation: \n Host:Prof. Tomer Shlomi \n Untargeted screening for small-molecule enzym e inhibitors via high-throughput metabolomics\nOMICS-based screening offer s a promising approach for untargeted drug discovery. Recently\, mass-spec trometry metabolomics and proteomics was used for inferring drug mechanism of action and off-target effects\, analyzing cellular response to treatme nt with numerous clinically approved drugs and tool compounds. Here\, we d eveloped a novel high-throughput LC-MS metabolomics screening pipeline and computational target deconvolution method\, enabling the identification o f novel compounds modulating cellular metabolism. Training our Graph Neura l Network (GNN)-based method on time- and dose-dependent metabolic respons es of cultured cells treated with 76 known metabolic inhibitors\, we corre ctly identified the target pathway within the top three ranked pathways fo r ~50% of the drugs. Applying this approach to a diversity library of 1\,0 20 drug-like compounds\, we discovered five novel inhibitors targeting cli nically relevant pathways and enzymes involved in purine and pyrimidine bi osynthesis and redox metabolism. Our pipeline is readily scalable for scre ening thousands of compounds to identify new\, clinically relevant metabol ic inhibitors. LOCATION:Hybrid- in the Faculty Auditorium/ZOOM: https://technion.zoom.us/j /2475665720?omn=93736958191 END:VEVENT BEGIN:VEVENT UID:1244@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20240926T131500 DTEND;TZID=Asia/Jerusalem:20240926T141500 DTSTAMP:20240925T075322Z URL:https://biology.technion.ac.il/en/seminars/phd-graduate-seminar-suchet a-chopra/ SUMMARY:PhD Graduate Seminar-Sucheta Chopra [No Categories] DESCRIPTION:Location: https://technion.zoom.us/j/96220819823 Meeting ID: 9 62 2081 9823 Sucheta Chopra\n Affiliation: \n Host:Dr. Fuchs Yaron and A ssociate Prof. Shalom-Feuerste Ruby\n Abstract:\n\nUnderstanding the intri cate mechanisms governing epidermal pattern formation\, particularly\n\nwi thin ectodermal appendages like hair follicles\, is a key pursuit in devel opmental biology.\n\nReciprocal interactions between mesenchymal and epith elial cells regulate hair follicle\n\ngrowth and development through vario us signaling pathways\, yet the underlying molecular\n\npathways remain el usive. Our investigation focuses on Thy1\, a cell surface protein tethered \n\nvia a glycosylphosphatidylinositol (GPI) anchor\, which plays a multif aceted role in cell-cell\n\nand cell-matrix adhesion. We found that Thy1 s ignificantly influences hair follicle\n\ndevelopment through the YAP (Yes- associated protein) mediated signaling pathway. In-vivo\n\ndeletion experi ments revealed a marked increase in hair follicle numbers upon Thy1\n\ndel etion\, attributable to the activation of the YAP/Integrin-β1/Src module. Additionally\,\n\nemploying ultrasound-guided lentiviral delivery and pha rmacological inhibition\, we elucidated\n\nthe pronounced regulatory role of YAP in hair follicle morphogenesis\, further delineating the\n\nThy1-de pendent phenotypes. Our findings underscore the pivotal role of YAP activi ty in\n\nregulating hair follicle development\, shedding light on potentia l therapeutic implications for\n\nhair-related disorders and presenting ex citing prospects in the realm of regenerative\n\nmedicine applications. LOCATION:https://technion.zoom.us/j/96220819823 Meeting ID: 962 2081 9823 END:VEVENT BEGIN:VEVENT UID:1242@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20240910T133000 DTEND;TZID=Asia/Jerusalem:20240910T140000 DTSTAMP:20240828T081259Z URL:https://biology.technion.ac.il/en/seminars/msc-graduate-seminar-shiran -rachel-peretz/ SUMMARY:MSc Graduate Seminar-Shiran Rachel Peretz [No Categories] DESCRIPTION:Location: Hybrid- in the Faculty Auditorium/ZOOM: https://techn ion.zoom.us/j/92090707928 Shiran Rachel Peretz\n Affiliation: \n Host:D r. Nadav Sharon \n In search of pancreatic beta cells with a regenerative potential\n\nShiran Rachel Peretz\n\n \;\n\nDepletion of β cell mass is a key characteristic of diabetes\, impairing insulin production and gl ucose regulation\, which sparks interest in restoring beta cell mass throu gh regeneration. While β cells rarely divide\, their expansion under spec ific conditions such as high-fat diet\, pregnancy\, or pancreatic injury s uggests that regulating mature β cell proliferation is possible. A key qu estion is whether all beta cells can proliferate or\, alternatively\, cert ain beta cell subsets have higher proliferative capacity.\n\nCharacterizin g dormant stem cell sub-populations is methodologically challenging becaus e the only way to determine if a cell has the potential to divide is to ob serve it proliferate\, but post-division\, its pre-proliferative character s may be lost and no longer observable.\n\nTo overcome the limitations of conditions that induce β cell proliferation\, we use an insulin receptor antagonist (S961)\, which acutely elevates blood glucose levels and mimics the type 2 diabetes state\, characterized by β cell proliferation.\n\nTo establish whether all beta cells can divide or not\, we adapted a CRISPR- based lineage tracing model (CARLIN) to become β cell specific\, enabling cell-specific genetic barcoding\, followed by triggering of beta cell rep lication. Disproportionate proliferation should lead to non-uniform barcod e distribution\, and thereby answer the question unequivocally.\n\nTo char acterize the proliferative cells further\, we combine S961-inducible repli cation with a tamoxifen-induced Ki67 Cre/loxp-TdTomato mouse model (M/T)\, which permanently labels dividing β cells and facilitates tracking them over time. Our results support the existence of a subpopulation of prolife rative β cells\, which is present in most islets.\n\n \; LOCATION:Hybrid- in the Faculty Auditorium/ZOOM: https://technion.zoom.us/j /92090707928 END:VEVENT BEGIN:VEVENT UID:1241@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20240910T130000 DTEND;TZID=Asia/Jerusalem:20240910T133000 DTSTAMP:20240826T155046Z URL:https://biology.technion.ac.il/en/seminars/msc-graduate-seminar-katery na-flyak/ SUMMARY:MSc Graduate Seminar- Kateryna Flyak [No Categories] DESCRIPTION:Location: Hybrid- in the Faculty Auditorium/ZOOM: https://techn ion.zoom.us/j/92090707928 Kateryna Flyak\n Affiliation: \n Host:Prof. Be njamin Podbilewicz \n Cell-cell fusion during C. elegans male tail morpho genesis\n\nCell-cell fusion is an essential process in the development and formation of body structures. The nematode Caenorhabditis elegans serves as a good model organism for studying cell-cell fusion\, since about one-t hird of its cells undergo fusion during development.\nSpecifically\, I am interested in Rn.p (n = 1-9) male-specific hypodermal cells in the tail\, which fuse during its morphogenesis to form the male copulatory structure\ , an important organ for its mating behavior. The Rn.p cells fuse into two distinct groups - R1.p to R5.p cells fuse together to form the male tail seam (SET)\, while R6.p to R9.p cells fuse with the largest hypodermal syn cytium\, hyp7. However\, it remains unknown which fusion protein/s (i.e. f usogen/s) mediate the fusion of Rn.p cells. My results suggest that two kn own fusogens in C. elegans – EFF-1 and AFF-1 participate in the formatio n of the SET. However\, only EFF-1 appears to mediate the fusion of R6.p t o R9.p with hyp7 syncytium. This functional separation between more than o ne fusogen suggests that the formation of the SET is a highly regulated pr ocess.\n LOCATION:Hybrid- in the Faculty Auditorium/ZOOM: https://technion.zoom.us/j /92090707928 END:VEVENT BEGIN:VEVENT UID:1240@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20240903T133000 DTEND;TZID=Asia/Jerusalem:20240903T140000 DTSTAMP:20240827T125528Z URL:https://biology.technion.ac.il/en/seminars/msc-graduate-seminar-noa-af ik/ SUMMARY:MSc Graduate Seminar- Noa Afik [No Categories] DESCRIPTION:Location: Hybrid- in the Faculty Auditorium/ZOOM: https://tech nion.zoom.us/j/9148448850?omn=98386595857 Noa Afik\n Affiliation: \n Ho st:Prof. Levenberg Shulamit\n The effect of cell-laden bioink preparation and 3D bioprinting process on cells and on tissue formation\nThis study ad dresses challenges in cultivated meat (CM) research\, driven by the increa sing demand for sustainable meat alternatives. With traditional meat produ ction raising environmental\, health\, and ethical issues\, alternative me thods\, such as 3D bioprinting has emerged as a promising solution. The re search aims to optimize 3D bioprinting by examining cell integrity and via bility\, and refining parameters for scalability and functionality. This w ork enhances our understanding of interactions between edible bioink and c ells\, advancing the development of innovative CM products LOCATION:Hybrid- in the Faculty Auditorium/ZOOM: https://technion.zoom.us/ j/9148448850?omn=98386595857 END:VEVENT BEGIN:VEVENT UID:1239@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20240903T130000 DTEND;TZID=Asia/Jerusalem:20240903T133000 DTSTAMP:20240827T125504Z URL:https://biology.technion.ac.il/en/seminars/msc-graduate-seminar-alexan der-khokhlov/ SUMMARY:MSc Graduate Seminar- Alexander Khokhlov [No Categories] DESCRIPTION:Location: Hybrid- in the Faculty Auditorium/ZOOM: https://tech nion.zoom.us/j/9148448850?omn=98386595857 Alexander Khokhlov\n Affiliat ion: \n Host:Associate Prof. Landau Meytal\n Structure-function Relations hips in fibril forming Antimicrobial peptide\nAmyloid-like fibrils formed by antimicrobial peptides (AMPs) and microbial toxins hold significant pro mise as novel antimicrobial therapeutics and targets for antivirulence str ategies. This study explores the relationship between amyloidogenic and an timicrobial properties\, shedding light on the structural diversity and fu nctional implications of these self-assembled biomaterials. Our laboratory previously discovered the cross-α amyloid conformation\, which is unique ly different from the established amyloid structure associated with the cr oss-β conformation. Furthermore\, the lab discovered a unique 'chameleon' -like behavior in fibril polymorphism of several AMPs\, showing a secondar y structure switch from cross-β to cross-α configurations\, often induce d by exposure to bacterial membranes. This suggests a highly adaptive regu lation mechanism. To identify more such chameleon toxic peptides\, computa tional tools were developed by Peleg RagonisBachar (sequence-based) and It ai Bloch (structure-based). Candidate sequences were tested and characteri zed by experimental investigations. The experimental results corroborate t he predictive capabilities of the computational tools developed\, allowing us to identify dozens of toxic sequences that form fibrils\, which led to high resolution structure determination and structure-function relationsh ip studies. This work offers novel insights into the design and characteri zation of AMPs and virulence factors with amyloidogenic features.\n LOCATION:Hybrid- in the Faculty Auditorium/ZOOM: https://technion.zoom.us/ j/9148448850?omn=98386595857 END:VEVENT BEGIN:VEVENT UID:1235@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20240806T130000 DTEND;TZID=Asia/Jerusalem:20240806T140000 DTSTAMP:20240710T131243Z URL:https://biology.technion.ac.il/en/seminars/phd-graduate-seminar-reut-s egal-erel/ SUMMARY:PhD Graduate Seminar- Reut Segal-Erel [No Categories] DESCRIPTION:Location: Hybrid- in the Faculty Auditorium/ZOOM: https://techn ion.zoom.us/j/91650895147 Reut Segal-Erel\n Affiliation: \n Host:Prof. Sh lomi Tomer \n Overcoming Metabolic T-Cell Suppression in Cancer Immunother apy Using Metabolic Engineering\n\nCancer immunotherapy has shown remarkab le success in hematologic cancers but remains less effective against solid tumors due to metabolic suppression in the tumor microenvironment (TME). The metabolic reprogramming of cancer cells limits nutrient availability\, leading to T-cell dysfunction.\n\nTo address this challenge\, we develope d a novel in vivo screening method to identify metabolic genes that enhanc e T-cell function through gene overexpression. Using this innovative strat egy\, we identified three candidate genes — SLC7A8\, G6PD\, and AKT1 — each showing substantial potential for improving T-cell function and are c urrently undergoing rigorous in vivo validation.\n\nOur approach to overco ming metabolic barriers in the TME could significantly enhance the efficac y of cancer immunotherapy\, paving the way for new and more effective trea tments for solid tumors.\n\n \;\n\n \; LOCATION:Hybrid- in the Faculty Auditorium/ZOOM: https://technion.zoom.us/j /91650895147 END:VEVENT BEGIN:VEVENT UID:1238@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20240805T130000 DTEND;TZID=Asia/Jerusalem:20240805T140000 DTSTAMP:20240731T095407Z URL:https://biology.technion.ac.il/en/seminars/faculty-seminar-dr-or-shaha r-cell-type-specific-detection-of-newly-synthesized-proteins-in-vivo-revea ls-neural-activity-dependent-translation-following-seizures/ SUMMARY:Faculty Seminar - Dr. Or Shahar-Cell-type-specific detection of new ly synthesized proteins in vivo reveals neural activity dependent translat ion following seizures [No Categories] DESCRIPTION:Location: Hybrid- in the Faculty Auditorium/ZOOM:https://techni on.zoom.us/j/95890487524 Dr. Or Shahar \n Affiliation: MIGAL Galilee Rese arch Institute\, Tel-Hai Academic College.\n Host:Dr. Dvir Aran\n Dear all \,\n\n \;\n\nOur next seminar will be given by Dr. Or Shahar from th e MIGAL Galilee Research Institute\, Tel-Hai Academic College.\n\n \; \n\nPlace and time: Biology auditorium\, Monday 5/8 at 13:00.\n\n \;\ n\nTitle: Cell-type-specific detection of newly synthesized proteins in v ivo reveals neural activity dependent translation following seizures\n\n&n bsp\;\n\nShahar's lab website: https://www.migal.org.il/en/molecular-neur odynamics\n\n \;\n\nLooking forward to seeing you all\,\n\nDvir\n\n&nb sp\;\n\nZoom link: https://technion.zoom.us/j/95890487524\n\nFor inquirie s regarding the course\, please contact Prof. Dedi Meiri <\;dmeiri@tec hnion.ac.il>\;. LOCATION:Hybrid- in the Faculty Auditorium/ZOOM:https://technion.zoom.us/j/ 95890487524 END:VEVENT BEGIN:VEVENT UID:1231@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20240730T010000 DTEND;TZID=Asia/Jerusalem:20240730T020000 DTSTAMP:20240701T131239Z URL:https://biology.technion.ac.il/en/seminars/phd-graduate-seminar-feras- machour/ SUMMARY:PhD Graduate Seminar- Feras Machour [No Categories] DESCRIPTION:Location: Hybrid- in the Faculty Auditorium/ZOOM: https://techn ion.zoom.us/j/96794050334 Feras Machour\n Affiliation: \n Host:Prof. Nab ieh Ayoub \n Harnessing DNA replication stress to target RBM10 deficiency in lung adenocarcinoma\n\nBackground and Motivation: Lung cancer has the h ighest mortality rate among all types of cancer worldwide. Strikingly\, th e RNA-binding motif protein 10 (RBM10) is the most mutated splicing fact or in lung adenocarcinoma (LUAD) (~9-25% of all cases). Most RBM10 cancer mutations are loss-of-function\, correlating with increased tumorigenesis and limiting the efficacy of current LUAD targeted therapies. Remarkably\, therapeutic strategies leveraging RBM10 deficiency remain unexplored\, hi ghlighting the urgency for innovative approaches to target RBM10 loss in L UAD.\nResearch Goal: Exploit the high mutation rate of RBM10 in LUAD for s elective eradication of RBM10-mutated LUAD tumors.\nResults: We conducted a CRISPR-Cas9 synthetic lethality (SL) screen and identified ~60 RBM10 SL genes\, including WEE1 kinase. WEE1 inhibition sensitized RBM10-deficient LUAD cells in-vitro and in-vivo. Intriguingly\, we identified a splicing-i ndependent role of RBM10 in regulating DNA replication fork progression an d replication stress response\, which underpins RBM10-WEE1 SL. Mechanistic ally\, we reveal that RBM10 physically interacts with active DNA replicati on forks and modulates R-loop homeostasis to maintain replication fork sta bility.\nConclusions: Our data reveal an unexpected function of RBM10 in f ine-tuning DNA replication\, independent of its canonical splicing functio n. In a broader context\, these findings reveal an unexplored aspect of DN A replication regulation involving a noncanonical function of RNA splicing factors. Moreover\, our data provide an arsenal of therapeutic targets\, such as WEE1\, that can be utilized to target RBM10-mutated LUAD tumors wi th immediate clinical applicability. LOCATION:Hybrid- in the Faculty Auditorium/ZOOM: https://technion.zoom.us/j /96794050334 END:VEVENT BEGIN:VEVENT UID:1237@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20240729T130000 DTEND;TZID=Asia/Jerusalem:20240729T140000 DTSTAMP:20240724T104934Z URL:https://biology.technion.ac.il/en/seminars/faculty-seminar-papers-of-t he-month/ SUMMARY:Faculty Seminar - Papers of the Month [No Categories] DESCRIPTION:Location: Biology auditorium Joshua Hazan\, Johannes Augus Ven ezian\, Guy Levin\, Dharanibalan Kasiviswanathan\n Affiliation: \n Host:Dr . Dvir Aran\n Dear all\,\n\n \;\n\nThis week we will have four short t alks by recent winners of the “paper of the month” award.\n\n Joshua Hazan\, Bester lab\nIntegration of transcription regulation and functional genomic data reveals lncRNA SNHG6’s role in hematopoietic differentiati on and leukemia (Journal of Biomedical Science\, 2024)\n Johannes Augus V enezian\, Shiber lab\nDiverging co-translational protein complex assembly pathways are governed by interface energy distribution (Nature Communicati ons\, 2024)\n Guy Levin\, Schuster lab\nDiverging co-translational protei n complex assembly pathways are governed by interface energy distribution (New Phytologist\, 2024)\n Dharanibalan Kasiviswanathan\, Shemer lab\nPro teasome gene expression is controlled by coordinated functions of multiple transcription factors (Journal of Cell Biology\, 2024)\n\n \;\n\nPlac e and time: Biology auditorium\, Monday 29/7 at 13:00.\n\n \;\n\nLook ing forward to seeing you all\,\n\nDvir\n\n \;\n\nZoom link: https:// technion.zoom.us/j/95890487524\n\nFor inquiries regarding the course\, ple ase contact Prof. Dedi Meiri <\;dmeiri@technion.ac.il>\;. LOCATION:Biology auditorium END:VEVENT BEGIN:VEVENT UID:1236@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20240722T130000 DTEND;TZID=Asia/Jerusalem:20240722T140000 DTSTAMP:20240716T093816Z URL:https://biology.technion.ac.il/en/seminars/faculty-seminar-prof-ravid- straussman/ SUMMARY:Faculty Seminar - Prof. Ravid Straussman [No Categories] DESCRIPTION:Location: Hybrid- in the Faculty Auditorium/ZOOM: https://tech nion.zoom.us/j/95890487524 Prof. Ravid Straussman\n Affiliation: departm ent of Molecular Cell Biology\, Weizmann Institute.\n Host: Dr. Dvir Aran\ n Dear all\,\n\n \;\n\nOur next seminar will be given by Prof. Ravid S traussman from the department of Molecular Cell Biology\, Weizmann Instit ute.\n\n \;\n\nPlace and time: Biology auditorium\, Monday 22/7 at 13: 00.\n\n \;\n\nTitle: The Tumor Microbiome and its Effects on the Respo nse to Treatment\n\n \;\n\nMerkel's website: https://www.weizmann.ac.i l/mcb/Straussman/home\n\n \;\n\nLooking forward to seeing you all\,\n\ nDvir\n\n \;\n\nZoom link: https://technion.zoom.us/j/95890487524\n\n For inquiries regarding the course\, please contact Prof. Dedi Meiri <\ ;dmeiri@technion.ac.il>\;. LOCATION:Hybrid- in the Faculty Auditorium/ZOOM: https://technion.zoom.us/ j/95890487524 END:VEVENT BEGIN:VEVENT UID:1234@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20240716T130000 DTEND;TZID=Asia/Jerusalem:20240716T133000 DTSTAMP:20240708T125123Z URL:https://biology.technion.ac.il/en/seminars/msc-graduate-seminar-gali-t zlil/ SUMMARY:MSc Graduate Seminar- Gali Tzlil [No Categories] DESCRIPTION:Location: Hybrid- in the Faculty Auditorium/ZOOM: https://tech nion.zoom.us/j/92948509720 Gali Tzlil\n Affiliation: \n Host:Prof. Oded Beja \n Rhodopsin-carotenoid complexes in marine microorganisms\n\nMicro bial rhodopsins are retinal-bound\, light-activated membranal proteins fou nd in diverse aquatic microbes. In the ocean’s photic zone\, >\;50% of microbes harbor a rhodopsin gene\, potentially enabling their phototropic lifestyle. Recently\, our lab reported on the widespread binding of carot ene antennas to microbial rhodopsins\, suggesting a significant impact on rhodopsin-mediated phototrophy.\nThus far\, we have characterized novel an tennas-rhodopsin complexes only from a bacterial origin. In this project\, we screen for novel antennas-rhodopsin complexes from diverse microbial o rigins. Surprisingly\, we found antennas-rhodopsin complexes originating f rom marine planktonic Asgard Archaea. Furthermore\, we demonstrate that th is rhodopsin can bind diverse hydroxylated carotenoids (e.g.\, lutein\, di atoxanthin and fucoxanthin) and transfer energy. Our results indicate that the use of light-harvesting antennas in microbial rhodopsins is potential ly utilized by open ocean Asgard Archaea to support phototrophic lifestyle LOCATION:Hybrid- in the Faculty Auditorium/ZOOM: https://technion.zoom.us/ j/92948509720 END:VEVENT BEGIN:VEVENT UID:1232@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20240709T010000 DTEND;TZID=Asia/Jerusalem:20240709T020000 DTSTAMP:20240724T064306Z URL:https://biology.technion.ac.il/en/seminars/phd-graduate-seminar-cameli a-shopen-gochev/ SUMMARY:PhD Graduate Seminar- Camelia Shopen Gochev [No Categories] DESCRIPTION:Location: Hybrid- in the Faculty Auditorium/ZOOM: https:https:/ /technion.zoom.us/j/93961845291 Camelia Shopen Gochev\n Affiliation: \n Host: Prof. Debbie Lindell \n Seasonality of infection:\nDynamics of c yanophage abundances and infection of their hosts\nMarine cyanobacteria ar e photosynthetic bacteria that are estimated to be responsible for a quart er of the ocean net primary production and are highly abundant. Their geog raphical distribution is shaped by environmental parameters such as temper ature\, nutrient availability\, light intensity but also by presence of mo rtality agents such as grazers and viruses. This work looks into how seaso nal changes in the environmental conditions affects viral abundances and i nfection patterns of their cyanobacterial host in two different oceanic re gions. Analysis of two years of monthly sampling from in the Sargasso Sea\ , North Atlantic Ocean\, a nutrient poor open ocean system\, revealed stro ng re-occurring seasonality for both cyanobacteria and their viruses\, wit h higher abundance and infection in the fall. In sub-Antarctic waters in t he South Pacific Ocean\, a high nutrient low chlorophyll region\, I observ ed overall similar abundance of cyanobacteria and their viruses but with d ifferent taxon-specific composition and higher surface infection. Gaining insight into the drivers of infection dynamics among primary producers wil l enhance our understanding and predictability of the fate of photosynthet ically fixed atmospheric CO2 and ocean biogeochemistry\, particularly as o ur oceans continue to warm.\n LOCATION:Hybrid- in the Faculty Auditorium/ZOOM: https:https://technion.zoo m.us/j/93961845291 END:VEVENT BEGIN:VEVENT UID:1233@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20240708T010000 DTEND;TZID=Asia/Jerusalem:20240708T020000 DTSTAMP:20240724T064835Z URL:https://biology.technion.ac.il/en/seminars/faculty-seminar-prof-gal-ma rkel-cellular-events-in-resistance-to-immunotherapy/ SUMMARY:Faculty Seminar - Prof. Gal Markel-Cellular events in resistance to immunotherapy [No Categories] DESCRIPTION:Location: Hybrid- in the Faculty Auditorium/ZOOM:https://techni on.zoom.us/j/95890487524 Prof. Gal Markel\n Affiliation: \n Host:Dr. Dvi r Aran\n Dear all\,\n\n \;\n\nOur next seminar will be given by Prof. Gal Markel\, the Director of Davidoff Cancer Center\, Co-founder &\; Chairman of Samueli Integrative Cancer Pioneering Institute &\; Deputy Director General\, Rabin Medical Center and Professor of Clinical Microb iology and Immunology at Tel-Aviv University.\n\n \;\n\nPlace and time : Biology auditorium\, Monday 8/7 at 13:00.\n\n \;\n\nTitle: Cellular events in resistance to immunotherapy\n\n \;\n\nMerkel's website: http s://gal.markel.md/en/\n\n \;\n\nLooking forward to seeing you all\,\n\ nDvir LOCATION:Hybrid- in the Faculty Auditorium/ZOOM:https://technion.zoom.us/j/ 95890487524 END:VEVENT BEGIN:VEVENT UID:1230@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20240702T130000 DTEND;TZID=Asia/Jerusalem:20240702T140000 DTSTAMP:20240619T075457Z URL:https://biology.technion.ac.il/en/seminars/phd-graduate-seminar-ariel- chazan/ SUMMARY:PhD Graduate Seminar- Ariel Chazan [No Categories] DESCRIPTION:Location: Hybrid- in the Faculty Auditorium/ZOOM: https://tec hnion.zoom.us/j/92872187327?pwd=DJMB4HKa34c56RjBhCev6KB1fHL87D.1 Ariel Ch azan\n Affiliation: \n Host:Prof. Oded Beja \n Mixing up the colors of th e seas:\nPhototrophy by antenna-containing rhodopsins in aquatic environme nts\n\nRhodopsin-based phototrophy is one of the two known ways by which m icroorganisms harvest sunlight energy. More than 50% of bacteria in the oc ean's surface contain a rhodopsin gene. Rhodopsins are defined as a two-co mponent system (protein + retinal) that relies on the retinal to capture s unlight energy. In two exotic and rare bacteria\, rhodopsins were demonstr ated to bind an additional antenna composed of a carotenoid molecule that captures additional light and enhances the activity of the complex. Such r hodopsins have been known for almost 20 years\, yet the isolated cases of a rhodopsin-carotenoid complex remained a curious phenomenon of marginal e cological significance.\n\nIn this project\, we designed a novel workflow that uses environmental samples to pull out from a native pool of caroteno ids the ones that might serve as antennas for rhodopsin. Surprisingly\, us ing this methodology\, we discovered that the ability of rhodopsins to bin d carotenoid antennas appears to be widespread in nature. We demonstrate t hat these antennas can significantly enhance rhodopsin activity\; moreover \, we predict that over a third of the rhodopsins found in aquatic microbe s can potentially utilize a carotenoid antenna to capture additional light energy. These antennas were neglected for almost 20 years\; we now unders tand that they may have a substantial impact on rhodopsin-mediated phototr ophy in the world’s lakes\, seas and oceans. LOCATION: Hybrid- in the Faculty Auditorium/ZOOM: https://technion.zoom.us /j/92872187327?pwd=DJMB4HKa34c56RjBhCev6KB1fHL87D.1 END:VEVENT BEGIN:VEVENT UID:1223@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20240626T123000 DTEND;TZID=Asia/Jerusalem:20240626T140000 DTSTAMP:20240530T122156Z URL:https://biology.technion.ac.il/en/seminars/biond-biologics-discovering -and-translating-innovative-science-into-breaking-biologics-to-treat-cance r/ SUMMARY:Biond Biologics - Discovering and Translating innovative science in to breaking Biologics to treat cancer [No Categories] DESCRIPTION:Location: Biology Auditorium Tehila Ben Moshe\n Affiliation: P h.D I Co-Founder\, Chairperson $ CEO\n Host:\n Biond Biologics – From Di scovery and Application of Innovative Science to Breakthrough Biological D rugs for Cancer Treatment\nSpeaker: Dr. Tehila Ben Moshe\, CEO\, Co-Founde r\, and Chairperson of the company\n\nIn this lecture\, Dr. Ben Moshe will present the unique technology developed by the company and its potential applications in medicine.\n\nLecture Date: Wednesday\, June 26th at 12:30 PM - Biology Auditorium\n\nSchedule:\n\n 12:30-1:30 PM: Seminar\, Biology Auditorium\n 1:30-2:00 PM: Open meeting with the speaker on the topic of Bridge to Industry\, light refreshments - Auditorium Lobby\n\nJoin us for a fascinating journey of discovery\, collaboration\, and innovation! LOCATION:Biology Auditorium END:VEVENT BEGIN:VEVENT UID:1220@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20240625T130000 DTEND;TZID=Asia/Jerusalem:20240625T140000 DTSTAMP:20240501T193636Z URL:https://biology.technion.ac.il/en/seminars/phd-graduate-seminar-rina-z uchman/ SUMMARY:PhD Graduate Seminar- Rina Zuchman [No Categories] DESCRIPTION:Location: Hybrid- in the Faculty Auditorium/ZOOM: https://techn ion.zoom.us/j/96303584862 Rina Zuchman\n Affiliation: \n Host:Prof. Ben jamin A. Horwitz\n Novel fungal MAP kinase signalling in response to a hos t plant small-molecule signal in the Cochliobolus-maize interaction\n\nOur study aims to investigate the relationship between fungi and their plant hosts during infection\, focusing on the maize pathogen C. heterostrophus \, which serves as a model for necrotrophic plant pathogens. Analysis of i nfected leaves at various stages of disease development\, using RNA-seq an d fluorescence microscopy\, uncovered a correlation between fungal hyphal development\, necrotrophic gene expression\, and plant defense mechanisms. Notably\, the host plant upregulates defense-related genes early in infec tion\, particularly those involved in phenolic acid biosynthesis. When ger minating spores are exposed to ferulic acid (FA)\, a phenolic compound abu ndant in the host plant\, the stress-activated MAP kinase Hog1 is\, surpri singly\, dephosphorylated and sequestered in cytoplasmic foci rather than phosphorylated and accumulated in the nucleus\, as expected in stress resp onses. This unique signalling pathway may play a role in attenuating cell death induced by plant defense compounds like FA. Our findings provide ins ights into the dynamics of pathogen cell death\, survival\, and proliferat ion within lesions\, while also shedding light on stress responses mediate d by MAP kinases. LOCATION:Hybrid- in the Faculty Auditorium/ZOOM: https://technion.zoom.us/j /96303584862 END:VEVENT BEGIN:VEVENT UID:1229@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20240624T130000 DTEND;TZID=Asia/Jerusalem:20240624T140000 DTSTAMP:20240618T130808Z URL:https://biology.technion.ac.il/en/seminars/faculty-seminar-dr-mor-nitz andecoding-multicellular-organization-in-space-and-time-from-single-cell-d ata/ SUMMARY:Faculty Seminar - Dr. Mor Nitzan:"Decoding multicellular organizati on in space and time from single-cell data" [No Categories] DESCRIPTION:Location: Hybrid- in the Faculty Auditorium/ZOOM: https://tech nion.zoom.us/j/95890487524 Dr. Mor Nitzan\n Affiliation: The Hebrew Univ ersity\, Jerusalem.\n Host:Dr. Dvir Aran\n  \;\n\n \;\n\nOur next seminar will be given by Dr. Mor Nitzan from the School of Computer Sc ience and Engineering\, The Hebrew University\, Jerusalem.\n\n \;\n\nP lace and time: Biology auditorium\, Monday 24/6 at 13:00.\n\n \;\n\nT itle: Decoding multicellular organization in space and time from single-c ell data\n\n \;\n\nNitzan lab website: https://www.nitzanlab.com/\n\n  \;\n\nRecent publications from the Nitzan lab:\nKarin et al. Nature B iotechnology (2023). https://www.nature.com/articles/s41587-023-01663-5\n Mages et al. Nature Biotechnology (2023). https://www.nature.com/articles /s41587-023-01657-3\n\nPiran et al. Nature Biotechnology (2024). https:// www.nature.com/articles/s41587-023-02079-x\n\n \;\n\nLooking forward t o seeing you all\,\n\nDvir\n\n \;\n\nZoom link: https://technion.zoom .us/j/95890487524\n\nFor inquiries regarding the course\, please contact  Prof. Dedi Meiri <\;dmeiri@technion.ac.il>\;. LOCATION:Hybrid- in the Faculty Auditorium/ZOOM: https://technion.zoom.us/ j/95890487524 END:VEVENT BEGIN:VEVENT UID:1225@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20240619T130000 DTEND;TZID=Asia/Jerusalem:20240619T140000 DTSTAMP:20240602T171057Z URL:https://biology.technion.ac.il/en/seminars/phd-graduate-seminar-tal-re fael/ SUMMARY:PhD Graduate Seminar- Tal Refael [No Categories] DESCRIPTION:Location: Hybrid- in the Faculty Auditorium/ZOOM: https://techn ion.zoom.us/j/94259170040 Tal Refael \n Affiliation: \n Host:Prof. Philip pa Melamed \n Novel enhancers in transcriptional regulation of the gonadot ropin genes\n\nThe pituitary gland luteinizing hormone (LH) and follicle s timulating hormone (FSH) control gonadal development and function\, their levels changing dramatically at puberty\, during the estrous/menstrual cyc le and at menopause\, in response to complex hormonal signals. We hypothes ized that distal DNA elements regulate Lhb and Fshb expression to mediate some of these effects. We identified a bi-directional enhancer and lncRNA which play distinct and sex-specific roles in Lhb expression\, and found t hat both elements are regulated by non-canonical DNA structures. Far upstr eam of Fshb\, we detected a gonadotrope-specific “super-enhancer” whos e activity affects Fshb mRNA levels. Protein binding and transcription of this region increased in response to activin\, and the transcription incre ased in a mouse model of menopause which is characterized by high levels o f activin activity. This indicates a role for the region in mediating the elevation of FSH at menopause\, which underlies the onset of several age-r elated diseases. Our findings reveal novel mechanisms involved in control of the reproductive axis\, and shed new light on transcriptional regulatio n via various distal non-coding genomic elements. LOCATION:Hybrid- in the Faculty Auditorium/ZOOM: https://technion.zoom.us/j /94259170040 END:VEVENT BEGIN:VEVENT UID:1227@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20240618T130000 DTEND;TZID=Asia/Jerusalem:20240618T140000 DTSTAMP:20240604T082044Z URL:https://biology.technion.ac.il/en/seminars/faculty-seminar-prof-leor-w einberger-discovery-of-cellular-dither-pathways/ SUMMARY:Faculty Seminar - Prof. Leor Weinberger-“Discovery of cellular 'd ither' pathways” [No Categories] DESCRIPTION:Location: Faculty Of Biology Auditorium Prof. Leor Weinberger\ n Affiliation: University of California\, San Francisco \n Host:Prof. Arav a Yoav\n LOCATION:Faculty Of Biology Auditorium END:VEVENT BEGIN:VEVENT UID:1228@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20240617T130000 DTEND;TZID=Asia/Jerusalem:20240617T140000 DTSTAMP:20240616T044949Z URL:https://biology.technion.ac.il/en/seminars/faculty-seminar-dr-oren-kol odny-the-role-of-the-host-associated-microbiome-in-hosts-ecology-and-evolu tion/ SUMMARY:Faculty Seminar - Dr. Oren Kolodny-"The role of the host-associated microbiome in hosts' ecology and evolution" [No Categories] DESCRIPTION:Location: Biology auditorium Dr. Oren Kolodny\n Affiliation: H ebrew University of Jerusalem.\n Host:Dr. Dvir Aran\n The faculty seminar will be given by Dr. Oren Kolodny from the Department of Ecology\, Evo lution\, and Behavior\, Hebrew University of Jerusalem.\n\n \;\n\nPl ace and time: Biology auditorium\, Monday 17/6 at 13:00.\n\n \;\n\nTi tle: The role of the host-associated microbiome in hosts' ecology and evo lution\n\n \;\n\nKolodny lab website: https://sites.google.com/view/o ren-kolodny-homepage LOCATION:Biology auditorium END:VEVENT BEGIN:VEVENT UID:1226@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20240610T130000 DTEND;TZID=Asia/Jerusalem:20240610T140000 DTSTAMP:20240603T151844Z URL:https://biology.technion.ac.il/en/seminars/faculty-seminar-prof-michae l-blank/ SUMMARY:Faculty Seminar - Prof. Michael Blank [No Categories] DESCRIPTION:Location: Hybrid- in the Faculty Auditorium/ZOOM: https://techn ion.zoom.us/j/95890487524 Prof. Michael Blank\n Affiliation: Faculty of Medicine\, Bar-Ilan University.\n Host:Dr. Dvir Aran\n Dear all\,\n\n  \;\n\nOur next seminar will be given by Prof. Michael Blank from the F aculty of Medicine\, Bar-Ilan University.\n\n \;\n\nPlace and time:  Biology auditorium\, Monday 10/6 at 13:00.\n\n \;\n\nTitle: SMURF2-me diated ubiquitin signaling in epigenetic regulation\, genome integrity mai ntenance\, and cancer\n\n \;\n\nBlank lab website: https://medicine.b iu.ac.il/en/Blank\n\nLooking forward to seeing you all\,\n\nDvir\n\n \ ;\n\nZoom link: https://technion.zoom.us/j/95890487524\n\nFor inquiries r egarding the course\, please contact Prof. Dedi Meiri <\;dmeiri@techni on.ac.il>\;. LOCATION:Hybrid- in the Faculty Auditorium/ZOOM: https://technion.zoom.us/j /95890487524 END:VEVENT BEGIN:VEVENT UID:1224@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20240603T130000 DTEND;TZID=Asia/Jerusalem:20240603T140000 DTSTAMP:20240602T050609Z URL:https://biology.technion.ac.il/en/seminars/faculty-seminar-prof-noam-s homron/ SUMMARY:Faculty Seminar - Prof. Noam Shomron [No Categories] DESCRIPTION:Location: Prof. Noam Shomron \n Affiliation: Department of Ce ll and Developmental Biology\, Tel-Aviv University.\n Host:Dr. Dvir Aran\n Dear all\,\n\n \;\n\nOur next seminar will be given by Prof. Noam Sh omron from the Department of Cell and Developmental Biology\, Tel-Aviv University.\n\n \;\n\nPlace and time: Biology auditorium\, Monday 3/6 at 13:00.\n\n \;\n\nTitle: Seeking microRNA regulators of diseases\n \n \;\n\nShomron lab website: https://nshomron.github.io/\n\nLooking forward to seeing you all\,\n\nDvir\n\n \;\n\nZoom link: https://tech nion.zoom.us/j/95890487524\n\nFor inquiries regarding the course\, please contact Prof. Dedi Meiri <\;dmeiri@technion.ac.il>\;. END:VEVENT BEGIN:VEVENT UID:1222@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20240527T130000 DTEND;TZID=Asia/Jerusalem:20240527T140000 DTSTAMP:20240520T123708Z URL:https://biology.technion.ac.il/en/seminars/faculty-seminar-prof-sagi-s nir-harnessing-genome-dynamics-for-phylogenetic-reconstruction/ SUMMARY:Faculty Seminar - Prof. Sagi Snir-Harnessing Genome Dynamics for Ph ylogenetic Reconstruction [No Categories] DESCRIPTION:Location: Biology auditorium Prof. Sagi Snir\n Affiliation: \n Host:Dr. Dvir Aran\n Dear all\,\n\n \;\n\nExcited to open up the seco nd semester Faculty of Biology Seminar Series. The opening seminar will be given by Prof. Sagi Snir from the Department of Evolutionary and Envir onmental Biology and The Institute of Evolution\, University of Haifa and  President of the Israel Society for Bioinformatics and Computational Bio logy.\n\n \;\n\nPlace and time: Biology auditorium\, Monday 27/5 at 1 3:00.\n\n \;\n\nTitle: Harnessing Genome Dynamics for Phylogenetic Re construction\n\n \;\n\nSnir lab website: https://sagi-snir.wixsite.co m/snir-lab\n\nLooking forward to seeing you all\,\n\nDvir\n\n \;\n\nHa rnessing Genome Dynamics for Phylogenetic Reconstruction\n\nThe dramatic d ecrease in time and cost for generating genetic sequence data has opened u p vast opportunities in molecular systematics\, one of which is the abilit y to decipher the evolutionary history of strains of a species. Under this fine systematic resolution\, the standard markers are often too crude to provide a reliable phylogenetic signal. Nevertheless\, among prokaryotes\, genome dynamics (GD) in the form of horizontal gene transfer (HGT)\, the transfer of genetic material between organisms not through lineal descent\ , seem to provide far richer information by affecting both gene order and gene content.\n\nIn modern systematics\, a common practice is to assume a stochastic model describing the behavior of the system.  Such modelling i s valuable\, as it allows advanced machine learning approaches to be appli ed to the data.\n\nHere we provide a first statistical\, two-level modelin g and analysis\, for GD under a very simple operation – the Jump operati on. Using this modeling we can infer several essential  characteristics f or genomes evolving along a tree and analytically infer HGT rate and time. \n\nWe applied this model to the new version of the orthology DB EggNOG co ntaining over 4.5K taxa. To the best of our knowledge\, this is the larges t gene-order-based tree constructed and it overcomes shortcomings found in previous approaches. Constructing a GD-based tree allows to confirm and c ontrast findings based on other phylogenetic approaches\, as we show.\n\nT he talk is self-contained and assumes no mathematical background. \n\n&nb sp\;\n\nRelated Papers: \n\n Katriel\, G.\, Mahanaymi\, U.\, Brezner\, S .\, Kezel\, N.\, Koutschan\, C.\, Zeilberger\, D.\, ... &\; Snir\, S. G ene Transfer-based Phylogenetics: Analytical Expressions and Additivity vi a Birth-Death Theory. Systematic biology\, syad060.\n Sevillya\, G.\, D. Doerr\, Y. Lerner\, J. Stoye\, M. Steel\, and S. Snir. 2019. Horizontal G ene Transfer Phylogenetics: A Random Walk Approach. Molecular Biology and Evolution (MBE)37:1470–1479.\n  Shifman\, A.\, N. Ninyo\, U. Gophna\, and S. Snir. 2013. Phylo si: a new genome-wide approach for prokaryotic ph ylogeny. Nucleic acids research (NAR)42:2391–2404.\n\n \;\n\nShort B io: Sagi Snir graduated in Computer Science from the Technion Israel\, foc using on analytical\, algebraic\, maximum likelihood solutions to phylogen etics. After a postdoc in the Math and the Computer Science depts at UC Be rkeley\, he returned to the dept of Evolutionary &\; Environmental biol ogy  at the University of Haifa in Israel\, where he has established the Bioinformatics program for grad students. He is now a professor of computa tional evolution at the University of Haifa and the President of the Israe li Society for Bioinformatics and Computational Biology.\n\nHis research c ombines algorithmic approaches to problems from evolution with focus on ph ylogenetic trees and networks. He has developed the Quartet MaxCut algorit hm to combine conflicting signals between evolutionary trees and other fun damental results on maximum likelihood of trees and networks. His papers h ave been published in both pure theoretical computer science venues and pu re evolution venues.\n\nAfter his army service he traveled for two years o n a motorcycle from the tip of South America (Tierra del Fuego) to Alaska. LOCATION:Biology auditorium END:VEVENT BEGIN:VEVENT UID:1219@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20240508T130000 DTEND;TZID=Asia/Jerusalem:20240508T140000 DTSTAMP:20240501T191317Z URL:https://biology.technion.ac.il/en/seminars/phd-graduate-seminar-itai-b loch/ SUMMARY:PhD Graduate Seminar- Itai Bloch [No Categories] DESCRIPTION:Location: Hybrid- in the Faculty Auditorium/ZOOM: https://techn ion.zoom.us/j/97680951856#success Itai Bloch\n Affiliation: \n Host:Asso ciate Prof. Meytal Landau \n Unraveling the Complexities of Fibril-Formin g Antimicrobial Peptides: A Computational Exploration\n\nMy research aims to explore and evaluate peptides capable of forming cross-α fibrillar str uctures. It introduces a grid-based energy estimation method that utilizes existing cross-structures as templates. A library of antimicrobial peptid es\, selected for high helical propensity and significant orthogonal hydro phobic moments\, was screened. Interaction energies between peptides and t he generated grids resulted in a dataset containing 23\,304 entries\, whic h is then refined through rigorous energy-based filters. Peptides are rank ed by their energy profiles\, and the top ranked candidates were selected for further experimental analysis. This study presents a novel systematic method for identifying and characterizing cross-α fibril-forming peptides \, potentially advancing our understanding of these intriguing molecules f or useful applications. LOCATION:Hybrid- in the Faculty Auditorium/ZOOM: https://technion.zoom.us/j /97680951856#success END:VEVENT BEGIN:VEVENT UID:1221@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20240507T130000 DTEND;TZID=Asia/Jerusalem:20240507T140000 DTSTAMP:20240502T094307Z URL:https://biology.technion.ac.il/en/seminars/phd-graduate-seminar-akmara l-rakhymzhanova/ SUMMARY:PhD Graduate Seminar- Akmaral Rakhymzhanova [No Categories] DESCRIPTION:Location: Hybrid- in the Faculty Auditorium/ZOOM: https://techn ion.zoom.us/j/99062456099 Akmaral Rakhymzhanova\n Affiliation: \n Host:D r. Noga Ron-Harel \n Alanine – a metabolic liability ‘by choice’\n\n Abstract:\n\nT lymphocytes\, the cellular arm of the adaptive immune syste m\, maintain host homeostasis and orchestrate an immune response to pathog ens and internal threats like tumors and injuries. Upon encountering their cognate antigen\, T cells enter a phase of rapid cell growth expansion. T his transition from quiescence to active growth is driven by the reprogram ming of cellular metabolism\, transitioning from low-rate catabolism to ma ssive biosynthesis. Success in this transformation relies on the microenvi ronment providing essential fuels such as glucose and amino acids. Our pre vious work highlighted T cell dependence of extracellular alanine pools fo r activation\, showing that T cells do not express GPT (Glutamate Pyruvate Transaminase)\, an alanine synthesizing enzyme.  As a result\, alanine d eprivation inhibited protein synthesis and arrested T cell activation. An intriguing question arose: Why do T cells ‘choose’ this metabolic liab ility?\n\nWe hypothesized that T cells purposefully suppress GPT expressio n to enable pyruvate flux into other metabolic pathways. In this study\, w e tested this hypothesis by overexpressing GPT in primary T cells and exam ining its effect on T cell metabolism and function. GPT overexpression res cued T cell growth\, activation\, and proliferation under conditions of al anine deprivation\, albeit with a concomitant decrease in cell viability. Untargeted metabolomics highlighted significant alterations in metabolism driven by GPT overexpression\, with lower carbon flux into the mitochondri a\, reduced cellular pools of aspartate and nucleotides\, and accumulation of 2-hydroxyglutarate (2-HG).  Intriguingly\, these robust changes in me tabolism did not affect proliferation but compromised cell viability.\n\nO ur findings shed light on T cells fuel portioning and the consequences of its interruption. LOCATION:Hybrid- in the Faculty Auditorium/ZOOM: https://technion.zoom.us/j /99062456099 END:VEVENT BEGIN:VEVENT UID:1216@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20240416T093000 DTEND;TZID=Asia/Jerusalem:20240416T153000 DTSTAMP:20240318T112803Z URL:https://biology.technion.ac.il/en/seminars/mini-symposium-for-clari-va lansi-on-developmental-cell-biology-and-neurosciences/ SUMMARY:Mini Symposium for Clari Valansi on Developmental Cell Biology and Neurosciences [No Categories] DESCRIPTION:Location: Biology Auditorium \n Affiliation: \n Host:\n Invite d Speakers :\n\n*Ori Avinoam\n\nWeizmann Institute of Science\n\n*Nicolas Brukman\n\nTechnion\n\n*Yael Iosilevskii\n\nTechnion\n\n*Meital Oren-Suiss a\n\nWeizmann Institute of Science\n\n*Amir Sapir\n\nUniversity of Haifa-O ranim\n\n \;\n\nPlease RSVP here: https://forms.gle/65JqCTiV6Ac27p1P6 \n\n \;\n\nOrganized by: Nir Blitz I Beni Podbilewicz  LOCATION:Biology Auditorium END:VEVENT BEGIN:VEVENT UID:1218@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20240403T130000 DTEND;TZID=Asia/Jerusalem:20240403T140000 DTSTAMP:20240321T102102Z URL:https://biology.technion.ac.il/en/seminars/phd-graduate-seminar-guy-le vin/ SUMMARY:PhD Graduate Seminar- Guy Levin [No Categories] DESCRIPTION:Location: Hybrid- in the Faculty Auditorium/ZOOM: https://techn ion.zoom.us/j/97557530438 Guy Levin\n Affiliation: \n Host:Professor Eme ritus Schuster Gadi\, Associate Prof. Yehezkeli Omer\n The unique mechanis ms that enable Chlorella ohadii to thrive in light intensities that are fa tal to most photosynthetic organisms\nAlthough light is required for photo synthesis\, too much light is harmful and may cause damage to the photosyn thetic proteins in a process known as photoinhibition. During photoinhibit ion\, photosynthesis is inhibited in plants\, algae\, and cyanobacteria\, and may lead to retarded growth and death. Improving photoinhibition resis tance to increase crop production is a long-standing goal for plant scient ists worldwide. Here we reveal the unique mechanisms of photoinhibition re sistance in the desert green algae Chlorella ohadii\, one of the most high -light tolerant organisms on the planet. We show that C. ohadii lacks some of the most important photoinhibition resistance mechanisms in other mode l organisms\, such as non-photochemical quenching (NPQ)\, the PsbS and Lhc SR proteins\, and state transitions. Instead\, C. ohadii protects photosyn thesis by eliminating the photosynthetic antenna and minimizing excess ene rgy uptake\, while maximizing cyclic electron flow around photosystem I an d antioxidant activity via carotenoids and enzymatic detoxification\, thus protecting the photosynthetic proteins. Our work describes a new efficien t mechanism for photoinhibition resistance under extreme light intensities and provides potential targets for improving photoinhibition resistance i n crop plants.\n LOCATION:Hybrid- in the Faculty Auditorium/ZOOM: https://technion.zoom.us/j /97557530438 END:VEVENT BEGIN:VEVENT UID:1215@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20240403T130000 DTEND;TZID=Asia/Jerusalem:20240403T140000 DTSTAMP:20240331T083602Z URL:https://biology.technion.ac.il/en/seminars/bridge-to-industry-1-beyond -birth-exploring-placental-potential-in-biomedical-innovation/ SUMMARY:PhD Graduate Seminar- Guy Levin [No Categories] DESCRIPTION:Location: Hybrid- in the Faculty Auditorium/ZOOM: https://techn ion.zoom.us/j/2085309787 Guy Levin\n Affiliation: CSO\, Pluri \n Host:Pr ofessor Emeritus Schuster Gadi\, Associate Prof. Yehezkeli Omer\n Bridge t o Industry\nA lecture series fostering collaboration between academia and industry. The Faculty of Biology is proud to present a series of meetings focused on groundbreaking research and innovation in Israel's life science s industry.\n\nJoin us as leading researchers and entrepreneurs discuss ch allenges and solutions\, fostering a dynamic community for:\n\n Enhanced Collaboration between academia and industry\n Building a Thriving Innovat ion Ecosystem with researchers\, entrepreneurs\, and students\n Advancing Applied Knowledge and breakthrough technologies in biotechnology\n\n## Le cture 1: Pluri - Beyond Birth: Exploring Placental Potential in Biomedical Innovation\n\nSpeaker: Dr. Arthur Machlenkin\, CSO of Pluri\n\nAbstract:\ n\nPluri\, an Israeli clinical-stage company\, is pioneering the developme nt of innovative cell products derived from the placenta. This study inves tigates the potential of Placenta eXpanded (PLX) mesenchymal-like stromal cells for regenerative medicine applications. Characterized by their uniqu e secretome\, PLX cells possess distinct immunomodulatory and regenerative capabilities\, making them promising candidates for therapeutic intervent ions. Specifically\, this research delves into the therapeutic potential o f PLX cells in treating acute radiation syndrome (ARS)\, capitalizing on t heir allogeneic nature and support for hematopoietic recovery. Additionall y\, Pluri explores the placenta as a source of non-conventional immune cel ls\, which can be genetically modified to confer specificity against cance r antigens\, thereby enhancing the efficacy of allogeneic immunotherapy of cancer. By concurrently investigating these avenues\, this study aims to unlock the full therapeutic potential of placenta-derived cells\, presenti ng innovative strategies for both regenerative medicine and cancer treatme nt.\n\nDon't miss this opportunity to connect and inspire!\n\n\n\n\n\n\n\n \n\n\n\n\nPlease secure your spot for the lecture via the link: https://di d.li/vEwrl\n\n\n\n\n\n\n\n\n\n\n\n LOCATION:Hybrid- in the Faculty Auditorium/ZOOM: https://technion.zoom.us/j /2085309787 END:VEVENT BEGIN:VEVENT UID:1217@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20240401T130000 DTEND;TZID=Asia/Jerusalem:20240401T140000 DTSTAMP:20240319T071703Z URL:https://biology.technion.ac.il/en/seminars/faculty-seminar-prof-oded-r echavi-molecular-memories/ SUMMARY:Faculty seminar - Prof. Oded Rechavi-Molecular Memories [No Categor ies] DESCRIPTION:Location: Hybrid- in the Faculty Auditorium/ZOOM: https://tech nion.zoom.us/j/91883783153 Prof. Oded Rechavi \n Affiliation: ife Science s\, Tel-Aviv University.\n Host:Prof. Dedi Meiri \n Dear all\,\n\nOur next seminar will be given by Prof. Oded Rechavi from the Department of Neu robiology\, The George S. Wise Faculty of Life Sciences\, Tel-Aviv Univers ity.\n\n \;\n\nPlace and time: Biology auditorium\, Monday 1/4 at 13: 00.\n\n \;\n\nTitle: Molecular Memories\n\n \;\n\nRechavi lab web site: https://www.odedrechavilab.com/\n\nLooking forward to seeing you al l\,\n\nDvir\n\nList of seminars: https://docs.google.com/spreadsheets/d/1 shMP8br8GdMjl6UUTrABd7YhmPLDglDSg2UHYY443o0/edit?usp=sharing\n\nZoom link:  https://technion.zoom.us/j/91883783153\n\nFor inquiries regarding the co urse\, please contact Prof. Dedi Meiri <\;dmeiri@technion.ac.il>\;. LOCATION:Hybrid- in the Faculty Auditorium/ZOOM: https://technion.zoom.us/ j/91883783153 END:VEVENT BEGIN:VEVENT UID:1214@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20240320T130000 DTEND;TZID=Asia/Jerusalem:20240320T140000 DTSTAMP:20240313T095526Z URL:https://biology.technion.ac.il/en/seminars/phd-graduate-seminar-omer-n adel-beja-lab/ SUMMARY:PhD Graduate Seminar- Omer Nadel-Beja Lab [No Categories] DESCRIPTION:Location: Hybrid- in the Faculty Auditorium/ZOOM: https://techn ion.zoom.us/j/91036219148 Omer Nadel\n Affiliation: \n Host:Prof. Oded Beja \n Title: Degradation of photosynthetic antennae by viral auxiliary m etabolic proteins\n\n \;\n\nAbstract: Cyabophage auxiliary metabolic g enes have a direct and substantial effect on oceanic photosynthesis and pr imary productivity Cyanophages often carry auxiliary metabolic genes (AMGs ) acquired from their cyanobacterial hosts\, believed to redirect host cel l metabolism for the phage’s benefit. Building on our previous work\, wh ich suggested that some uncultured marine cyanophages encode active NblA p roteins responsible for phycobilisome (PBS) degradation in cyanobacteria\, we knocked out the nblA gene in a marine cyanophage\, and also constructe d a marine cyanobacterial strain overexpressing the viral nblA gene\, to i nvestigate the role of NblA in viral fitness. Our study revealed that duri ng infection\, cyanophages utilize NblA for targeted PBS degradation. When comparing the infection courses of the wildtype (WT) cyanophage and the n blA deletion mutant in the host cells\, we observed faster propagation in the WT\, suggesting that the nblA gene significantly enhances infection pr ogression. Infections by the WT cyanophage led to more than 50% reduction in cyanobacterial photosynthesis\, compared to those infected by the nblA deletion mutant. Based on metagenomic data\, we conclude that cyanophages carrying such nblA genes are widespread and compose between 35% (in surfac e waters) to 65% (in Deep Chlorophyll Maximum depths) of oceanic T7-like c yanophages. Our data suggest that cyanophage-encoded AMGs such as nblA hav e a direct and substantial effect on oceanic photosynthesis and primary pr oductivity. LOCATION:Hybrid- in the Faculty Auditorium/ZOOM: https://technion.zoom.us/j /91036219148 END:VEVENT BEGIN:VEVENT UID:1209@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20240318T130000 DTEND;TZID=Asia/Jerusalem:20240318T140000 DTSTAMP:20240214T074335Z URL:https://biology.technion.ac.il/en/seminars/faculty-seminar-paper-of-th e-month-winners-graduate-student-lectures/ SUMMARY:Faculty Seminar- "Paper Of The Month" winners- Graduate Students le ctures [No Categories] DESCRIPTION:Location: Biology auditorium Ariel Chazan\,Anwar Bdarneh\,Pel eg Ragonis Bachar\,Bella Ben-Oz\n Affiliation: \n Host:Associate Prof. M eiri David\n The Faculty of Biology will host our Graduate Students who wo n the prize for the outstanding "Paper Of The Month" in recent months at t he Faculty of Biology:\n\n Ariel Chazan- Beja Lab- Ariel won the prestig ious award for the "outstanding paper of the year- for 2023" in the Facult y of Biology for his paper: "Phototrophy by antenna-containing rhodopsin p umps in aquatic environments" Nature.\n Anwar Bdarneh-Glickman Lab- "Alt ered ubiquitin signaling induces Alzheimer’s disease-like hallmarks in a three-dimensional human neural cell culture model"\, Nature Communication s.\n Peleg Ragonis Bachar-Landau Lab: "What can AlphaFold do for antimic robial amyloids?" Proteins.\n Bella Ben-Oz-Ayoub Lab-"A dual role of RBM 42 in modulating splicing and translation of CDKN1A/p21\nduring DNA damage response". Nature Communications.\n LOCATION:Biology auditorium END:VEVENT BEGIN:VEVENT UID:1205@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20240313T130000 DTEND;TZID=Asia/Jerusalem:20240313T140000 DTSTAMP:20240130T094318Z URL:https://biology.technion.ac.il/en/seminars/phd-graduate-seminar-hodaya -baruchi-farber/ SUMMARY:PhD Graduate Seminar- Hodaya Baruchi Farber [No Categories] DESCRIPTION:Location: Hybrid- in the Faculty Auditorium/ZOOM: https://techn ion.zoom.us/j/7465533221 Hodaya Baruchi Farber\n Affiliation: \n Host:Pr of. Shlomi Tomer\n Identifying metabolic alterations and vulnerabilities i n therapy-induced senescent cancer cells\n\nCellular senescence\, cell cyc le arrest due to stress conditions\, is a defense mechanism against accumu lation of mutations and tumorigenesis. Therapy-induced senescence (TIS) is caused by treating cancer cells with sub-cytotoxic doses of chemotherapy. Senescence was thought of as irreversible\, hence\, serving as a valid en d-point for cancer therapy\, inhibiting cancer progression. New evidence r eveals ways for escaping senescence\, resulting in senescent cancer cells which are resistant to classical chemotherapy\, which can in time lead to cancer relapse. Moreover\, the senescence process is accompanied by senesc ence-associated secretory phenotype (SASP)\, involving the secretion of in flammatory cytokines that enhances inflammation in the tumor microenvironm ent and cancer progression. Our research aims to identify cellular metabol ic alterations and vulnerabilities associated with TIS. To address this ch allenge\, we used LC-MS based metabolomics and isotope tracing to characte rize metabolic alterations in cancer cell lines treated with the chemother apeutic drug doxorubicin to induce TIS. Isotope tracing experiments with 1 3C glucose and glutamine revealed decreased pyruvate dehydrogenase (PDH) a ctivity in senescent cells (versus non-proliferating quiescent cells) and an overall decrease in mitochondrial respiration. We further observe an in crease in the relative contribution of glucose versus glutamine-derived TC A cycle anaplerosis via pyruvate carboxylase in TIS. Additionally\, our li pidomics results show major changes in the intracellular concentration of lipids synthesized from recycled FAs. Our results call for further researc h on characterizing metabolic alterations associated with TIS and finding of induced essentiality of metabolic enzymes that could be targeted for th erapeutic purposes. LOCATION:Hybrid- in the Faculty Auditorium/ZOOM: https://technion.zoom.us/j /7465533221 END:VEVENT BEGIN:VEVENT UID:1213@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20240311T130000 DTEND;TZID=Asia/Jerusalem:20240311T140000 DTSTAMP:20240306T074439Z URL:https://biology.technion.ac.il/en/seminars/faculty-seminar-prof-itay-t irosh-glioma-cellular-heterogeneity-in-time-and-space/ SUMMARY:Faculty seminar - Prof. Itay Tirosh-Glioma cellular heterogeneity i n time and space [No Categories] DESCRIPTION:Location: Hybrid- in the Faculty Auditorium/ZOOM: https://techn ion.zoom.us/j/91883783153 Prof. Itay Tirosh\n Affiliation: \n Host:Prof. Dedi Meiri \n Dear all\,\n\n \;\n\nThis week the seminar will be given by Prof. Itay Tirosh from the Department of Molecular Cell Biology a t he Weizmann Institute of Science.\n\n \;\n\nPlace and time: Biology auditorium\, Monday 11/3 at 13:00.\n\n \;\n\nTitle: Glioma cellular h eterogeneity in time and space\n\n \;\n\nTirosh lab website: https:// www.weizmann.ac.il/mcb/tirosh/home\n\nLooking forward to seeing you all\,\ n\nDvir\n\n \;\n\nZoom link: https://technion.zoom.us/j/91883783153\n \nFor inquiries regarding the course\, please contact Prof. Dedi Meiri & lt\;dmeiri@technion.ac.il>\;. LOCATION:Hybrid- in the Faculty Auditorium/ZOOM: https://technion.zoom.us/j /91883783153 END:VEVENT BEGIN:VEVENT UID:1211@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20240306T130000 DTEND;TZID=Asia/Jerusalem:20240306T133000 DTSTAMP:20240222T074750Z URL:https://biology.technion.ac.il/en/seminars/msc-graduate-seminar-mallik -monalisha/ SUMMARY:Msc Graduate Seminar-Monalisha Mallik [No Categories] DESCRIPTION:Location: Hybrid- in the Faculty Auditorium/ZOOM: https://techn ion.zoom.us/j/94790301143 Mallik Monalisha\n Affiliation: \n Host: Prof. Arava Yoav\n Role of Amino-acyl tRNA synthetases in the regulation of tra nslation of mRNAs encoding for enzymes in amino acid biosynthesis pathways \nAmino-acyl tRNA synthetases are enzymes that catalyse the aminoacylation reaction\, where an amino acid is covalently linked to its cognate tRNA. Besides this canonical function of tRNA aminoacylation\, aaRSs have a role in several metabolic and signalling pathways. A role in post-transcriptio nal regulation is known through binding to mRNA. Recent RIP-seq results fr om our lab revealed mRNA repertoire bound by many yeast aaRS. Interestingl y many mRNAs encoding proteins involved in amino acid biosynthesis and rib osome biogenesis were detected. This implies that aaRS might induce regula tion on these biological functions via the mRNA binding. The role of aaRS in amino acid biosynthesis and the mechanism of this regulation is explore d in this project. To achieve this\, we perform amino acid starvation expe riments to study how starvation causes alteration in the expression of the mRNAs and their binding to aaRS. Further\, we study whether this alterati on is due to a translation regulatory impact of the bound aaRS. Most impor tantly\, as the mRNAs bound by aaRS show\nenrichment of tRNA anticodon-lik e structures\, we are also checking the impact of tRNA overexpression on t he binding of mRNAs. This work uncovers new mechanisms of translation cont rol by aaRSs\, and the role of tRNA-like sequences in this process.\n LOCATION:Hybrid- in the Faculty Auditorium/ZOOM: https://technion.zoom.us/j /94790301143 END:VEVENT BEGIN:VEVENT UID:1212@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20240304T130000 DTEND;TZID=Asia/Jerusalem:20240304T140000 DTSTAMP:20240229T072300Z URL:https://biology.technion.ac.il/en/seminars/faculty-seminar-prof-moshe- elkabets/ SUMMARY:Faculty seminar - Prof. Moshe Elkabets [No Categories] DESCRIPTION:Location: Hybrid- in the Faculty Auditorium/ZOOM: https://techn ion.zoom.us/j/91883783153 Prof. Moshe Elkabets\n Affiliation: \n Host:Pro f. Dedi Meiri \n  \;\n\n \;\n\nThis week the seminar will be given by Prof. Moshe Elkabets from the Department of Microbiology\, Immunolo gy\, and Genetics at Ben-Gurion University.\n\n \;\n\nPlace and time:  Biology auditorium\, Monday 4/3 at 13:00.\n\n \;\n\nTitle: Novel th erapeutic and diagnostic tools to fight cancer\n\n \;\n\nElkabets lab website: https://www.elkabetslab.com/\n\nLooking forward to seeing you al l\,\n\nDvir\n\n \;\n\nZoom link: https://technion.zoom.us/j/918837831 53\n\nFor inquiries regarding the course\, please contact Prof. Dedi Meir i <\;dmeiri@technion.ac.il>\;. LOCATION:Hybrid- in the Faculty Auditorium/ZOOM: https://technion.zoom.us/j /91883783153 END:VEVENT BEGIN:VEVENT UID:1204@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20240228T130000 DTEND;TZID=Asia/Jerusalem:20240228T140000 DTSTAMP:20240124T141303Z URL:https://biology.technion.ac.il/en/seminars/phd-graduate-seminar-yael-i osilevskii/ SUMMARY:PhD Graduate Seminar- Yael Iosilevskii [No Categories] DESCRIPTION:Location: hybrid- in the Faculty Auditorium/ZOOM: https://techn ion.zoom.us/j/92242652675 Yael Iosilevskii\n Affiliation: \n Host:Prof. Benjamin Podbilewicz \n The highly arborized PVD neuron has male-specific function and structure in C. elegans\nThe link between sensory neuron mor phology and function remains difficult to ascertain\, particularly in comp lex organisms. The nematode Caenorhabditis elegans provides a simpler mode l to investigate the morphogenesis and function of dendritic arbors. I foc us on the bilateral neuron pair PVD\, which has been extensively studied i n hermaphrodites\, but not in males. My results reveal PVD develops a male -specific dendritic structure into the copulatory organ and plays a new ro le during the complex mating behavior of the male. The morphological sexua l dimorphism seems to stem from a male-specific expression pattern of a se x-shared guidance pathway controlled by the Menorin complex. In particular \, the epidermally expressed SAX-7/L1 Cell Adhesion Molecule (L1CAM) guide s PVD branches into the male copulatory organ during adulthood\, while the behavioral aspect likely involves several sensory circuits and depends on animal age. LOCATION:hybrid- in the Faculty Auditorium/ZOOM: https://technion.zoom.us/j /92242652675 END:VEVENT BEGIN:VEVENT UID:1210@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20240226T130000 DTEND;TZID=Asia/Jerusalem:20240226T140000 DTSTAMP:20240221T141926Z URL:https://biology.technion.ac.il/en/seminars/faculty-seminar-dr-yaara-or en/ SUMMARY:Faculty Seminar - Dr. Yaara Oren [No Categories] DESCRIPTION:Location: Hybrid- in the Faculty Auditorium/ZOOM: https://tec hnion.zoom.us/j/91883783153 Dr. Yaara Oren \n Affiliation: \n Host:Prof. Dedi Meiri \n Dear all\,\n\n \;\n\nThis week the seminar will be given by Dr. Yaara Oren from the School of Medicine at Tel Aviv University.\ n\n \;\n\nPlace and time: Biology auditorium\, Monday 26/2 at 13:00.\ n\n \;\n\nTitle: The day after the drug: Investigating drug-induced  cellular memory\n\n \;\n\nOren lab website: https://www.yaaraoren.s ites.tau.ac.il/\n\n \;\n\nZoom link: https://technion.zoom.us/j/91883 783153\n\nFor inquiries regarding the course\, please contact Prof. Dedi Meiri <\;dmeiri@technion.ac.il>\;. LOCATION:Hybrid- in the Faculty Auditorium/ZOOM: https://technion.zoom.us /j/91883783153 END:VEVENT BEGIN:VEVENT UID:1207@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20240214T133000 DTEND;TZID=Asia/Jerusalem:20240214T140000 DTSTAMP:20240130T111758Z URL:https://biology.technion.ac.il/en/seminars/msc-graduate-seminar-maram- halabi/ SUMMARY:Msc Graduate Seminar- Maram Halabi [No Categories] DESCRIPTION:Location: Hybrid- in the Faculty Auditorium/ZOOM: https://techn ion.zoom.us/j/94568387345 Maram Halabi\n Affiliation: \n Host: Prof. Arav a Yoav\n Impact of pseudouridylation on mitochondrial tRNA recognition by cognate synthetase\n\n\n\nMitochondrial tRNAs (mt-tRNAs) undergo an extens ive post-transcriptional modification. One such common modification is pse udouridylation\, the conversion of uridine to a 5’-ribosyl isomer of uri dine. Although it is the most abundant modified nucleoside to be known in RNA\, in most cases the contribution of this modification to the translati on process is not clear. Previous research conducted\, by Levi O and Arava YS\, in our lab has shown that pseudouridine in cytosolic tRNA affects th e regulation of translation. Specifically\, the deletion of Pus6 resulted in a reduction of MetRS binding to tRNAMet. Yet no studies have been condu cted to test this on mt-tRNAs. Here we analyzed this impact by removal of specific pseudouridine enzymes that worked on several mt-tRNAs (tRNAArg\, tRNALys\, tRNASer). We generated yeast strains deleted of these enzymes: P us2\, Pus4\, Pus6\, or Pus9. We tested the in vivo impact on the binding o f each tRNA to its cognate aminoacyl tRNA synthetase (aaRS). Our results s how that Pus4 plays a role in the SerRS binding tRNASer and tRNALys\, Pus6 deletion impacts the LysRS binding to tRNASer\, and Pus4 deletion impacts the binding of ArgRS to non-cognate tRNAs. This study presents the first in vivo characterization of pseudouridylation impact on mt-tRNA binding to cognate mt-aaRS\, shedding new light on the role of this modification in mitochondrial translation regulation. LOCATION:Hybrid- in the Faculty Auditorium/ZOOM: https://technion.zoom.us/j /94568387345 END:VEVENT BEGIN:VEVENT UID:1206@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20240214T130000 DTEND;TZID=Asia/Jerusalem:20240214T133000 DTSTAMP:20240130T111511Z URL:https://biology.technion.ac.il/en/seminars/msc-graduate-seminar-inna-p igalchucke/ SUMMARY:Msc Graduate Seminar- Inna Pigalchucke [No Categories] DESCRIPTION:Location: Hybrid- in the Faculty Auditorium/ZOOM: https://techn ion.zoom.us/j/94568387345 Inna Pigalchuck\n Affiliation: \n Host:Prof. N abieh Ayoub\n  \;\nCharacterizing a role of RBM15B in  DNA Repair\n&n bsp\;\n\nDNA double-strand breaks (DSBs) are considered among the most cyt otoxic DNA lesions. Cells utilize various DSB repair pathways\, including homologous recombination (HR)\, which is executed at S/G2 phases of the ce ll cycle. Interestingly\, RNA modifications and RNA-binding proteins have essential roles in HR repair. The RNA-Binding Motif 15B (RBM15B) protein i s implicated in m6A positioning on RNA\, but its role in DNA damage remain s elusive. Here\, we show that RBM15B is rapidly recruited to DSB sites. M oreover\, we show that RBM15B negatively regulates R-loop and global N6-me thyladenosine (m6A) levels on RNA\, consequently promoting HR repair of DS Bs. Accordingly\, RBM15B-deficient cells show an increase in the levels of the replication stress markers pCHK1(S345) and pRPA32(S33)\, and are hype rsensitive to various genotoxic agents. Collectively\, our data establish RBM15B as a novel regulator of HR repair of DSBs\, presumably by regulatin g the cellular levels of m6A and R-loops LOCATION:Hybrid- in the Faculty Auditorium/ZOOM: https://technion.zoom.us/j /94568387345 END:VEVENT BEGIN:VEVENT UID:1202@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20240110T133000 DTEND;TZID=Asia/Jerusalem:20240110T140000 DTSTAMP:20240102T072302Z URL:https://biology.technion.ac.il/en/seminars/msc-graduate-seminar-esti-c armel/ SUMMARY:Msc Graduate Seminar- Esti Carmel [No Categories] DESCRIPTION:Location: Hybrid- in the Faculty Auditorium/ZOOM: https://tech nion.zoom.us/j/94192535896 Esti Carmel\n Affiliation: \n Host:Dr. Sharon Nadav \n Characterization of a Novel Macrophage Population with a Protecti ve Potential Against Immune Attack in T1D\n\nType 1 Diabetes (T1D) is an a utoimmune disease that is characterized by insulin deficiency caused by sp ecific destruction of pancreatic β­-cells. The defects in the immune sys tem that initiate the attack upon β­-cells are unknown\, and scarcity of human samples hampers analysis of the pre-diabetic pancreas. The Non-Obes e Diabetic (NOD) mouse develops spontaneous autoimmune diabetes with genet ic and environmental features similar to the human disease\, and is theref ore a powerful tool to study the origins of T1D. An intriguing feature of the immune attack in both mouse and humans may hold the potential to revea l the origins of T1D: The attack is asynchronous\, so that infiltrated Isl ets and intact islets are often seen in close proximity.\nIn order to char acterize the cellular composition of each configuration\, we performed sin gle-cell RNA sequencing of attacked and non-attacked islets from NOD mice\ , and characterized the cell population in each. While attacked islets har bor a plethora of immune cells\, we identified a distinct population of ma crophages with anti-inflammatory properties in the non-attacked islets. Th rough combined RNA-FISH and immunofluorescence\, we found that these cells are present in the beginning of the immune attack\, disappear when the im mune attack is at its’ peak and reappear at the end of it. In addition\, we have also identified a similar population in the human pancreas with d ifferent expression patterns between healthy\, T1D and T2D patients. These observations suggest that these macrophages are a dynamic population of c ells that are influenced by the current status of the immune attack and ch ange accordingly.\nExploring the dynamics and properties of this interesti ng population could aid in gaining a better understanding of the complex “battlefield” of T1D. LOCATION:Hybrid- in the Faculty Auditorium/ZOOM: https://technion.zoom.us/ j/94192535896 END:VEVENT BEGIN:VEVENT UID:1203@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20240110T133000 DTEND;TZID=Asia/Jerusalem:20240110T140000 DTSTAMP:20240102T072528Z URL:https://biology.technion.ac.il/en/seminars/msc-graduate-seminar-heba-o mbashe/ SUMMARY:Msc Graduate Seminar- Heba Ombashe [No Categories] DESCRIPTION:Location: Hybrid- in the Faculty Auditorium/ZOOM: https://tech nion.zoom.us/j/94192535896 Heba Ombashe\n Affiliation: \n Host:Dr. Noga Ron-Harel \n Heme: A Novel Driver of Immune Aging\n\nAge-related morbidity \, including the increased rate of infectious diseases\, cancer\, and auto immune disorders\, is driven by the decline in immune potency. The aged im mune system is characterized by systemic inflammation and compromised adap tive immunity. T lymphocytes\, the cellular arm of the adaptive immune res ponse\, are one of the most negatively affected populations. Recently\, we made a surprising observation that the functionality of aged T cells depe nds on the organ they reside in\; T cells purified from an aged spleen fai l to proliferate\, whereas T cells isolated from the lymph nodes of the sa me donor respond like young cells. Whole-cell proteomics identified heme a s a potential driver of this phenotype\, as we quantified a significant up regulation of enzymes involved in heme catabolism only in T cells derived from the aged spleen. Why are T cells exposed to heme in the aged spleen? We found age-driven changes in spleen morphology\, leading to loss of boun daries between the lymphocyte compartment (white pulp) and the site of red blood cell recycling (red pulp). Strikingly\, exposing young T cells to h eme ex vivo or to the aged spleen microenvironment in vivo was sufficient to drive multiple\, aging-like phenotypes. Previous studies have shown tha t introducing aged/dysfunctional T cells into a young host promotes aging- like phenotypes in multiple organs. Our studies highlight the intricate re lationship between lymphocytes and their immediate microenvironment\, emph asizing how age-driven changes in tissue function impact T cell immunity a nd identify heme as a novel driver of immune dysfunction with aging. LOCATION:Hybrid- in the Faculty Auditorium/ZOOM: https://technion.zoom.us/ j/94192535896 END:VEVENT BEGIN:VEVENT UID:1201@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20231227T130000 DTEND;TZID=Asia/Jerusalem:20231227T133000 DTSTAMP:20231221T082737Z URL:https://biology.technion.ac.il/en/seminars/msc-graduate-seminar-galia- polyak/ SUMMARY:Msc Graduate Seminar- Galia Polyak [No Categories] DESCRIPTION:Location: Hybrid- in the Faculty Auditorium/ZOOM: https://techn ion.zoom.us/j/9909936173?omn=94601376175 Galia Polyak\n Affiliation: \n Host:Prof. Yael Mandel-Gutfreund \n Combining RNA- and protein-centric ap proaches to discover new functions of non-coding RNAs during stem cell dif ferentiation\nNon-coding RNAs are at the interplay between transcription a nd post transcription regulation. Long non-coding RNAs\, in particular\, o ften exert their function by interacting with proteins. In this study\, we applied high throughput methodologies combining RNA-centric and protein-c entric approaches to identify RNA-protein interactions involved in transcr iption regulation in pluripotency.\nWe started by revealing the protein-bo und transcriptome of hESCs\, embryoid bodies\, and each germ layer. We ide ntified the lncRNAs that changed their binding without correlating changes in expression\, as well as those unique to pluripotency\, differentiated cells\, or each germ layer specifically.\nWe chose the epigenetic factor D NMT3b to further study protein-RNA interactions in hESCs. We found it inte racts with the RNAs of 283 genes related to development and transcription\ , and enriched in CpG islands. DNMT3b’s RNA targets were simultaneously significantly more methylated at the DNA level than other expressed genes\ , and more expressed. We also found that DNMT3b binds the same motifs at t he RNA and DNA level. These DNMT3b/RNA interactions could modulate DNMT3b ’s DNA binding and methylation to regulate the expression of key genes i n development.\n LOCATION:Hybrid- in the Faculty Auditorium/ZOOM: https://technion.zoom.us/j /9909936173?omn=94601376175 END:VEVENT BEGIN:VEVENT UID:1200@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20231213T130000 DTEND;TZID=Asia/Jerusalem:20231213T140000 DTSTAMP:20231206T092901Z URL:https://biology.technion.ac.il/en/seminars/phd-graduate-seminar-shir-y aish/ SUMMARY:PhD Graduate Seminar-shir yaish [No Categories] DESCRIPTION:Location: : hybrid- in the Faculty Auditorium/ZOOM: https://tec hnion.zoom.us/j/99469132988 shir yaish\n Affiliation: \n Host: Prof. Beja Oded\n  \;\n\nHeliorhodopsins function in Gram-positive bacteria\n\nR hodopsins are light sensing proteins that span across all kingdoms of life . They absorb light using retinal. As a response to light\, rhodopsins can function as ion pumps\, channels\, enzymes\, and photo sensory receptors. Heliorhodopsins (HeRs) are a new rhodopsin family discovered in our lab. HeRs are present in all domains of life\, they react to light\, yet their end function is currently unknown. Recently\, a HeR gene was discovered in a strain of Lactococcus lactis and in Alkalibacterium pelagium\, another culturable bacterium related to L. lactis. Interestingly\, acquisition of HeR genes happened several times within the order Lactobacillales\, such that the heliorhodopsins from A. pelagium and L. lactis appear to have i ndependent origins. We confirmed that the Lactococcus HeR (LlHeR) is trans cribed in this L. lactis\, and then over-expressed LlHeR and ApHeR in Esc herichia coli. Next\, mutant strains of L. lactis were used to perform RNA Seq analysis in an attempt to shed light on LlHeR role in L. lactis.\n\n&n bsp\; LOCATION:: hybrid- in the Faculty Auditorium/ZOOM: https://technion.zoom.us /j/99469132988 END:VEVENT BEGIN:VEVENT UID:1199@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20231122T130000 DTEND;TZID=Asia/Jerusalem:20231122T140000 DTSTAMP:20231120T101413Z URL:https://biology.technion.ac.il/en/seminars/phd-graduate-seminar-anwar- bdarneh/ SUMMARY:PhD Graduate Seminar- Anwar Bdarneh [No Categories] DESCRIPTION:Location: : hybrid- in the Faculty Auditorium/ZOOM: https://tec hnion.zoom.us/j/94240537873 Anwar Bdarneh\n Affiliation: \n Host:Prof. M ichael Glickman \n Elucidating the mysterious ubiquitin ligase mechanism o f Ubiquitin C-terminal Hydrolase-L1 (UCH-L1)\n\nUbiquitination is a post-t ranslational modification that has emerged as a key regulator of most cell ular processes\, ranging from subcellular localization to protein function \, cell signaling\, and protein degradation by the proteasome or the lysos ome.\nLike other PTMs\, ubiquitination is reversible due to the activity o f specific protases called deubiquitinating enzymes (DUBs). A unique DUB i s ubiquitin C-terminal hydrolase L1 (UCH-L1)\, which is restricted to the cleavage of small adducts from the C-terminus of ubiquitin.\nUCH-L1 is abu ndantly expressed in neurons\, yet its biological function in neuronal cel ls remains a mystery. Different studies have shown that UCH-L1 plays a rol e in neurodegeneration. Moreover\, we showed that UCH-L1 over-expression d elays the accumulation of Alzheimer's hallmarks\, which suggests that UCH- L1 plays a unique role in prolonging neuronal health.\nIn addition to its extensively studied hydrolase activity as a DUB\, we characterize an addit ional enzymatic activity\, in which UCH-L1 acts as a ligase. We succeeded in identifying\, for the first time\, a new active site that is responsibl e for this distinct activity. Furthermore\, we demonstrated that the two a ctive sites work independently of each other. Additionally\, we provide an initial characterization of the enzymatic cascade in which it participate s.\nWe are currently delineating which of the two distinct enzymatic activ ities is essential for UCH-L1's role in suppressing Alzheimer's hallmarks. The investigation into the biochemical mechanisms underlying UCH-L1's dua l enzymatic activities aims to unravel the mystery of its unique function in neurons.\n LOCATION:: hybrid- in the Faculty Auditorium/ZOOM: https://technion.zoom.us /j/94240537873 END:VEVENT BEGIN:VEVENT UID:1193@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20230919T130000 DTEND;TZID=Asia/Jerusalem:20230919T133000 DTSTAMP:20230906T070407Z URL:https://biology.technion.ac.il/en/seminars/msc-graduate-seminar-loai-n aom/ SUMMARY:Msc Graduate Seminar-Loai Naom [No Categories] DESCRIPTION:Location: Hybrid- in the Faculty Auditorium/ZOOM: https://techn ion.zoom.us/j/91259160283?pwd=OTg2eFExanJRSDNwNEMyd0w4UER5QT09 security co de for zoom: 035378 \n Affiliation: \n Host:Dr. Dvir Aran\n Prediction o f Response to Immune Checkpoint Blockade Treatments Using Tumour Microenvi ronment Cellular Landscape\n\n\n\nImmune checkpoint blockade (ICB) treatme nts hold great promise in the realm of cancer therapy. However\, they are not flawless\, and it remains crucial to pinpoint the characteristics that impact the effectiveness of these treatments. In this study\, we theorize that the primary factor determining response is the cellular composition in the tumour microenvironment.\nTo that end\, we utilize cellular compres sion as a prediction for ICB treatment outcomes.\nThe seminar will be give n: Hybrid- in the Faculty Auditorium/ZOOM:\nhttps://technion.zoom.us/j/912 59160283?pwd=OTg2eFExanJRSDNwNEMyd0w4UER5QT09 security code for zoom: 0353 78 LOCATION:Hybrid- in the Faculty Auditorium/ZOOM: https://technion.zoom.us/j /91259160283?pwd=OTg2eFExanJRSDNwNEMyd0w4UER5QT09 security code for zoom: 035378 END:VEVENT BEGIN:VEVENT UID:1195@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20230912T133000 DTEND;TZID=Asia/Jerusalem:20230912T140000 DTSTAMP:20230824T070730Z URL:https://biology.technion.ac.il/en/seminars/msc-graduate-seminar-caroli na-khoury/ SUMMARY:Msc Graduate Seminar- Carolina Khoury [No Categories] DESCRIPTION:Location: hybrid- in the Faculty Auditorium/ZOOM: https://techn ion.zoom.us/j/92857653725 Carolina Khoury\n Affiliation: \n Host:Dr. Bes ter Assaf\n Identification and Characterization of Functional LncRNA  Reg ulation of Mitochondrial Respiration\n\nCarolina Khoury\, Dr. Assaf C. Bes ter \n\nThe central dogma of molecular biology traditionally emphasizes RN A's role as a messenger\, bridging ‎the information repository in DNA wi th protein synthesis at the ribosome. However\, the human ‎genome encode s a vast array of non-protein-coding RNA (ncRNA) molecules with diverse fu nctions. ‎In fact\, in many species\, protein-coding genes comprise only a small fraction of the total genome.‎\n\nAmong ncRNAs\, long non-codin g RNAs (lncRNAs)--transcripts longer than 200 nucleotides that are not tra nslated into proteins--represent the largest and most heterogeneous group of RNA in the human genome Recent research has begun to uncover lncRNAs' d iverse roles\, linking them to various biological processes and diseases\, including apoptosis\, metastasis\, proliferation\, and metabolism.\n\nMet abolic rewiring is pivotal in cancer\, emphasizing the need to identify ge nes that regulate both normal and malignant metabolism. While protein-codi ng genes' functions are well-studied\, the complex interactions between ln cRNAs and cellular metabolism remain largely uncharted .\n\nThis study emp loyed screening techniques to identify lncRNAs influencing mitochondrial r espiration in leukemia cells\, pinpointing four lncRNAs that significantly affect energy metabolism and cellular fitness. Through cell-based assays and molecular characterization\, a regulatory network impacting mitochondr ial function was revealed. Notably\, the research highlights the lncRNA kn own as the negative regulator of P-body association (NBDY) in controlling multiple metabolic genes.\n\nFurther investigation of NBDY's mechanisms an d potential therapeutic applications will enrich our understanding of meta bolic regulation. The findings not only contribute to our understanding of RNA biology but also may open new avenues for therapeutic interventions in metabolic diseases.\n\n \; LOCATION:hybrid- in the Faculty Auditorium/ZOOM: https://technion.zoom.us/j /92857653725 END:VEVENT BEGIN:VEVENT UID:1194@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20230912T130000 DTEND;TZID=Asia/Jerusalem:20230912T133000 DTSTAMP:20230823T121754Z URL:https://biology.technion.ac.il/en/seminars/msc-graduate-seminar-hadas- gruber/ SUMMARY:Msc Graduate Seminar- Hadas Gruber [No Categories] DESCRIPTION:Location: Faculty Of Biology Auditorium/ZOOM:https://technion.z oom.us/j/92857653725 Hadas Gruber\n Affiliation: \n Host: Prof. Melamed Philippa\n  \n\nFoxl2 and Nr5a1 regulation in gonadotrope cells of the a nterior pituitary\n\n \;\n\nThe mammalian reproductive system is regul ated by gonadotrope cells in the anterior pituitary gland. These cells pro duce and secrete the gonadotropin hormones\, luteinizing hormone (LH) and follicle stimulating hormone (FSH)\, responsible for germ cell maturation. Gonadotrope differentiation in the developing pituitary is driven by seve ral transcription factors (TFs)\, among them FOXL2 and SF-1 (encoded by FO XL2 and NR5A1\, respectively). FOXL2 and SF-1 also support mature gonadotr ope function\, notably expression of FSHB which encodes the FSH β-subunit . Despite their essential role in gonadotropes\, little is known about how these factors are regulated in the pituitary. In this research\, we aimed to find what regulates FOXL2 and NR5A1 in both differentiating and mature gonadotrope cells. We hypothesized that expression of both genes is activ ated by pituitary-specific factors and regulatory elements. We discovered\ , surprisingly\, that activin A and GnRH\, which both stimulate Fshb expre ssion\, repress Foxl2 and Nr5a1 expression in murine gonadotrope cells. Bo th Foxl2 and Nr5a1 have adjacent sequences transcribed to divergent long n on-coding RNAs (lncRNAs)\, Foxl2os and Nr5a1os\, that are co-expressed in a tissue-specific manner and respond to the same stimulus as the protein c oding genes. Of these lncRNAs\, Foxl2os shows potential as a Foxl2 regulat or\, possibly through the formation of G-quadruplexes and iMotifs that we detected and appear to impact Foxl2os levels. Additionaly\, using publishe d ATAC-seq data\, we have identified a putative gonadotrope specific super -enhancer upstream of the Foxl2 promoter. Targeting dCas9-KRAB to this reg ion reduced Foxl2 mRNA levels\, indicating a functional role. This functio n is supported by the presence of annotated ChIP-seq binding of TFs that a re expressed in differentiating pre-gonadotropes prior to Foxl2. These res ults offer novel candidates for the regulation of two genes crucial for hu man fertility.\n\n \;\n\nThe seminar will be given in English.\n\n  LOCATION:Faculty Of Biology Auditorium/ZOOM:https://technion.zoom.us/j/9285 7653725 END:VEVENT BEGIN:VEVENT UID:1198@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20230905T133000 DTEND;TZID=Asia/Jerusalem:20230905T140000 DTSTAMP:20230903T094317Z URL:https://biology.technion.ac.il/en/seminars/msc-graduate-seminar-miryam -steinberg/ SUMMARY:Msc Graduate Seminar-Miryam Steinberg [No Categories] DESCRIPTION:Location: Hybrid- in the Faculty Auditorium/ZOOM: https://tech nion.zoom.us/j/97039787933 Miryam Steinberg\n Affiliation: \n Host:Associ ate Prof. David Meiri\n CBDV modulates myeloid suppressor cells in the tum or microenvironment\n \;\n\nDuring solid tumor progression\, the tumor microenvironment (TME) evolves into a highly immunosuppressive milieu. Ke y players in the immunosuppressive environment are regulatory myeloid cell s\, including myeloid-derived suppressor cells (MDSCs) and tumor-associate d macrophages (TAMs). Therefore\, the modulation of immunosuppressive cell s in the TME to create a more active environment is a compelling strategy for preventing tumor progression. Here\, we found that Cannabidivarin (CBD V)\, a minor cannabinoid\, directly reduces the immunosuppressive properti es of MDSCs and shifted their differentiation from TAMs to M1-like macroph ages. Treating myeloid suppressor cells with CBDV led to restored CD8+ T-c ell activation and proliferation in a co-culture model. Tumor-bearing mice treated with CBDV presented reduced tumor progression\, and myeloid suppr essor cells in the TME showed a reduction in immunosuppressive markers\, i n line with enhancing CD8+ T-cell activity. CBDV was also effective in hum an cells\, reducing immunosuppressive markers by human myeloid suppressor cells. Altogether\, our findings indicate CBDV holds the potential to repr ogram immune system cells within the TME to strengthen the immune response against cancer.\n\n \; LOCATION: Hybrid- in the Faculty Auditorium/ZOOM: https://technion.zoom.us/ j/97039787933 END:VEVENT BEGIN:VEVENT UID:1191@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20230905T130000 DTEND;TZID=Asia/Jerusalem:20230905T133000 DTSTAMP:20230903T085708Z URL:https://biology.technion.ac.il/en/seminars/msc-graduate-seminar-roy-gu rwicz/ SUMMARY:Msc Graduate Seminar-Roy Gurwicz [No Categories] DESCRIPTION:Location: Faculty Of Biology Auditorium/ZOOM: https://technion. zoom.us/j/97039787933 Roy Gurwicz\n Affiliation: \n Host:Dr. Sharon Nadav \n Identification of molecules which control in-vitro progenitor to endocr ine cell differentiation of hESCs-derived pancreatic cells\n\n\nType 1 dia betes is a chronic disease\, caused by the loss of insulin-producing β-ce lls which reside in the pancreatic islets of Langerhans. In-vitro differen tiation of human embryonic stem cells into β-cells could serve as a trans plantation source\, but the high cost and low yield of current protocols m ake this promising therapy unaffordable for most patients. Although endocr ine cells rarely divide\, in-vitro differentiation includes an intermediat e progenitor cell-state which\, if maintained\, could serve to expand the differentiating-cells' number\, and reduce costs.\nTo identify factors whi ch control the progenitor-endocrine balance\, we performed a high throughp ut screen using RNA-sequencing Of Selected Amplicons (ROSA-HTS) which allo ws targeted sequencing of hundreds of genes from thousands of samples. Of 1280 molecules\, we performed full RNA-sequencing on 89 “hits”\, and d iscovered novel effector molecules that shift progenitor-to-endocrine bala nce. Among these\, we discovered acetylcholine-receptor effectors (Nicotin ic agonist and Muscarinic antagonist) which induced progenitor gene-expres sion\, whereas PI3K\, AKT or mTOR inhibition induced an early endocrine st ate. In addition\, we discovered novel molecular pathways which were not d irectly targeted by the screen\, but whose mediated regulation uncovers a potential influence on pancreatic differentiation. For instance\, Interfer on-I inhibition seems to induce endocrine state\, whereas Interleukins 2 a nd 18 activation seems to induce progenitor state.\nAchieving the optimal combination of molecules which effect the progenitor-to endocrine balance is expected to have a synergic effect\, and thus increase yield of existin g protocols for β-cell differentiation.\n\n\n\n LOCATION:Faculty Of Biology Auditorium/ZOOM: https://technion.zoom.us/j/970 39787933 END:VEVENT BEGIN:VEVENT UID:1196@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20230904T133000 DTEND;TZID=Asia/Jerusalem:20230904T140000 DTSTAMP:20230829T084207Z URL:https://biology.technion.ac.il/en/seminars/msc-graduate-seminar-stav-s hotan/ SUMMARY:Msc Graduate Seminar- Stav Shotan [No Categories] DESCRIPTION:Location: Faculty Of Biology Auditorium/ZOOM: https://technion. zoom.us/j/99587628620 Stav Shotan\n Affiliation: \n Host:Associate Prof. David Meiri \n A novel cannabinoid reduces uterine hyperplasia caused b y tamoxifen in mice\nUterine hyperplasia is characterized by overgrowth of cells in the lining of the uterus\, causing it to become thicker than usu al. Uterine hyperplasia can lead to irregular or heavy menstrual bleeding\ , and in more severe cases\, it can increase the risk of developing endome trial cancer. The hormone estrogen plays a central role in endometrial pro liferation\, by binding to the estrogen receptor (ER) in the epithelial en dometrium. Many ER-positive breast cancer patients develop uterine hyperpl asia\, and it was found that some Selective Estrogen Receptor Modulators ( SERMs) such as tamoxifen act as antagonists in the breast and as agonists in the uterus. In the breast\, tamoxifen blocks estrogen from binding the ER and hinders cell proliferation\, while in the uterus tamoxifen binds th e ER and coactivators complex and induces cell proliferation. In the Meiri ’s lab we have found a novel cannabinoid that reduces the expression of the ER through the Hippo signaling pathway\, and enhances the effect of ta moxifen on breast cancer. Therefore\, we hypothesized this cannabinoid may reduce ER expression in the endometrium\, and thus attenuate tamoxifen-in duced uterine hyperplasia. We utilized a new model to study tamoxifen-indu ced hyperplasia\, and found the cannabinoid treatment decreased uterine ma ss\, luminal thickness and proliferation of epithelial cells\, resulting a lso in less tissue dysmorphology. To conclude\, this novel cannabinoid can relieve uterine hyperplasia manifestations\, and could be combined with t amoxifen for ER-positive breast cancer patients. By treating endometrial h yperplasia patients may avoid surgery and preserve fertility\, have increa sed long-term health and quality of life and adhere to SERMs treatment. LOCATION:Faculty Of Biology Auditorium/ZOOM: https://technion.zoom.us/j/995 87628620 END:VEVENT BEGIN:VEVENT UID:1197@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20230904T130000 DTEND;TZID=Asia/Jerusalem:20230904T133000 DTSTAMP:20230829T084133Z URL:https://biology.technion.ac.il/en/seminars/msc-graduate-seminar-galit- cohen/ SUMMARY:Msc Graduate Seminar- Galit Cohen [No Categories] DESCRIPTION:Location: Faculty Of Biology Auditorium/ZOOM:https://technion.z oom.us/j/99587628620 Galit Cohen\n Affiliation: \n Host:Associate Prof. Shenhav Cohen \n Developing a nutrient-based formulation to attenuate muscle wasting\nMuscle atrophy causes weakness and disability in aging\, i nactivity\, and in many diseases. This loss of muscle mass and strength is primarily due to the accelerated degradation of muscle proteins by the ub iquitin-proteasome system (UPS). The ubiquitin ligases\, F-Box (MAFbx/Atro gin-1) and Muscle RING-Finger 1 (MuRF-1)\, are induced in most types of at rophy and currently represent the best markers for atrophy. Their expressi on increases also by the Transforming Growth Factor-β (TGF-β) family mem ber\, myostatin\, which functions as a negative regulator of skeletal musc le mass. Myostatin is produced by muscle\, and is excessively active in sy stemic catabolic conditions (including cancer cachexia and aging)\, causin g a severe muscle atrophy. Its inhibition is currently considered as the b est therapeutic approach to prevent or retard atrophy. Here we focus on th e development of a nutrient-based formulation that specifically targets my ostatin signaling for the treatment of muscle wasting in humans. LOCATION:Faculty Of Biology Auditorium/ZOOM:https://technion.zoom.us/j/9958 7628620 END:VEVENT BEGIN:VEVENT UID:1192@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20230829T133000 DTEND;TZID=Asia/Jerusalem:20230829T140000 DTSTAMP:20230822T093245Z URL:https://biology.technion.ac.il/en/seminars/msc-graduate-seminar-dolev- elisha/ SUMMARY:Msc Graduate Seminar- Dolev Elisha [No Categories] DESCRIPTION:Location: Dolev Elisha\n Affiliation: \n Host:Associate Prof . Henn Arnon \n Title:\n\nRole of Myo19\, an actin-based mitochondria moto r\, during collective cell migration.\n\n \n\nAbstract:\n\nCellular migra tion is essential for embryonic development\, wound healing\, immune defen se\, and angiogenesis\, but it also is an enhancer of cancer metastasis an d inflammation. Cell migration is described as cycles of continuous actin branching at the cell leading edge\, focal adhesion (FA) sites assembly\, and disassembly and contraction of the cell trailing end. These highly ene rgy-consuming processes require positioning the mitochondria at FA sites a nd the leading edge of cells to supply ATP. In eukaryotes\, mitochondria a re solely associated with actin and microtubule filaments. The actin-based transport of mitochondria is mainly by the molecular motor Myo19\, which has been shown to transport mitochondria to actin protrusions at the cell ’s leading edge during cellular stress. We hypothesize that Myo19 plays an essential role in the motility and positioning of mitochondria in the c ell’s leading edge during migration. My goal is to determine the contrib ution of Myo19 during cellular migration. I will generate stable cell line s of inducible KD of Myo19 and perform collective in vitro cell migration by automated high throughput scratch assay ('wound healing') on stable Myo 19 KD cells. To this end\, the results display a significant reduction in cell migration rates in several cell lines. This suggests that Myo19 plays a role in coupling mitochondria positioning and mobility during cellular migration. Further research on the regulation of Myo19 might provide a new approach to metastatic cancer therapy.\n\n \;\n\n \; END:VEVENT BEGIN:VEVENT UID:1188@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20230828T130000 DTEND;TZID=Asia/Jerusalem:20230828T140000 DTSTAMP:20230814T095029Z URL:https://biology.technion.ac.il/en/seminars/phd-graduate-seminar-miriam -fokra/ SUMMARY:PhD Graduate Seminar- Miriam Fokra [No Categories] DESCRIPTION:Location: hybrid- in the Faculty Auditorium/ZOOM: https://techn ion.zoom.us/j/9391176471 \n Affiliation: \n Host:Prof. Shlomi Tomer\n &nb sp\;\n\nGlycine decarboxylase maintains mitochondrial protein lipoylation to support tumor growth\n\nThe folic acid cycle mediates the transfer of o ne-carbon (1C) units to support nucleotide biosynthesis. While the importa nce of serine as a mitochondrial and cytosolic donor of folate-mediated 1C units in cancer cells has been thoroughly investigated\, a potential role of glycine oxidation remains unclear. We developed an approach for quanti fying mitochondrial glycine cleavage system (GCS) flux by combining stable and radioactive isotope tracing with computational flux decomposition. We find high GCS flux in hepatocellular carcinoma (HCC)\, supporting nucleot ide biosynthesis. Surprisingly\, other than supplying 1C units\, we found that proper function of GCS is important for maintaining protein lipoylati on and mitochondrial activity. Genetic silencing of glycine decarboxylase (GLDC) inhibits the lipoylation and activity of pyruvate dehydrogenase (PD H) and impairs tumor growth\, suggesting a novel drug target for HCC.\n\n& nbsp\; LOCATION:hybrid- in the Faculty Auditorium/ZOOM: https://technion.zoom.us/j /9391176471 END:VEVENT BEGIN:VEVENT UID:1190@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20230816T130000 DTEND;TZID=Asia/Jerusalem:20230816T133000 DTSTAMP:20230813T085515Z URL:https://biology.technion.ac.il/en/seminars/msc-graduate-seminar-alina- trestin/ SUMMARY:Msc Graduate Seminar- Alina Trestin [No Categories] DESCRIPTION:Location: hybrid- in the Faculty Auditorium/ TEAMS \n Affiliat ion: \n Host:Associate Prof. Henn Arnon\n MyoIC's effect on nucleolar stru cture and organization\nMyosins are predominantly recognized for their rol e in muscle contraction and cellular cargo transport. Interestingly\, one member of class IC myosin\, MyolC16 (Nuclear Myosin I\, NMI)\, exhibits lo calization within the nucleus and the nucleolus in addition to its cytopla smic localization and functions. Our lab and others demonstrated that NMI and actin are important for rRNA transcription by RNAPI in the nucleolus. In addition\, it was recently found to function in repairing heterochromat ic DNA damage in mammalians. In parallel unrelated studies\, it was shown how the integrity of DNA\, RNAPI transcription\, and rRNA aberrant transcr iption are highly correlated to cancer\, extensive cell proliferation\, an d neurodegenerative diseases like Alzheimer's and Parkinson's diseases. We hypothesize that NMI utilizes its contractile activity to provide the nuc leolus with its structure\, function\, and physiology. In my thesis\, I ai m to understand the molecular mechanism of NMI contractile activity in the dynamic nature of the nucleolus assembly essential for RNAPI transcriptio n. Thus\, my research aims to investigate the behavior and dynamics of the nucleolus at the molecular level. Using a genetic approach of Myo1C KD an d Super Resolution Microscopy\, I show that the presence of MyoIC necessit ates the formation of nucleolar substructures. This and more provide a new frontier targeting Myo1C's contribution to the pathophysiological manifes tations of the unhealthy nucleolus as the initiator and propagator of neur odegenerative diseases.\n\n \;\n\nlink for TEAMS\n\nhttps://teams.micr osoft.com/l/meetup-join/19%3ameeting_ODM1OWRjMDQtMDdmOC00NTIzLTk2ZTAtOTFiM jkxMGY5MDU4%40thread.v2/0?context=%7b%22Tid%22%3a%22f1502c4c-ee2e-411c-971 5-c855f6753b84%22%2c%22Oid%22%3a%2279fcd2a9-a77d-47c3-93f8-b11b4d98dce3%22 %7d\n\nMeeting ID: 356 067 562 467\n\nPasscode: nf6rcu LOCATION:hybrid- in the Faculty Auditorium/ TEAMS END:VEVENT BEGIN:VEVENT UID:1189@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20230808T130000 DTEND;TZID=Asia/Jerusalem:20230808T140000 DTSTAMP:20230717T091311Z URL:https://biology.technion.ac.il/en/seminars/phd-graduate-seminar-bar-co hen/ SUMMARY:PhD Graduate Seminar- Bar Cohen [No Categories] DESCRIPTION:Location: hybrid- in the Faculty Auditorium /ZOOM:https://techn ion.zoom.us/j/92052655538 \n Affiliation: \n Host:Prof. Arava Yoav\n mRNA s Co-transport with Mitochondria in Neuronal Cells: Sequence Elements and Protein Factors\nNeurons are polarized cells with high energetic demands\, which are highly dependent on localized translation of nuclear-encoded mR NAs. Yet\, the transport mechanisms of the translation machinery component s\, namely the mRNA\, are largely unknown. We showed that mRNAs of nuclear -encoded mitochondrial genes are associated with mitochondria\, in both mo use neural-like cell lines and primary neurons. Furthermore\, live-imaging of mRNAs\, revealed that one of these mRNAs\, Cox7c\, is not only associa ted but also co-transported with moving mitochondria along neurites. Inter estingly\, the Cox7c mRNA coding sequence\, and specifically the predicted mitochondrial targeting sequence (MTS)\, rather than its 3’untranslated region\, was the significant domain for the mechanism. Our results sugges t that mRNAs encoding mitochondrial proteins are associated and transporte d with mitochondria in a manner that might involve translation. Genome-wid e analysis of mitochondria-associated mRNAs revealed diverse groups of mRN As\, implying a broad phenomenon. To identify the mediators of this associ ation we performed a proteomic identification of mRNA-associated proteins and investigated key candidate’s role in the co-transport. Together\, th e results support the idea that mitochondria can serve as mRNA shuttles an d help regulate the distribution of mRNAs in specific locations within neu rons. LOCATION:hybrid- in the Faculty Auditorium /ZOOM:https://technion.zoom.us/j /92052655538 END:VEVENT BEGIN:VEVENT UID:1187@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20230716T120000 DTEND;TZID=Asia/Jerusalem:20230716T130000 DTSTAMP:20230709T141418Z URL:https://biology.technion.ac.il/en/seminars/special-seminar-prof-cynthi a-wolberger-histone-h2b-ubiquitination-in-transcription-regulation/ SUMMARY:Special Seminar - Prof. Cynthia Wolberger-Histone H2B ubiquitinatio n in transcription regulation [No Categories] DESCRIPTION:Location: Faculty Of Biology Auditorium Prof. Cynthia Wolberge r \n Affiliation: \n Host:Prof. Michael Glickman and Prof. Ashraf Brik.\n Histone H2B ubiquitination in transcription regulation\n\nAbstract \n\nPos t-translational modifications of histones play a central role in regulatin g all cellular processes requiring access to DNA. Cross-talk between histo ne modifications\, in which one histone modification regulates deposition of a second\, provides an additional layer of regulation and specificity. Monoubiquitinated histone H2B-K120 (humans\; K123 in yeast) is a hallmark of actively transcribed genes that plays multiple roles in activating tran scription. Our structural studies have revealed how H2B is specifically ub iquitinated and deubiquitinated\, as well as the mechanism by which H2B ub iquitination stimulates the enzymes that methylate histone H3K4 and H3K79\ , two other marks of actively-transcribed genes. H2B ubiquitination also r egulates access to the nucleosome acidic patch\, a hotspot for interaction s with other chromatin-modifying enzymes\, and our studies have provided i nsights into the underlying mechanism. We will also present work on identi fying novel inhibitors of USP22\, an H2B deubiquitinating enzyme subunit o f the SAGA coactivator.\n\n \;\n\n \; LOCATION:Faculty Of Biology Auditorium END:VEVENT BEGIN:VEVENT UID:1186@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20230711T133000 DTEND;TZID=Asia/Jerusalem:20230711T140000 DTSTAMP:20230703T081337Z URL:https://biology.technion.ac.il/en/seminars/msc-graduate-seminar-michae l-samin/ SUMMARY:MSc. Graduate Seminar- Michael Samin [No Categories] DESCRIPTION:Location: hybrid- in the Faculty Auditorium/ZOOM: https://techn ion.zoom.us/j/97047969393 \n Affiliation: \n Host:Prof. Schuster Gadi\n S cavenging singlet oxygen - A key to avoid photoinhibition\n\n \;\n\nLi ght drives most life on earth as photosynthetic organisms convert it to a chemical energy. However\, too much light causes photodamage that may lead to photoinhibition (PI). Photodamage happens when photosynthetic electron s/energy are being transferred from the excited chlorophyll molecule to ox ygen. Those excited oxygen molecules are called ROS and they tend to damag e the photosynthetic complexes and particularly the D1 of photosystem II. Living in the desert\, the microalgae Chlorella ohadii is exhibiting excep tional resistance to extreme high light intensity. Here\, we analyzed the ROS formation in C. ohadi grown at high light intensity where other photos ynthetic organisms cannot survive. Examining the formation of different RO S revealed that singlet oxygen was almost completely depleted in HL cells compared to low light (LL) grown cells. These results implied that when gr own in HL\, a condition where massive amounts of protective carotenoids ac cumulate in the thylakoids\, singlet oxygen formation is significantly red uced. Together with additional PI protection mechanisms that evolved in C. ohadii (Levin et al Plant J. 2021) the enormous quenching of ROS accumula tion enables this alga to thrive at light intensities where others cannot survive. LOCATION:hybrid- in the Faculty Auditorium/ZOOM: https://technion.zoom.us/j /97047969393 END:VEVENT BEGIN:VEVENT UID:1185@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20230711T130000 DTEND;TZID=Asia/Jerusalem:20230711T133000 DTSTAMP:20230703T081623Z URL:https://biology.technion.ac.il/en/seminars/msc-graduate-seminar-nitsan -yehi-shalom/ SUMMARY:MSc. Graduate Seminar-Nitsan Yehi Shalom [No Categories] DESCRIPTION:Location: hybrid- in the Faculty Auditorium/ZOOM:https://techni on.zoom.us/j/97047969393 \n Affiliation: \n Host:Prof. Schuster Gadi \, Prof. Bronstein Alexander and Dr. Marx Ailie \n Silently Shaping Structur e- Exploring the role of synonymous genetic coding in shaping the local pr otein backbone structure\n\nIn the mid-20th century Christian Anfinsen\, l ater Nobel Prize winner\, showed that RNaseA can be denatured to lose stru cture and function and then subsequently renatured to regain both\, settin g the bedrock of our understanding of what governs protein folding. His ex periments suggested that proteins carry no memory of the genetic sequence from which they were translated\, despite 18 out of the 20 amino acids bei ng translated from non-unique\, synonymous\, codons. Subsequently\, geneti c alterations leaving the amino acid sequence unchanged were termed and la rgely considered `silent`. Later findings demonstrated that synonymous mut ations can alter translation speeds and accuracy affecting co-translationa l folding and the overall\, globular\, structure of the resultant protein. We have recently shown that synonymous codon usage is associated with the local structure (backbone dihedral angle distribution) of the translated amino acid. However\, these computational results are unable to establish causality\; the association may be evolutionary\, or an active translation -dependent effect. The goal of this project is to explore the latter\; can synonymous mutations alter the local structure of the encoded amino acids ? We are exploring this hypothesis by targeting proteins that on one hand give high-resolution X-ray diffraction patterns and on the other hand cont ain short noninteracting sequences whose initial (codon- sensitive) struct ure should be minimally affected by protein folding. LOCATION:hybrid- in the Faculty Auditorium/ZOOM:https://technion.zoom.us/j/ 97047969393 END:VEVENT BEGIN:VEVENT UID:1184@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20230703T130000 DTEND;TZID=Asia/Jerusalem:20230703T140000 DTSTAMP:20230625T073153Z URL:https://biology.technion.ac.il/en/seminars/faculty-seminar-dr-naama-ge va-zatorsky-monday-2-7-at-1300/ SUMMARY:Faculty Seminar: Dr. Naama Geva-Zatorsky\, Monday 3/7 at 13:00 [No Categories] DESCRIPTION:Location: Auditorium\, Faculty of Biology Dr. Naama Geva-Zaors ky\n Affiliation: Faculty of Medicine\, Technion\n Host:Sagi Levy\n The im munomodulatory treasure-trove of the gut microbiota\n\nEmerging evidence d emonstrates the pivotal role of gut microbes in shaping our immune system. Studies have shown a handful of immunomodulatory activities of a few indi vidual microbes and several consortia. We systematically characterized the role of over 50 human gut microbes from diverse genera and phyla\, repres enting the gut microbiota diversity. We find most microbes to have immunom odulatory effects spanning from innate to adaptive responses\, and with th e potential to be effective in a variety of diseases. Surprisingly\, these effects were not encoded in microbial phylogenetic background (i.e. micro bes from distant phyla could elicit similar effects and vice versa). And t hus\, this study opens a databank for immunomodulatory effects across phyl ogenetically diverse human gut microbes\, as well as a basis for our follo w-up studies on both the mechanisms of these interactions and the molecule s at play. LOCATION:Auditorium\, Faculty of Biology END:VEVENT BEGIN:VEVENT UID:1179@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20230627T130000 DTEND;TZID=Asia/Jerusalem:20230627T140000 DTSTAMP:20230608T121017Z URL:https://biology.technion.ac.il/en/seminars/biodesign-israel-innovation -meeting-in-the-faculty-of-biology-dr-lior-lev-tov/ SUMMARY:Biodesign Israel Innovation- meeting in the Faculty of Biology- Dr. Yona Vaisbuch Founder of Biodesign Israel [No Categories] DESCRIPTION:Location: Faculty Of Biology Auditorium Dr. Yona Vaisbuch \n A ffiliation: \n Host:\n Dear Biology Faculty Students\,\n\nWe are excited t o invite you to an exclusive meeting with a visionary leader in the health tech field\, and our esteemed Founding Director\, Yona Vaisbuch\, where yo u will have the opportunity to explore the fascinating intersection of Bio design and Biology. Together\, we'll delve into the proven healthtech inno vation method that originated at Stanford CA\, 'design thinking' as a way of life\, and the transformative power of a multidisciplinary approach. Jo in us on Tuesday\, June 27\, 2023\, from 1pm to 2pm to uncover how this on e-year program connects you to the vibrant ecosystem and industry upon you r graduation. We believe that the convergence of Biodesign and Biology hol ds immense promise for shaping the future of healthcare. By participating in our program\, you'll embark on a transformative journey where your expe rtise in biology intersects with the practical applications of healthtech innovation.\n\nThrough hands-on experiences and collaborations with expert s from diverse fields\, including engineering\, medicine\, and business\, you'll gain a comprehensive understanding of the healthcare landscape. We' ll explore how to identify unmet medical needs\, scope and develop innovat ive solutions and navigate the intricacies of bringing them to market. Dur ing this meeting\, we'll discuss how Biodesign Israel nurtures your potent ial\, connects you to the industry\, and fosters a mindset of innovation.\ n\nWe look forward to welcoming you to this engaging meeting!\n\nBest rega rds\n\nBiodesign Israel LOCATION:Faculty Of Biology Auditorium END:VEVENT BEGIN:VEVENT UID:1183@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20230626T130000 DTEND;TZID=Asia/Jerusalem:20230626T140000 DTSTAMP:20230613T054645Z URL:https://biology.technion.ac.il/en/seminars/faculty-seminar-dr-viviane- slon-monday-26-6-at-1300/ SUMMARY:Faculty Seminar: Dr. Viviane Slon\, Monday 26/6 at 13:00 [No Catego ries] DESCRIPTION:Location: Dr. Viviane Slon\n Affiliation: \n Host:Dr. Sagi L evy\n Sedimentary Ancient DNA as a tool to study Human Evolution\n\n \ ;\n\nViviane Slon1\,2\n\n \;\n\n Department of Anatomy and Anthropolo gy and Department of Human Molecular Genetics and Biochemistry\, Sackler F aculty of Medicine\, Tel Aviv University\, Israel\n The Dan David Center for Human Evolution and Biohistory Research\, Tel Aviv University\, Israel \n\n \;\n\n \;\n\nIn the past years\, DNA retrieved from ancient h uman remains have been instrumental in furthering our understanding of our own evolutionary past\, as well as that of our closest extinct relatives\ , the Neandertals and the Denisovans. Such studies\, however\, are inheren tly limited to sites and timeframes where such remains have been found and made available for sampling. A complementary approach can be to recover h uman DNA fragments from ancient sediments – a source material present in any archaeological site. Yet\, this approach is complicated by the need t o accurately identify the genuinely ancient human DNA fragments present in a sample\, out of a mixture of DNA from various sources. Here\, I will ou tline a methodology to do so\, including its highlights and pitfalls\, and demonstrate the potential of this research avenue using examples from pre historic sites in Europe and Asia.\n\n \; END:VEVENT BEGIN:VEVENT UID:1182@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20230619T130000 DTEND;TZID=Asia/Jerusalem:20230619T140000 DTSTAMP:20230613T054434Z URL:https://biology.technion.ac.il/en/seminars/faculty-seminar-prof-lior-a ppelbaum-monday-19-6-at-1300/ SUMMARY:Faculty Seminar: Prof. Lior Appelbaum\, Monday 19/6 at 13:00 [No Ca tegories] DESCRIPTION:Location: Prof. Lior Appelbaum\n Affiliation: \n Host:Dr. Sag i Levy\n Imaging DNA damage and neuronal maintenance in live sleeping anim als\n\nAbstract\n\nSleep is vital for survival of all animals\, ranging fr om jellyfish to fish and humans. Sleep improves brain performance\, such a s memory and learning\, however\, even invertebrates with simple nervous s ystem sleep\, and the core cellular function of this enigmatic behavior is unclear. We propose that single neuron\, located within intact networks\, require sleep across evolution. We combined real time imaging of single c hromosomes and repair proteins\, 3D particle motion analysis\, optogenetic s stimulation\, genetic manipulations\, calcium imaging\, as well as video tracking of behavior to study the interaction between sleep\, neuronal ac tivity\, DNA damage and repair in various species. We suggest that sleep u pregulates nuclear maintenance in neurons.\n\n \; END:VEVENT BEGIN:VEVENT UID:1180@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20230612T131500 DTEND;TZID=Asia/Jerusalem:20230612T141500 DTSTAMP:20230606T091420Z URL:https://biology.technion.ac.il/en/seminars/faculty-seminar-dr-omri-wur tzel-monday-12-6-at-1300/ SUMMARY:Faculty Seminar: Dr. Omri Wurtzel\, Monday 12/6 at 13:15 [No Catego ries] DESCRIPTION:Location: Faculty Of Biology Auditorium Dr. Omri Wurtzel\n Aff iliation: Department of Biochemistry and Molecular Biology at the Faculty of Life Sciences in Tel Aviv University\n Host:Dr. Sagi Levy\n No commitme nts: Planarian stem cells in regeneration and homeostasis\n\nAbstract\n\nR egeneration\, the regrowth of missing organs\, is a widespread survival st rategy contributing to recovery from injury and disease. My lab studies fu ndamental aspects of regeneration by using invertebrate model organisms th at have a remarkable capacity to regenerate: They can grow their entire he ad. In the seminar\, I will present two studies from our lab\, the first o n stem cell differentiation regulation by RNA modifications\, and the se cond on RNAi memory in stem cells. Together\, these studies provide insig hts into molecular mechanisms that facilitate regeneration and maintenance of pluripotency in adult organisms.\n\n \;\n\n \; LOCATION:Faculty Of Biology Auditorium END:VEVENT BEGIN:VEVENT UID:1181@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20230612T111500 DTEND;TZID=Asia/Jerusalem:20230612T121500 DTSTAMP:20230607T094906Z URL:https://biology.technion.ac.il/en/seminars/prof-jackie-schiller-from-t he-faculty-of-medicine-in-the-technion/ SUMMARY:Prof. Jackie Schiller from the Faculty of Medicine in the Technion [No Categories] DESCRIPTION:Location: Biology auditorium Prof. Jackie Schiller \n Affiliat ion: Faculty of Medicine in the Technion \n Host:Prof. Yuval Garini\n Prof . Jackie Schiller from the Faculty of Medicine in the Technion as part of the André Cohen Deloro Research Prize Ceremony. The Schiller lab studies cortical computation. LOCATION:Biology auditorium END:VEVENT BEGIN:VEVENT UID:1178@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20230605T130000 DTEND;TZID=Asia/Jerusalem:20230605T140000 DTSTAMP:20230524T093309Z URL:https://biology.technion.ac.il/en/seminars/faculty-seminar-associate-p rof-meytal-landau-virulent-and-antimicrobial-amyloids-in-infections-and-ne urodegeneration/ SUMMARY:Faculty Seminar- Associate Prof. Meytal Landau-Virulent and Antimic robial Amyloids in Infections and Neurodegeneration [No Categories] DESCRIPTION:Location: Faculty Of Biology Auditorium Associate Prof. Meytal Landau\n Affiliation: \n Host:Dr. Levy Sagi\n Virulent and Antimicrobial Amyloids in Infections and Neurodegeneration\n\n \;\n\nMeytal Landau\n \n \;\n\nAmyloids are protein fibers with robust structures\, which ar e known mainly in the context of neurodegenerative diseases yet are secret ed by species across kingdoms of life to carry out physiological function and help survival and activity. For example\, several microbial amyloids s erve as key “weapons” making infections more aggressive. Thereby\, the y exposed new routes for the development of novel antivirulence drugs\, wh ich may elicit less resistance as the evolutionary pressure on the microbe is less profound compared to bactericidal drugs. Our laboratory published the first structures of bacterial amyloid fibrils involved in virulent ac tivities. Our findings thus far exposed an extreme structural diversity\, extending beyond canonical amyloid cross-β structures\, and encoding diff erent activities. In particular\, the discovery of a novel class of cross- α amyloid fibrils of toxic peptides presented a unique protein architectu re\, offered drug targets and leads\, and opened a fresh perspective to st udy amyloid-related toxicity. Moreover\, we revealed that amyloids secrete d by bacteria highly abundant in the microbiome and food sources show simi larities in molecular structures to human amyloids involved in neurodegene rative diseases such as Alzheimer’s and Parkinson’s. This might raise concerns about the involvement of microbes in facilitating these diseases\ , similar to prion proteins transmitted by contaminated meat that elicit t he Creutzfeldt-Jakob disease.  In addition\, we identified peptides produ ced across species that provide antimicrobial protection that form amyloid fibrils and determined their first high resolution structures. This amylo id-antimicrobial link signifies a physiological role in neuroimmunity for human amyloids. Such antimicrobial fibrils can facilitate the design of fu nctional and stable nanostructures to serve as a stable coating for medica l devices or implants\, industrial equipment\, food packing and more.\n\nA tomic structures of amyloid fibrils determined by X-ray crystallography an d cryogenic electron microscopy (cryo-EM) of microbial and antimicrobial a myloids. A scanning electron micrograph shows cells damaged by a cytotoxic bacterial amyloid peptide\, and transmission electron micrographs display fibrils of antimicrobial peptides covering bacterial cells\, and of massi ve fibrils formed by biofilm-associated amyloids.\n\n \n\nReferences\n\n Tayeb-Fligelman\, O. Tabachnikov\, A. Moshe\, O. Goldshmidt-Tran\, M.R. S awaya\, N. Coquelle\, J-P. Colletier\, and M. Landau. Science 355(6327): 8 31-833\; 2017\n Salinas\, A. Moshe\, J-P. Colletier\, and M. Landau. Nat. Commun. 9(1):3512\; 2018.\n Perov\, O. Lidor\, N. Salinas\, N. Golan\, E . Tayeb-Fligelman\, M. Deshmukh\, D. Willbold\, and M. Landau. PLoS Pathog 15(8): e1007978\; 2019\n Tayeb-Fligelman\, N. Salinas\, O. Tabachnikov\, and M. Landau. Structure S0969-2126(19)30445-9\; 2020\n Engelberg and M. Landau. Nat. Commun. 11\, 3894\; 2020\n Salinas\, E. Tayeb-Fligelman\, M . Sammito\, D. Bloch\, R. Jelinek\, D. Noy\, I. Uson\, and M. Landau. PNAS 118 (3) e2014442118\; 2021\n Engelberg\, P. Ragonis-Bachar and M. Landau .    Biomacromolecules2022\n Bücker\, C. Seuring\, C. Cazey\, K. Vei th\, M. García-Alai\, K. Grünewald\, and M. Landau. The Cryo-EM Structu res of two Amphibian Antimicrobial Cross-β Amyloid Fibrils.  Nat. Commu n 13: 4356\; 2022\n Ragonis-Bachar*\, B. Rayan*\, E. Barnea\, Y.Engelberg \, A. Upcher\, M. Landau. Natural Antimicrobial Peptides Self-assemble as alpha/beta Chameleon Amyloids. ACS Biomacromolecules 12\;23(9):3713-3727 2 022\n LOCATION:Faculty Of Biology Auditorium END:VEVENT BEGIN:VEVENT UID:1176@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20230529T130000 DTEND;TZID=Asia/Jerusalem:20230529T140000 DTSTAMP:20230508T114857Z URL:https://biology.technion.ac.il/en/seminars/faculty-seminar-prof-yaser- hashem/ SUMMARY:Faculty Seminar: Prof. Yaser Hashem [No Categories] DESCRIPTION:Location: Biology auditorium Prof. Yaser Hashem\n Affiliation: \n Host:Prof. Michael Glickman and Dr. Ayala Shiber\n Structural snapshot s of the cytosolic and mitochondrial mRNA translation machineries in kinet oplastids\n\nmRNA translation is a universally conserved process consistin g on translating the genetic code into proteins. Translation is mainly ope rated by the ribosome and because of its essentiality\, it is the target o f numerous prescribed antibiotics\, in part thanks to the large structural and functional discrepancies between the bacterial and human ribosomes. H owever\, when the pathogen is a eukaryotic organism\, such as a kinetoplas tid (e.g.\, trypanosomes and leishmania)\, this strategy become difficult to apply\, because of the conservation of the eukaryotic ribosome. Among t he most infamously known kinetoplastids related to human health\, Trypano soma cruzi and Leishmania major\, responsible of the Chagas disease and various leishmaniasis. While it is accepted that the eukaryotic ribosome is highly conserved\, substantial species-specific structural and regulato ry differences can exist among eukaryotes\, especially in the case of mito chondrial ribosomes that are highly specialized and only translates a doze n proteins most of which are subunits of the respiratory chain complexes. I will describe some of the kinetoplastids-specific features of cytosolic and mitochondrial mRNA translation\, which were unveiled mainly thanks to structural biology and the use of cryogenic electron microscopy (cryo-EM). \n\n \; LOCATION:Biology auditorium END:VEVENT BEGIN:VEVENT UID:1175@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20230522T130000 DTEND;TZID=Asia/Jerusalem:20230522T140000 DTSTAMP:20230508T114722Z URL:https://biology.technion.ac.il/en/seminars/faculty-seminar-prof-asya-r olls/ SUMMARY:Faculty Seminar: Prof. Asya Rolls [No Categories] DESCRIPTION:Location: Biology auditorium Prof. Asya Rolls \n Affiliation: \n Host:Dr. Sagi Levy\n Immunoception: brain representation and control of peripheral immunity \n\n \;\n\nThoughts and emotions can impact phys iology. This connection is evident in the emergence of disease following s tress\, psychosomatic disorders\, or recovery in response to placebo treat ment. Nevertheless\, this fundamental aspect of physiology remains largely unexplored. In this talk\, I will focus on the bidirectional communicatio n between the brain and the immune system\, a mechanism we recently coined as immunoception. The brain represents that state of the immune response and forms “immunengrams” that can regulate different immune reactions. In this talk\, I will discuss how the brain stores and represents immune information and how the brain’s predictive capacity can be implemented i n central immune system control. A mechanistic understanding of the neuro- immune dialog has potential implications for understanding and treating ps ychosomatic and autoimmune disorders and may offer new avenues for immune- modulation. LOCATION:Biology auditorium END:VEVENT BEGIN:VEVENT UID:1177@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20230516T130000 DTEND;TZID=Asia/Jerusalem:20230516T140000 DTSTAMP:20230509T053152Z URL:https://biology.technion.ac.il/en/seminars/phd-graduate-seminar-nimrod -golan/ SUMMARY:PhD Graduate Seminar-Nimrod Golan [No Categories] DESCRIPTION:Location: Place: Hybrid - In the faculty auditorium and on Zoom https://technion.zoom.us/j/91249440287 Nimrod Golan\n Affiliation: \n Ho st:Associate Prof. Landau Meytal \n The Dance of the Amyloids: The Intrica te Interactions of Pseudomonas aeruginosa Biofilm-Associated Amyloids FapB and FapC\n\nIn my study\, I delved into the intricate interactions of Fap B and FapC\, the main amyloid proteins involved in stabilizing biofilms fo rmed by the opportunistic pathogen Pseudomonas aeruginosa. Biofilm formati on is a key factor in the pathogen's virulence and persistence in patients with lung disease and other comorbidities. We examined the effects of dif ferent environmental conditions on the fibrillation rates\, morphologies\, and biophysical properties of FapB and FapC. Our investigation also looke d into the stability of these proteins in harsh conditions and explored th eir interactions within varying environmental factors. We hypothesized the reasons for having two different amyloid proteins in the same system. Add itionally\, we identified promising molecules that can inhibit FapC fibril formation\, potentially reducing biofilm biomass in P. aeruginosa strains . Overall\, this study enhances our understanding of the roles played by F apB and FapC in biofilm formation and highlights potential strategies to d isrupt P. aeruginosa biofilms. LOCATION:Place: Hybrid - In the faculty auditorium and on Zoom https://tech nion.zoom.us/j/91249440287 END:VEVENT BEGIN:VEVENT UID:1174@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20230515T130000 DTEND;TZID=Asia/Jerusalem:20230515T140000 DTSTAMP:20230508T114441Z URL:https://biology.technion.ac.il/en/seminars/faculty-seminar-prof-zeev-a rad/ SUMMARY:Faculty Seminar: Prof. Zeev Arad [No Categories] DESCRIPTION:Location: Biology auditorium Prof. Zeev Arad\n Affiliation: \n Host:Dr. Sagi Levy\n Eco-physiological research and wetland conservation: insights from pelican and cormorant studies in Israel. \n\n \n\nThe dete rioration of wetlands resulting from global climate change\, development\, and habitat fractionation render long-distance migrating birds face diffi culties in finding proper sites for rest and re-fueling. In Israel\, which is a bottleneck for some 600 million migrating birds\, the drainage of th e Hula Lake resulted in serious conflicts with intensive fisheries and agr iculture. Implementation of various deterrence methods\, including killing \, failed to solve these conflicts. We have offered the concept that only the understanding of the biology of the organism in question may give us t he tools (indications) for a proper management that will solve such confli cts while helping the preservation of natural assets such as wetlands.\n\n We demonstrate this in solutions reached in the case studies of pelicans a nd cormorants. We have studied their physiological condition\, food prefer ence\, energy demands and ecological constraints. As a result\, we were ab le to offer differential management and implement our suggested solutions with the full cooperation of the fishermen and the nature preservation aut horities. We have shown that such solutions are economically helpful for f ishermen and enable the preservation of the wetland habitat.  \n\n \; \n\n \; LOCATION:Biology auditorium END:VEVENT BEGIN:VEVENT UID:1173@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20230509T130000 DTEND;TZID=Asia/Jerusalem:20230509T133000 DTSTAMP:20230430T100204Z URL:https://biology.technion.ac.il/en/seminars/msc-graduate-seminar-joelle -lahmi/ SUMMARY:Msc Graduate Seminar- Joelle Lahmi [No Categories] DESCRIPTION:Location: https://technion.zoom.us/j/92411416633 Joelle Lahmi\ n Affiliation: \n Host:Prof. Mandel-Gutfreund Yael \n Studying RNA transcr iption regulation via RNA-binding proteins\n\n \;\n\nDRBP are proteins capable of binding DNA and RNA. Due to their dual capacity\, those protei ns can act at different steps of the gene expression pathway.  Recent stu dies employing ChIP-seq have shown that several RNA-binding proteins (RBPs ) bind chromatin at the promoter region\, suggesting a relationship betwee n RBPs and transcription regulation.  However\, only a few overlaps were shown between the binding sites of the RBPs on DNA and on RNA. The aim of my thesis is to explore RNA binding protein interactions with chromatin vi a transcription factors. We first employed an experimental approach\, usin g the CUT&\;RUN technique on SRSF1\, a splicing factor that belongs to the human SR family protein. We show that in human embryonic stem cells\, SRSF1 binds DNA\, preferably at gene promoter regions\, in a sequence spec ific manner.  We found that the preferred binding motif of SRSF1 resemble s the binding motif of the NFY transcription factor (TF) family\, suggesti ng that it binds the DNA through TF interaction. We further employed a com putational approach for exploring  the binding preferences of other RBPs on the DNA We further  developed a motif search approach and a position-b ased approach for predicting putative interactions between RBPs and TFs   and applied it on  publicly available  high throughput binding data from human K562 cells.\n\n \; LOCATION:https://technion.zoom.us/j/92411416633 END:VEVENT BEGIN:VEVENT UID:1170@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20230503T130000 DTEND;TZID=Asia/Jerusalem:20230503T140000 DTSTAMP:20230419T094311Z URL:https://biology.technion.ac.il/en/seminars/phd-graduate-seminar-amir-a rgoetti/ SUMMARY:PhD Graduate Seminar- Amir Argoetti [No Categories] DESCRIPTION:Location: Faculty Of Biology Auditorium: https:https://technion .zoom.us/j/91517111637 Amir Argoetti\n Affiliation: \n Host:Prof. Mandel- Gutfreund Yael\n Transcription Factors-RNA interaction: a new layer of cel lular regulation\n\nGene expression is a complex process tightly regulated by various proteins\, including DNA-binding proteins (DBPs) and RNA-bindi ng proteins (RBPs). However\, little is known about proteins that can bind both DNA and RNA\, referred to as DNA-RNA binding proteins (DRBPs). In th is study\, we identified over 40 transcription factors (TFs) including the pluripotent factors OCT4 and STAT3\, the latter known also for it’s rol es in immune system and cancer progression. Using enhanced-CLIP we found t hat STAT3 directly interacts the long non-coding RNA involved in DNA stabi lity\, NORAD. Further\, by conducting extensive functional analyses we sho w that the binding of NORAD to STAT3 has a key role in anti-viral response both in pluripotent and fully differentiated cells. In healthy cells\, it effectively silences the antiviral pathway\, while upon infection it allo ws a rapid shift towards activation of\, viral defense genes. Intriguingly \, we found that the function of NORAD is unique to humans and not observe d in mice\, despite the conservation of other functions across mammalian e volution.\n\nThe identification of a direct interaction between STAT3 and NORAD\, its mechanism and its function\, adds a new dimension of knowledge regarding DRBPs' roles in rapid cellular response to the environment. Add itionally\, this human-specific function of NORAD underscores the contribu tion of this study to understanding species-specific gene regulation.\n\n& nbsp\; LOCATION:Faculty Of Biology Auditorium: https:https://technion.zoom.us/j/91 517111637 END:VEVENT BEGIN:VEVENT UID:1168@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20230501T130000 DTEND;TZID=Asia/Jerusalem:20230501T140000 DTSTAMP:20230418T103650Z URL:https://biology.technion.ac.il/en/seminars/faculty-seminar-assoc-prof- sigal-savaldi-goldstein/ SUMMARY:Faculty Seminar -Assoc. Prof. Sigal Savaldi-Goldstein [No Categorie s] DESCRIPTION:Location: Biology auditorium Assoc. Prof. Sigal Savaldi-Goldst ein\n Affiliation: \n Host:Dr.Sagi Levy\n The ins and outs of meristem fun ction and shape\n\n \;\n\nAbstract:\n\n \;\n\nGrowth extent and di rection determine cell and whole-organ architecture. How they are spatio-t emporally coordinated across distinct cell types is one of the questions t ackled in our lab. Using a variety of approaches ranging from developmenta l genetics to precise single-cell tools that quantify growth parameters in 4D\, we study the role of hormonal signaling\, tissue identity and mechan ical constraints that together dictate the developmental output. We focus on the Arabidopsis root as a model organ and on the critical brassinostero id signaling pathway\, as an entry point to elucidate developmental proces ses and their interaction with the environment. This talk will present our current understanding regarding growth directionality at both the cell an d meristem levels\, coordination between meristematic cells as well as the function of the meristem.\n\n \;\n\n \;\n\n \;\n\n \; LOCATION:Biology auditorium END:VEVENT BEGIN:VEVENT UID:1167@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20230404T130000 DTEND;TZID=Asia/Jerusalem:20230404T140000 DTSTAMP:20230316T121733Z URL:https://biology.technion.ac.il/en/seminars/phd-graduate-seminar-bella- ben-oz/ SUMMARY:PhD Graduate Seminar- Bella Ben-Oz [No Categories] DESCRIPTION:Location: Faculty Of Biology Auditorium:https://technion.zoom.u s/j/94957315009 Bella Ben-Oz\n Affiliation: \n Host:Associate Prof. Nabi eh Ayoub\n A dual role of RBM42 in modulating splicing and translation dur ing DNA damage response: A spotlight on CDKN1A/p21 gene\n\n \;\n\nAbst ract\n\np53-mediated cell cycle arrest during DNA damage is dependent on t he induction of p21 protein\, encoded by the CDKN1A gene. p21 inhibits cyc lin-dependent kinases required for cell cycle progression to guarantee acc urate repair of DNA lesions. Hence\, fine-tuning of p21 levels is crucial for maintaining genomic stability. Currently\, the multilayered regulation  of p21 levels during DNA damage is not fully understood. Herein\, we ide ntified the human RNA binding motif protein 42 (RBM42) as a novel regulato r of p21 levels during DNA damage. Genome-wide transcriptome and interacto me analysis revealed that RBM42 alters the expression of p53-regulated gen es during DNA damage. Specifically\, we demonstrated that RBM42 facilitate s CDKN1A splicing during DNA damage by counteracting the splicing inhibito ry activity of RBM4 protein. Unexpectedly\, we also showed that RBM42 toge ther with its proximity translation factor\, CUGBP1\, underpins translatio n of various splicing targets\, including CDKN1A\, following DNA damage. C oncordantly\, transcriptome-wide mapping of RBM42-RNA interactions using e CLIP revealed that following DNA damage\, RBM42 binds the 5’UTR of hundr eds of genes. These findings suggest that RBM42 is primarily involved in m odulating DNA damage-induced translation. Collectively\, our data show tha t RBM42 couples splicing and translation machineries to fine-tune gene exp ression during DNA damage response.\n\n \; LOCATION:Faculty Of Biology Auditorium:https://technion.zoom.us/j/949573150 09 END:VEVENT BEGIN:VEVENT UID:1169@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20230403T130000 DTEND;TZID=Asia/Jerusalem:20230403T140000 DTSTAMP:20230321T084159Z URL:https://biology.technion.ac.il/en/seminars/faculty-seminar-prof-david- sprinzak/ SUMMARY:Faculty Seminar: Prof. David Sprinzak [No Categories] DESCRIPTION:Location: Faculty Of Biology Auditorium Prof. David Sprinzak\n Affiliation: \n Host:Dr. Sagi Levy\n Precise patterning in the inner ear\ n\n \;\n\nAbstract:\n\n \;\n\nPrecise periodic organization of cel ls is required for the function of many organs and tissues. It is often un clear\, however\, how such precise patterns emerge during development. The mammalian hearing organ\, the organ of Corti\, consists of a remarkably o rganized pattern of four rows of hair cells (HC) interspersed by non-senso ry supporting cells (SC). These four rows further split into three rows of outer HC and one row of inner HC separated by a single row of pillar cell s. The checkerboard-like pattern of HC and SC emerges from a disordered ep ithelium over several days\, yet the transition from a disordered to an or dered cellular pattern is not well understood. Using time-lapse imaging of mouse cochlear explants and mathematical modeling\, we show how mechanica l forces drive dynamic intercalation and delamination events enabling the transition from an initially disordered salt-and-pepper pattern to a preci sely organized pattern of HC and SC. We first show that the organization o f the three outer HC rows is driven by a tissue-wide shear motion that coo rdinates intercalation and delamination events to achieve precision patter ning. We next show that the single row of inner HCs is refined from an ini tial 2-3 rows wide salt-and-pepper pattern through a combination of two ma in morphological transitions: (i) A novel type of an intercalation process \, termed ‘hopping intercalation’\, where future HC ‘hop’ from one apical position to another. This is performed by sending a sub-apical pro trusion that opens a new apical surface next to the pillar cell row. (ii) Cells that are selected to become HC\, but fail to contact the pillar cell row\, are delaminated and remove from the tissue. Mathematical modeling t hat combines feedback between regulatory processes (i.e. Notch mediated la teral inhibition) and mechanical processes can capture the main experiment al observations and generates testable predictions. Overall\, our experime ntal and theoretical analysis suggests that a feedback between Notch media ted differentiation and mechanically driven morphological transitions unde rlies the development of precise periodic HC patterning in the inner ear.\ nSprinzak lab: https://www.sprinzak.sites.tau.ac.il/ LOCATION:Faculty Of Biology Auditorium END:VEVENT BEGIN:VEVENT UID:1165@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20230328T130000 DTEND;TZID=Asia/Jerusalem:20230328T133000 DTSTAMP:20230308T082329Z URL:https://biology.technion.ac.il/en/seminars/msc-graduate-seminar-shiraz -schiller/ SUMMARY:MSc. Graduate Seminar- Shiraz Schiller [No Categories] DESCRIPTION:Location: Faculty Of Biology Auditorium: https://technion.zoom. us/j/93656461086 Shiraz Schiller\n Affiliation: \n Host:Associate Prof. Meiri David\n Estrogen Receptor Modulation by a Newly-Identified Phytocann abinoid in a Preclinical Model of Breast Cancer\n\nBreast cancer is made u p of different subtypes that respond differently to treatments. Tumors tha t express estrogen receptor alpha (ERα) and depend on estrogen for propag ation constitute 60%-70% of all cases. They are commonly treated with endo crine therapy such as Selective Estrogen Receptor Modulators (SERMs)\, the best known of which is Tamoxifen. However\, despite its obvious benefits\ , many patients that start Tamoxifen therapy do not complete the whole tim e-course because of adverse effects. Here\, we identified a novel phytocan nabinoid from whole extracts of Cannabis\, which we termed 373.15b\, that was able to prime ER-positive tumors to the cytotoxic effect of tamoxifen without any toxicity by itself. Thus\, allowing the use of significantly l ower doses while still achieving the same outcome. A similar effect of 373 .15b was demonstrated in combination with other types of SERMs as well. 37 3.15b affects estrogen signaling by decreasing the protein expression leve ls of ERα and its transcriptional activity. We show its mechanism of acti on involves the modulation of the Hippo signaling pathway. Our work sugges ts that co-therapy for ER-positive breast cancer patients with SERMs and 3 73.15b can reduce the treatment dosage of the conventional therapy and by that diminish the associated adverse effects and improve patient quality o f life.\n\n \;\n\n \; LOCATION:Faculty Of Biology Auditorium: https://technion.zoom.us/j/93656461 086 END:VEVENT BEGIN:VEVENT UID:1166@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20230321T130000 DTEND;TZID=Asia/Jerusalem:20230321T140000 DTSTAMP:20230316T070946Z URL:https://biology.technion.ac.il/en/seminars/phd-graduate-seminar-layla- saied/ SUMMARY:PhD Graduate Seminar- Layla Saied [No Categories] DESCRIPTION:Location: hybrid- in the Faculty Auditorium/ZOOM: https://techn ion.zoom.us/https://technion.zoom.us/j/98681053470?pwd=Tk1lR3pqOTdEMy9oQW8 zbFFDOUxoUT09 Layla Saied\n Affiliation: \n Host:Dr. Kleifeld Oded \n Cha racterization of Peroxismoal Proteins Changes in Response to Stress\n\n&nb sp\;\n\nPeroxisomes are organelles with a single bilayer membrane that enc loses a soluble matrix space. Their importance is highlighted by the sever e inherited diseases that result from impairments in one or more peroxisom al functions. These organelles are highly diverse and can contain various sets of enzymes. Most types of peroxisomes are involved in beta-oxidation of fatty acids and maintaining reactive oxygen species homeostasis. Peroxi somes can adapt to different functions by importing different proteins and enzymes.\n\nProper functionality of this organelle requires specific qual ity control. One of the enzymes that have an important role in maintaining the peroxisome homeostasis and functionality is the peroxisomal isoform L on peptidase 2 (LonP2). The enzyme has both a chaperone activity and prote olytic activity. However\, not a lot is known about the function of this L on protease isoform.\n\nI will present a new method developed to study the peroxisomal import machinery and the results obtained from it. Additional ly\, I will outline the results obtained through various cellular\, bioche mical\, and proteomics approaches regarding the role of LonP2.\n\n \;\ n\n \; LOCATION:hybrid- in the Faculty Auditorium/ZOOM: https://technion.zoom.us/h ttps://technion.zoom.us/j/98681053470?pwd=Tk1lR3pqOTdEMy9oQW8zbFFDOUxoUT09 END:VEVENT BEGIN:VEVENT UID:1164@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20230308T130000 DTEND;TZID=Asia/Jerusalem:20230308T140000 DTSTAMP:20230302T101734Z URL:https://biology.technion.ac.il/en/seminars/phd-seminar-nimrod-krupnik/ SUMMARY:PhD. Seminar-Nimrod Krupnik [No Categories] DESCRIPTION:Location: hybrid- in the Faculty Auditorium/ZOOM: https://techn ion.zoom.us/j/96415693766 Nimrod Krupnik\n Affiliation: \n Host:Associate Prof. Meiri David\n Anti-cancer compounds from East Mediterranean seaweed s\n\nThis project is aimed to study the anti-cancer effect of the East Med iterranean seaweeds to point out seaweeds of interest for future investiga tion and to highlight the importance of understanding their chemical compo sition for future drugs development. By Integrating statistical models\, w e aim to supply deep insight into potential seaweed-based compounds for fu rther research as anti-cancer agents. In this work frame\, we conducted a thorough annual screening of 38 genera of East Mediterranean seaweeds for anti-cancer activity against non-small cell lung carcinoma (NCSLC) A549\, prostate cancer (PC3)\, and colon carcinoma (HT29) cell lines. Based on ou r results\, we focused on the red seaweeds Jania rubens and Asparagopsi s teaxiformies as potential candidates for the isolation of bioactive com pounds. We further analyze each extract with High-Resolution Mass Spectrom etry Ultra-High-Performance Liquid Chromatography (HRMS-UHPLC) and analyze d the metabolomic profile through GNPS workflow to visualize the Molecular Network of natural products. Combining of the biological and the spectral data allows us to apply statistical models such as PLS-DA and Spearman’ s correlation to point out compounds of interest with biological effect. LOCATION:hybrid- in the Faculty Auditorium/ZOOM: https://technion.zoom.us/j /96415693766 END:VEVENT BEGIN:VEVENT UID:1160@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20230215T133000 DTEND;TZID=Asia/Jerusalem:20230215T140000 DTSTAMP:20230131T080213Z URL:https://biology.technion.ac.il/en/seminars/msc-graduate-seminar-hila-b en-arie-zilberman/ SUMMARY:MSc Graduate Seminar- Hila Ben-arie Zilberman [No Categories] DESCRIPTION:Location: hybrid- in the Faculty Auditorium/ZOOM: https://techn ion.zoom.us/j/6141638094 Hila Ben-arie Zilberman\n Affiliation: \n Host: Dr. Shiber Ayala\n  \;\n\nISG15 and ISGylation at the ribosome: mecha nistic analysis\, innate immune response\, and impact on translation\n\n&n bsp\;\n\nThe innate immune response is the first line of defense against a ll pathogens. The response incorporates the secretion of cytokines like ty pe I interferons (IFN-I). There are hundreds of interferon-stimulated gene s (ISGs)\, with ISG15 being one of the primary ones. ISG15 is a ubiquitin -like protein\, which rapidly modifies a vast array of cellular and viral targets via a mechanism known as ISGylation. Like ubiquitination\, ISGylat ion is mediated via an E1-E2-E3 enzymatic cascade. The main ISG15-E3 ligas e has been associated with translating ribosomes\, suggesting ISG15 prefer ably modifies newly synthesized proteins. Yet\, their effects on the cellu lar translatome\, protein turnover\, and feedback to the transcriptome rem ain largely unknown. Here we provide structural modeling analysis of the k nown ISG15 ligases: HERC5\, HHARI\, and TRIM25. This revealed putative ISG 15 and substrate interaction sites\, as well as putative binding sites nea r the ribosome exit tunnel. Analyzing HeLa-/-isg15 deletion cells by polys ome profiling\, we found a cellular translation inhibition phenotype. Thes e cells display lower translation levels\, with and without interferon tre atment. This is in stark contrast to WT HeLa cells\, displaying inhibition of translation\, only following IFN treatment. Transfection of HeLa-/-isg 15  cells with an IFN-induced vector carrying ISG15 rescued the translati on inhibition phenotype. Next\, we will perform proteomics and mRNA analys is of translating ribosomes purified from HeLa\, HeLa-/-isg15\, and U2OS c ells\, with and without IFN treatment. This will provide mechanistic insig ht into ISG15 and ribosomal function during infection.\n\n \;\n\nWill be in English LOCATION:hybrid- in the Faculty Auditorium/ZOOM: https://technion.zoom.us/j /6141638094 END:VEVENT BEGIN:VEVENT UID:1159@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20230215T130000 DTEND;TZID=Asia/Jerusalem:20230215T133000 DTSTAMP:20230124T124120Z URL:https://biology.technion.ac.il/en/seminars/msc-graduate-seminar-muhamm ad-makhzumy/ SUMMARY:MSc Graduate Seminar- Muhammad Makhzumy [No Categories] DESCRIPTION:Location: hybrid- in the Faculty Auditorium/ZOOM: https://techn ion.zoom.us/https://technion.zoom.us/j/6141638094 Muhammad Makhzumy\n Af filiation: \n Host:Dr. Shiber Ayala\n Developing a single molecule approac h to selective ribosome profiling\n\n \;\n\nmRNA-protein interactions are at the center of the translation process. Ribosome-associated factors\ , from modifying enzymes to molecular chaperones\, play a pivotal role in facilitating the folding of the emerging nascent chain\, protecting it fro m aberrant interactions in the crowded cytoplasm. However\, the interplay between the various ribosome-associated factors remains largely obscure. W hat is the mode of interplay? Do they compete for binding? Is there a coor dinated handover? By only observing population averages we can miss crucia l mechanistic features. To address this\, we are developing a single molec ule approach\, targeting two canonical ribosome-associated chaperones:  R AC-SSB1  and NAC-alpha (Stress-Seventy subfamily B subunit of the ribosom e-associated complex and Alpha subunit of the Nascent Polypeptide-Associat ed Complex\, respectively). We have generated two chimeric constructs unde r an inducible promoter\; Fusing the co-translationally acting factor RAC- SSB1 with N6-adenosine methyltransferase IME4\, and the co-translationally acting factor NAC-alpha with RNA-specific adenosine deaminase ADAR2 catal ytic domain. Recent development in Oxford nanopore sequencing platform sen sitivity has allowed for the identification of enzymatically modified nucl eotides. We are utilizing this advance to detect co-translational interact ion in vivo\, by labeling the mRNAs nucleotides in close proximity to thos e interactions. Using immunoprecipitation\, we demonstrated that our chime ric constructs show a strong ribosomal association.  Polysome profiling d emonstrated that the attached RNA-modifying enzymes are in proximity to tr anslated mRNA. RNA extraction following induction and sequencing of the en tire orfs using NanoPore revealed significant changes in the electrical ou tput of samples\, strongly suggesting the presence of modified bases in th e test strain. Further analysis will reveal the interplay between SSB1 and NACα and establish a platform for analysis of various co-translational f actors interaction in single-molecule resolution.\n\nThe lecture will be g iven in English LOCATION:hybrid- in the Faculty Auditorium/ZOOM: https://technion.zoom.us/h ttps://technion.zoom.us/j/6141638094 END:VEVENT BEGIN:VEVENT UID:1162@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20230214T130000 DTEND;TZID=Asia/Jerusalem:20230214T133000 DTSTAMP:20230129T091648Z URL:https://biology.technion.ac.il/en/seminars/msc-graduate-seminar-2/ SUMMARY:Msc Graduate Seminar- Shany Greenstein [No Categories] DESCRIPTION:Location: hybrid- in the Faculty Auditorium/ZOOM: https://te chnion.zoom.us/j/93416730395 Shany Greenstein\n Affiliation: \n Host:Prof . Glickman Michael\n Understanding the turnover of the truncated form of m utant ubiquitin UBB+1\, UBBG76Y\n\nUbiquitin is a 76 amino acid molecule t hat labels proteins for degradation. Its C-terminus at 76 glycine is conju gated to the side chain of a substrate lysine. The only known ubiquitin mu tant is ubiquitin B+1 (UBB+1)\, caused by a non-heredity missense mutation during transcription of the UBB gene. The resulting protein is a ubiquiti n domain with a G76Y mutation and an additional 19 amino acids (AA) tail. This UBB+1 protein is found in sporadic and familial AD brains. It was rec ently shown in our lab that the expression of UBB+1 accelerates AD patholo gy. UBB+1 has been claimed to be cleaved by a carboxyl-terminal hydrolase isozyme L3 (UCHL3)\, resulting in a truncated form of UBB+1: ubiquitin wit h a G76Y mutation (UBG76Y). Lacking a C-terminal glycine at position 76\, UBG76Y is unable to conjugate to substrates. To date\, little is known abo ut UBG76Y. We wanted to study the fate of UBG76Y and understand whether it alleviates or exacerbates the stress imposed by UBB+1. We generated a UCH L3 KO cell line in HEK293 using CRISPR/Case9 and showed that UCHL3 is the main enzyme that cleaves UBB+1 in mammalian cells. We also expressed UBG76 Y in HEK293 cells and observed that UBG76Y does not accumulate  to the sa me extent as UBB+1. In addition\, by inhibiting degradation pathways we pr ovide evidence that UBG76Y is degraded by autophagy. To summarize\, conver ting UBB+1 to UBG76Y may be a strategy of cells to alleviate the stress as sociated with UBB+1 . LOCATION: hybrid- in the Faculty Auditorium/ZOOM: https://technion.zoom.u s/j/93416730395 END:VEVENT BEGIN:VEVENT UID:1163@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20230208T130000 DTEND;TZID=Asia/Jerusalem:20230208T133000 DTSTAMP:20230129T135244Z URL:https://biology.technion.ac.il/en/seminars/msc-graduate-seminar-mahmou d-yazbak/ SUMMARY:Msc Graduate Seminar-Mahmoud Yazbak [No Categories] DESCRIPTION:Location: hybrid- in the Faculty Auditorium/ZOOM: https://techn ion.zoom.us/j/91959760710 Mahmoud Yazbak\n Affiliation: \n Host:Dr. Aran Dvir\n Reference-based deep examination of single-cell RNA-seq clusters\n \nIdentifying the biological state of each single cell is arguably the mos t challenging task in scRNA-seq data analysis. Doing so requires bridging the gap between the current dataset and prior biological knowledge\, and t he latter is not always available in a consistent manner. To improve this process\, we've developed reference datasets for mouse and human containin g over 60\,000 samples of over 200 cell types each\, from publicly availab le studies. Using these reference datasets\, we've developed a refined ver sion of our previously published scRNA-seq annotation tool SingleR\, which allows us to discover new findings within scRNA-seq datasets\, such as ce ll type annotations\, errors made in previous annotation and clustering at tempts\, subtypes or substates of cells and clusters\, identification of r are or diseased cell types\, and more. LOCATION:hybrid- in the Faculty Auditorium/ZOOM: https://technion.zoom.us/j /91959760710 END:VEVENT BEGIN:VEVENT UID:1161@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20230206T130000 DTEND;TZID=Asia/Jerusalem:20230206T140000 DTSTAMP:20230129T083333Z URL:https://biology.technion.ac.il/en/seminars/phd-graduate-seminar-rawad- hanna/ SUMMARY:PhD Graduate Seminar-Rawad Hanna [No Categories] DESCRIPTION:Location: hybrid- in the Faculty Auditorium/ZOOM: https://techn ion.zoom.us/j/92993324901 Rawad Hanna\n Affiliation: \n Host:Dr. Kleifel d Oded \n Title: comprehensive terminomic characterization of biological s ystems.\n\nSeminar abstract:\n\nProtein termini carry valuable information related to protein activity\, localization\, interaction and stability. L earning these various properties can be detrimental to the complete unders tanding of different biological systems. Characterization of all protein t ermini (terminome) by standard proteomic approaches is challenging due to their small amounts in the whole proteome sample. Therefore\, enrichment m ethods for the N- and C-termini of proteins have been developed\, and they have provided insights that would otherwise be difficult to obtain. Yet\, all current enrichment methods have many limitations preventing them from revealing the complete terminome. Aiming to in-depth characterization of protein termini and their modifications\, we developed two methods that we termed LATE and CAPE as novel N-terminal and C-terminal enrichment method s. We deployed our methods in various biological systems. Among our key fi ndings was the cross-talk between proteolysis and post-translational Nt-ac etylation\, which we identified and characterized in apoptosis. In additio n\, we discovered hundreds of novel putative substrates of caspase-3 and h ighlighted a putative proteolysis-derived translation inhibition mechanism . LOCATION:hybrid- in the Faculty Auditorium/ZOOM: https://technion.zoom.us/j /92993324901 END:VEVENT BEGIN:VEVENT UID:1157@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20230201T130000 DTEND;TZID=Asia/Jerusalem:20230201T140000 DTSTAMP:20230115T131149Z URL:https://biology.technion.ac.il/en/seminars/phd-graduate-seminar-iris-w yrobnik/ SUMMARY:PhD Graduate Seminar- Iris Wyrobnik [No Categories] DESCRIPTION:Location: hybrid- in the Faculty Auditorium/ZOOM: https://te chnion.zoom.us/j/94968602637 \n Affiliation: Iris Wyrobnik\n Host:Associ ate Prof. David Meiri Lab\n  \;\n\nDecreased melanoma CSF-1 secretion by Cannabigerol treatment reprograms regulatory myeloid cells and reduces tumor progression\n\n \;\n\nDuring solid tumor progression\, the tumor microenvironment (TME) evolves into a highly immunosuppressive milieu. Ke y players in the immunosuppressive environment are regulatory myeloid cell s\, including Myeloid-derived suppressor cells (MDSCs) and tumor-associate d macrophages (TAMs)\, which are recruited and activated via tumor-secrete d cytokines such as colony-stimulating factor 1 (CSF-1). Therefore\, the d epletion of tumor-secreted cytokines is a leading anticancer strategy. Her e\, we found that CSF-1 secretion by melanoma cells is decreased following treatment with Cannabis extracts. Cannabigerol (CBG) was identified as th e bioactive cannabinoid responsible for the effects. Conditioned media fro m cells treated with pure CBG or the high-CBG extract reduced the expansio n and macrophage transition of the monocytic-MDSC subpopulation. Treated M O-MDSCs also expressed lower levels of iNOS\, leading to restored CD8+ T-c ell activation. Tumor-bearing mice treated with CBG presented reduced tumo r progression\, lower TAM frequencies and reduced TAM/M1 ratio. A combinat ion of CBG and αPD-L1 was more effective in reducing tumor progression an d increasing the infiltration of activated cytotoxic T-cells than each tre atment separately. We show a novel mechanism for CBG in modulating the TME and enhancing immune checkpoint blockade therapy\, underlining its promis ing therapeutic potential for the treatment of a variety of tumors with el evated CSF-1 expression. LOCATION: hybrid- in the Faculty Auditorium/ZOOM: https://technion.zoom.u s/j/94968602637 END:VEVENT BEGIN:VEVENT UID:1154@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20230126T130000 DTEND;TZID=Asia/Jerusalem:20230126T140000 DTSTAMP:20230112T082616Z URL:https://biology.technion.ac.il/en/seminars/dr-avner-wallach-zuckerman- mind-brain-and-behavior-institute-at-columbia-university-ny/ SUMMARY:Dr. Avner Wallach - Zuckerman Mind\, Brain\, and Behavior Institute at Columbia University\, NY [No Categories] DESCRIPTION:Location: Faculty Of Biology Auditorium Dr. Avner Wallach\n Af filiation: \n Host:Prof. Benjamin Podbilewicz \n An Internal Model of Sen sorimotor Context in Freely Swimming Electric Fish\n\nInternal models that predict the sensory consequences of motor actions are vital for sensory\, motor\, and cognitive functions. However\, under real-world conditions\, the relationships between motor action and sensory input are complex and m ay vary moment-to-moment depending on the environmental context. At the ne ural circuit level\, little is known about how predictions are generated u nder such challenging conditions. Using novel methods for underwater neura l recording\, quantitative analysis of unconstrained behavior\, and comput ational modeling\, I’ve found evidence for an unexpectedly sophisticated internal model at the first stage of active electrosensory processing in mormyrid fish. Closed-loop manipulations reveal that individual electrosen sory lobe neurons are capable of learning and storing multiple context-spe cific predictions of the sensory consequences of motor commands. These res ults provide mechanistic insights into how internal\, motor-related signal s and information about environmental context are combined within cerebell um-like circuitry to predict the sensory consequences of natural behavior. Finally\, I will discuss using the electric fish as a model for studying the interactions between low-level sensorimotor circuits and high-level me mory and decision-making circuits.\n\n \;\n\n \; LOCATION:Faculty Of Biology Auditorium END:VEVENT BEGIN:VEVENT UID:1158@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20230125T130000 DTEND;TZID=Asia/Jerusalem:20230125T140000 DTSTAMP:20230115T131359Z URL:https://biology.technion.ac.il/en/seminars/phd-graduate-seminar-inbar- arman/ SUMMARY:PhD Graduate Seminar- Inbar Arman [No Categories] DESCRIPTION:Location: hybrid- in the Faculty Auditorium/ZOOM: https://tech nion.zoom.us/j/99468656897 \n Affiliation: \n Host:Prof. Reiter Yoram\n I mmunomodulation of EAE with Antibodies Targeting Autoreactive T-Cell Epito pes\n\n \;\n\nMultiple sclerosis (MS) is a demyelinating autoimmune di sease influencing more than 2.5 million people around the world. Damage ca used in this disease\, which is mediated by auto-reactive CD4+ T cells\, d isrupts nerve cell signaling\, resulting in variety of symptoms\, such as blurred vision\, muscle stiffness and numbness. Previous studies suggested that human MS disease is associated with HLA-DR2 (DRB1*1501) MHC class II allele. Presentation of myelin associated epitopes\, such as myelin oligo dendrocyte glycoprotein (MOG) on HLA-DR2 by Antigen Presenting Cells (APCs ) to autoreactive CD4+ T cells in a pro-inflammatory context\, results in autoreactive T cell activation and consequently demyelination and nerve ce lls damage. Since MHC:TCR interaction is the immune response core driving force and is also the most specific check-point in the inflammatory proces s\,   targeting myelin associated epitopes presented in the context of M HC class II molecules by APCs may decrease myelin-specific autoreactive CD 4+ T cell activation and consequently reduce the inflammatory process duri ng MS. This goal may be achieved using T cell receptor like (TCRL) antibod y- based (a) Chimeric Antigen Receptor (CAR) T cells\, targeted against my elin associated epitopes presented by APCs\, aiming for APCs destruction/s uppression or (b) TCRL-PDL1 conjugated molecule\, targeted against both PD 1+ autoreactive T cells and myelin associated epitopes presented by APCs\, delivering specific immune response attenuation against self\, mediated b y the TCRL arm\, while inducing local autoreactive T cell inhibition via t he PD-L1 arm. Accordingly\, we have isolated and characterize TCRL antibod ies with specificity toward MOG/DR2 epitope and tested their MS therapeuti c effect as MOG/DR2-CAR-T cells and MOG/DR2-PDL1 bi-specific molecules. Ou r results suggests that anti-MOG/DR2-CD8+ CAR T cells show specific elimin ation of MOG/DR2 presenting APCs in-vitro\, but exacerbate disease symptom s in-vivo\, while anti-MOG/DR2 CAR T regulatory cells induce autoreactive T cell inhibition ex-vivo and should be further examined in-vivo. Also\, a dministration of anti-MOG/DR2-PDL1 bi-specific molecules induce target-spe cific autoreactive T cell inhibition ex-vivo but shows inconclusive result s in-vivo and accordingly should be further optimized and examined as MS t herapeutic tool. LOCATION: hybrid- in the Faculty Auditorium/ZOOM: https://technion.zoom.us/ j/99468656897 END:VEVENT BEGIN:VEVENT UID:1153@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20230123T130000 DTEND;TZID=Asia/Jerusalem:20230123T140000 DTSTAMP:20230112T082313Z URL:https://biology.technion.ac.il/en/seminars/dr-tomer-shpilka-department -of-molecular-cell-and-cancer-biology-at-the-university-of-massachusetts-c han-medical-school/ SUMMARY:Dr. Tomer Shpilka - Department of Molecular\, Cell and Cancer Biolo gy at the University of Massachusetts Chan Medical School [No Categories] DESCRIPTION:Location: Faculty Of Biology Auditorium Dr. Tomer Shpilka\n Af filiation: \n Host:Prof. Benjamin Podbilewicz \n The UPRmt coordinates mi tochondrial network expansion and peroxisome biogenesis in the model organ ism Caenorhabditis elegans\n\nAs organisms develop\, individual cells gene rate mitochondria and peroxisomes to fulfill their physiological requireme nts. A decline\, or dysfunction in these organelles is associated with age ing and a vast array of clinical manifestations including metabolic disord ers and neurodegenerative diseases. Despite this\, it is unknown how mitoc hondrial network expansion and peroxisome biogenesis is scaled to cell gro wth\, and what compensatory pathways cells employ to maintain the organell es’ function. The mitochondrial unfolded protein response (UPRmt) is a s ignaling pathway mediated by the transcription factor ATFS-1. Using geneti c and biochemical approaches in the model organism Caenorhabditis elegans we demonstrate that ATFS-1 mediates an adaptable mitochondrial network exp ansion and peroxisome biogenesis program that is active throughout normal development. We characterized the molecular mechanism and signaling events that regulate the UPRmt and uncovered a peroxisomal retrograde response t hat is required for peroxisome biogenesis. These findings as well as the t herapeutic potential and future directions of my studies will be presented .\n\n \;\n\n \; LOCATION:Faculty Of Biology Auditorium END:VEVENT BEGIN:VEVENT UID:1152@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20230119T130000 DTEND;TZID=Asia/Jerusalem:20230119T140000 DTSTAMP:20230109T131736Z URL:https://biology.technion.ac.il/en/seminars/dr-tal-iram-department-of-n eurology-and-neurological-sciences-and-the-neurosciences-institute-at-stan ford-university-school-of-medicine/ SUMMARY:Dr. Tal Iram - Department of Neurology and Neurological Sciences an d the Neurosciences Institute at Stanford University School of Medicine. [No Categories] DESCRIPTION:Location: Faculty Of Biology Auditorium Dr. Tal Iram\n Affilia tion: \n Host:Prof. Benjamin Podbilewicz \n Oligodendrocyte plasticity in cognitive aging and neurodegeneration\n\nAbstract\n\nRecent understanding of how the systemic environment shapes the brain throughout life has led to numerous intervention strategies to slow brain aging. Cerebrospinal flu id (CSF) makes up the immediate environment of brain cells\, providing the m with nourishing compounds. We discovered that infusing young CSF directl y into aged brains improves memory function. Unbiased transcriptome analys is of the hippocampus identified oligodendrocytes to be most responsive to this rejuvenated CSF environment. We further showed that young CSF boosts oligodendrocyte progenitor cell (OPC) proliferation and differentiation i n the aged hippocampus and in primary OPC cultures. Using SLAMseq to metab olically label nascent mRNA\, we identified serum response factor (SRF)\, a transcription factor that drives actin cytoskeleton rearrangement\, as a mediator of OPC proliferation following exposure to young CSF. With age\, SRF expression decreases in hippocampal OPCs\, and the pathway is induced by acute injection with young CSF. We screened for potential SRF activato rs in CSF and found that fibroblast growth factor 17 (Fgf17) infusion is s ufficient to induce OPC proliferation and long-term memory consolidation i n aged mice while Fgf17 blockade impairs cognition in young mice. These fi ndings demonstrate the rejuvenating power of young CSF and identify Fgf17 as a key target to restore oligodendrocyte function in the aging brain.\n\ n \;\n\n \; LOCATION:Faculty Of Biology Auditorium END:VEVENT BEGIN:VEVENT UID:1156@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20230118T123000 DTEND;TZID=Asia/Jerusalem:20230118T143000 DTSTAMP:20230112T101658Z URL:https://biology.technion.ac.il/en/seminars/jacobs-graduate-research-da y/ SUMMARY:Jacobs Graduate Research Day [No Categories] DESCRIPTION:Location: Churchill Building | Wednesday \n Affiliation: \n Ho st:\n Posters that were chosen as excellent in the departmental research d ays\, will be presented by the graduate students.\n\nA panel of judges wil l choose the winning posters. A “Crowd Favorite” poster will be chosen by the participants\n\ngood luck to the Faculty of Biology representives:  \n\n Nitsan Yehi Shalom (Schuster Lab)\n Akmaral Rakhymzhanova (Ron-Ha rel Lab)\n Inbar Arman (Reiter Lab) \n LOCATION:Churchill Building | Wednesday END:VEVENT BEGIN:VEVENT UID:1151@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20230116T130000 DTEND;TZID=Asia/Jerusalem:20230116T140000 DTSTAMP:20230109T131549Z URL:https://biology.technion.ac.il/en/seminars/dr-tanita-wein-department-o f-molecular-genetics-at-the-weizmann-institute-of-science/ SUMMARY:Dr. Tanita Wein -Department of Molecular Genetics at the Weizmann I nstitute of Science [No Categories] DESCRIPTION:Location: Faculty Of Biology Auditorium Dr. Tanita Wein\n Affi liation: \n Host:Prof. Benjamin Podbilewicz \n Understanding the ancient evolution and function of innate immunity\n\nThe human innate immune syste m has long been considered the result of extensive evolutionary innovation s in metazoans. However\, this dogma has now been challenged. Recent studi es show that essential components of the cell-autonomous innate immune sy stem have ancient evolutionary roots in prokaryotic defense systems that p rotect bacteria from phages. Nonetheless\, while we know that certain comp onents of the innate immune response were inherited from prokaryotes\, a l arge portion of functional and mechanistic diversity across the tree of l ife remains so far uncharted territory. Therefore\, in my future research\ , I will explore the evolutionary links between prokaryotic and eukaryotic immune systems. For this\, I aim to focus on evolutionary transitions su ch as lifestyle changes in bacteria and basal eukaryotes that have the pot ential to elucidate the evolutionary history and function of central innat e immune components. Utilizing a bottom-up approach harnessing the diversi ty of microbes will lead to the discovery of novel concepts\, functions a nd processes in immunity across all domains of life including plants and a nimals.\n\n \;\n\n \; LOCATION:Faculty Of Biology Auditorium END:VEVENT BEGIN:VEVENT UID:1148@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20230111T130000 DTEND;TZID=Asia/Jerusalem:20230111T140000 DTSTAMP:20221229T073424Z URL:https://biology.technion.ac.il/en/seminars/phd-graduate-seminar-ilana- alona-goor/ SUMMARY:PhD Graduate Seminar-Ilana (Alona) Goor [No Categories] DESCRIPTION:Location: hybrid- in the Faculty Auditorium/ZOOM: https://techn ion.zoom.us/j/99170022526 Ilana (Alona) Goor\n Affiliation: \n Host:Prof. Yoram Reiter\n Study of Antigen Presentation and Antigen-Specific Immunom odulation in Multiple Sclerosis by T cell Receptor-mimic Antibodies\nDurin g autoimmune diseases\, like Multiple Sclerosis (MS)\, the immune system i s downregulated in a non-specific manner in order to reduce inflammation. Consequently\, targeting and specifically inhibiting autoreactive T cells is highly desirable as a treatment for autoimmune disease. We hypothesize that during the inflammatory process in MS\, APCs can present several myel in derived epitopes simultaneously and consequently activate a variety of autoreactive T cells. Accordingly\, targeting one of these epitopes with T cell receptor- mimic (TCRm) antibody (Ab) could result in the elimination of specific APCs\, thus prevent epitope spreading\, decrease myelin-speci fic T cells` activation\, affect differentiated T cell p\nopulations and m ost importantly decrease disease exacerbation. To this end\, we have isola ted and characterized two TCRm Abs directed against MOG 35-55/ HLA-DR2 epi topes. These TCRm Abs can obtain their function via two mechanisms of acti on: (i) block peptide-MHC interactions between pathogenic T cells and APCs \, and (ii) specifically eliminate APCs presenting MS-associated autoantig ens by ADCC or CDC. The TCRm Abs exhibit specific inhibition of T cell pro liferation in vitro and ex vivo. Moreover\, the TCRm Abs were able to medi ate specific killing of MOG- presenting APCs. According to these data\, an tigen-specific TCRm Abs are valuable molecules that may facilitate importa nt studies related to antigen presentation in autoimmunity and contribute to the development of innovative therapeutic and diagnostic agents for tre ating autoimmune disorders such as MS. LOCATION:hybrid- in the Faculty Auditorium/ZOOM: https://technion.zoom.us/j /99170022526 END:VEVENT BEGIN:VEVENT UID:1150@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20230109T130000 DTEND;TZID=Asia/Jerusalem:20230109T140000 DTSTAMP:20230103T071116Z URL:https://biology.technion.ac.il/en/seminars/dr-li-av-segev-zarko-depart ment-of-microbiology-and-immunology-at-stanford-university-school-of-medic ine/ SUMMARY:Dr. Li-av Segev Zarko -Department of Microbiology and Immunology at Stanford University School of Medicine. [No Categories] DESCRIPTION:Location: Faculty Of Biology Auditorium Dr. Li-av Segev Zarko \n Affiliation: \n Host:Prof. Benjamin Podbilewicz \n How One Eukaryotic Cell Invades Another: Dissecting Invasion by Apicomplexa\nThe phylum Apico mplexa includes several of the most prevalent and important human eukaryot ic\npathogens\, such as Plasmodium spp.\, which causes malaria\, and Toxop lasma gondii\, which causes toxoplasmosis.\nHost cell invasion by these ob ligatory intracellular parasites is a remarkable and active process that\n depends on protein injection into the host cell and involves the coordinat ed action of apical organelles and\ncytoskeletal components. By coupling m olecular tools with state-of-the-art imaging techniques\, including\ncryog enic-electron microscopy\, we revealed striking conservation and differenc es in the invasion machinery\nused by Toxoplasma and Plasmodium. We identi fied mechanistic processes that promote protein secretion\nand resolved st ructural elements in the invasion machinery at subnanometer resolution\, p roviding new information\non how these important parasites accomplish the essential step of invasion.\n\n \;\n\n \; LOCATION:Faculty Of Biology Auditorium END:VEVENT BEGIN:VEVENT UID:1149@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20230102T130000 DTEND;TZID=Asia/Jerusalem:20230102T140000 DTSTAMP:20221229T073558Z URL:https://biology.technion.ac.il/en/seminars/faculty-seminar-dr-anat-kah an/ SUMMARY:faculty seminar -Dr. Anat Kahan [No Categories] DESCRIPTION:Location: Biology auditorium Dr. Anat Kahan \n Affiliation: De partment of Biology and Biology Engineering at the California Institute of Technology\n Host:Prof. Benjamin Podbilewicz \n Estrous cycle and Egg re lease resets inspired by neurodynamics in the circadian pacemaker\n\n  \;\n\nJet lag and shift work disrupt the menstrual cycle and decrease fert ility. The circadian pacemaker\, the suprachiasmatic nucleus (SCN)\, is kn own to modulate ovulation\, but the mechanism is unclear. My work explores this connection by tracking the dynamics of vasoactive intestinal peptide (VIP)-expressing neurons in the SCN in freely-behaving mice. We show that SCNVIP activity is time-of-day- and sex-dependent\, and estrous-state-dep endent in the late afternoon\, gating downstream activation of GnRH neuron s. Consistent with a light-responsive switch\, afternoon light\, as well a s specific activation of SCNVIP neurons\, rescues estrous cycle regularity and egg release in animals in limited-light conditions. Our results revea l the dynamic mechanism by which SCNVIP neurons mediate light responses to regulate estrous states and demonstrate light-induced fertility rescue\, a finding with potential therapeutic implications. LOCATION:Biology auditorium END:VEVENT BEGIN:VEVENT UID:1146@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20221229T203000 DTEND;TZID=Asia/Jerusalem:20221229T213000 DTSTAMP:20221222T131510Z URL:https://biology.technion.ac.il/en/seminars/clear-the-smoke-a-lecture-o n-cannabis-the-endocannabinoid-system-and-cancer/ SUMMARY:"Clear the smoke’’ a lecture on cannabis\, the endocannabinoid system and cancer [No Categories] DESCRIPTION:Location: Climbing wall - "Performance Rock"\, 32 Hanamal St.\, Lower City\, Haifa Associate Prof. Dedi Meiri\n Affiliation: Faculty of Biology\, Technion\n Host:\n The third lecture in the "Science Talk on the Bar" series of the Faculty of Biology\nAbout:\n• Is cannabis the antibi otics of the 21st century?\n• How many patients in Israel and around the world use cannabis as a medicine and for which indications?\n• How will you find the cannabis strain best suited for you and in what way does thi s wonderful plant open a bridge between modern and traditional medicine?\n \nDid you think that with the medical cannabis revolution in the world\, t he world of scientific research would know everything there is to know abo ut the plant?\nWell as it turns out the answer is no! The field of medical cannabis research and the use of the plant as a medicine is still in its infancy.\nThere are dozens of different cannabis strains\, and sometimes e ven a tiny change in the composition of the plant can cause your body to r eact differently and affect the symptoms of the disease in an entirely dif ferent way.\n\nOver one hundred and twenty thousand patients in Israel are prescribed medical cannabis provided by the Ministry of Health.\nThe numb er of patients in the world consuming cannabis as a medicine is estimated at tens to hundreds of millions for diverse reasons such as pain relief\, epilepsy\, Parkinson's\, post-traumatic stress disorder\, and more. But wh at do these patients actually get? What is cannabis? And what are the acti ve ingredients?\nApparently\, very little research in the world tries to a nswer these questions and the knowledge in the field is very limited...\n\ nThe Meiri Lab in the Faculty of Biology is one of few in the world curren tly able to answer these questions. In the lecture\, we will explain what is cannabis\, what are the differences between the various types of plants \, what are the active ingredients\, and how and who today receives a pres cription and approval for the use of medical cannabis.\nThen we will tell you about some of the research conducted in our lab\, including the study of cannabis’s anti-cancer properties\, its anti-epileptic qualities\, an d more...\n\nAbout the lecturer: Professor Dedi Meiri of the Technion is a world-leading researcher in the field of medical cannabis. He happened to stumble on the plant as part of the anti-cancer research being conducted in his lab. “I am not a big fan of cannabis\,” he said in his TEDxTelA viv talk\, “but you can’t take it away from cancer patients\, autistic children\, and the many people it has improved their quality of life.”\ n\nLocation: Climbing wall - "Performance Rock"\, 32 Hanamal St.\, Lower C ity\, Haifa\n\nA special benefit for those coming to the lecture: "Free cl imbing" + 1+1 sale on "Malka" beer.\n\nEntry is free\, subject to pre-regi stration - please secure your place here in the form: https://forms.gle/5 QruPe97614V6gc4A LOCATION:Climbing wall - "Performance Rock"\, 32 Hanamal St.\, Lower City\, Haifa END:VEVENT BEGIN:VEVENT UID:1147@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20221228T130000 DTEND;TZID=Asia/Jerusalem:20221228T140000 DTSTAMP:20221225T093632Z URL:https://biology.technion.ac.il/en/seminars/phd-graduate-seminar-xiaohu i-li/ SUMMARY:PhD Graduate Seminar-Xiaohui Li [No Categories] DESCRIPTION:Location: hybrid- in the Faculty Auditorium/ZOOM: https://techn ion.zoom.us/j/95603525366 Xiaohui Li \n Affiliation: \n Host:Prof. Benjam in Podbilewicz\n \nArchaeal origins of gamete fusion\n\nSexual reproductio n consists of genome reduction by meiosis and subsequent gamete fusion. Fu sexins\, are a superfamily of structurally conserved proteins (fusogens) t hat mediate three types of exoplasmic membrane fusion events: eukaryotic g amete fusion\, somatic cell-cell fusion\, and entry of enveloped viruses t o host cells. Here\, we unveil a fourth family of fusexins in genomes of A rchaea and metagenomes from different environments. We provide structural\ , functional and evolutionary evidence indicating that these archaeal prot eins are cellular fusogens: First\, the crystal structure of a trimeric ar chaeal Fusexin1 reveals high similarity to eukaryotic fusexins and in part icular to gamete GCS1/HAP2 fusogens from plants and protists. Second\, ect opically expressed Fusexin1 can fuse mammalian cells\, and this process in volves the conserved fusion loop and the additional globular domain. Third \, genomic analyses indicate that archaeal fusexins are carried by integra ted mobile genetic elements\, suggesting potential roles in cell fusion an d gene exchange in archaea\, as well as different scenarios for the evolut ionary history of fusexins. We will also discuss work in progress to LOCATION:hybrid- in the Faculty Auditorium/ZOOM: https://technion.zoom.us/j /95603525366 END:VEVENT BEGIN:VEVENT UID:1145@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20221226T130000 DTEND;TZID=Asia/Jerusalem:20221226T130000 DTSTAMP:20221222T093039Z URL:https://biology.technion.ac.il/en/seminars/a-twist-in-the-protein-fold ing-dogma/ SUMMARY:Prof. Alex Bronstein and Dr. Ailie Marx from the Faculty of Compute r Science at the Technion - "A twist in the protein folding dogma" [No Cat egories] DESCRIPTION:Location: Biology auditorium Prof. Alex Bronstein and Dr. Aili e Marx \n Affiliation: Faculty of Computer Science at the Technion\n Host: Prof. Benjamin Podbilewicz \n Abstract:\nThe fact that some amino acid ch ains fold alone into natively structured and fully functional proteins in solution\, has led to the commonly accepted “one sequence-one structure ” notion. However\, within the cell\, protein chains are not formed in i solation\, to fold alone once produced. Rather\, they are translated from genetic coding instructions (for which many versions exist to code a singl e amino acid sequence) and begin to fold before the chain has fully formed through a process known as co-translational folding. The effect of coding and co-translational folding mechanisms on the final protein structure ar e not well understood. There are no studies showing side-by-side structura l analysis of protein pairs having alternative synonymous coding. We are u sing the wealth of high-resolution protein structures available in the Pro tein Data Bank to computationally explore the association between genetic coding and local protein structure and pinpoint positions of alternate con formations in homologous proteins which cannot be readily explained by the amino acid sequence or protein environment\nBronstein lab: https://bron.c s.technion.ac.il/ LOCATION:Biology auditorium END:VEVENT BEGIN:VEVENT UID:1139@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20221222T100000 DTEND;TZID=Asia/Jerusalem:20221222T150000 DTSTAMP:20221205T112751Z URL:https://biology.technion.ac.il/en/seminars/arie-admon70-symposia/ SUMMARY:Arie Admon@70 Symposia [No Categories] DESCRIPTION:Location: Faulty of Biology Auditorium \n Affiliation: \n Host :\n Arie Admon@70 symposia – Celebrating Arie's 35 years of Science\n"My Life with Mass Spectrometers\, Proteomics\, and Immunopeptidomics”\n\nT hursday\, December 22\, 2022\; 10:00-15:00\nFaculty of Biology Auditorium\ , Technion-Israel Institute of Technology\n\n10:00-10:30 - Gathering\, cof fee\, and cakes\n10:30-10:40 - Opening Remarks\, Faculty Dean\, Yael Mande l Gutfreund\n10:40-10:50 – Introduction\, Yoram Reiter\n10:50-11:40– J on Yewdell\, Cellular Biology Section\, Laboratory of Viral Diseases\, NIA ID\, NIH\nDRiPs and SLiPs and Retirees! Oh My!\n11:40-12:10 – Aaron Ciec hanover\, Faculty of Medicine\, Technion\nNutritional control of proteasom e dynamics – implications to cancer therapy\n12:10-12:40 – Michal Bass ani-Sternberg\, Lausanne University Hospital\, The Center for Experimental Therapies\nThe tumor antigenic landscape associated with T cell infiltrat ion and immunoediting\n12:40-13:10 – Yifat Merbl\, Department of Systems Immunology\, Weizmann Institute of Science –\nIlluminating the dark mat ter of the immunopeptidome\n13:10-14:00 – Lunch\n14:00-14:30 – Yuval A dmon\, Head of the Haifa Bay Development Directorate and Deputy Head of th e National\nEconomic Council at The Prime Minister's Office.\nChanging the face of Haifa Bay - what is expected to happen?\nיובל אדמון\, ר אש המנהלת לפיתוח מפרץ חיפה וסגן ראש המוע צה הלאומית לכלכלה במשרד ראש הממשלה\nשינו י פני מפרץ חיפה- מה צפוי לקרות"\n14:30-15:00 – Ar ie Admon -\nDeciphering myth from reality in immunopeptidomics - mass spec trometry to the rescue. LOCATION:Faulty of Biology Auditorium END:VEVENT BEGIN:VEVENT UID:1143@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20221219T190000 DTEND;TZID=Asia/Jerusalem:20221219T200000 DTSTAMP:20221211T103737Z URL:https://biology.technion.ac.il/en/seminars/science-talk-over-the-count er-led-by-faculty-pi-oded-beja-bacteria-metagenomics-and-solar-energy-harv esting/ SUMMARY:"Science Talk over the counter" led by faculty PI Oded Beja - "Bact eria\, metagenomics and solar energy harvesting" [No Categories] DESCRIPTION:Location: The Nola Sox Bar\, 4 Shalom Aleichem Street\, Ziv Cen ter Haifa Prof. at the Faculty of Biology Oded Beja\n Affiliation: \n Hos t:\n Abstract:\n\n What are "Light Sensing" proteins and how were they di scovered in the waters of the Sea of Galilee\, for the first time since 19 71?\n What is "harvesting solar energy"\, what is the connection to photo synthesis\, and how are these indirectly related to the visual system of v arious animals and also humans?\n What are rhodopsins? What are bacteria and how is the color "deep purple" related to them?\n\nThe main way throug h which energy enters the food webs on Earth is with the help of protein s ystems that absorb energy from sunlight. Beja laboratory investigates the various systems with which microorganisms "harvest" energy from sunlight t o satisfy their energy requirements.\n\nIn the lecture\, I will talk about new families of light-sensing proteins (rhodopsins) that were discovered in the waters of the Sea of Galilee. Proteins that are responsible for har vesting solar energy (using solar energy to create chemical energy). Proce sses carried out by various microbes. I will describe the role of proteins in absorbing light of different colors and turning it into energy availab le to cells.\n\nIn the lecture\, I will also talk about the field of "meta genomics". A method that allows us to look at the genomes of bacteria and viruses without the need to grow them.\nUsually\, when you want to study t he genomes of bacteria and small creatures - you are required to grow them in what is called a "pure culture” in the laboratory. And since 98% of those marine microbes cannot be grown in the laboratory\, you have to find other ways to look at their genomes and make predictions about what they do for a living in the sea.\n\nlocation: The Nola Sox Bar\, 4 Shalom Aleic hem St.\, Ziv Center Haifa.\n\nEntry is free\, you must reserve places in advance here in the form: https://forms.gle/mHTLV7aoPyxmv8CT8\n\nThe lect ure would be given in Hebrew.\n\n \;\n\n \; LOCATION:The Nola Sox Bar\, 4 Shalom Aleichem Street\, Ziv Center Haifa END:VEVENT BEGIN:VEVENT UID:1144@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20221219T130000 DTEND;TZID=Asia/Jerusalem:20221219T140000 DTSTAMP:20221211T115715Z URL:https://biology.technion.ac.il/en/seminars/dr-danielle-karo-atar-tales -from-the-crypt-on-helminth-regulation-of-the-stem-cell-compartment/ SUMMARY:Dr. Danielle Karo-Atar-Tales from the crypt: on helminth regulation of the stem cell compartment [No Categories] DESCRIPTION:Location: Faculty Of Biology Auditorium Dr. Danielle Karo-Atar \n Affiliation: \n Host:Prof. Benjamin Podbilewicz \n Tales from the cryp t: on helminth regulation of the stem cell compartment\n\nAbstract:\n\nInt estinal helminths remain pervasive throughout the animal kingdom by manipu lating host defense pathways to prioritize tissue adaptation and repair ov er parasite expulsion. These parasites form intimate physical connections with the intestinal epithelium\, yet little is known about the ability of helminths to directly shape the fate of this barrier tissue. By interrogat ing Heligmosomoides polygyrus bakeri (Hpb) infection in mice\, we demonstr ate that these parasites directly reprogram the ISC compartment\, independ ent of host-derived factors. This reprogramming event coincides with adult parasite colonization of the intestinal lumen and is characterized by act ivation of a regenerative fetal-like\, signature and the emergence of Clus terin-expressing ‘revival’ stem cells (revSC). Using lineage-tracing\, transcriptomics and advanced imaging techniques both in vitro in organoid s cultures and in vivo\, we show that Hpb-mediated revSC generation is cri tically regulated by oxidative stress\, occurs independent of host-derived immune signals and inhibits type 2 cytokine-driven differentiation of sec retory epithelial lineages that promote worm expulsion. Reciprocally\, typ e 2 cytokine signals limit revSC differentiation and\, consequently\, Hpb fitness indicating that helminths co-opt a tissue development program to c ounter type 2 immune-mediated expulsion and maintain chronic infection. LOCATION:Faculty Of Biology Auditorium END:VEVENT BEGIN:VEVENT UID:1142@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20221212T130000 DTEND;TZID=Asia/Jerusalem:20221212T140000 DTSTAMP:20221129T101143Z URL:https://biology.technion.ac.il/en/seminars/dr-yoel-klug-sucking-up-the -fat-mechanism-of-lipid-droplet-formation/ SUMMARY:Dr. Yoel Klug-Sucking up the fat: mechanism of lipid droplet format ion [No Categories] DESCRIPTION:Location: Faculty Of Biology Auditorium Dr. Yoel Klug\n Affili ation: \n Host:Prof. Benjamin Podbilewicz \n Abstract\n\nAll cells have e volved the means to store energy and thereby minimize the effects of fluct uations in nutrient availability. Cells store energy in the form of neutra l lipids\, such as triacylglycerol\, in specialized organelles called lipi d droplets (LDs). Besides storage of metabolic energy\, LDs play important roles in lipid and protein homeostasis and their deregulation is observed in a wide range of pathologies from obesity and atherosclerosis to diabet es. Despite their central roles in cellular metabolism\, the mechanisms of LD biogenesis remained largely unknown. LD biogenesis occurs at the endop lasmic reticulum and is coordinated by the evolutionary conserved membrane protein Seipin\, which is mutated in lipodystrophy. Despite the clear lin k between Seipin and LD formation\, how Seipin promoted and influenced LD formation remained unclear.\n\nWe addressed this major open question in th e field. Using structural\, biochemical and molecular dynamics simulation approaches we revealed the mechanism of LD formation by the yeast Seipin S ei1 and its membrane partner Ldb16. We showed that Sei1 luminal domain ass embles a homooligomeric ring\, which\, in contrast to other Seipins\, is u nable to concentrate triacylglycerol. Instead\, Sei1 positions Ldb16\, whi ch concentrates triacylglycerol within the Sei1 ring through critical hydr oxyl residues. Triacylglycerol recruitment to the complex is further promo ted by Sei1 transmembrane segments\, which also control Ldb16 stability. I n vivo studies using chimeras between yeast and human Seipin indicate that triacylglycerol-binding activity by Seipin is conserved across eukaryotes \, thus defining a unifying mechanism for Seipin mediated LD formation and lipid storage LOCATION:Faculty Of Biology Auditorium END:VEVENT BEGIN:VEVENT UID:1140@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20221211T210000 DTEND;TZID=Asia/Jerusalem:20221211T220000 DTSTAMP:20221127T123229Z URL:https://biology.technion.ac.il/en/seminars/science-talk-over-the-count er-led-by-faculty-pi-meytal-landau-bacteria-alzheimers-and-particle-accele rators/ SUMMARY:"Science TALK over the counter" led by faculty PI Meytal Landau - " Bacteria\, Alzheimer's\, and particle accelerators" [No Categories] DESCRIPTION:Location: Sleek Bar HAIFA Meytal Landau\n Affiliation: \n Host :\n During December\, the faculty will hold a series of "Science TALKS ove r the counter" led by faculty PI in selected locations throughout Haifa an d the north district. We are thrilled to invite you all to the first lectu re in the series: "Bacteria\, Alzheimer's\, and particle accelerators".\n\ nWhen? Sunday\, 11.12 at 21:00 . Opening Doors: 19:00\, Beginning of Lectu re: 21:00\nWhere? Slick Bar\, 124 Hanasi street\, HAIFA\n*The lecture is f ree of charge and open to the general public.\n*To hold a spot\, you must register for the lecture in advance via the link :https://forms.gle/YZE9wZ bzxN65zpnL9\nAbout the lecture:\n How is the "urgent threat" of antibio tic-resistant super bacteria related to drug development?\n Does a bact erium disguise itself as infected meat and cause "mad cow" style diseases? \n What is all of this having to do with particle accelerators and how do they help us decipher a connection between apparently unrelated disease s?\n\nThe lecture will discuss drug development in the past\, present\, an d future. We will describe the role of proteins as pathogens and also as a therapeutic measure. How we use particle accelerators (synchrotrons) to u nderstand proteins and use the information to develop drugs and materials for biotechnological uses.\n\nWe will learn for the first time about prote ins that create "super fibers" (strong and durable fibers) called amyloids which are produced by bacteria\, viruses\, and fungi and cause severe inf ectious diseases. Amyloids are proteins that are known mainly due to their connection to neurodegenerative diseases\, and we will deal with the ques tion of whether there is a connection between infectious diseases and Alzh eimer’s\, Parkinson's\, and mad cow disease. LOCATION:Sleek Bar HAIFA END:VEVENT BEGIN:VEVENT UID:1128@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20221207T130000 DTEND;TZID=Asia/Jerusalem:20221207T133000 DTSTAMP:20221102T093818Z URL:https://biology.technion.ac.il/en/seminars/msc-graduate-seminar-or-hev deli-aran-lab/ SUMMARY:Msc Graduate Seminar-Or Hevdeli [No Categories] DESCRIPTION:Location: hybrid- in the Faculty Auditorium/ZOOM: Or Hevdeli\n Affiliation: \n Host:Dr. Dvir Aran\n  \;\n\nReducing scRNA-seq data v ia nonnegative matrix factorization for annotation and clustering analysis \n\nabstract: \n\nSingle-cell RNA sequencing (scRNA-seq) provides an unpre cedented opportunity to dissect tissue heterogeneity and characterize indi vidual cells. Clustering similar cells and determining their cell type is an essential step for analyzing scRNA-seq data. Due to the high dimension of gene expression data and technical limitations of scRNA-seq\, to achiev e good clustering we first need to perform dimensionality reduction on the transcriptional data. Unsupervised approaches\, such as PCA\, are the com mon approach\, however\, current clustering algorithms that use the top PC s often fail to separate closely related\, but different cells from one an other\n\nHere\, we propose a novel mixed semi-supervised and unsupervised nonnegative matrix factorization (NMF)-based framework for both dimensiona lity reduction and annotation. The framework consists of three phases: dec omposition\, projection\, and annotation prediction. In the first phase\, variant methods of NMFs are tested to identify the latent genes base for r eference transcriptomic datasets of pure cell types. These latent bases de monstrate a combination of relating genes that generate a low-dimensional space. Then\, unlabeled data is represented by the latent bases via solvin g a linear least squares problem. In the annotation phase\, the correlatio n between the reference and the test data is calculated using SingleR\, ba sed on the new representation. The proposed algorithm is evaluated on seve ral pairs of scRNA-seq datasets for annotation. Experimental results demon strate the effectiveness of our method when compared with annotation metho ds without dimensionality reduction. Furthermore\, it is possible to use l atent bases not only to reduce dimensions but also to characterize relatio nships between genes and discover new markers. We hope this approach will assist researchers in extracting more accurate and novel insights from the ir scRNA-seq data and will encourage follow-up research in this field. LOCATION:hybrid- in the Faculty Auditorium/ZOOM: END:VEVENT BEGIN:VEVENT UID:1141@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20221205T090000 DTEND;TZID=Asia/Jerusalem:20221205T100000 DTSTAMP:20221129T093619Z URL:https://biology.technion.ac.il/en/seminars/dr-tal-iram-oligodendrocyte -plasticity-in-cognitive-aging-and-neurodegeneration/ SUMMARY:Dr. Tal Iram-Oligodendrocyte plasticity in cognitive aging and neur odegeneration [No Categories] DESCRIPTION:Location: https://technion.zoom.us/j/99631311196. Dr. Tal Ira m\n Affiliation: \n Host:Prof. Benjamin Podbilewicz \n Abstract\n\nRecent understanding of how the systemic environment shapes the brain throughout life has led to numerous intervention strategies to slow brain aging. Cer ebrospinal fluid (CSF) makes up the immediate environment of brain cells\, providing them with nourishing compounds. We discovered that infusing you ng CSF directly into aged brains improves memory function. Unbiased transc riptome analysis of the hippocampus identified oligodendrocytes to be most responsive to this rejuvenated CSF environment. We further showed that yo ung CSF boosts oligodendrocyte progenitor cell (OPC) proliferation and dif ferentiation in the aged hippocampus and in primary OPC cultures. Using SL AMseq to metabolically label nascent mRNA\, we identified serum response f actor (SRF)\, a transcription factor that drives actin cytoskeleton rearra ngement\, as a mediator of OPC proliferation following exposure to young C SF. With age\, SRF expression decreases in hippocampal OPCs\, and the path way is induced by acute injection with young CSF. We screened for potentia l SRF activators in CSF and found that fibroblast growth factor 17 (Fgf17) infusion is sufficient to induce OPC proliferation and long-term memory c onsolidation in aged mice while Fgf17 blockade impairs cognition in young mice. These findings demonstrate the rejuvenating power of young CSF and i dentify Fgf17 as a key target to restore oligodendrocyte function in the a ging brain. LOCATION:https://technion.zoom.us/j/99631311196. END:VEVENT BEGIN:VEVENT UID:1135@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20221128T130000 DTEND;TZID=Asia/Jerusalem:20221128T140000 DTSTAMP:20221114T084140Z URL:https://biology.technion.ac.il/en/seminars/rony-dahan-antibody-mediate d-immunity-and-immunotherapy/ SUMMARY:Rony Dahan -Antibody Mediated Immunity and Immunotherapy [No Catego ries] DESCRIPTION:Location: Faculty Of Biology Auditorium Rony Dahan \n Affilia tion: Department of Immunology\, Weizmann Institute of Science\n Host:Sagi Levy and Yoram Reiter\n LOCATION: Faculty Of Biology Auditorium END:VEVENT BEGIN:VEVENT UID:1138@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20221123T130000 DTEND;TZID=Asia/Jerusalem:20221123T140000 DTSTAMP:20221117T103313Z URL:https://biology.technion.ac.il/en/seminars/dr-ariel-jaimovich-director -of-bioinformatics-ultima-genomics-cost-efficient-sequencing-platform-usin g-novel-sequencing-by-synthesis-chemistry-and-open-fluidics-platform/ SUMMARY:Dr. Ariel Jaimovich Director of Bioinformatics\, Ultima Genomics-Co st-efficient sequencing platform using novel sequencing-by-synthesis chemi stry and open fluidics platform [No Categories] DESCRIPTION:Location: Faculty Of Biology Auditorium Dr. Ariel Jaimovich Di rector of Bioinformatics\, Ultima Genomics\n Affiliation: \n Host:Dr. Dvir Aran\n  \;\n\nhttps://en.globes.co.il/en/article-genome-sequencing-co -ultima-genomics-raises-600m-1001414037\n\n \;\n\nGenome sequencing co mpany Ultima Genomics has come out of stealth and announced $600 million i n financing. Founded in 2016 by its Israeli CEO Gilad Almogy\, the company has 350 employees including 50 in Israel at development centers in Rehovo t and Hod Hasharon. The company has now revealed that it has developed a sequencing machine\, which it claims\, backed up by research set to be pub lished in leading scientific periodicals\, allows genome sequencing for $1 00\, compared with the $500-600 it costs using its rival Illumina. In addi tion\, Ultima Genomics claims that its genomic sequencing is faster and de eper - in other words\, it provides more data about the genome\, more quic kly.\n\n \; LOCATION:Faculty Of Biology Auditorium END:VEVENT BEGIN:VEVENT UID:1134@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20221121T130000 DTEND;TZID=Asia/Jerusalem:20221121T130000 DTSTAMP:20221117T070109Z URL:https://biology.technion.ac.il/en/seminars/oded-kleifeld-faculty-of-bi ology-technion/ SUMMARY:Oded Kleifeld - Faculty of Biology\, Technion [No Categories] DESCRIPTION:Location: Faculty Of Biology Auditorium Oded Kleifeld\n Affil iation: \n Host:Sagi Levy\n Tales of protein tails and the proteases that generate them\n\nProteolysis is one of the mechanisms that allows cells to alter their proteome in response to different conditions or signals. A pr oteolytic process can result in either protein degradation\, which removes proteins and breaks them down to peptides and amino acids\, or a fine and specific proteolytic process which produces precise modifications to prot ein chains. With over 560 proteases in humans\, and with proteases encompa ssing ~2% of the gene content of many organisms\, proteolysis affects the fate of every protein. Malfunctions of the proteolysis are implicated in m ultiple human diseases. In this talk I will describe some of the proteomic methods that we developed and how we utilized them to characterize and pr ofile active proteases\, define different proteolytic products and to iden tify novel protease substrates.\n\n \;\n\n \;\n\n \;\n\n \ ; LOCATION:Faculty Of Biology Auditorium END:VEVENT BEGIN:VEVENT UID:1129@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20221116T130000 DTEND;TZID=Asia/Jerusalem:20221116T133000 DTSTAMP:20221031T125750Z URL:https://biology.technion.ac.il/en/seminars/msc-graduate-seminar-liam-k imel/ SUMMARY:MSc Graduate Seminar-Liam kimel [No Categories] DESCRIPTION:Location: hybrid- in the Faculty Auditorium/ZOOM:https://techni on.zoom.us/j/93465319106 Liam kimel\n Affiliation: \n Host:Associate Prof . Tom Shemesh \n  \;\n\nThermodynamic models for the homeostasis and development of the epidermis and spherical organoids\n\nEpithelial tissues formed of layered cell surfaces are prevalent in multiple tissues and pla y an essential role in key biological processes such as development\, orga n homeostasis and cancer.  In this work we study the mechanical aspects o f layered multi-cell systems using pseudo-thermodynamic models. First\, by use of stochastic simulations we were able to characterize the proliferat ion properties of a new type of stem cell in the mouse interfollicular epi dermis. Further\, we used both deterministic and stochastic computer simul ations to investigate the interplay and between the biological and mechani cal properties of concentric\, multilayered spherical cell systems. We fou nd that localized active contractility in the outer cell layers is critica l in maintaining system homeostasis\, and further controls dynamic propert ies such as the system growth rate and fluctuations about the steady-state . Our findings go towards gaining a mechanistic understanding of multilaye red epithelial systems and suggest strategies by which they may be modulat ed. LOCATION:hybrid- in the Faculty Auditorium/ZOOM:https://technion.zoom.us/j/ 93465319106 END:VEVENT BEGIN:VEVENT UID:1133@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20221114T130000 DTEND;TZID=Asia/Jerusalem:20221114T140000 DTSTAMP:20221106T085210Z URL:https://biology.technion.ac.il/en/seminars/prof-itai-yanai-cell-state- dynamics-and-plasticity-in-tumorigenesis-and-drug-resistance/ SUMMARY:Prof. Itai Yanai - Cell state dynamics and plasticity in tumorigene sis and drug resistance [No Categories] DESCRIPTION:Location: Auditorium\, Faculty of Biology Itai Yanai\n Affilia tion: Institute for Systems Genetics & Biochemistry and Molecular Pharma cology\, New York University School of Medicine\n Host:Benny Podbilewicz\n Abstract:\n\nCellular plasticity is emerging as an important driving forc e underlying cancer progression and drug resistance. In this talk\, I will discuss the concept of cancer cell states present in the tumor prior to t reatment\, as well as those that accompany resistance to increasing drug d oses. In particular\, I will discuss work published in our recent manuscri pt 'Cancer cell states recur across tumor types and form specific interact ions with the tumor microenvironment' and recent developments in this proj ect. Second\, I will discuss our new work of 'Drug-induced adaptation alon g a resistance continuum in cancer cells'. In this work we provide evidenc e that the dose and treatment duration together drive the resistance of ov arian cancer cells to targeted therapy along a trajectory of cellular adap tation\, that we denote the ‘resistance continuum’. We report that gra dual dose exposure and prolonged treatment promote a continuous increase i n fitness\, and show that this process is mediated by evolving transcripti onal\, epigenetic and genetic changes that promote multiple cell state tra nsitions. The resistance continuum is underpinned by the assembly of gene expression programs and epigenetically reinforced stress response regulati on. Using both in vivo and in vitro models\, we found that this process in volves widespread reprogramming of cell survival pathways\, including inte rferon response\, lineage reprogramming\, metabolic rewiring and oxidative stress regulation. Together\, the resistance continuum reveals the dynami c nature of cellular adaptation\, and carries implications for cancer ther apies\, as initial exposure to lower doses primes cells over time for incr eased resistance to higher doses. LOCATION:Auditorium\, Faculty of Biology END:VEVENT BEGIN:VEVENT UID:1131@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20221114T103000 DTEND;TZID=Asia/Jerusalem:20221114T113000 DTSTAMP:20221106T085137Z URL:https://biology.technion.ac.il/en/seminars/prof-itai-yanai-night-scien ce-the-creative-side-of-the-scientific-process/ SUMMARY:Prof. Itai Yanai - ‘Night Science’: The creative side of the sc ientific process [No Categories] DESCRIPTION:Location: Auditorium\, Faculty of Biology Itai Yanai\n Affilia tion: Institute for Systems Genetics & Biochemistry and Molecular Pharma cology\, New York University School of Medicine\n Host:Benjamin Podbilewic z \n Abstract:\n\n \;\n\nThe formal scientific method tells you how t o rigorously and objectively test a hypothesis. But where do hypotheses co me from in the first place? Posing fruitful new questions\, having ideas f or novel hypotheses\, and inventing new experimental technologies all requ ire scientific creativity. Itai Yanai (NYU) and Martin Lercher (Düsseldor f University) have been exploring this hidden side of the scientific proce ss in editorials and a podcast. In this talk\, Itai will discuss the tools for the generation of scientific ideas\, including how anthropomorphic la nguage unlocks intuitive brain capacities\; how new questions can be ident ified by honing in on contradictions\; how a hypothesis can be a liability for making new discoveries\; and how ideas can be imported and exported a cross research fields. This talk is relevant to anyone interested in a dee per understanding and further development of their scientific creativity. LOCATION:Auditorium\, Faculty of Biology END:VEVENT BEGIN:VEVENT UID:1130@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20221107T130000 DTEND;TZID=Asia/Jerusalem:20221107T140000 DTSTAMP:20221102T092451Z URL:https://biology.technion.ac.il/en/seminars/dna-damage-repair-mechanism s-and-therapeutic-implications/ SUMMARY:Nabieh Ayoub (Faculty of Biology) - DNA damage repair : Mechanisms and therapeutic implications [No Categories] DESCRIPTION:Location: Biology Auditorium Nabieh Ayoub\n Affiliation: \n Ho st:Sagi Levy\n The Ayoub lab studies DNA damage repair\, genome stability and cancer.\nAyoub lab: http://ayoubn.net.technion.ac.il/ LOCATION:Biology Auditorium END:VEVENT BEGIN:VEVENT UID:1127@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20221031T130000 DTEND;TZID=Asia/Jerusalem:20221031T130000 DTSTAMP:20221023T051434Z URL:https://biology.technion.ac.il/en/seminars/hadas-benisty-department-of -neuroscience-yale-university/ SUMMARY:Hadas Benisty - Department of Neuroscience\, Yale University [No Ca tegories] DESCRIPTION:Location: Faculty of Biology Auditorium Hadas Benisty\n Affili ation: Department of Neuroscience\, Yale University\n Host:Benjamin Podbil ewicz \n Graph Theory Approaches for Network Analysis of Neuronal Signals and Behavior\n\nHow does the brain encode behavior? What are the internal mechanisms affecting neuronal network organization and configuration at d ifferent scales? I will introduce novel approaches for analysis of network s based on viewing neuronal activity as high dimensional observations of a dynamic system\, with the ultimate goal of revealing the intrinsic mechan isms giving rise to biological processes. I will introduce our new analyti cal framework for investigating time-varying functional connectivity in ne ural networks based on Graph Theory and Riemannian Geometry. By extracting the latent dynamics of functional connectivity I demonstrate how local ci rcuits and global cortical networks encode spontaneous behaviors. Furtherm ore\, I will present how this analytic framework discovers spatio-temporal patterns of functional cortical activity closely linked to behavior LOCATION:Faculty of Biology Auditorium END:VEVENT BEGIN:VEVENT UID:1126@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20221026T130000 DTEND;TZID=Asia/Jerusalem:20221026T140000 DTSTAMP:20221031T130053Z URL:https://biology.technion.ac.il/en/seminars/phd-graduate-seminar/ SUMMARY:PhD Graduate Seminar-Matan Yampolsky [No Categories] DESCRIPTION:Location: hybrid- in the Faculty Auditorium/ZOOM: https://techn ion.zoom.us/j/9849342142 Matan Yampolsky\n Affiliation: \n Host: Dr. Yaro n Fuchs and Associate Prof. Shalom-Feuerste Ruby \n Adult stem cells (SCs) are tissue-specific resident cells that serve to replenish and maintain t he tissue. Two significant SC populations co-exist in the hair follicle: h air follicle SCs (HFSCs) and melanocytes SCs (McSCs). These populations ar e localized to the lower part of the follicle during the resting phase. Up on hair cycle activation these SCs divide generating differentiated progen itors for hair construction and pigmentation. As long-lived cells\, SCs ar e exposed to environmental stress for long periods of time. Therefore\, th ey are equipped with pro-survival mechanisms which prevent their loss by c ell death processes\, primarily via apoptosis. While the anti-apoptotic na ture of HFSCs has been previously investigated\, very little is known rega rding apoptotic regulation in McSCs.\n\nWe found that chemical inhibition of apoptotic related proteins in vivo result in the rapid elimination of M cSCs\, leading to irreversible coat-depigmentation (whitening). Interestin gly\, local damage to HFSCs niche by hair depilation acquire McSCs with re sistance to cell death. Furthermore\, we found that hair depilation induce s release of pro-survival factors that enhance McSC resistance to cell dea th. These findings pave the way for therapeutic approaches for pigmentatio n disorders that originate from McSC-pool depletion. LOCATION:hybrid- in the Faculty Auditorium/ZOOM: https://technion.zoom.us/j /9849342142 END:VEVENT BEGIN:VEVENT UID:1125@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20221024T130000 DTEND;TZID=Asia/Jerusalem:20221024T130000 DTSTAMP:20221011T072435Z URL:https://biology.technion.ac.il/en/seminars/ori-avinoam/ SUMMARY:Ori Avinoam - Department of Biomolecular Sciences\, Weizmann Instit ute of Science [No Categories] DESCRIPTION:Location: Faculty of Biology Auditorium Ori Avinoam\n Affiliat ion: Department of Biomolecular Sciences\, Weizmann Institute of Science\n Host:Sagi Levy and Benjamin Podbilewicz \n Exocytosis by membrane crumpl ing maintains homeostasis during exocrine secretion\n\nDynamic membrane re modeling is essential for life. Cells\, organelles\, and vesicles must con stantly acquire\, maintain and modify their shape and composition to fulfi ll a plethora of important physiological functions ranging from neuronal t ransmission to fertilization and muscle contraction. My lab focuses on elu cidating the membrane remodeling pathways that mediate the trafficking of material and information in and between cells. These include endocytosis\, exocytosis\, extracellular-vesicles\, and cell-to-cell fusion. We are com mitted to gaining previously inaccessible insights into the molecular mech anisms and physiological functions of membrane remodeling in the context o f tissue morphogenesis and homeostasis. To this end\, we take an interdisc iplinary approach combining the strengths of biochemistry\, genetics\, and multimodal imaging\, including the development of three-dimensional corre lative light and electron microscopy (CLEM) approaches. We apply these sta te-of-the-art techniques to a variety of cell culture and in vivo models\, including flies and mice\, to pursue several major research directions\, which include membrane remodeling during exocytosis of large secretory ves icles and differentiation and fusion of vertebrate skeletal muscles. These systems offer the unique opportunity to understand how membrane remodelin g processes adapt to the changing demands of cellular life and the life of the organism. LOCATION:Faculty of Biology Auditorium END:VEVENT BEGIN:VEVENT UID:1123@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20221023T100000 DTEND;TZID=Asia/Jerusalem:20221023T150000 DTSTAMP:20220929T075545Z URL:https://biology.technion.ac.il/en/seminars/danny-zilberstein70-symposi a/ SUMMARY:Danny Zilberstein@70 symposia: Celebrting Dan Zilberstein's 35 year s of Science [No Categories] DESCRIPTION:Location: Faculty of Biology Auditorium\, Technion-Israel Insti tute of Technology Michael Boshart (Genetics - Biocenter LMU\, München)\ , Shula Michaeli (Bar-Ilan University)\, Peter Myler (Seattle Children's R esearch Institute)\, Michal Shapira (Ben-Gurion University)\n Affiliation: \n Host:\n 10:00-10:30 - Gathering\, coffee\, and cakes\n10:30-10:40 - Op ening Remarks\, Faculty Dean Yael Mandel Gutfreund\n10:40-10:50 – Introd uction\, Yoram Reiter\n10:50-11:20 - Michael Boshart\, Genetics - Biocente r LMU\, München\nProtein Kinase A and cyclic nucleotide signaling in kine toplastids\n11:20-11-50 - Shula Michaeli\, Bar-Ilan University\nNon-coding RNAs and EpiRNomics regulate the developmental cycle in trypanosomatids.\ n11:50-12:20 - Peter Myler\, Seattle Children's Research Institute\nSystem s biology of Leishmania differentiation\n12:20-12:50 - Michal Shapira\, Be n-Gurion University\nThe fascinating genome of Leishmania and its translat ion machinery.\n12:50-13:50 - Lunch\n13:50-15:00 - Family\, Friends\, Facu lty\, Memories LOCATION:Faculty of Biology Auditorium\, Technion-Israel Institute of Techn ology END:VEVENT BEGIN:VEVENT UID:1124@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20221018T130000 DTEND;TZID=Asia/Jerusalem:20221018T140000 DTSTAMP:20220929T102024Z URL:https://biology.technion.ac.il/en/seminars/phd-graduate-seminar-of-mor -cohen-harel-meiri-lab/ SUMMARY:PhD Graduate Seminar of Mor Cohen-Harel (Meiri Lab) [No Categories] DESCRIPTION:Location: hybrid- in the Faculty Auditorium/ZOOM: https://techn ion.zoom.us/j/98617011894 Mor Cohen-Harel (Meiri Lab)\n Affiliation: \n H ost:\n "The Antitumor Effects of Cannabinoids in Glioblastoma Multiforme"\ nGlioblastoma multiforme is an aggressive brain tumor whose current treatm ents are insufficient due to its high invasiveness and heterogeneity\, rap id growth and acquired therapy resistance. There is a great need to develo p therapeutics that overcome this resistance and improve the treatment. So me studies have shown that the major cannabinoids from the Cannabis plant\ , Δ9-tetrahydrocannabinol (Δ9-THC) and Cannabidiol (CBD)\, can improve g lioblastoma cell response to radiation and chemotherapy\, and moreover\, d irectly affect tumor growth and cell viability.\nAs our lab routinely char acterizes over 140 phytocannabinoids that exist in cannabis extracts in ad dition to THC and CBD\, this research focused on discovering phytocannabin oids with antitumor effects on glioblastoma and understanding their mechan ism of action. We studied each extract's properties\, recognized the minim al effective concentration that induces cell death in glioblastoma and def ined the most effective cannabis extract.\nWe examined the combination of this extract with Bortezomib (BTZ)\, a proteasome inhibitor currently used as a second-line treatment in glioblastoma\, and demonstrated a stronger and more rapid apoptotic response\, in an additive manner.\nFrom this effe ctive extract\, we isolated and identified Cannabigerol (CBG) as the essen tial cannabinoid for inducing glioblastoma programmed cell death. CBG show ed great potency also as a single treatment when used in a high dose. We f ound that CBG targets glioblastoma via the CB1 receptor of the endocannabi noid system. It's signaling pathway involves a significant upregulation of the transcription factor EGR1\, which leads to an increase in multiple do wnstream apoptotic markers and directs the cell to apoptosis. We were able to demonstrate that CBG works in a similar manner also in an in-vivo mice model. Therefore\, we believe that CBG is a promising therapeutic candida te that may be used\, alone or in a combination with BTZ\, in the treatmen t of glioblastoma patients. LOCATION:hybrid- in the Faculty Auditorium/ZOOM: https://technion.zoom.us/j /98617011894 END:VEVENT BEGIN:VEVENT UID:1122@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20220913T133000 DTEND;TZID=Asia/Jerusalem:20220913T140000 DTSTAMP:20220906T065847Z URL:https://biology.technion.ac.il/en/seminars/msc-graduate-seminar/ SUMMARY:MSc Graduate Seminar [No Categories] DESCRIPTION:Location: hybrid- in the Faculty Auditorium/ZOOM \n Affiliatio n: \n Host:\n What mechanism protects the heart from fasting-induced atrop hy?\n\nSkeletal muscles atrophy upon systemic fasting\, when blood glucose and insulin levels are low. However\, the heart is relatively protected\, and atrophy to a much lesser extent than skeletal muscles. We demonstrate that despite the low levels of circulating insulin\, insulin-PI3K-AKT sig naling is enhanced in the heart and promotes basal rates of protein synthe sis. The activation of this pathway reduces degradation of myofibrillar an d soluble proteins\, enabling preservation of cardiac muscle mass. Consist ently\, chemical labeling of cellular proteins followed by mass spectromet ry analysis indicated that proteasome and ribosome subunits are reduced in amounts. Maintenance of insulin-PI3K-AKT activity is critical for protect ing the heart from atrophy\, and the underlying mechanisms appear independ ent from the ligand insulin.\n\nZOOM Link: https://technion.zoom.us/j/947 09397738 LOCATION:hybrid- in the Faculty Auditorium/ZOOM END:VEVENT BEGIN:VEVENT UID:1121@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20220913T130000 DTEND;TZID=Asia/Jerusalem:20220913T133000 DTSTAMP:20220906T065214Z URL:https://biology.technion.ac.il/en/seminars/msc-graduate-seminar-leo-na uman/ SUMMARY:MSc Graduate Seminar- Leo Nauman [No Categories] DESCRIPTION:Location: hybrid- in the Faculty Auditorium/ZOOM Leo Nauman\n Affiliation: \n Host:\n Revealing Hormone-Mediated Tissue-Specific Nuclear Proteome and Signaling Output in the Meristem\n\nOur lab seeks to underst and the principles underlying developmental programs in plants. Using root s as a model organ\, we ask for example\, how growth is coordinated among cells at different developmental stages\, from the stem cells and division stage to differentiation. In the past decade\, it has become clear that t he steroid hormone brassinosteroid (BR) signaling pathway plays an importa nt role in these processes. Moreover\, we establish that their regulatory effect occurs in a cell-specific and non-autonomous manner. However\, curr ent research regarding the precise manner of tissue-specific BR signaling is lacking and forms the basis of our research – how do different cells respond to BR and produce a tissue-specific response? To address this ques tion\, we have employed two methods\, considering both the input and the o utput levels (i.e.\, the signaling pathway and the transcriptional outcome \, respectively). On the input level\, we seek to employ a BioID-based sys tem\, whose calibration is underway\, to detect tissue-specific interactin g partners along the BR signaling pathway. On the output level\, we sought to develop synthetic fluorescent markers\, to monitor the transcriptional response to BR via live imaging. Current results will be presented and di scussed.\n\nZoom Link:  https://technion.zoom.us/j/94709397738  LOCATION:hybrid- in the Faculty Auditorium/ZOOM END:VEVENT BEGIN:VEVENT UID:1120@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20220907T130000 DTEND;TZID=Asia/Jerusalem:20220907T133000 DTSTAMP:20220906T064705Z URL:https://biology.technion.ac.il/en/seminars/msc-graduate-seminar-amitai -friedman/ SUMMARY:Msc Graduate Seminar-Amitai Friedman [No Categories] DESCRIPTION:Location: hybrid- in the Faculty Auditorium/ZOOM Amitai Fried man\n Affiliation: \n Host:\n The Effect of Cannabinoids on Microglial Pha gocytosis of Amyloid-beta: Implications for Alzheimer’s Disease\n\nDurin g the progression of the neurodegenerative Alzheimer’s disease\, amyloid -β peptides accumulate in the brain to form toxic plaques. As neurotoxici ty rises\, microglia cells\, the resident macrophages of the brain\, are i nhibited in their ability to efficiently clear these amyloid plaques. Phyt ocannabinoids\, specialized metabolites found in the Cannabis plant\, are known to effect various functions of microglia cells. In this presented th esis\, we evaluated and investigated the ability of Cannabis extracts and specific phytocannabinoids to increase microglial phagocytosis of amyloid- β.\n\nhybrid- in the Faculty Auditorium/ZOOM: https://technion.zoom.us/j /94380183367 LOCATION: hybrid- in the Faculty Auditorium/ZOOM END:VEVENT BEGIN:VEVENT UID:1119@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20220906T130000 DTEND;TZID=Asia/Jerusalem:20220906T130000 DTSTAMP:20220906T063724Z URL:https://biology.technion.ac.il/en/seminars/special-faculty-seminar-dr- stefano-recanatesi/ SUMMARY:Special Faculty Seminar: Dr. Stefano Recanatesi [No Categories] DESCRIPTION:Location: Biology auditorium Dr. Stefano Recanatesi \n Affilia tion: The Center for Computational Neuroscience and Swartz Center for Theo retical Neuroscience at the University of Washington\, Seattle.\n Host:Pro f. Benjamin Podbilewicz\n Title: Linking learning to behaviour via neural representation geometry.\n\nAbstract: Recent developments in experimental neuroscience enable us to simultaneously record the activity of a large nu mber of neurons and to target specific components of neural circuits with genetic techniques. These methods pave the way to a deeper understanding o f how the brain's collective dynamics instantiate learning and behaviour. Obtaining such a conceptual understanding from large\, high-dimensional ne ural datasets\, however\, requires concurrent advances in theoretically dr iven circuit modelling. By examining network mechanisms that underlie the emergence of complex behaviour\, I will show that neural representation ge ometry may be the key approach to tying animal behaviour and learning to c ircuit mechanisms. I will demonstrate how neural activity from cortical ar eas unfolds through temporal sequences of neural states organized in behav ioural plans or episodes. Then\, I will illustrate how these neural repres entations in premotor areas drive the generation of actions\, allowing us to predict the intention to act. Finally\, I will investigate how key geom etrical aspects of these representations emerge\, de novo\, as a result of learning to predict upcoming sensory experience. Altogether\, I will show how both learning mechanisms and behavioural demands shape the geometry o f neural representations. I will build these results by using theoretical and computational techniques that combine dynamical systems\, machine lear ning\, and statistical physics approaches. LOCATION:Biology auditorium END:VEVENT BEGIN:VEVENT UID:1113@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20220830T130000 DTEND;TZID=Asia/Jerusalem:20220830T133000 DTSTAMP:20220818T115014Z URL:https://biology.technion.ac.il/en/seminars/msc-graduate-seminar-eden-s adaka/ SUMMARY:MSc Graduate Seminar-Eden Sadaka [No Categories] DESCRIPTION:Location: \n Affiliation: \n Host:\n Programmed Cell Death Re gulatesSebaceous Gland Homeostasis and Pathology\n\n \;\n\nIn the past decade\, most studies investigating mammalian skin havefocused on the epi dermis and the hair follicle\, whereas much less is knownregarding the seb aceous gland (SG). Specifically\, the modes of programmed celldeath contri buting to the homeostasis of SG cells remains uncharacterized.Interestingl y\, morphological changes of the SG cells display characteristicsincluding cell swelling\, loss of cell membrane integrity and lack of nuclearchroma tin as represent in necrotic cells. Here\, we report that key necroptoticp roteins pMLKL and pRIPK3 are highly expressed in the mature and necrotic z onesof the SG. Additionally\, we demonstrate a significant effect on SG ar ea withrespect to cell number and sebum production after exogenous activat ion orinhibition of necroptosis\, indicating an important homeostatic role . ​Furtherunderstanding of these critical processes will not only enable development ofnew approaches for modeling SG dysregulation and identifica tion of therapeutictargets\, but also establishment of novel platforms for investigatingnecroptosis. END:VEVENT BEGIN:VEVENT UID:1112@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20220823T130000 DTEND;TZID=Asia/Jerusalem:20220823T140000 DTSTAMP:20220818T114910Z URL:https://biology.technion.ac.il/en/seminars/phd-graduate-seminar-roi-an kawa/ SUMMARY:PhD Graduate Seminar-Roi Ankawa [No Categories] DESCRIPTION:Location: \n Affiliation: \n Host:\n Apoptoticcells represent a dynamic stem cell niche governing proliferation and tissueregeneration\ n\n \n\nSummery\n\nStem cells (SCs) play a key role inhomeostasis and rep air. While many studies have focused on SC self-renewal anddifferentiation \, little is known regarding the molecular mechanism regulatingSC eliminat ion and compensation upon loss. Here\, we report that Caspase-9deletion in hair follicle SCs (HFSCs) attenuates the apoptotic cascade\,resulting in significant temporal delays. Surprisingly\, Casp9-deficient HFSCsaccumulat e high levels of cleaved caspase-3 and are improperly cleared due toan ess ential caspase-3/caspase-9 feedforward loop. These SCs are retained in ana poptotic-engaged state\, serving as mitogenic signaling centers by continu ouslyreleasing Wnt3 and instructing proliferation. Investigating the under lyingmechanism\, we reveal a caspase-3/Dusp8/p38 module responsible for Wn t3induction\, which operates in both normal and Casp9-deleted HFSCs. Notab ly\,Casp9-deleted mice display accelerated wound repair and de novo hair f ollicleregeneration. Taken together\, we demonstrate that apoptotic cells represent adynamic SC niche\, from which emanating signals drive SC prolif eration andtissue regeneration. END:VEVENT BEGIN:VEVENT UID:1111@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20220822T130000 DTEND;TZID=Asia/Jerusalem:20220822T140000 DTSTAMP:20220818T114812Z URL:https://biology.technion.ac.il/en/seminars/phd-graduate-seminar-ofri-l evi/ SUMMARY:PhD Graduate Seminar-Ofri Levi [No Categories] DESCRIPTION:Location: \n Affiliation: \n Host:\n Roles of Aminoacyl tRNA synthetases in mRNA regulation\n\nAminoacyl tRNA synthetases (aaRSs) are a well-studied family of enzymes with a canonical role in charging tRNA wit h specific amino acid. Yet\, these proteins appear to exert non-canonical roles\, including post-transcriptional regulation. We performed a comprehe nsive analysis of mRNAs bound by almost all S. cerevisiae cytosolic aaRSs. Interestingly\, we revealed that aaRSs preferential association with targ et mRNA that contains structure and modification mimicry of their cognate tRNAs. Point mutations that disassemble the anticodon mimic or the modific ation sites decrease aaRSs binding and affect the target mRNA translation. Together\, our results reveal a novel post-transcriptional regulatory mec hanism that exploits structure and modification mimicry to control mRNA tr anslation according to tRNA charging demands END:VEVENT BEGIN:VEVENT UID:1114@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20220815T130000 DTEND;TZID=Asia/Jerusalem:20220815T133000 DTSTAMP:20220818T115348Z URL:https://biology.technion.ac.il/en/seminars/msc-graduate-seminar-noa-sh imon/ SUMMARY:MSc Graduate Seminar-Noa Shimon [No Categories] DESCRIPTION:Location: \n Affiliation: \n Host:\n Studying the functionals ignificance of RNA editing and duplicated genomic regions in Caenorhabditi selegans\n\nRNAediting is a phenomenon of RNA sequence alteration after tr anscription ineukaryotes. In mammals\, the most common alterations studied are -Adenosine-to-Inosine (A-to-I editing) and Cytidine-to-Uridine (C-to- U editing).A-to-I RNA editing is catalyzed by the conserved ADAR (Adenosin e Deaminasesthat Act on RNA) members on dsRNAs. To date\, in C. elegans\, only thistype of editing has been demonstrated. The second alteration – C-to-U editing-is known to be catalyzed by the APOBEC (ApolipoProtein B mR NA Editing enzyme\,Catalytic polypeptide) family in mammals within ssDNA a nd RNA. Our lab hasrecently found that the protein-coding gene with an unk nown function ZK287.1(termed abec-1) in C. elegans is homologous to the hu man APOBECfamily\, both in sequence and structure. Therefore\, we looked f or C-to-U editingin the nematode. We could not detect C-to-U RNA editing a nd have indicationsthat C-to-U editing on DNA does not occur as well. Howe ver\, in worms lackingZK287.1\, we observed expression and editing changes in A-to-I edited genes\,indicating a possible function of ZK287.1 on A-to -I RNA editing process.\n\nWe alsostudied how wide the gene duplication ph enomena is in C. elegans and itspurpose. Therefore\, we built a computatio nal pipeline to identify duplications.We found 242 different genes or pseu dogenes that have duplications\, identicalin sequence. We hypothesized tha t the duplicated pairs regulate the expressionof each other via the genera tion of dsRNA\, whichis recognized by the RNAi pathway and A-to-I RNA edit ing. Studying A-to-I RNAediting\, we found that 24% of the genes with du plications are edited\,which is highly significant. Furthermore\, our anal ysis of siRNA-sequencing dataof wildtype C. elegans worms and ADAR mutan t worms (adr-1(tm668) I\; adr-2 (ok735) III)\, at two different deve lopmental stages\,revealed that siRNAs targeting the genes with duplicatio ns are significantlyupregulated in the ADAR mutant worms\, similarly to th e pattern exhibitedby A-to-I edited genes. Surprisingly\, our analyses of RNA-sequencing dataof the same worm strains did not detect downregulation of the genes withduplications\, as observed in edited genes. Thus\, possi bly duplicated genes aretargeted by ADAR proteins\; however\, we still do not know if this editingaffects the regulation of expression or function a nd how.\n\n \n\n \n\n 13 END:VEVENT BEGIN:VEVENT UID:1115@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20220809T133000 DTEND;TZID=Asia/Jerusalem:20220809T140000 DTSTAMP:20220818T115511Z URL:https://biology.technion.ac.il/en/seminars/msc-graduate-seminar-anas-k abaha/ SUMMARY:MSc Graduate Seminar-Anas Kabaha [No Categories] DESCRIPTION:Location: \n Affiliation: \n Host:\n Shape readout by the tra nscription factor ETS1 of its RE's\n\n \;\n\nTranscription in eukaryot es is under the control oftranscription factors (TFs) binding to specific DNA binding sites. ETS proteinsare a family of general TFs that have a con served DNA binding domain. The ETS1protein regulates the expression of sev eral genes related to differentiation\,cell growth\, and cancer developmen t. The ETS1 conserved DNA binding domaincontacts the major groove of the D NA double helix at the 5'-GGA/T-3' core DNAmotif through its helix-turn-he lix. Extensive studies show a direct interactionbetween ETS1 protein and t he DNA double helix\, but there is no data to show howETS1 can differentia te between its multitude of specific DNA binding sites.This research aims therefore to study the global structural and dynamicproperties of consensu s-like ETS1 REs\, to assess their role in ETS1/DNA interaction.In addition \, this study probed the ability of ETS1 to bend the DNA doublehelix\, as there are conflicting studies on this question. Both aims werestudied usin g the cyclization kinetics of the DNA mini-circles method\, a methodknown to be able to quantify global aspects of DNA structure and dynamics in ari gorous manner. END:VEVENT BEGIN:VEVENT UID:1116@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20220809T130000 DTEND;TZID=Asia/Jerusalem:20220809T133000 DTSTAMP:20220818T115606Z URL:https://biology.technion.ac.il/en/seminars/msc-graduate-seminar-nitzan -goldberger/ SUMMARY:MSc Graduate Seminar-Nitzan Goldberger [No Categories] DESCRIPTION:Location: \n Affiliation: \n Host:\n Research subject:\n\nThe role of caspase-9 in hairfollicle stem cells.\n\nSummary:\n\nProgramed ce ll death(PCD) serves many important functions in mammalian development and tissuehomeostasis. These include shaping tissue morphology during organog enesis and eliminatingaberrant cells within the adult organism. Given thei r capacity forself-renewal and differentiation into various cell types\, i t is unsurprisingthat stem cells (SCs) have been demonstrated to utilize P CD in the form ofapoptosis for maintenance of homeostasis and tissue repai r in the adultorganism. Recently\, new insights regarding the unique mecha nism that instructselimination of these cells have been found. In our rese arch\, we examine theapoptotic machinery in the hair follicle\, which hous es a multitude of distinct stemcell populations\, and how this in turn aff ects the environment. We foundthat deletion of Caspase-9 (Casp9) in hair f ollicle stemcells attenuates the apoptotic cascade\, resulting in signific ant temporaldelays that prevent cells from being rapidly cleared. As a res ult\, Casp9-deletedcells become mitogenic and secrete Wnt3 to the environm ent via acaspase-3/Dusp8/p38 pathway.\n\nThe seminar will be given inEngli sh END:VEVENT BEGIN:VEVENT UID:1117@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20220802T130000 DTEND;TZID=Asia/Jerusalem:20220802T140000 DTSTAMP:20220818T115705Z URL:https://biology.technion.ac.il/en/seminars/phd-graduate-seminar-jessy- safieh/ SUMMARY:PhD Graduate Seminar-Jessy Safieh [No Categories] DESCRIPTION:Location: \n Affiliation: \n Host:\n  \;\n\nThe mechanist ic origin of p53 selectivity and functionalityOne of the master transcript ional regulation hubs of every human cell is the transcription factor (TF) p53 protein. p53 is activated in response to cellular stress\, and is inv olved in the regulation of many cellular outcomes. To initiate transcripti on of downstream genes\, p53 binds in a sequence-specific manner to many s ites on the genome\, called response elements (REs). Even after almost 40 years of intensive research in the field of p53\, the fundamental question concerning how p53 activates its p53-dependent genes in response to the s everity of the stress signal and consequently coordinates the functional o utcome in a timely manner is still poorly understood. In this research\, w e showed that p53-dependent functional outcome groups can be differentiate d by their RE flexibility. p53-dependent genes belonging to pathways activ ated early upon stress (e.g. DNA damage response) contain REs that are mor e flexible than REs of genes involved in pathways that are likely to be mo re strictly regulated\, or that should occur at late stages in the respons e to stress (e.g. intrinsic apoptosis\, p53 negative regulation). Moreover \, based on data of chosen REs\, genes that are part of outcome categories in which a response is needed immediately\, timewise\, have REs that are capable of transactivating the genes at a faster rate and at low levels of p53\, because they are flexible. Thus\, the flexibility of p53 RE contrib utes to the time-wise expression of p53 target genes and thereby plays a k ey role in cell-faith decisions in the p53 circuity. In addition\, we have indications\, using SELEX-seq technique\, that the mechanistic source of selectivity in p53/REs interactions is encoded in the kinetic of p53/REs i nteractions\, rather than in the thermodynamics of the interaction. END:VEVENT BEGIN:VEVENT UID:1171@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20220802T130000 DTEND;TZID=Asia/Jerusalem:20220802T140000 DTSTAMP:20230424T094239Z URL:https://biology.technion.ac.il/en/seminars/phd-graduate-seminar-jessy- safieh-2/ SUMMARY:PhD Graduate Seminar- Jessy Safieh [No Categories] DESCRIPTION:Location: Faculty Of Biology Auditorium \n Affiliation: \n Hos t:Associate Prof. Haran Tali \n  \;\n\nOne of the master transcription al regulation hubs of every human cell is the transcription factor (TF) p5 3 protein. p53 is activated in response to cellular stress\, and is involv ed in the regulation of many cellular outcomes. To initiate transcription of downstream genes\, p53 binds in a sequence-specific manner to many site s on the genome\, called response elements (REs). Even after almost 40 yea rs of intensive research in the field of p53\, the fundamental question co ncerning how p53 activates its p53-dependent genes in response to the seve rity of the stress signal and consequently coordinates the functional outc ome in a timely manner is still poorly understood.\n\n \;\n\nIn this r esearch\, we showed that p53-dependent functional outcome groups can be di fferentiated by their RE flexibility. p53-dependent genes belonging to pat hways activated early upon stress (e.g. DNA damage response) contain REs t hat are more flexible than REs of genes involved in pathways that are like ly to be more strictly regulated\, or that should occur at late stages in the response to stress (e.g. intrinsic apoptosis\, p53 negative regulation ). Moreover\, based on data of chosen REs\, genes that are part of outcome categories in which a response is needed immediately\, timewise\, have RE s that are capable of transactivating the genes at a faster rate and at lo w levels of p53\, because they are flexible. Thus\, the flexibility of p53 RE contributes to the time-wise expression of p53 target genes and thereb y plays a key role in cell-faith decisions in the p53 circuity.\n\n \; \n\nIn addition\, we have indications\, using SELEX-seq technique\, that t he mechanistic source of selectivity in p53/REs interactions is encoded in the kinetic of p53/REs interactions\, rather than in the thermodynamics o f the interaction. LOCATION:Faculty Of Biology Auditorium END:VEVENT BEGIN:VEVENT UID:1094@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20220726T133000 DTEND;TZID=Asia/Jerusalem:20220726T140000 DTSTAMP:20220713T072620Z URL:https://biology.technion.ac.il/en/seminars/m-sc-graduate-seminar-yuval -ben-eliahu/ SUMMARY:M.Sc. Graduate Seminar-Yuval Ben Eliahu [No Categories] DESCRIPTION:Location: \n Affiliation: \n Host:\n  “CRISPRscreen to ide ntify lncRNA genes critical for SARS-CoV-2 infection” Coronavirus disea se(COVID-19) is caused by the infection of Severe Acute Respiratory Syndro meCoronavirus 2 (SARS-CoV-2). The viral entry into host cells is mediated by aSpike glycoprotein\, which binds to the cell surface receptorangiotens in-converting enzyme 2 (ACE2). Long non-coding RNAs (lncRNA) are thelarges t and most diverse group of non-coding genes in the human genome and weres hown to regulate a variety of cellular functions. Whereas coding genes cru cialfor SARS-Cov2 infection have been identified\, lncRNAs that mediate th einfection remain elusive. Our research objective is to perform a CRISPR s creenof functional lncRNAs critical for SARS-CoV-2 infection.   END:VEVENT BEGIN:VEVENT UID:1093@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20220726T130000 DTEND;TZID=Asia/Jerusalem:20220726T133000 DTSTAMP:20220713T072620Z URL:https://biology.technion.ac.il/en/seminars/m-sc-graduate-seminar-susie -altalef-mishaan/ SUMMARY:M.Sc. Graduate Seminar-Susie Altalef Mishaan [No Categories] DESCRIPTION:Location: \n Affiliation: \n Host:\n  Throughoutthe last num ber of years\, the non-protein-coding portion of the human genomehas gone from being considered “junk DNA” to “hot spots” in the area of lif escience. Genome-wide transcriptome studies indicate that this portion cov ers75-90% of the genome\, whereas only 2% of the human genome comprisespro tein-coding genes. The non-protein-coding areas in the genome generatenon -coding RNAs (ncRNAs) that are subsequently divided according to theirfunc tion and size. In the human genome\, the majority of these ncRNAs areclass ified as long non-coding RNAs (lncRNAs)\, transcripts of more than 200nucl eotides that are not translated into proteins. lncRNAs have been foundto be involved in many biological processes\, such as in chromatinmodificatio ns. Despite their apparent importance\, only a handful oflncRNAs have bee n discovered and characterized\; their function and mechanismsof action re main elusive. My research objective was to identify andcharacterize lncRNA s\, especially those that are hypothesized to be functionaland work in a s equence-specific trans-regulating manner.  END:VEVENT BEGIN:VEVENT UID:1102@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20220704T130000 DTEND;TZID=Asia/Jerusalem:20220704T140000 DTSTAMP:20220713T072650Z URL:https://biology.technion.ac.il/en/seminars/martin-akerman-learn-about- great-options-in-the-industry-in-the-interface-between-biology-and-compute r-science/ SUMMARY:Martin Akerman-"learn about great options in the industry in the in terface between biology and computer science" [No Categories] DESCRIPTION:Location: \n Affiliation: \n Host:\n Learn about great option s in the industry at the interface of biologyand computer science Martin Akerman is a Technion Alumni who completed his undergraduate and  PhD at the Faculty of Biology. He isthe co-founder and CTO of Envisagenics\, an A rtificial Intelligence-drivenbiotechnology company based in New York\, tha t focuses onthe discovery of new drug targets for RNA therapeutics and imm unotherapies.  Envisagenics’ principal technologyis the SpliceCore® di scovery platform\, that applies machine learning algorithmsto RNA-seq data \, to uncover new treatments forneurodegeneration and cancer. In his pres entation\, Martin will discuss how his company partners withbiopharmaceuti cal companies and academic institutions to advance their drugdiscovery cap abilities. He will discuss the role that machine learning plays in today ’s  biopharmaindustry and Envisagenics’ approach to produce actionabl e and  transparent predictions that sparkdrug development collaborations END:VEVENT BEGIN:VEVENT UID:1101@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20220628T130000 DTEND;TZID=Asia/Jerusalem:20220628T140000 DTSTAMP:20220713T072650Z URL:https://biology.technion.ac.il/en/seminars/phd-graduate-seminar-sofia- khazan-kost/ SUMMARY:Phd Graduate Seminar-Sofia Khazan Kost [No Categories] DESCRIPTION:Location: \n Affiliation: \n Host:\n Time: Thursday June 28t h 13:00Place: hybrid- in the Faculty Auditorium/ZOOMhttps://technion.zoom .us/j/97658538324The HLA Peptidome of Lung Cancer: Towards the Development of Personalized ImmunotherapyLung cancer is the leading cause of cancer-re lated death worldwide\, mainly due to late diagnosis\, metastases\, accumu lation of pleural effusions\, and resistance to chemotherapy. Immunotherap y is emerging as a new treatment modality revolutionizing cancer care. How ever\, much progress is still needed for its implementation for lung cance r. Identification of tumor-specific antigens among the HLA peptidome of lu ng cancer may facilitate the development of effective personalized immunot herapy. This research aimed to identify HLA peptides that can be used as t argets or biomarkers for lung cancer. To achieve these goals we analyzed t he HLA peptidome from pleural effusions of lung cancer patients as well as cell lines\, including chemotherapy-resistant cultures. Many of the ident ified putative HLA ligands derived from tumor-associated antigens and mult i-drug resistance proteins. Such peptides are candidate targets for person alized immunotherapy and biomarkers. Importantly\, the immunogenicity of s elected peptides was demonstrated with T cells of a healthy donor\, indica ting a potential value of this approach for future clinical implementation . END:VEVENT BEGIN:VEVENT UID:1084@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20220627T130000 DTEND;TZID=Asia/Jerusalem:20220627T140000 DTSTAMP:20220713T072650Z URL:https://biology.technion.ac.il/en/seminars/prof-shalev-itzkovitz-depar tment-of-molecular-cell-biology-weizmann-institute-of-science/ SUMMARY:Prof. Shalev Itzkovitz\, Department of Molecular Cell Biology\, Wei zmann Institute of Science [No Categories] DESCRIPTION:Location: \n Affiliation: \n Host:\n Title: Spatial transcri ptomics ofmammalian tissuesAbstract: Mammaliantissues are composed of rep eating anatomical units that are polarized bymorphogens or directional blo od flow. As a result\, cells at different tissuecoordinates sub-specialize in distinct physiological functions\, a phenomenontermed ‘zonation’. I will describe approaches based on single cell RNAsequencing\, single mol ecule transcript imaging and spatial transcriptomics tocharacterize zonati on in the key metabolic organs – the liver and intestine. Iwill discuss emerging design principles that facilitate optimal organ functionthrough s patial division of labor. I will also describe the impact of zonationon di verse pathological states. Host: Sagi Levy END:VEVENT BEGIN:VEVENT UID:1083@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20220620T130000 DTEND;TZID=Asia/Jerusalem:20220620T140000 DTSTAMP:20220713T072650Z URL:https://biology.technion.ac.il/en/seminars/prof-ronny-helmanfaculty-of -agriculture-food-and-environment-the-hebrew-university-of-jerusalem/ SUMMARY:Prof. Nissan Yissachar\, The Mina and Everard Goodman Faculty of Li fe Sciences Bar-Ilan Institute of Nanotechnology and Advanced Materials Th e Gonda Multidisciplinary Brain Research Center Bar-Ilan University\, Isr ael [No Categories] DESCRIPTION:Location: \n Affiliation: \n Host:\n Title: Thinking outside the mouse: ex-vivo dissections of host-microbiome cross-talksKey points:  ·        We developed a novel 3D gut organ culture system\, as a uniquetool for studying host-microbiome interactions.·        Ent eric neuro-immune-microbiome cross-talks control regulatoryand effector T- cells development.·        The gut organ culture system provides insights into thefunctional consequences of microbial dysbiosis in mice an d humans. ·        Development of a novel ‘on-chip gut permeabi lity assay’\, for trackingreal-time changes in gut permeability.·         Dysbiotic\, chemotherapy-disrupted microbiome alters gutpermeabi lity\, suggesting that barrier-modulating microbes may promotechemotherapy -induced gastrointestinal inflammation. Host: Sagi Levy END:VEVENT BEGIN:VEVENT UID:1082@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20220613T130000 DTEND;TZID=Asia/Jerusalem:20220613T140000 DTSTAMP:20220713T072650Z URL:https://biology.technion.ac.il/en/seminars/prof-yonatan-stelzer-depart ment-of-molecular-cell-biology-weizmann-institute-of-science/ SUMMARY:Prof. Yonatan Stelzer\, Department of Molecular Cell Biology\, Weiz mann Institute of Science [No Categories] DESCRIPTION:Location: \n Affiliation: \n Host:\n Title: Rethinking Mamma lian Embryonic Development: An Integrated View of Epigenetics and Cell Com mitmentAbstract:One of the mostremarkable processes in biology is the deve lopment of a single fertilized egginto a complete multi-cellular embryo wi thin a short time period of rapidgrowth and cellular diversification. Yet\ , how variation is achieved while basicunits (cells) in this system compri se identical genetic information\, representsa deep and fundamental open q uestion in biology. Single-celltechnologies are transforming our ability t o elucidate embryonic cellspecification. We recently generated a time-reso lved transcriptional model ofmouse gastrulation based on single-cell data from over 150 individually isolatedand processed embryos. Since each embry o independently progresses at its ownpace\, toward ultimate convergence at a common outcome\, individual cells makingup each embryo could be placed on a bona fide time continuum. This facilitateda unified flow model that c onsiders continuous\, parallel\, and convergeddifferentiation towards mult iple lineages. Based on the detailed temporalmodel\, we devised a robust e xperimental framework for interpreting embryonicphenotypes resulting from genetic or epigenetic alterations. In this manner\, weutilize individual m ouse chimera embryos to systematically dissect thecell-intrinsic effects o f Tet-mediated DNA demethylation on embryonic cellspecification. We demons trate that interpretation of Tet function is dependenton separating tempor al\, lineage\, and cell-autonomous/inter-cellular effects.Knocking out the three Tet genes (Tet-TKO) in the entire embryo gives rise tomajor gastrul ation defects. But when Tet-TKO cells are allowed to develop in aWT niche\ , they retain differentiation capacity to nearly all embryonic lineages.Th is leads to a revised conceptual framework supporting the notion thatTet-m ediated demethylation is dispensable towards most differentiationprograms\ , but rater involves fine-tuning of gene expression pervasivelythroughout the genome. Our work demonstrates an unbiased approach for definingintrins ic and extrinsic embryonic gene function based on temporaldifferentiation atlases\, and disentangles the intracellular effects of thedemethylation m achinery from its broader tissue-level ramifications. Host: Sagi Levy END:VEVENT BEGIN:VEVENT UID:1081@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20220606T130000 DTEND;TZID=Asia/Jerusalem:20220606T140000 DTSTAMP:20220713T072650Z URL:https://biology.technion.ac.il/en/seminars/prof-inna-slutsky-departmen t-of-physiology-and-pharmacology-school-of-medicine-tel-aviv-university/ SUMMARY:Prof. Inna Slutsky\, Department of Physiology and Pharmacology\, Sc hool of Medicine\, Tel Aviv University [No Categories] DESCRIPTION:Location: \n Affiliation: \n Host:\n Title:Activity Homeostas is in Neural Circuits: From Basic Principles to MalfunctionsAbstract:Maint aining averageactivity level within a set-point range constitutes a fund amentalproperty of central neural circuits. Accumulated evidence suggests that firingrate distributions and their means represent physiological var iables regulatedby homeostatic systems during sleep-wake cycle in central neuralcircuits. While intracellular Ca2+ has long beenhypothesized as a feedback control signal\, the source of Ca2+ andthe molecular machinery enabling network-wide homeostatic responses remainlargely unknown. I will present our experimental framework onidentification of homeostatic regul ators in neural circuits. Next\, I willshow our new results on the molec ular machinery underlying regulation ofactivity set-points and feedback re sponses. Finally\, I will provide an evidenceof state-dependent dysregulat ion of activity set-points at the presymptomaticdisease stage in familial Alzheimer’s models.Host: Sagi Levy END:VEVENT BEGIN:VEVENT UID:1080@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20220530T130000 DTEND;TZID=Asia/Jerusalem:20220530T140000 DTSTAMP:20220713T072650Z URL:https://biology.technion.ac.il/en/seminars/prof-ido-amit-department-of -immunology-weizmann-institute-of-science/ SUMMARY:Prof. Ido Amit\, Department of Immunology\, Weizmann Institute of S cience [No Categories] DESCRIPTION:Location: \n Affiliation: \n Host:\n Title: The power of ONE :Immunology in the age of single cell genomicsAbstract:The immune system i s a complex\, dynamic and plastic networkcomposed of various interacting c ell types that are constantly sensing andresponding to environmental cues. From very early on\, the immunology field hasinvested great efforts to ch aracterize the various immune cell types andelucidate their functions. How ever\, accumulating evidence indicates thatcurrent technologies and classi fication schemes are limited in their ability toaccount for the functional heterogeneity of immune processes. Single cellgenomics hold the potential to revolutionize the way we characterize compleximmune cell assemblies an d study their spatial organization\, dynamics\, clonaldistribution\, pathw ays\, and crosstalk. This emerging field can greatly affectbasic and trans lational research of the immune system. I will discuss howrecent single ce ll genomic studies are changing our perspective of variousimmune related p athologies from cancer to autoimmune disease and neurodegeneration.Finally \, I will consider recent and forthcoming technological and analyticaladva nces in single cell genomics and their huge potential impact on the future of immunology research and immunotherapy.Host: Sagi Levy END:VEVENT BEGIN:VEVENT UID:1100@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20220525T130000 DTEND;TZID=Asia/Jerusalem:20220525T140000 DTSTAMP:20220713T072650Z URL:https://biology.technion.ac.il/en/seminars/prof-teresa-pawlowska-schoo l-of-integrative-plant-scienceplant-pathology-plant-microbe-biology-cornel l-universityusa/ SUMMARY:Prof. Teresa Pawlowska\, School of Integrative Plant Science\,Plant Pathology & Plant-Microbe Biology\, Cornell University\,USA [No Categorie s] DESCRIPTION:Location: \n Affiliation: \n Host:\n Title: Innate immunity infungi: Is regulated cell death involved?Host: Benjamin Horwitz END:VEVENT BEGIN:VEVENT UID:1079@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20220523T130000 DTEND;TZID=Asia/Jerusalem:20220523T140000 DTSTAMP:20220713T072650Z URL:https://biology.technion.ac.il/en/seminars/prof-luca-jovine-department -of-biosciences-and-nutrition-karolinska-institute-sweden/ SUMMARY:Prof. Luca Jovine\, Department of Biosciences and Nutrition\, Karol inska Institute\, Sweden [No Categories] DESCRIPTION:Location: \n Affiliation: \n Host:\n Title: From the Egg to the Kidney… and BackAbstract:Whatconnects the union of gametes at fertil ization\, a fundamental processthat ensures the transmission of genetic ma terial through the generations\, tothe defense against pathogens causing u rinary tractinfection (UTI) — the most common type of non-epidemic bacte rial infection inhumans? In my talk\, I will describe how our work on repr oductive proteins ledus to visualize uromodulin\, the most abundant protei n in human urine\,as well as glycoprotein 2\, a related defense molecule a cting at the level ofour gastrointestinal tract. By integrating cryo-EM\, X-ray crystallography andAlphaFold modeling\, these studies not only shed light on the molecular basis ofUTI prevention\, but also revealed an addit ional layer of complexity invertebrate egg-sperm recognitionHost: Benjamin Podbilewicz END:VEVENT BEGIN:VEVENT UID:1099@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20220517T130000 DTEND;TZID=Asia/Jerusalem:20220517T140000 DTSTAMP:20220713T072650Z URL:https://biology.technion.ac.il/en/seminars/phd-graduate-seminar-yizhaq -engelberg/ SUMMARY:PhD Graduate Seminar-Yizhaq Engelberg [No Categories] DESCRIPTION:Location: \n Affiliation: \n Host:\n Time: Tuesday May 17\, 2 022\, 13:00 PMPlace: Hybrid – The Faculty og Biology AuditoriumZOOM: htt ps://technion.zoom.us/j/91251316715Functional Super Molecular Structures o f Self-assembled ProteinsAntimicrobial peptides are secreted by the innate immune system of almost every organism on this planet. Surprisingly\, man y of them are capable to self-assemble into ordered supramolecular structu res. In this work\, we provided a high- resolution structure of the fibril form of a human derived antimicrobial peptide\, LL3717-29\, and supported the critical role of self-assembly via structure-guided mutational analys is. Based on the findings\, we engineered controllable antimicrobial activ ity via the formation of supramolecular structures sensitive to specific e nvironmental conditions. In a second collaborative project\, we fabricated supramolecular structures of a food derived protein\, to serve as intesti nal delivery system. This system controllably and gradually releases nutra ceuticals compounds.Overall\, we have revealed new properties\, morphologi es\, regulation\, and applications for self-assembled protein systems. END:VEVENT BEGIN:VEVENT UID:1078@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20220516T130000 DTEND;TZID=Asia/Jerusalem:20220516T140000 DTSTAMP:20220713T072650Z URL:https://biology.technion.ac.il/en/seminars/prof-maya-schuldiner-depart ment-of-molecular-genetics-weizmann-institute-of-science/ SUMMARY:Prof. Maya Schuldiner\, Department of Molecular Genetics\, Weizmann Institute of Science [No Categories] DESCRIPTION:Location: \n Affiliation: \n Host:\n Title: New insights int operoxisomes - small organelles with exciting biology and a huge impact on humanhealth.Abstract: Peroxisomes arecentral metabolic organelles whose decreased function gives rise to severe peroxisomaldiseases. It is recentl y becoming clear that beyond such inborn errors ofmetabolism\, that the gr adual deterioration of peroxisomal functions with age as well as small alt erations in peroxisomal functionsdue to gene variants\, contributes also t o multiple and prevalent diseases suchas cancer\, viral infection\, diabet es and neurodegeneration. Despite the clearimportance of peroxisomes in pa thophysiological processes\, the research onperoxisomes is dramatically la gging behind research on other metabolicorganelles such as mitochondria. T his is perhaps due to the misconception thatperoxisomes play only ancillar y or redundant roles with mitochondria. This isfar from true since the maj ority of peroxisomal functions cannot be replaced byother organelles. I wi ll discuss our efforts in the last years tosystematically uncover the pero xisomal proteome and the diversity ofperoxisomal functions.Host: Sagi Levy END:VEVENT BEGIN:VEVENT UID:1077@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20220509T130000 DTEND;TZID=Asia/Jerusalem:20220509T140000 DTSTAMP:20220303T090136Z URL:https://biology.technion.ac.il/en/seminars/prof-asya-rolls-faculty-of- medicine-technion/ SUMMARY:Prof. Asya Rolls\, Faculty of Medicine\, Technion [No Categories] DESCRIPTION:Location: \n Affiliation: \n Host:\n Title: Physiological mec hanisms of brain-body interactions\nHost: Sagi Levy END:VEVENT BEGIN:VEVENT UID:1076@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20220502T130000 DTEND;TZID=Asia/Jerusalem:20220502T140000 DTSTAMP:20220713T072650Z URL:https://biology.technion.ac.il/en/seminars/prof-gali-prag-department-o f-biochemistry-and-molecular-biology-tel-aviv-university/ SUMMARY:Prof. Gali Prag\, Department of Biochemistry and Molecular Biology\ , Tel Aviv University [No Categories] DESCRIPTION:Location: \n Affiliation: \n Host:\n Title: Decoding uniquiti n signalsAbstract:UbiquitinE3-ligases regulate most of the cellular pathwa ys and consequently are tightlyregulated themselves. Several allosteric me chanisms for regulation of HECTE3-ligases that were identified and charact erized in our lab will be presented.Deep structural insights combined with our unique E. coli-based toolsfacilitated the development of compounds th at affect these regulatorymechanisms and opened the door for pharmacologic al intervention. We willdemonstrate the downstream effect of these regulat ions with a spectrum ofsoluble to membrane proteins including the proteaso mal ubiquitin-receptorRpn10\, the endocytic machinery protein Rvs167 (amph iphysin in human)\, the RTKprotein EGFR1 and the heart/brain potassium cha nnel KCNQ1.Host: Sagi Levy END:VEVENT BEGIN:VEVENT UID:1075@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20220425T130000 DTEND;TZID=Asia/Jerusalem:20220425T140000 DTSTAMP:20220303T090136Z URL:https://biology.technion.ac.il/en/seminars/prof-assaf-zinger-faculty-o f-chemical-engineering-technion/ SUMMARY:Prof. Assaf Zinger\, Faculty of Chemical Engineering\, Technion [No Categories] DESCRIPTION:Location: \n Affiliation: \n Host:\n Title: Nano drug deliver y\nHost: Sagi Levy END:VEVENT BEGIN:VEVENT UID:1098@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20220411T143000 DTEND;TZID=Asia/Jerusalem:20220411T153000 DTSTAMP:20220713T072649Z URL:https://biology.technion.ac.il/en/seminars/phd-graduate-seminar-inbar- magid-gold/ SUMMARY:PhD Graduate Seminar-Inbar Magid Gold [No Categories] DESCRIPTION:Location: \n Affiliation: \n Host:\n Title: The regulatory ro le of free ISG15Interferons(IFNs) are a group of cytokinesinduced by viral infection. IFN production leads to a series of protein conformationalrear rangements and interactions as well as production of specific proteins. In terferonStimulated Gene 15 (ISG15) is one protein which is highly induced in responseto IFN production. ISG15 is an abundant ubiquitin-like post-tra nslationmodification that\, similar to Ubiquitin (Ub)\, marks hundreds of cellularproteins following viral or bacterial infections. ISG15’s target s include bothviral proteins and cellular proteins spanning an array of ce llular compartmentsand metabolic pathways. As opposed to Ub\, that is cons umed almost completelyand is hardly present in its free form\, ISG15 can b e found in the cell in twoforms: free ISG15 and as a part of a chain. It i s known that free ISG15 can besecreted and act as a cytokine like protein\ , inducing the IFN pathway of theneighboring cells. In our research\, we f ound a different regulatory role of thefree ISG15. By investigating its bi nding partners\, we found that ISG15 can bindthe transcription factor that enables its production in the first place\, thusacting as autoregulator o f its own level and effect the innate immune responseof the cell.   END:VEVENT BEGIN:VEVENT UID:1074@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20220411T130000 DTEND;TZID=Asia/Jerusalem:20220411T140000 DTSTAMP:20220713T072649Z URL:https://biology.technion.ac.il/en/seminars/prof-naama-barkai-departmen t-of-molecular-genetics-weizmann-institute-of-science/ SUMMARY:Prof. Naama Barkai\, Department of Molecular Genetics\, Weizmann In stitute of Science [No Categories] DESCRIPTION:Location: \n Affiliation: \n Host:\n Title: Howtranscription factors recognize binding sites in large genomes: the role ofintrinsically disordered regions.  Abstract:Transcription factors (TFs) regulate genee xpression by binding DNA sequences recognized by their DNA-binding domains (DBDs).DBD-recognized motifs are short and highly abundant in genomes. Th e ability ofTFs to bind a specific subset of motif-containing sites\, and to do so rapidlyupon activation\, is fundamental for gene expression in al l eukaryotes. Despiteextensive interest\, our understanding of the TF-targ et search process isfragmented\; I will discuss our results which implicat e intrinsically disorderedregions (IDRs) in this process\, and the possibl e implications ofthe 'distributed specificity' paradigm implemented by th ese regions in explainingbinding specificity while reducing the TF-target search time.  END:VEVENT BEGIN:VEVENT UID:1097@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20220407T123000 DTEND;TZID=Asia/Jerusalem:20220407T130000 DTSTAMP:20220713T072649Z URL:https://biology.technion.ac.il/en/seminars/sc-graduate-seminar-jordan- mc-carthy/ SUMMARY:Sc Graduate Seminar- Jordan Mc Carthy [No Categories] DESCRIPTION:Location: \n Affiliation: \n Host:\n Place: hybrid- inthe Fac ulty Auditorium/ZOOM:https://technion.zoom.us/j/93473479861The role of pre gnancy in skin regenerationAbstract: The physiology of mammalian skin chan gesdramatically during pregnancy due to immunological\, metabolic\, and ho rmonalshifts. Estrogens are major regulators of these homeostatic changes and arealso known to affect the hair cycle. We have found that during preg nancy\, hairfollicle stem cells (HFSCs) become active and initiate hair gr owth. This cellcycle entry is dependent upon estrogen signaling. In this s tate\, upon woundinfliction HFSCs vastly contribute to the repair process. Importantly\, we findthat skin repair and hair follicle regeneration is i mproved during pregnancy.Taken together our findings could potentially giv e rise to novel therapeuticavenues for regenerative medicine.  END:VEVENT BEGIN:VEVENT UID:1096@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20220405T143000 DTEND;TZID=Asia/Jerusalem:20220405T153000 DTSTAMP:20220713T072649Z URL:https://biology.technion.ac.il/en/seminars/prof-max-heiman-department- of-genetics-at-harvard-medical-school-and-division-of-genetics-and-genomic s-boston-childrens-hospital-ma/ SUMMARY:Prof. Max Heiman\, Department of Genetics at Harvard Medical School \, and Division of Genetics and Genomics\, Boston Children's Hospital\, MA [No Categories] DESCRIPTION:Location: \n Affiliation: \n Host:\n Title:  Tracking the d evelopment and assembly of single cellsAbstract:  While high-throughput m ethods provide a sweepingbirds-eye view of development\, different insight s can be gained by zooming into study how a single cell develops.  This i s especially true in C.elegans\, where each cell's identity\, morphology\, and connections are highlystereotyped.  Here\, we follow the specificati on and assembly of a singleneuron-glia pair in C. elegans.  First\, we ex amine how someprogenitors escape lineage fate restriction in order to unde rgo convergentdifferentiation\, giving rise to a glial cell type that is i dentical to thatproduced by unrelated lineages.  Second\, we show how a s ingle neuron pairsoff with one of these glial cells by using its cilium to mediate cell-celladhesion. In-depth analysis of individual gene functions in single cellsprovides a counterpoint to the trend towards massive syste ms-level descriptionsof entire cell populations.Host: Sagi Levy END:VEVENT BEGIN:VEVENT UID:1073@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20220404T130000 DTEND;TZID=Asia/Jerusalem:20220404T140000 DTSTAMP:20220713T072649Z URL:https://biology.technion.ac.il/en/seminars/prof-igor-ulitsky-departmen t-of-biological-regulation-weizmann-institute-of-science/ SUMMARY:Prof. Igor Ulitsky\, Department of Biological Regulation\, Weizmann Institute of Science [No Categories] DESCRIPTION:Location: \n Affiliation: \n Host:\n Title: Cis-acting gene r egulationby long noncoding RNAs.  Abstract:It is now clear that many inte rgenic regions in eukaryoticgenomes give rise to a range of processed and regulated transcripts that do notappear to code for functional proteins. A subset of these are long (>200nt)\, capped\, and polyadenylated RNAs tran scribed by RNA polymerase II andcollectively called long noncoding RNAs (l ncRNAs). The recent estimates arethat the human genome may have >50\,000 d istinct lncRNA-producing loci\, manyof which show tissue-specific activity and dysregulation in human disease\,including cancer and neurodegeneratio n.  Giventhe growing number of lncRNAs implicated in human disease or req uired forproper development\, fundamental questions that need to be addres sed are: WhichlncRNAs are functional? How is functional information encode d in the lncRNAsequence? Is this information interpreted in the context of the mature or thenascent RNA? What are the identities and functional role s of specific sequencedomains within lncRNA genes? These are challenging questions\, primarilybecause of the substantial heterogeneity in mechanism s utilized by lncRNAs andthe current paucity of lncRNAs with well-understo od mechanisms. We are tacklingthese questions by combination of experiment al methods with a focus on lncRNAfunctions in early cell fate decisions an d computational methods focused onlncRNA evolution. I will describe our ef forts to decode conserved combinationsof short functional sequence element s in lncRNAs\, with a particular focus onthe Chaserr/Chd2 and Silc1/Sox11 pathways.Host: Sagi Levy END:VEVENT BEGIN:VEVENT UID:1072@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20220328T130000 DTEND;TZID=Asia/Jerusalem:20220328T140000 DTSTAMP:20220713T072649Z URL:https://biology.technion.ac.il/en/seminars/prof-moran-shalev-benami-de partment-of-chemical-and-structural-biology-weizmann-institute-of-science/ SUMMARY:Dr. Moran Shalev-Benami\, Department of Chemical and Structural Bio logy\, Weizmann Institute of Science [No Categories] DESCRIPTION:Location: \n Affiliation: \n Host:\n The ‘Hunger Games’- Structural Studies of the MC4 Receptor Reveal Mechanism for SatietyHost: S agi LevyAbstract: Obesity is aglobal epidemic causing increased morbidity and impaired quality of life. Themelanocortin receptor 4 (MC4R) is at the crux of appetite\, energy homeostasis\,and body-weight control in the cen tral nervous system and is a prime target foranti-obesity drugs. MC4R is a member of the GPCR superfamily and signalsprimarily through the heterotri meric G protein Gs. Throughcombination of structural-\, biochemical- and c ellular- studies we determinedthe cryo-EM structure of the human MC4R-Gs s ignaling complex\, andexplored the cellular conduits for signal transducti on in health and disease.The work reveals the mechanism of MC4R activation \, highlighting a molecularswitch that signals satiation. These results fi ll a major gap in understandingMC4R activation and guide the design of fut ure weight management drugs. END:VEVENT BEGIN:VEVENT UID:1071@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20220322T130000 DTEND;TZID=Asia/Jerusalem:20220322T133000 DTSTAMP:20220713T072649Z URL:https://biology.technion.ac.il/en/seminars/msc-graduate-seminar-oren-m ilman/ SUMMARY:MSc Graduate Seminar- Oren Milman [No Categories] DESCRIPTION:Location: \n Affiliation: \n Host:\n Systematicidentification of gene-altering programmed inversions across the bacterialdomain Progra mmedchromosomal inversions allow bacteria to generate intra-population gen otypicand functional heterogeneity\, a bet-hedging strategy important in c hangingenvironmental challenges\, such as bacteriophages and antibiotic dr ugs. Someprogrammed inversions modify coding sequences\, producing differe nt alleles inseveral gene families\, most notably in specificity-determini ng genes such asphage-tail\, outer-membrane receptors and Type I restricti on-modificationsystems\, where systematic searches revealed cross phylum a bundance. Yet\, abroad systematic search for gene-altering programmed inve rsions\, not guided bypreviously known gene families\, has been absent\, a nd little is known abouttheir prevalence across gene families and their co mmon genomic architectures.Here\, scanning for intra-species variation in genomes of over 35\,000 species\,we develop a predictive model of gene-alt ering inversions\, revealing keyattributes of their genomic architectures\ , including recombinase-proximity andgene-pseudogene size asymmetry. The m odel predicted over 1200 gene-alteringloci covering known gene families as well as Type II restriction-modificationsystems previously not characteri zed for programmed inversions. Publiclyavailable long-read sequencing data sets validated representatives of recurringpredicted inversion-targeted ge ne families\, confirming intra-population geneticheterogeneity\, even with multiple co-existing combinatorial variants inmultiple inversion systems. Together\, these results reveal gene-alteringprogrammed inversions as a k ey strategy adopted across the bacterial domain\,and highlight inversions of Type II restriction-modification systems as apossible new mechanism for maintaining intra-population heterogeneity. END:VEVENT BEGIN:VEVENT UID:1070@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20220321T130000 DTEND;TZID=Asia/Jerusalem:20220321T140000 DTSTAMP:20220713T072649Z URL:https://biology.technion.ac.il/en/seminars/prof-ziv-shulman-department -of-immunology-weizmann-institute-of-science/ SUMMARY:Dr. Ziv Shulman\, Department of Immunology\, Weizmann Institute of Science [No Categories] DESCRIPTION:Location: \n Affiliation: \n Host:\n Title: Anti-tumor antib odies in ovarian cancer patients. Host: Sagi Levy END:VEVENT BEGIN:VEVENT UID:1069@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20220316T130000 DTEND;TZID=Asia/Jerusalem:20220316T140000 DTSTAMP:20220303T090135Z URL:https://biology.technion.ac.il/en/seminars/phd-graduate-seminar-ben-ba r-sade/ SUMMARY:PhD Graduate Seminar-Ben Bar-Sade [No Categories] DESCRIPTION:Location: \n Affiliation: \n Host:\n Underlying mechanisms of re-programingreproduction following early life adversityA high burden of inflammatory diseasewas correlated with later puberty onset and earlier me nopause in a study ofmigrant women\, possibly suggesting an adaptive respo nse to optimizereproductive success. We combined data from that human stud y with anappropriate mouse model to investigate the molecular mechanisms i nvolved inthis response. We found altered DNA methylation and expression l evels ofseveral genes in reproductive tissues\, and showed direct effects of thesealterations on reproductive function. Understanding the molecular eventsinduced by early-life stress and identification these stable epigene tic marksmight be used to help assess a woman’s reproductive status and predict the length of herreproductive lifespan.Time: Tuesday\, March 16\, 2022\, 13:00pm. Place: Hybrid- in the Faculty Auditorium / ZOOM:https://t echnion.zoom.us/j/98476893981 END:VEVENT BEGIN:VEVENT UID:1068@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20220309T133000 DTEND;TZID=Asia/Jerusalem:20220309T140000 DTSTAMP:20220713T072649Z URL:https://biology.technion.ac.il/en/seminars/msc-graduate-seminar-reemy- ali-nasser/ SUMMARY:MSc Graduate Seminar-Reemy Ali Nasser [No Categories] DESCRIPTION:Location: \n Affiliation: \n Host:\n Early-life experiencere- organizes neuromodulatory regulation of developmental patterns of behavior and individuality   Early-life experiences may promote robust and long- lastingbehavioral outputs within populations\, but also patterns of behavi oralresponses that are variable among individuals\, even when initially ex posed tothe same early stimulus. In my project\, I studied how early-life starvationmodifies behavior and inter-individual diversity across developm ent bymonitoring C. elegans individual behaviors continuously throughout a lldevelopmental stages\, at high spatiotemporal resolution and under tight lycontrolled conditions. My results show that early starvation generates d istinctand discontinuous behavioral effects across different life stages. Bothdopamine and serotonin mediate stage-specific behavioral responses to earlystarvation. While serotonin promotes behavioral sensitivity during ea rly andlate stages of development\, dopamine buffers the behavioral respon se viaspecific receptors during intermediate stages. Moreover\, by quantif yinginter-individual behavioral diversity across development within stress ed andnon-stressed populations\, I found that neuromodulators restrict alt erations inindividuality levels by stress. My research reveals that early- life experiencesgenerate complex neuromodulatory regulation of behavioral patterns andindividuality across development.  END:VEVENT BEGIN:VEVENT UID:1067@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20220309T130000 DTEND;TZID=Asia/Jerusalem:20220309T133000 DTSTAMP:20220303T090135Z URL:https://biology.technion.ac.il/en/seminars/msc-graduate-seminar-mai-sh ahwan/ SUMMARY:MSc Graduate Seminar- Mai Shahwan [No Categories] DESCRIPTION:Location: \n Affiliation: \n Host:\n Decipheringthe role of a lanine as a novel metabolic regulator of T cell immunity Abstract:T lymph ocytes survey our body for threats. Under homeostasis\, thesecells rarely proliferate. Upon encountering their cognate antigen and dangersignals\, w ithin hours\, they enter a phase of robust proliferation to generatean arm y of lymphocytes to fight the threat. These rapid changes require reprogr amming the cell’s metabolism. Indeed\,as T cells get activated\, they si multaneously induce multiple anabolic pathwaysto induce biomass production and effector functions. Such metabolicreprogramming relies on extracellul ar pools of precursor nutrients\, includingglucose and amino acids. Even a mino acids that are otherwise considered‘non-essential’. Recently\, we identified alanine as an essential amino acid forT cells during early act ivation. This finding was surprising especially sincealanine is a non-esse ntial amino acid that can be made by a one-step reactionfrom pyruvate\, a product of glycolysis\, one of the most highly induced pathwaysin activate d T cells. In agreement\, we found that glutamate pyruvatetransaminase (GP T)\, the enzyme catalyzing alanine production was not expressedin T cells\ , even when deprived of alanine. We hypothesized that T cellspurposefully suppress GPT expression and rely on extracellular alanine toenable pyruvat e flux into other metabolic pathways. In this study\, we testedthis hypoth esis by overexpressing GPT in primary T cells and examining itseffect on T cells’ metabolism and function. We found that GPT overexpressionrescued growth\, activation\, and proliferation of T cells grown in alanine-depri vedmedia but decreased cell viability.  Furthermore\,GPT overexpression c aused significant changes in cellular metabolic flux andmetabolite concent rations. Future studies will investigate how these metabolicshifts could a ffect T cell functions. END:VEVENT BEGIN:VEVENT UID:1058@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20220202T130000 DTEND;TZID=Asia/Jerusalem:20220202T133000 DTSTAMP:20220214T084943Z URL:https://biology.technion.ac.il/en/seminars/msc-graduate-seminar-lea-re uveni/ SUMMARY:MSC Graduate Seminar-Lea Reuveni [No Categories] DESCRIPTION:Location: \n Affiliation: \n Host:\n The seminar will be give n Hybrid: In the Faculty of Biology Auditorium and in ZOOM:https://technio n.zoom.us/j/98596900607?pwd=UXk4eWk5dmZPOUFuMEl2Q1dCZ2puUT09Meeting ID: 98 5 9690 0607Passcode: 845596.Research Topic:Selection for resistance in ma rine cyanobacteria against generalist and specialist phages END:VEVENT BEGIN:VEVENT UID:1049@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20220131T130000 DTEND;TZID=Asia/Jerusalem:20220131T140000 DTSTAMP:20220117T111324Z URL:https://biology.technion.ac.il/en/seminars/dr-daniel-benhalevy-nationa l-institute-of-arthritis-and-musculoskeletal-and-skin-diseases-nih/ SUMMARY:Dr. Daniel Benhalevy\, National Institute of Arthritis and Musculos keletal and Skin Diseases\, NIH [No Categories] DESCRIPTION:Location: In hybird format: Auditorium + zoom \n Affiliation: \n Host:\n Title: Studying RNA Binding Proteins at Subcellular Resolution to Uncover their Roles in Health and Dysregulation in Disease\n\n\nZoom: https://technion.zoom.us/j/96006672617\n\n\nAbstract: Regulation of gene expression is at the basis of cell function. It is well established how th e multitude of cellular signals is transduced to regulate transcription. I n contrast\, it remains to be defined how signals and cellular pathways ar e wired to factors that regulate gene expression post-transcriptionally (s uch as RNA BindingProteins and noncoding RNAs). This conceptual gap stems from technical challenges but is reflected in the relatively detached fiel ds of RNA biology and cell biology.\n\nI will present concepts learned whi le studying the function of CNBP\, an RNA Binding Protein that is conserve d throughout eukaryotes\, and causative for Myotonic dystrophy type 2. Whi le identifying CNBP function we uncovered the dominant effect of RNAG-quad ruplex structures when they are formed in the cytoplasm (Benhalevy*\,Gupta * et al. Cell Reports\, 2017\, Sauer\, …\, Benhalevyet al. Nature Comm\, 2019). Our more recent analyses hint at a possible mechanism for why CNBP mutations elicit specifically a muscle disease\, but testing our model re quires studying RNA biology at subcellular resolution. I will show why stu dying RNA Binding Proteins at subcellular resolution is often crucial\, an d why it is a challenge. Then I will present novel methodologies I develop ed to study RNA biology at subcellular resolution that overcomes this chal lenge (Benhalevy* et al. Methods\, 2017\, Benhalevyet al. Nature Methods\, 2018\, Benhalevy† and Hafner†\,MiMB\, 2020\, Anastasakis*\, Benhalevy *† etal. CPMB\, 2020\, and unpublished data).\n\nThese results enable me to pursue the following research goals: 1. Applying concrete\, in-depth\, study of RNA regulation at subcellular resolution to infer general concep ts in post-transcriptional gene regulation. In the long run\, these will c ontribute to linking RNA biology with pathways of cellular biology. 2. Dev eloping unprecedented tools to study subcellular RNA biology in uncultured cells with direct applicability to human tissue-derived cells\, and with the intention to expose new aspects of RNA biology in health and disease\n \nHost: Sagi Levy LOCATION:In hybird format: Auditorium + zoom END:VEVENT BEGIN:VEVENT UID:1040@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20220126T130000 DTEND;TZID=Asia/Jerusalem:20220126T140000 DTSTAMP:20220117T111224Z URL:https://biology.technion.ac.il/en/seminars/phd-graduate-seminar-abraha m-rutenberg/ SUMMARY:PhD. Graduate Seminar- Abraham Rutenberg [No Categories] DESCRIPTION:Location: Faculty of Bilogy Auditorium \n Affiliation: \n Host :\n Tcell starvation and nutrient competition at the tumor micro environme nt is considered a major limiting factor in cancer immunotherapy. Metaboli c suppression hampers T cell activation\, differentiation\, and effector f unctions\, leading to T cell anergy and apoptosis\, resulting in tumor esc ape and immunotherapy failure. We propose a novel nanotechnology-based app roach to overcome metabolic T cell suppression: specific feeding of T cell s with nanoparticles encapsulating essential metabolites during the ex-viv o phase of adoptive CAR Tor TIL therapy. This creates an internal cellular reservoir of controlled release nutrients that will support T cell metabo lic requirements upon reaching the nutrient-depleted tumor microenvironmen t. In order to achieve high metabolite loading\, we use a core-shell archi tecture in which we polymerize a nano-meter silica shell on a nano-sized c ore of the desired metabolite obtained by grinding. By controlling the sol -gel synthesis parameters we can tailor shell thickness and porosity and d etermine metabolite release rate and encapsulation efficiency. Our prelimi nary work focuses on L-arginine as a model system – one of the keys most important amino acids for T cell activation depleted at the tumor microen vironment of many cancers. We generate arginine-loaded nanoparticles and d emonstrated arginine-controlled release kinetics. In order to enable T cel l uptake\, we conjugate anti-CD3 antibodies to the nanoparticle surface. F inally\, we demonstrate that arginine starvation leads to inhibition of T cell proliferation\, reduced activation markers expression\, and impaired survival\; while prior feeding of the T cells with arginine-encapsulating nanoparticles partially rescues the activation phenotype. Based on these p reliminary results we propose that feeding T cells with metabolite encapsu lating nanoparticles may potentially relieve metabolic immune suppression in adoptive cell therapies and result in superior CAR T andTIL cancer immu notherapies. LOCATION:Faculty of Bilogy Auditorium END:VEVENT BEGIN:VEVENT UID:1039@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20220124T130000 DTEND;TZID=Asia/Jerusalem:20220124T140000 DTSTAMP:20220117T111454Z URL:https://biology.technion.ac.il/en/seminars/dr-yulia-shwartz-department -of-stem-cell-and-regenerative-biology-harvard-university/ SUMMARY:Dr. Yulia Shwartz\, Department of Stem Cell and Regenerative Biolog y\, Harvard University [No Categories] DESCRIPTION:Location: In hybrid format: Auditorium + Zoom - https://technio n.zoom.us/j/95140358269 \n Affiliation: \n Host:\n Title: Hair Raising T ale: Nerve – Stem Cell Interactions\n\nZoom: https://technion.zoom.us/j /95140358269\n\nAbstract: Piloerection (goosebumps) requires concerted ac tions of the hair follicle\, the arrector pili muscle\, and the sympatheti c nerve\, providing a model to study interactions across epithelium\, mese nchyme\, and nerves. We show that arrector pili muscles and sympathetic ne rves form a dual component niche to modulate hair follicle stem cell activ ity. Sympathetic nerves form synapse-like structures with hair follicle st em cells and regulate them directly through norepinephrine\, whereas arrec tor pili muscles maintain sympathetic innervation to the stem cells. Witho ut norepinephrine signaling\, hair follicle stem cells enter deep quiescen ce by up-regulating quiescence regulators Foxp1 and Fgf18. Cold exposure\, elevates sympathetic nerve activity\, triggering both goosebumps and acce lerating stem cell activation and hair growth. During development\, hair f ollicle stem cells progeny secretes Sonic Hedgehog(SHH) to direct the form ation of this muscle-nerve niche\, which in turn controls hair follicle re generation in adults. Our study reveals a reciprocal interdependence betwe en a regenerative tissue and its niche at different stages and demonstrate s sympathetic nerves can modulate stem cells through synapse-like connecti ons and neurotransmitters to couple tissue production with environmental d emands.\n\nHost: Prof. Benjamin Podbilewicz LOCATION:In hybrid format: Auditorium + Zoom - https://technion.zoom.us/j/9 5140358269 END:VEVENT BEGIN:VEVENT UID:1038@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20220117T130000 DTEND;TZID=Asia/Jerusalem:20220117T140000 DTSTAMP:20220117T111604Z URL:https://biology.technion.ac.il/en/seminars/dr-noa-lamm-shalem-sydney-m edical-school-sydney-university-childrens-medical-research-institute-sydne y/ SUMMARY:Dr. Noa Lamm-Shalem\, Sydney Medical School\, Sydney University. Ch ildren's Medical Research Institute\, Sydney [No Categories] DESCRIPTION:Location: In hybrid format: Auditorium + Zoom (see link below) \n Affiliation: \n Host:\n Title: Filamentous actin drives nuclear arch itectural changes to maintain genome stability\n\nZOOM:  https://technio n.zoom.us/j/91878900904\n\nAbstract: Cell proliferation requires efficien t and accurate DNA replication. The complexity of replication\, however\, renders genome copying susceptible to endogenous and exogenous threats. An y process hindering replication is referred to as “replication stress\, ” and the cellular processes that countervail replication threats are th e “replication stress response”. Most of the genome instability that d rives oncogenesis results from replication stress\, and consequently\, can cer cells typically suffer from endogenous replication stress and are susc eptible to replication stress response challenges.\n\nActin is a cytoskele tal protein that polymerizes from monomeric to filamentous form(F-actin) t o provide cells with mechanical support\, transport pathways\, and a drivi ng force for movement. While actin is traditionally considered a cytoplasm ic protein\, nuclear actin polymerization was recently identified to contr ibute to various nuclear functions.\n\nI employed live-cell and super-reso lution imaging\, chromatin fiber analysis\, biochemistry\, and cell and mo lecular biology to discover a novel replication stress response pathway wh ere polymerization of nucleus-specific filamentous actin (F-actin) promote s replication stress repair. In this pathway\, nuclear F-actin cables incr ease nuclear volume and sphericity and enhance the mobility of replication stressed chromatin. This includes directed movement of stressed replicati on foci along F-actin towards the nuclear periphery where replication stre ssed loci interact with nuclear pore complexes to promote their repair. Th ese data substantially broaden our understanding of the nucleus as a dynam ic environment shaped by nuclear actin forces. This is a conceptual advanc e in nuclear biology only beginning to be explored.\n\nHost: Prof. Benjam in Podbilewicz LOCATION: In hybrid format: Auditorium + Zoom (see link below) END:VEVENT BEGIN:VEVENT UID:1037@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20220110T130000 DTEND;TZID=Asia/Jerusalem:20220110T140000 DTSTAMP:20220104T065918Z URL:https://biology.technion.ac.il/en/seminars/dr-dror-chorev-department-o f-chemistry-oxford-united-kingdom/ SUMMARY:Dr. Dror Chorev\, Department of Chemistry\, Oxford\, United Kingdom [No Categories] DESCRIPTION:Location: \n Affiliation: \n Host:\n Title: The importance o f being in the membraneZoom Link: :  https://technion.zoom.us/j/95594834 686Abstract: With in cell membranes are numerous proteins and protein com plexes that are responsible for the execution of a multitude of functions essential to maintain life. To study these membrane proteins\, they are ty pically extracted and removed from their native lipid environment by deter gents and polymers. In this talk\, I will present a recent break-through\, in which we have been able to eject and analyse membrane proteins and the ir associated small molecules directly from vesicles derived from their me mbrane of origin\, inside a mass spectrometer\, with no recourse to any ch emical additives. From bacterial membrane protein insertases to respirator y complexes and G-protein coupled receptors\, this approach has revealed n ew insights into the structure and function of membrane proteins\, emphasi zing the importance of the native membrane to the proteins that reside wit hin it.Host: Prof. Benjamin Podbilewicz END:VEVENT BEGIN:VEVENT UID:1041@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20220103T130000 DTEND;TZID=Asia/Jerusalem:20220103T140000 DTSTAMP:20220104T070153Z URL:https://biology.technion.ac.il/en/seminars/dr-maya-maor-nof-department -of-genetics-stanford-university-school-of-medicine/ SUMMARY:Dr. Maya Maor-Nof\, Department of Genetics\, Stanford University Sc hool of Medicine [No Categories] DESCRIPTION:Location: \n Affiliation: \n Host:\n Title: The diverse cell ular and molecular mechanisms driving neuronal and axonal degenerationZoom : https://technion.zoom.us/j/98391777547Abstract: Aberrations in protein folding\, processing and degradation are common features of neurodegenerat ive diseases\, resulting in their accumulation. Amyotrophic lateral sclero sis (ALS) and frontotemporal dementia(FTD) are two neurodegenerative disea ses that share genetic and neuropathological features. The most common gen etic cause of both ALS and FTD is a hexanucleotide repeat expansion in the C9orf72 gene. In both diseases aggregation of the protein TDP-43 is the m ajor pathological hallmark. How theC9orf72 hexanucleotide repeat expansion and the TDP-43 protein accumulations contribute to neurodegeneration is l argely unknown. To study the cellular mechanisms driving neurodegeneratio n\, I developed a platform to interrogate the chromatin accessibility land scape and transcriptional program within neurons in response to pathogenic protein accumulation. I provide evidence that neurons expressing the dipe ptide repeat protein poly(proline-arginine)\, translated from the C9orf72 nucleotide repeat expansion\, activate a highly specific transcriptional p rogram\, exemplified by a single transcription factor p53. Ablating p53 in mice completely rescued neurons from cell death and axonal degeneration a nd markedly increased survival in a C9orf72 mouse model. Furthermore\, p53 reduction was sufficient to rescueC9orf72 ALS patient iPSC-derived motor neurons from degeneration. Mechanistically\, p53 is stabilized\, binds to DNA and activates a downstream transcriptional program\, including Puma\, which drives neurodegeneration. These data demonstrate neurodegenerative m echanisms are dynamically regulated through transcription factor binding e vents controlling gene expression programs and provide a framework to appl y chromatin accessibility and transcription program profiles to neurodegen eration.Host: Prof. Benjamin Podbilewicz END:VEVENT BEGIN:VEVENT UID:1029@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20211227T130000 DTEND;TZID=Asia/Jerusalem:20211227T140000 DTSTAMP:20211212T125811Z URL:https://biology.technion.ac.il/en/seminars/dr-alex-rosenbergdepartemen t-of-molecular-microbiology-school-of-medicine-washington-university-in-st -louis/ SUMMARY:Dr. Alex Rosenberg\,Departement of Molecular Microbiology\, School of Medicine\, Washington University in St. Louis [No Categories] DESCRIPTION:Location: \n Affiliation: \n Host:\n Title: Toxoplasma gondi i - a master manipulator: From effectordiscovery to novel concepts in ce ll death.Abstract: Toxoplasma gondii translocates effector proteins into its host cell tosubvert various host pathways. T. gondii effector TgIST bl ocks thetranscription of interferon-stimulated genes to reduce immune defe nse.Interferons upregulate numerous genes\, including protein kinase R (PK R)\, whichinduce necrosome formation to activate mixed-lineage-kinase-doma in-like (MLKL)pseudokinase and induce necroptosis. Whether these interfero n functions aretargeted by Toxoplasma is unknown. Here\, we examine secret ed effectors thatlocalize to the host cell nucleus and find that the chron ic bradyzoite stagesecretes effector TgNSM that targets the NCoR/SMRT comp lex\, a repressor forvarious transcription factors\, to inhibit interferon -regulated genes involvedin cell death. TgNSM acts with TgIST to block IFN -driven expression of PKR andMLKL\, thus preventing host cell necroptotic death and protecting the parasite'sintracellular niche. The mechanism of a ction of TgNSM uncovers a role ofNCoR/SMRT in necroptosis\, assuring survi val of intracellular cysts and chronicinfection.Host: Beni Podbilewicz END:VEVENT BEGIN:VEVENT UID:1028@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20211222T130000 DTEND;TZID=Asia/Jerusalem:20211222T140000 DTSTAMP:20211212T125810Z URL:https://biology.technion.ac.il/en/seminars/msc-graduate-seminar-naama- mor/ SUMMARY:MSc Graduate Seminar- Naama Mor [No Categories] DESCRIPTION:Location: \n Affiliation: \n Host:\n Antigen-SpecificImmunomo dulation in Multiple Sclerosis by IL-10 -TCell Receptor-Like Antibodies (T CRL) Fusion ProteinsMultiple sclerosis (MS) is anautoimmune disease of the central nervous system (CNS) leading to demyelinationand disability. MS t reatments are particularly effective during the earlyphase\, but have litt le effect during the progressive phase\, which is targetedby a local innat e immune response.This study aims to construct\,produce\, and characterize an IL-10 TCRL Ab fusion protein directed against theMS autoantigen MOG35- 55 in a context of HLA-DR2 complex conjugated with thestrong anti-inflamma tory cytokine Interleukin-10 (IL-10)\, and test its abilityto induce site- specific immunomodulation. END:VEVENT BEGIN:VEVENT UID:1027@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20211220T130000 DTEND;TZID=Asia/Jerusalem:20211220T140000 DTSTAMP:20211212T125810Z URL:https://biology.technion.ac.il/en/seminars/dr-uria-alcombri-swiss-fede ral-institute-of-technology-zurich/ SUMMARY:Dr. Uria Alcombri\, Swiss Federal Institute of Technology\, Zurich [No Categories] DESCRIPTION:Location: \n Affiliation: \n Host:\n Title: “Unravelling th e microscale mechanisms driving particle degradation in the ocean”Abstra ct: The sinking of organic particles to the ocean depths is the main drivi ng force of thebiological pump\, the process responsible for the export of more than 50 Gt of fixed CO2 annuallyand one of the major fluxes in the o ceans’ carbon cycle. Yet\, the mechanisms determining themagnitude of th e pump remain poorly understood\, limiting our ability to predict this car bon fluxin future ocean scenarios. Current ocean models assume that the bi ological pump is governed bythe competition between sinking speed and degr adation rate\, with the two processesindependent from one another. In this talk\, I will demonstrate that contrary to this paradigm\,sinking itself is a primary determinant of the rate at which bacteria enzymatically degra departicles in the ocean. By combining video microscopy and microfluidic e xperiments to directlyobserve and quantify bacterial degradation of indivi dual organic particles in flow\, I will show thateven modest sinking speed s of 8 meters per day enhance degradation rates more than 10-fold. Iwill f urther discuss the molecular mechanism behind the sinking-enhanced degrada tion\, as wellas possible ways by which bacteria can slow the sinking of p articles. Finally\, using the resultsobtained from a mathematical model\, I will show that the flow associated with sinking is a majorcontributor to the observed magnitude of the vertical carbon flux in the ocean\, and wil l outlinemajor open questions in the field. Host: Benjamin Podbilewicz END:VEVENT BEGIN:VEVENT UID:1026@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20211215T133000 DTEND;TZID=Asia/Jerusalem:20211215T140000 DTSTAMP:20211212T125810Z URL:https://biology.technion.ac.il/en/seminars/msc-graduate-seminar-kapil- jain/ SUMMARY:MSC Graduate Seminar-Kapil Jain [No Categories] DESCRIPTION:Location: \n Affiliation: \n Host:\n Regulation of mitochondr ial trafficking by Myosin XIX during cell migration.\n\n Myosin XIX (Myo19 ) is an actin-based molecular motor that is anchored to the outer mitochon dria membrane (OMM) via its unique membrane binding motif. Myo19 is a stro ng effector of filopodia formation under cellular stress conditions mediat ed by glucose starvation\, ROS and EGF. Filopodia are actin protrusions im portant for many cellular dynamic processes such as cell migration\, angio genesis\, wound healing\, limb regeneration and sensing extracellular envi ronment\, among others. In mammals\, Myo19’s ability to induce filopodia is strongly coupled to mitochondrial transport on the actin filaments whi ch is achieved by the enzymatic adaptation of its active motor as an ensem ble of molecules bound to mitochondria. However\, the cellular processes w hich are essentially required for triggering Myo19 based mitochondrial mot ility to filopodia are not known. In addition\, the role of these mitochon dria rich filopodia actin protrusions are yet to be coupled to their cellu lar functions. Cell migration being a fundamental process in both physiolo gy and pathophysiology requires actin cytoskeleton remodeling\, and hence we hypothesize that Myo19 will play a role during cell migration. Interest ingly\, we have found that siRNA mediated Myo19 knockdown cells exhibit a reduction in the rate of cell migration measured using 2D in-vitro cell sc ratch assay. This phenotype is most likely robust in several cell lines th at we have explored. We have also begun to identify key signaling evens th at may be related to triggering mitochondrial motility to filopodia. These findings provide the basis for the direct involvement of Myo19 in various physiological process that are manifested by actin protrusions. END:VEVENT BEGIN:VEVENT UID:1008@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20211215T130000 DTEND;TZID=Asia/Jerusalem:20211215T133000 DTSTAMP:20211118T122724Z URL:https://biology.technion.ac.il/en/seminars/msc-graduate-seminar-adi-be n-yehuda/ SUMMARY:MSc graduate seminar-Adi Ben-Yehuda [No Categories] DESCRIPTION:Location: \n Affiliation: \n Host:\n  Studying AlternativePo lyadenylation in Human Cells and Clinical Samples during Human Cytomegalo virus (HCMV)Infection  HCMV infection is the leadingcause for congenital abnormalities in the western world. We studiedtranscriptomic changes in hu man fibroblast and in clinical placenta samplesinfected by HCMV. Specifica lly\, we followed the changes in 3’ UTR lengthresulting from alternative polyadenylation (APA) upon viral infection. Our datarevealed that HCMV in fection induces extensive APA changes in infected cells\,mostly associated with 3’UTR shortening. Interestingly\, we found that APA ismore pronoun ced in infected placentas from women who have not been exposed tothe virus before. Our results suggested that changes in APA are widespread inHCMV i nfection and can potentially be used to predict disease severity incongeni tal HCMV. END:VEVENT BEGIN:VEVENT UID:1025@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20211213T130000 DTEND;TZID=Asia/Jerusalem:20211213T140000 DTSTAMP:20211212T125810Z URL:https://biology.technion.ac.il/en/seminars/prof-ronen-segev-life-scien ces-department-and-zlotowski-center-for-neuroscience-ben-gurion-university -of-the-negev/ SUMMARY:Prof. Ronen Segev\, Life Sciences Department and Zlotowski Center f or Neuroscience\, Ben Gurion University of the Negev [No Categories] DESCRIPTION:Location: \n Affiliation: \n Host:\n Title: What can fishes t each us about the brain?Abstract: Fishes have diverged in evolution from t he mammalian linage some 450million years ago and as a result fishes’ br ain structure is different from thefundamental design of the mammalian\, r eptilian and avian brains. This raisesthe question what can we learn from the ability of fishes to solve differenttasks. I will discuss aspects of h ow visual processing is implemented in thearcherfish brain and how navigat ion is implemented in the goldfish brain.Host: Sagi Levy END:VEVENT BEGIN:VEVENT UID:1017@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20211206T130000 DTEND;TZID=Asia/Jerusalem:20211206T140000 DTSTAMP:20211201T140946Z URL:https://biology.technion.ac.il/en/seminars/prof-debora-fass-department -of-chemical-and-structural-biology-weizmann-institute-of-science/ SUMMARY:Prof. Debora Fass\, Department of Chemical and Structural Biology\, Weizmann Institute of Science [No Categories] DESCRIPTION:Location: \n Affiliation: \n Host:\n Title: Golgi Redox and G ut Health: the Elegant Mechanism for ConstructingIntestinal MucusGuest: De borah Fass\, Departmentof Chemical and Structural Biology\, WeizmannInstit ute of Science AbstractThreats to the body’s physical integrity come in a varietyof forms: pathogens\, chemical poisons and irritants\, and mecha nical injuries.Early in animal development\, a multifunctional safety net evolved to protectagainst such hazards. This safety net is built of the mu cus hydrogels that coverand shield the hundreds of square meters of vulner able epithelia in the body\,most notably in the lungs and intestines. Mucu s forms by disulfide bond cross-linkingof enormous glycoproteins called “mucins.” Using X-ray crystallography andcryo-electron microscopy\, we determined structures of the region of theintestinal mucin involved in cr oss-linking. These structures revealed how themucus scaffold is organized and led us to the discovery that mucus protectsagainst even more dangers t han was previously appreciated. In parallel\, wefound that a catalyst of d isulfide bond formation in the Golgi apparatus isnecessary for constructin g functional mucus\, but\, surprisingly\, not for carryingout the actual c ross-linking. Instead\, disulfide bonding in the Golgicontributes to mucus functionality in an unexpected manner\, revealing a newcell biological pr inciple likely to be relevant to other processes in additionto mucus produ ction.Host: Sagi Levy END:VEVENT BEGIN:VEVENT UID:1007@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20211122T130000 DTEND;TZID=Asia/Jerusalem:20211122T140000 DTSTAMP:20211118T122724Z URL:https://biology.technion.ac.il/en/seminars/prof-yoav-arava-faculty-of- biology-technion/ SUMMARY:Prof. Yoav Arava\, Faculty of Biology\, Technion [No Categories] DESCRIPTION:Location: \n Affiliation: \n Host:\n Title: Factors andmechan isms in mRNA localization and translationAbstract:The expression ofgenes i nto a functional unit is regulated at multiple steps\, from the initial RN Atranscription\, through its processing\, intracellular localization\, and finally proteintranslation and degradation. In my talk I will focus on tw o of these steps thatmy lab had been working on for several years: mRNA lo calization and translation.First\, I will describe work that we did on dec iphering the factors that areinvolved in localization of mRNA to the proxi mity of mitochondria and thefunctional consequences of this localization. Through extensive work in yeastwe identified several protein factors that coordinate localization and most recentlyuncovered an unexpected role for localization in transport of mRNA alongneuronal axons. In the second part of my talk\, I will focus on RNA binding factorsthat regulate mRNA transla tion. We recently discovered that a well-studiedfamily of tRNA binding pro teins can also bind mRNA. mRNA binding occurs atelement that mimic the cog nate tRNA binding sites and allows regulation oftarget mRNA translation. T hus\, binding two types of RNA (i.e. tRNA and mRNA) bythe same RNA binding protein allows coordination between tRNA charging and mRNAtranslation\, a nd may have significant implications to cellular physiology inhealth and d isease. Host: Sagi Levy END:VEVENT BEGIN:VEVENT UID:1006@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20211115T130000 DTEND;TZID=Asia/Jerusalem:20211115T140000 DTSTAMP:20211118T110055Z URL:https://biology.technion.ac.il/en/seminars/prof-idan-efroni-faculty-of -agriculture-food-and-environment-the-hebrew-university-of-jerusalem/ SUMMARY:Prof. Idan Efroni\, Faculty of Agriculture\, Food and Environment. The Hebrew University of Jerusalem [No Categories] DESCRIPTION:Location: \n Affiliation: \n Host:\n TitleSame organ\, differ ent place - conserved regulation of a transient stem-cellstate in the init iation of multiple root types AbstractPlantsadjust their post-embryonic g rowth in response to environmental cues by formingnew organs in different developmental contexts. Underground lateral rootsinitiate from prepatterne d cells in the main root\, but cells can also bypassthe root/shoot traject ory separation and generate shoot-borne-roots through anunknown mechanism. We mapped tomato (Solanum lycoperiscum)shoot-borne-roots development at s ingle-cell resolution and show that theyinitiate from differentiated phloe m-associated cells via a unique transitionalstem-cell-like state. This sta te required the activity of a transcriptionfactor which we named SHOOTBORN E ROOTLESS (SBRL). SBRL functionand regulation was deeply conserved in ang iosperms and phylogenetic analysisrevealed that it arose as an ancient dup licated superlocus with its paralogsshowing root-type-specific transient e xpression in wound-induced and lateralroot initiation. We propose a new mo del for root initiation in plants\, wherethe activation of a common transi tional stem-cells is controlled by multiplecontext-specific regulators. Th us\, the evolutionary expansion of theseregulators underlies the remarkabl e plasticity of plant root systems.Host: Sagi Levy and Sigal Savaldi-Golds tein END:VEVENT BEGIN:VEVENT UID:990@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20211108T130000 DTEND;TZID=Asia/Jerusalem:20211108T140000 DTSTAMP:20211028T103628Z URL:https://biology.technion.ac.il/en/seminars/prof-yuval-garini-faculty-o f-biomedical-engineering-technion/ SUMMARY:Prof. Yuval Garini\, Faculty of Biomedical Engineering\, Technion [ No Categories] DESCRIPTION:Location: \n Affiliation: \n Host:\n Title: Themulti-scale st ructure of chromatin in the nucleus\nHost: Sagi Levy END:VEVENT BEGIN:VEVENT UID:1005@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20211108T130000 DTEND;TZID=Asia/Jerusalem:20211108T140000 DTSTAMP:20211118T110055Z URL:https://biology.technion.ac.il/en/seminars/prof-yuval-garini-faculty-o f-biomedical-engineering-technion-2/ SUMMARY:Prof. Yuval Garini\, Faculty of Biomedical Engineering\, Technion [ No Categories] DESCRIPTION:Location: \n Affiliation: \n Host:\n The multi-scale structur e of chromatin in the nucleusYuval GariniBiomedical Engineering Faculty\,T echnionYuval.garini@technion.ac.il  \,  www.garini-lab.com/  The DNA in a human cell which is ~3 meters long is packed in a ~10 μmradius nucleus . The DNA is immersed in a condensed soup of proteins\, RNA andenzymes and it is highly dynamic while taking part in many nuclear processessuch as p rotein expression and cell division.Nevertheless\, it must stay organized to prevent chromosomeentanglement and for genome expression control. Study ing this nanometer –micrometer scale structure is difficult\, as it requ ires to use both highspatial and temporal resolutions for studying its cha racteristics.Studying the nucleus organization is complex and we developed variousmethods\, including live-cell imaging\, time-resolved spectroscopy \, chromosomeconformation capture (3C)\, FISH\, spectral karyotyping and s ingle moleculemethods such as AFM. The results are followed by biophysical modeling and allowedus to identify that a single protein\, lamin A\, is t he most important player inthe chromatin organization mechanism. It forms chromatin loops therebyrestricting the chromatin dynamics in the whole nuc leus volume. Other proteinshave a secondary effect.We conclude that the or ganization of the DNA in the nucleus is basedon a “chromatin network”\ , a structure that we describe here for the first time.Host: Sagi Levy END:VEVENT BEGIN:VEVENT UID:1004@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20211027T130000 DTEND;TZID=Asia/Jerusalem:20211027T140000 DTSTAMP:20211118T110055Z URL:https://biology.technion.ac.il/en/seminars/phd-graduate-seminar-rina-b en-el-october-27th-1300pm-2/ SUMMARY:PhD Graduate Seminar-Rina Ben-El- October 27th 13:00PM [No Categori es] DESCRIPTION:Location: \n Affiliation: \n Host:\n “Computational approac h to identify new roles for long non-coding RNAs involved in pluripotency and differentiation”Recently long non coding RNAs (lncRNAs) have emerged as regulators of pluripotency and differentiation\, however their contrib ution to specific lineage commitment is yet largely unknown. We generated RNA-seq data\, in human induced Pluripotent Stem cells (iPSc) and applied a network approach to help assign lncRNAs with unknown functions to these processes. We found many differentially expressed lncRNAs highly co-expres sed with known markers of differentiation. These results were validated wi th ChiP-seq data suggesting a possible regulatory relationship between the TFs and the lncRNAs.  END:VEVENT BEGIN:VEVENT UID:989@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20211027T130000 DTEND;TZID=Asia/Jerusalem:20211027T140000 DTSTAMP:20211028T104601Z URL:https://biology.technion.ac.il/en/seminars/phd-graduate-seminar-rina-b en-el-october-27th-1300pm/ SUMMARY:PhD Graduate Seminar-Rina Ben-El- October 27th 13:00PM [No Categori es] DESCRIPTION:Location: \n Affiliation: \n Host:\n “Computational approac h to identifynew roles for long non-coding RNAs involved in pluripotency a nddifferentiation”\n\necently long non coding RNAs (lncRNAs) have emerge d asregulators of pluripotency and differentiation\, however their contrib ution tospecific lineage commitment is yet largely unknown. We generated R NA-seq data\,in human induced Pluripotent Stem cells (iPSc) and applied a network approach tohelp assign lncRNAs with unknown functions to these pro cesses. We found manydifferentially expressed lncRNAs highly co-expressed with known markers ofdifferentiation. These results were validated with Ch iP-seq data suggesting apossible regulatory relationship between the TFs a nd the lncRNAs. END:VEVENT BEGIN:VEVENT UID:1003@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20211025T130000 DTEND;TZID=Asia/Jerusalem:20211025T140000 DTSTAMP:20211118T110055Z URL:https://biology.technion.ac.il/en/seminars/assoc-prof-tali-haran-facul ty-of-biology-technion-2/ SUMMARY:Assoc. Prof. Tali\, Haran\, Faculty of Biology\, Technion [No Categ ories] DESCRIPTION:Location: \n Affiliation: \n Host:\n DNA dynamicsdictates p53 functional outcomeTali E. Haran AbstractThe tumor suppressor protein p53 issituated in the midst of a complex cellular network that is activated i nresponse to cellular stress. Activated p53 functions mainly as a transcri ptionfactor\, regulating the expression of numerous genes involve in vario us cellularpathways critical for preventing cancer\, and in pathways unrel ated to cancersurveillance. An unresolved question in the field is how p53 is able to parseits myriad functions in response to the severity of the s tress signal andconsequently to coordinate the functional outcome in a tim ely manner. We havepreviously shown that DNA torsional flexibility disting uishes between differentp53 response elements (REs). I will show that acro ss the genome p53 targetgenes belonging to pathways acting early in the st ress response (e.g.\, DNAdamage response and innate immunity) have REs tha t are significantly moreflexible than REs of genes involved in pathways th at need to be more strictlyregulated\, or that their functional outcome oc curs later in the response tostress (e.g.\, intrinsic apoptosis and p53 ne gative regulation). We validatedthese statistical findings by several comp lementary experimental approaches\, invitro and in cells\, for six p53 REs belonging to pathways that operate atdifferent times post p53 induction. Our results clearly demonstrate that theflexibility of p53 REs contributes significantly to the temporal expression ofp53 target genes and thereby t o life versus death decisions in the p53 system.  END:VEVENT BEGIN:VEVENT UID:992@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20211025T130000 DTEND;TZID=Asia/Jerusalem:20211025T140000 DTSTAMP:20211028T104012Z URL:https://biology.technion.ac.il/en/seminars/assoc-prof-tali-haran-facul ty-of-biology-technion/ SUMMARY:Assoc. Prof. Tali\, Haran\, Faculty of Biology\, Technion [No Categ ories] DESCRIPTION:Location: \n Affiliation: \n Host:\n DNA dynamicsdictates p53 functional outcomeTali E. Haran AbstractThe tumor suppressor protein p53 issituated in the midst of a complex cellular network that is activated i nresponse to cellular stress. Activated p53 functions mainly as a transcri ptionfactor\, regulating the expression of numerous genes involve in vario us cellularpathways critical for preventing cancer\, and in pathways unrel ated to cancersurveillance. An unresolved question in the field is how p53 is able to parseits myriad functions in response to the severity of the s tress signal andconsequently to coordinate the functional outcome in a tim ely manner. We havepreviously shown that DNA torsional flexibility disting uishes between differentp53 response elements (REs). I will show that acro ss the genome p53 targetgenes belonging to pathways acting early in the st ress response (e.g.\, DNAdamage response and innate immunity) have REs tha t are significantly moreflexible than REs of genes involved in pathways th at need to be more strictlyregulated\, or that their functional outcome oc curs later in the response tostress (e.g.\, intrinsic apoptosis and p53 ne gative regulation). We validatedthese statistical findings by several comp lementary experimental approaches\, invitro and in cells\, for six p53 REs belonging to pathways that operate atdifferent times post p53 induction. Our results clearly demonstrate that theflexibility of p53 REs contributes significantly to the temporal expression ofp53 target genes and thereby t o life versus death decisions in the p53 system.  END:VEVENT BEGIN:VEVENT UID:988@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20211012T130000 DTEND;TZID=Asia/Jerusalem:20211012T140000 DTSTAMP:20211011T111923Z URL:https://biology.technion.ac.il/en/seminars/graduate-msc-seminar-noa-sc hneider/ SUMMARY:Graduate MSC Seminar -Noa Schneider [No Categories] DESCRIPTION:Location: \n Affiliation: \n Host:\n Abstract:RNA editing is a highly conserved mechanism by which theAdenosine Deaminases Acting on RN A (ADAR) enzymes convert adenosines (A) intoinosines (I)\, which are recog nized by the splicing and translationalmachineries as guanosines (G). This seemingly small modification has anextensive effect both on the structure and function of the edited RNA. RNAediting has been found to be involved in viral RNA defense\, mRNA recoding\, andneuronal diseases. Because RNA e diting is important for neuronal function\,ADARs are essential in mammals. However\, in Caenorhabditis elegans\,deletion of either or both of its AD AR genes is not lethal\, making thiswell-characterized model organism idea l for this kind of research.  In my work I studied the localization of A DR-2\, thecatalytically active ADAR in C. elegans\, how this localization isregulated and how it affects RNA editing activity. Also\, I found differ ences intarget selection between human ADAR2 and C. elegans ADR-2. Exploit ingthese differences\, I built a system to predict human ADAR2 target sele ction.   END:VEVENT BEGIN:VEVENT UID:1002@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20211012T130000 DTEND;TZID=Asia/Jerusalem:20211012T140000 DTSTAMP:20211118T110055Z URL:https://biology.technion.ac.il/en/seminars/graduate-msc-seminar-noa-sc hneider-2/ SUMMARY:Graduate MSC Seminar -Noa Schneider [No Categories] DESCRIPTION:Location: \n Affiliation: \n Host:\n Abstract:RNA editing is a highly conserved mechanism by which theAdenosine Deaminases Acting on RN A (ADAR) enzymes convert adenosines (A) intoinosines (I)\, which are recog nized by the splicing and translationalmachineries as guanosines (G). This seemingly small modification has anextensive effect both on the structure and function of the edited RNA. RNAediting has been found to be involved in viral RNA defense\, mRNA recoding\, andneuronal diseases. Because RNA e diting is important for neuronal function\,ADARs are essential in mammals. However\, in Caenorhabditis elegans\,deletion of either or both of its AD AR genes is not lethal\, making thiswell-characterized model organism idea l for this kind of research.  In my work I studied the localization of A DR-2\, thecatalytically active ADAR in C. elegans\, how this localization isregulated and how it affects RNA editing activity. Also\, I found differ ences intarget selection between human ADAR2 and C. elegans ADR-2. Exploit ingthese differences\, I built a system to predict human ADAR2 target sele ction.   END:VEVENT BEGIN:VEVENT UID:1001@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20210817T130000 DTEND;TZID=Asia/Jerusalem:20210817T140000 DTSTAMP:20211118T110054Z URL:https://biology.technion.ac.il/en/seminars/msc-graduate-seminar-of-dav id-scher-arazi-stern-lab-2/ SUMMARY:MSc Graduate Seminar of David Scher-Arazi (Stern lab ) [No Categor ies] DESCRIPTION:Location: \n Affiliation: \n Host:\n A Computational Pipeline for the Quantification of Social Interactions Across DevelopmentLittle is known about how social behavior changes across different stages of develo pment in animals. The nematode C. elegans offers the opportunity to study the dynamics of social behavior via its short 2.5 days of development from egg to adulthood. A previously developed imaging system was extended to t rack the behavior of many pairs of individuals simultaneously throughout t heir full development time. I developed a computational pipeline to extrac t social behavioral data and to analyze the effects of different neuromodu latory and mechanosensory deficiencies on long-term inter-individual inter actions. Additionally\, I quantify temporal patterns of social interaction s over days of measurements and how these temporal patterns are affected b y neuromodulatory and mechanosensory mutants. I conclude that C. elegans s hows complex dynamics of social interaction across development and that bo th neuromodulation and mechanosensation play a crucial role in controlling inter-individual interaction at specific developmental windows.zoom link: https://technion.zoom.us/j/314396039Meeting ID : 314 396 039 END:VEVENT BEGIN:VEVENT UID:971@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20210817T130000 DTEND;TZID=Asia/Jerusalem:20210817T140000 DTSTAMP:20210914T131740Z URL:https://biology.technion.ac.il/en/seminars/msc-graduate-seminar-of-dav id-scher-arazi-stern-lab/ SUMMARY:MSc Graduate Seminar of David Scher-Arazi (Stern lab ) [No Categor ies] DESCRIPTION:Location: \n Affiliation: \n Host:\n A Computational Pipeline for the Quantification of Social Interactions Across DevelopmentLittle is known about how social behavior changes across different stages of develo pment in animals. The nematode C. elegans offers the opportunity to study the dynamics of social behavior via its short 2.5 days of development from egg to adulthood. A previously developed imaging system was extended to t rack the behavior of many pairs of individuals simultaneously throughout t heir full development time. I developed a computational pipeline to extrac t social behavioral data and to analyze the effects of different neuromodu latory and mechanosensory deficiencies on long-term inter-individual inter actions. Additionally\, I quantify temporal patterns of social interaction s over days of measurements and how these temporal patterns are affected b y neuromodulatory and mechanosensory mutants. I conclude that C. elegans s hows complex dynamics of social interaction across development and that bo th neuromodulation and mechanosensation play a crucial role in controlling inter-individual interaction at specific developmental windows.zoom link: https://technion.zoom.us/j/314396039Meeting ID : 314 396 039 END:VEVENT BEGIN:VEVENT UID:969@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20210721T130000 DTEND;TZID=Asia/Jerusalem:20210721T140000 DTSTAMP:20210802T130802Z URL:https://biology.technion.ac.il/en/seminars/msc-graduate-seminar-noga-a harony-2/ SUMMARY:MSC Graduate seminar- Noga Aharony [No Categories] DESCRIPTION:Location: \n Affiliation: \n Host:\n Whilemobile genetic elem ents play a consequential part in bacterial adaptation andantibiotic resis tance\, relatively little is known about their role inwithin-host pathogen evolution. To explore their function\, we constructed acomputational pipe line that identifies variations in gene content amongbacteria of the same strain and applied it to a dataset of over a thousandisolates from recurri ng urinary tract infections. We discovered that aconsiderable number of pa thogens had variations in gene content upon theirrecurrence. The elements belonged to diverse types\, including phage\,transposon\, or plasmid. Nota bly\, some of the mobile elements contained knownantibiotic resistance gen es and lead to an increase in the isolate'sresistance. We therefore conclu de that changes in gene content are common andrapid\, and may be functiona lly important for clinical outcomes of antibiotictreatment. END:VEVENT BEGIN:VEVENT UID:968@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20210720T130000 DTEND;TZID=Asia/Jerusalem:20210720T140000 DTSTAMP:20210802T125905Z URL:https://biology.technion.ac.il/en/seminars/msc-graduate-seminar-ran-ta han-2/ SUMMARY:MSC Graduate seminar-Ran Tahan [No Categories] DESCRIPTION:Location: \n Affiliation: \n Host:\n Researchtopic: The dualr ole of a cyanophage thioredoxinAbstract:Marinecyanobacteria are highly abu ndant photosynthetic organisms that contributegreatly to global primary pr oduction. Their viruses\, marine cyanophages\, arealso extremely abundant and have a major effect on cyanobacterial populations\,diversity and evolu tion. One abundant family of cyanophages\, the T7-likecyanopodoviruses can be divided into two major clades\, A and B\, which areclosely related but differ significantly in their infection dynamics\, as wellas in their abu ndance and distribution. Here\, we set out to test whether thethioredoxin gene\, found only in clade A phages\, contributes to the differencesbetwee n the clades. We hypothesized that it is involved in phage DNAreplication similar to the role of the host gene in the T7-E. colisystem. To test our hypothesis\, we used a newly developed gene inactivationsystem to study th e thioredoxin gene\, trxA in the clade A phages Syn5.We found that the del etion of this gene caused a decline in phage DNAreplication. To our surpri se\, we also found that trxA expression inhibitsthe growth of the cyanobac terial host. Our work revealed how a non-essential host-acquiredgene contr ibutes in more than one way to cyanophage fitness. Furthermore\, ourresult s indicate that some of the physiological differences between the twoclade s of the T7-like cyanopodoviruses can be attributed to a clade-specific ge ne. END:VEVENT BEGIN:VEVENT UID:967@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20210714T130000 DTEND;TZID=Asia/Jerusalem:20210714T140000 DTSTAMP:20210802T125905Z URL:https://biology.technion.ac.il/en/seminars/phd-graduate-seminar-egor-s edov-2/ SUMMARY:PhD Graduate Seminar-Egor Sedov [No Categories] DESCRIPTION:Location: \n Affiliation: \n Host:\n Anchoredcells of the bas al epidermis constantly undergo proliferation in an overcrowdedenvironment . One important regulator of epidermal proliferation is YAP\, whichcan be controlled by both cell-matrix and cell-cell interactions. During myPh.D.\ , I discovered that Thy1\, a GPI anchored protein\, inhibits epidermal YAP activity through converging molecular mechanisms. We found that Thy1 defic iencyleads to increased adhesion by activating the Integrin-β1/Srcmodule. Notably\, regardless of high cellular densities\, the absence of Thy1lead s to the dissociation of an adherensjunction complex that enables the rele ase and translocation of YAP. Due toincreased YAP-dependent proliferation\ , Thy1-/-micedisplay enhanced wound repair and YAP-dependent hair follicle regeneration.Taken together\, our work reveals Thy1 as a critical regulat or of cell-matrixand cell-cell interactions that controls YAP activity in skin homeostasis\,regeneration and tumorigenesis. END:VEVENT BEGIN:VEVENT UID:966@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20210706T130000 DTEND;TZID=Asia/Jerusalem:20210706T140000 DTSTAMP:20210802T125905Z URL:https://biology.technion.ac.il/en/seminars/phd-graduate-seminar-elleno re-koren-2/ SUMMARY:PhD Graduate Seminar-Ellenore Koren [No Categories] DESCRIPTION:Location: \n Affiliation: \n Host:\n Stem Cells: a Matter of Life and DeathStemcells ( play a pivotal role in fueling homeostasis and r egeneration Whilemuch focus has been given to self renewal and differentia tion pathways regulatingSC fate\, little is known regarding the specific m echanisms utilized for theirelimination During my Ph D I determined that t he pro apoptotic protein ARTS(a Septin 4 isoform) is highly expressed in c ells comprising the intestinal SC (niche and that its deletion protects ce lls from undergoing apoptosis As a result\,the Sept 4 /ARTS crypt displays heightened proliferation and\, in culture\, generatesmassive cystic organ oids due to enhanced Wnt/β catenin signaling Importantly\, micedeleted fo r Sept 4 /ARTS exhibit resistance against intestinal damage in a mannerdep endent upon ISCs Finally\, I was able to show that ARTS interacts with XIA P inintestinal crypt cells and that deletion of XIAP can abrogate Sept 4 / ARTSdependent phenotypes in an epistatic manner (Koren et al Nature Commun ications\,2018 These results indicate that ISCs utilize specific apoptotic proteins for theirelimination representing a unique therapeutic targetCur rentlyI am testing distinct compounds that have been identified via highth roughput in vitro and in silico screening platforms\, for their potential totherapeutically block the ARTS/ XIAP interface It is my greatest hope th at my findingsmay one day serve as a staple for human disease treatmentsIn the skin\, the presence of a distinct SC population that maintains the int erfollicularepidermis ( is highly debated We found that basal keratinocyte s marked by Thy 1do not express T cell markers\, express a unique transcri ptional profile\, cyclesignificantly slower than basal epidermal progenito rs and display significantexpansion potential in vitro Multicolor lineage tracing analyses and mathematicalmodeling reveals that Thy 1 basal keratin ocytes do not compete neutrally alike IFEprogenitors and contribute long t erm to both epidermal replenishment and woundrepair Importantly\, ablation of Thy 1 cells in T cell deficient mice strongly impairsthese processes\, thus indicating the non redundant function of Thy 1 SCs in theepidermis T aken together\, these findings indicate the existence of a distinct slowcy cling SC population that plays a critical role in epidermal homeostasis an d END:VEVENT BEGIN:VEVENT UID:965@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20210629T130000 DTEND;TZID=Asia/Jerusalem:20210629T140000 DTSTAMP:20210802T125905Z URL:https://biology.technion.ac.il/en/seminars/msc-graduate-seminar-lama-a amar-2/ SUMMARY:MSc Graduate Seminar-Lama Aamar [No Categories] DESCRIPTION:Location: \n Affiliation: \n Host:\n  The development and gr owth of the plant body are regulated by aninterplay between plant hormone signaling pathways that both interpret anddetermine their accumulation and distribution. Brassinosteroids (BRs) are oneof these hormones. Although t he BR signaling pathway is well known\, there arestill gaps in our knowled ge regarding the site of BR production\, the extent ofBR movement\, and ho w its signaling pathway is decoded at the tissue andcellular levels. Using the Arabidopsis root as a developmental system\, recentstudies showed tha t BR biosynthesis genes are expressed in different tissues\,suggesting tha t the BR hormone might move radially between tissues. Inaddition\, BR sign aling has been shown to have different developmental effectson the root me ristem\, depending on the tissue in which it is perceived\,suggesting that BR signaling is decoded in a tissue-specific manner. Thisthesis was condu cted with the following open questions in mind: do activehormones or their precursors move between tissues in the root\, istissue-specific BR signal ing essential for meristem development\, and howcellular BR activity can b e quantified in the growing root. To address these questions\, I applied established approaches and alsoevaluated new strategies. These were design ed to cover the three main steps ofthe hormone action: i) biosynthesis\, i i) signaling input (i.e.\, receptoractivity)\, and iii) signaling output ( i.e.\, regulation of gene expression). Forthe first part\, I took a tissue -specific-complementation approach for BRproduction to evaluate the extent of BR movement in the root meristem. This wasperformed alongside the char acterization of the root system architecture andits dependency on BR biosy nthesis. For studies involving BR signaling input\, Iapplied a novel appro ach for a tissue-specific knockout using the CRISPR-CAS9technology. This t ool aimed to target the BR receptor BRI1 in select tissues asa means to in fer the essentiality of BRI1’s activity in a particular tissue inthe mer istem. Finally\, I started to develop a spatiotemporal transcriptionalread out for BR signaling output as part of a collaborative effort. Thisstrateg y is based on designing a promoter sequence that includes conservedmotifs from promoters activated as a response to BR presence. This promoter isfus ed to nuclear localization fragment and fluorophore to detect BR responses ites in the meristem different tissues of the root. The results of theseap proaches will be presented and discussed. END:VEVENT BEGIN:VEVENT UID:964@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20210628T130000 DTEND;TZID=Asia/Jerusalem:20210628T140000 DTSTAMP:20210802T125905Z URL:https://biology.technion.ac.il/en/seminars/prof-michael-berger-the-fac ulty-of-medicine-the-hebrew-university-of-jerusalem-2/ SUMMARY:Prof. Michael Berger\, The faculty of medicine\, The Hebrew Univers ity of Jerusalem [No Categories] DESCRIPTION:Location: \n Affiliation: \n Host:\n Title: Improving T cell effector functionsby limiting mitochondrial-derived ATP transfer to the c ytosolHost: Noga Ron Harel & Ayala Shiber Zoom: https://technion.zoom.us /j/93293373229 END:VEVENT BEGIN:VEVENT UID:963@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20210622T143000 DTEND;TZID=Asia/Jerusalem:20210622T153000 DTSTAMP:20210802T125905Z URL:https://biology.technion.ac.il/en/seminars/msc-graduate-seminar-hila-w eil-2/ SUMMARY:MSC Graduate Seminar-Hila Weil [No Categories] DESCRIPTION:Location: \n Affiliation: \n Host:\n Title: "A novel microflu idic assay foradhesion-free migration reveals a polarized motility mode"Ab stract:Cell motility is a key factor in various processes such ascancer me tastasis\, immune response\, and wound healing.  The mode ofcell migrati on depends on the chemical\, mechanical andgeometrical properties ofthe  extra-cellular environment. While adhesive modes of motilityare well  understood\, the mechanisms underlying migration in the absence ofcell-mat rix and cell-cell adhesions are yet to be understood.  Here\, wepresent a novel high-resolution microfluidic assay for the study of cellularmotilit y in confined environments. We employ this setup to study cellularcrawling motility under different conditions\, where cellular ability to exerttrac tion forces on their environment is modulated.  Our results uncovered a p reviouslyuncharacterized\, adhesion-free\, motility mode in MDA-MB 231 bre ast cancercells. In the absence of traction forces and low friction enviro nments\, confinementalone is sufficient to enable a non-adhesive migration phenotype. We find thatunder asymmetric confinement conditions\, non-adhe sive cellular migrationbecomes polarized\, with a directionality that is d etermined by extra-cellulargeometrical cues\, as well as by cellular chara cteristics\, such as cell size.Our results suggest that topography cues pl ay a significant role in regulatingcell behaviors. Understanding the mecha nisms governing cell migration inconfinement is critical to fully understa nd key processes\, such as theplasticity of cancer cells motility modes. O ur micro-channel essay may be usedin further studies for characterization of cellular response to variedconfinement conditions.   END:VEVENT BEGIN:VEVENT UID:962@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20210621T130000 DTEND;TZID=Asia/Jerusalem:20210621T140000 DTSTAMP:20210802T125905Z URL:https://biology.technion.ac.il/en/seminars/prof-rebecca-taylor-neurobi ology-division-mrc-molecular-biology-biomedical-campus-cambridge-2/ SUMMARY:Prof. Rebecca Taylor\, Neurobiology Division\, MRC\, Molecular Biol ogy\, Biomedical Campus\, Cambridge [No Categories] DESCRIPTION:Location: \n Affiliation: \n Host:\n Title: “Understanding the systemic control of proteostasis”Host: Ayala ShiberZoom: https://te chnion.zoom.us/j/93293373229 END:VEVENT BEGIN:VEVENT UID:961@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20210615T130000 DTEND;TZID=Asia/Jerusalem:20210615T140000 DTSTAMP:20210802T125905Z URL:https://biology.technion.ac.il/en/seminars/phd-graduate-seminar-cfir-d avid-2/ SUMMARY:PhD Graduate Seminar-Cfir David [No Categories] DESCRIPTION:Location: \n Affiliation: \n Host:\n The regulation of Tet1 b y steroidhormones in proliferating gonadotrope precursor cellsThe hydroxym ethylase\, Tet1\, plays amajor role in regulating gene expression\, and it s knockdown specificallyaffects fertility. Reproductive function is activa ted by hormones produced ingonadotrope cells of the pituitary gland\, whic h are tightly controlled by thegonadal steroids. We found that Tet1 is exp ressed in proliferatinggonadotrope precursor cells\, but is down-regulated to allow their maturation\,and hypothesized that gonadal steroids might b e responsible for thisrepression. Exposure to androgens or estrogens inhib ited Tet1 expressionand we have demonstrated two distinct mechanisms. Firs t\, the steroid receptorsbind several regulatory regions upstream of Tet1 and induce changes tothe chromatin structure and histone modifications to hinder Tet1transcription initiation. In addition\, estradiol lowers Tet1 m RNAstability by decreasing the m6A methylation. Asides from playing a cruc ial rolein the central control of reproduction\, the regulationof Tet1 exp ression by gonadal steroid hormones has implications in the context of cel l proliferationand differentiation in other steroid-responsive tissues\, i ncludingsteroid-dependent cancers. END:VEVENT BEGIN:VEVENT UID:960@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20210614T130000 DTEND;TZID=Asia/Jerusalem:20210614T140000 DTSTAMP:20210802T125905Z URL:https://biology.technion.ac.il/en/seminars/prof-knut-drescher-max-plan ck-institute-for-terrestrial-microbiology-marburg-germany-2/ SUMMARY:Prof. Knut Drescher\, Max Planck Institute for Terrestrial Microbio logy\, Marburg\, Germany [No Categories] DESCRIPTION:Location: \n Affiliation: \n Host:\n Title: Unicellularand m ulticellular stress responses in bacterial biofilmsHost: Roy Kisony & Ayal a ShiberZoom: https://technion.zoom.us/j/93293373229 END:VEVENT BEGIN:VEVENT UID:959@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20210608T130000 DTEND;TZID=Asia/Jerusalem:20210608T140000 DTSTAMP:20210802T125905Z URL:https://biology.technion.ac.il/en/seminars/phd-graduate-seminar-olga-s nitser-2/ SUMMARY:PhD Graduate seminar-Olga Snitser [No Categories] DESCRIPTION:Location: \n Affiliation: \n Host:\n Community-associated met hicillin-resistant Staphylococcusaureus (CA-MRSA) has spread worldwide and is threatening public health. Itshallmark is the mecA gene\, whichconfers resistance to nearly all β-lactam antibiotics. However\, it is unknownwh ether mecA provides additionalselective advantages or disadvantages across other chemical environments. In myseminar\, I will present a new competit ion-based assay that we’ve developed todetermine the fitness effect of m ecA.In the assay\, we compete between differentially fluorescently-labeled wild-typeCA-MRSA and a mecA deleted strain in1536-well plates in the pres ence of ~57\,000 diverse chemical compounds and cefoxitin\,a β-lactam\, a t a sub-inhibitory concentration. Surprisingly\, and in contrast toother r esistant mechanisms\, we find that mecAprovides a ubiquitous advantage in diverse chemical environments\, includingantibiotics\, non-antibiotic ther apeutic drugs and even natural products andsynthetic compounds. I will sha re our findings as well as our insights for themechanism underlying this a dvantage. Overall\, our findings suggest a wide basisto explain CA-MRSA re markable success and rapid dissemination worldwide. END:VEVENT BEGIN:VEVENT UID:958@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20210607T130000 DTEND;TZID=Asia/Jerusalem:20210607T140000 DTSTAMP:20210802T125905Z URL:https://biology.technion.ac.il/en/seminars/prof-shimon-bershtein-depar tment-of-life-science-ben-gurion-university-of-the-negev-2/ SUMMARY:Prof. Shimon Bershtein\, Department of Life Science\, Ben-Gurion U niversity of the Negev [No Categories] DESCRIPTION:Location: \n Affiliation: \n Host:\n Seminarin memory of Prof . Dan Tawfik -“thedynamics and molecular mechanisms of microbial evoluti on”Host:  Ayala ShiberZoom https://technion.zoom.us/j/93293373229 END:VEVENT BEGIN:VEVENT UID:957@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20210531T130000 DTEND;TZID=Asia/Jerusalem:20210531T140000 DTSTAMP:20210802T125905Z URL:https://biology.technion.ac.il/en/seminars/prof-juan-fernandez-recio-i nstituto-de-ciencias-de-la-vid-y-del-vino-icvv-csic-logrono-spain-2/ SUMMARY:Prof. Juan Fernández-Recio\, Instituto de Ciencias de la Vid y del Vino (ICVV-CSIC): Logroño Spain [No Categories] DESCRIPTION:Location: \n Affiliation: \n Host:\n Title: “Structural and energy-based modeling of protein complexes: biotechnological applications  ”Host: FabianGlasser& Ayala ShiberJoin ZoomMeeting https://technion.zo om.us/j/93293373229 Meeting ID: 932 9337 3229     END:VEVENT BEGIN:VEVENT UID:956@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20210524T130000 DTEND;TZID=Asia/Jerusalem:20210524T140000 DTSTAMP:20210802T125904Z URL:https://biology.technion.ac.il/en/seminars/prof-katrien-vandoorne-facu lty-of-biomedical-engineering-technion-2/ SUMMARY:Prof. Katrien Vandoorne\, Faculty of Biomedical Engineering\, Techn ion [No Categories] DESCRIPTION:Location: \n Affiliation: \n Host:\n Title:Invivo Multi Scale Imaging of Vascular-Immune Interactions in CardiovascularDisease”Host: Dvir Aran & Ayala ShiberZoom: https://technion.zoom.us/j/93293373229 END:VEVENT BEGIN:VEVENT UID:955@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20210511T130000 DTEND;TZID=Asia/Jerusalem:20210511T140000 DTSTAMP:20210802T125904Z URL:https://biology.technion.ac.il/en/seminars/phd-graduate-seminar-rotem- gross-2/ SUMMARY:PhD Graduate Seminar-Rotem Gross [No Categories] DESCRIPTION:Location: \n Affiliation: \n Host:\n \, " Evolutionary paths tohigh-level ampicillin resistance ""  Thewidespread use of beta-lactams has resulted in a growing prevalence of highlyresistant pathogens.Indeed\ , clinical isolates can have very high resistance to beta-lactams\, mostpr ominently to ampicillin where resistance level could even exceed 1000 µg/ ml. Yet\, instriking contrast\, bacteria evolved in laboratory settings\, typically plateauon much lower levels of resistance. Here\, evolving Esche richiacoli onthe Microbial Evolution and Growth Arena (MEGA) plate\, we fo undthat large population sizes circumvent the previously observed saturati on ofresistance under ampicillin selection\, selecting for mutants resista nt toampicillin at over 5000 µg/mg. Whole-genome sequencing of resistant isolatesrevealed that this high ampicillin resistance was acquired via a c ombination ofsingle-point mutations (SNP) and increasingly focused gene am plification ofresistant genes\, most notably the beta-lactamase enzyme Amp C. Importantlythough\, blocking AmpC-mediated resistance only slightly red uced the adaptivepotential: strains deleted for ampC were able to evolve h igh-level resistancethrough combinations of genetic changes in genes invol ved in multidrugresistance such as efflux pumps\, transcriptional regulato rs\, and porins. Ourresults reveal that combinations of distinct genetic m utations\, accessible atlarge population sizes\, can drive high-level resi stance to ampicillin evenindependently of beta-lactamases. " Thelink:Join Zoom Meeting https://technion.zoom.us/j/92305007772 Meeting ID: 923 0500 7772 END:VEVENT BEGIN:VEVENT UID:954@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20210510T130000 DTEND;TZID=Asia/Jerusalem:20210510T140000 DTSTAMP:20210802T125904Z URL:https://biology.technion.ac.il/en/seminars/prof-ella-preger-ben-noon-d epartment-of-genetics-and-developmental-biology-the-rappaport-faculty-of-m edicine-and-research-institute-technion-2/ SUMMARY:Prof. Ella Preger-Ben Noon\, Department of Genetics and Development al Biology\, The Rappaport Faculty of Medicine and Research Institute\, Te chnion [No Categories] DESCRIPTION:Location: \n Affiliation: \n Host:\n Title: Theevolution of a complex morphology at a single-cell resolution”Host: Ayala ShiberZoom:  https://technion.zoom.us/j/93293373229 END:VEVENT BEGIN:VEVENT UID:953@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20210503T130000 DTEND;TZID=Asia/Jerusalem:20210503T140000 DTSTAMP:20210802T125904Z URL:https://biology.technion.ac.il/en/seminars/prof-wolfgang-keil-multisca le-physics-biology-chemistry-and-cancer-curie-labquantitative-developmenta l-biology-2/ SUMMARY:Prof. Wolfgang Keil\, Multiscale Physics-Biology-Chemistry and canc er\, Curie Lab\,Quantitative Developmental Biology [No Categories] DESCRIPTION:Location: \n Affiliation: \n Host:\n Title: “KeepingTime wi th TranscriptionHost: Ayala ShiberZoom: https://technion.zoom.us/j/932933 73229 END:VEVENT BEGIN:VEVENT UID:952@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20210427T130000 DTEND;TZID=Asia/Jerusalem:20210427T140000 DTSTAMP:20210802T125904Z URL:https://biology.technion.ac.il/en/seminars/phd-graduate-seminar-may-le vin-2/ SUMMARY:PHD GRADUATE SEMINAR-May Levin [No Categories] DESCRIPTION:Location: \n Affiliation: \n Host:\n Mechanisms of chemoresis tance in relapsed AMLpatients: towards efficacious precision medicineAcute myeloid leukemia (AML) remains a devastating disease with a 5-year surviva lrate of less than 30%. AML treatment has undergone significant advances i nrecent years\, incorporating novel targeted therapies along with improvem ents inallogeneic bone marrow transplantation techniques. However\, the st andard ofcare remains cytarabine and anthracyclines\, and the primary hind rance towardscurative treatment is the frequent emergence of anticancer dr ug resistance. Herein\, we characterizedchemoresistance mechanisms in huma n leukemia cell lines in vitro and inspecimens derived from individual AML patients ex vivo. We further explored potential pre-clinical treatment st rategies tosurmount chemoresistanceas well as attempted to implement these findings towards efficacious personalized medicine.Todecipher the mechani sms underlying cytarabine resistance we establishedcytarabine-resistant su blines derived from human leukemia cells andcharacterized the expression o f cytarabine transport and metabolism genes usingreal-time PCR and Western blot analyses. These analyses were followed by growthinhibition assays an d isobologram analysis determining the sublines’sensitivity to the clini cally approved drugs hydroxyurea (HU) andazidothymidine (AZT)\, compared t o their parental cells.Cytarabine-resistant sublines displayed marked hype rsensitivityto HU and AZT compared to parental cells. The HU and AZT combi nation exhibiteda synergistic growth inhibitory effect on leukemia cells a nd AML patient specimens\,which was intensified upon acquisition of cytara bine resistance. These findingsestablish HU and AZT as a promising combina tion for the potential futuretreatment of relapsed and refractory AML.Towa rdsthe translation of these findings to the clinical setting\, we explored twocases of relapsed AML patients. We determined the expression levels of specificgenes mediating drug transport and metabolism\, nucleotide biosyn thesis\, andapoptosis\, to decipher the molecular mechanisms underlying in trinsic and/oracquired chemoresistance modalities in individual relapsed p atients. Thisanalysis revealed pre-existing differences in gene expression levels betweenthese relapsed patients and patients with lasting remission s following the sametreatment\, as well as drug-induced alterations at dif ferent relapse stagescompared to diagnosis.Ourfindings highlight the burni ng need for standardized evaluation of key drugtransport and metabolism ge nes as an integral component of routine AMLmanagement\, thereby allowing f or the tailoring of treatment regimens forindividual patients. This approa ch could facilitate the design of efficaciouspersonalized treatment regime ns\, thereby reducing relapse rates of a notorious therapyrefractory disea se. END:VEVENT BEGIN:VEVENT UID:951@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20210420T143000 DTEND;TZID=Asia/Jerusalem:20210420T153000 DTSTAMP:20210802T125904Z URL:https://biology.technion.ac.il/en/seminars/phd-graduate-seminar-boris- sarvin-2/ SUMMARY:PHD GRADUATE SEMINAR-BORIS SARVIN [No Categories] DESCRIPTION:Location: \n Affiliation: \n Host:\n Research Topic: Mass spe ctrometry approaches for studying cancermetabolism  Mass spectrometry bas ed metabolomics is a widely usedapproach in biomedical research. However\, current methods coupling massspectrometry with chromatography (LC-MS) are time-consuming and not suitablefor high-throughput analysis of thousands of samples. In a paper recentlypublished in Nature Communications wedescri be an approach for high-throughput metabolomics based on flow-injectionmas s spectrometry (FI-MS) in which samples are directly injected to theioniza tion source. We show how MS overloading with this approach can be overcome by analyzing the distribution of ion m/z values and computationally determ ininga series of optimal scan ranges for getting highly reproducible data. In afollow up work\, we developed a sub one-minute LC-MS based metabolomi cs methodand demonstrate comparable analytical performance to a standard 2 5 minutesLC-MS method. We are currently using these approaches as a basis for developingearly diagnosis methods for the top-5 frequent cancers in Is rael basedthousands of serum samples obtained from Rambam Hospital. Anothe r focus of my research was developing a LC-MS basedmethod for investigatio n of one-carbon (1C) metabolism. Folate metabolism supplies 1C units for b iosynthesisand methylation and has long been a target for cancer chemother apy. In arecently published article in CellMetabolism we showed that while mitochondrial metabolism is considered themajor source of 1C units in can cer\, it is actually the cytosolic pathway that predominantlyproduce 1C un its in a variety of tumors under physiological conditions.Tumor-specific r eliance on cytosolic 1C flux is associated with poor capacityto retain int racellular folates\, which is determined by the expression of Reducedfolat e carrier (RFC1). We showed that silencing SHMT1 (cytosolic 1C producingen zyme) in cells with low RFC1 expression impairs pyrimidine biosynthesis an dtumor growth in vivo. Overall\, ourfindings reveal major diversity in can cer cell utilization of the cytosolicversus mitochondrial folate cycle acr oss tumors and RFC1 expression as a markerfor increased reliance on SHMT1. END:VEVENT BEGIN:VEVENT UID:950@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20210419T130000 DTEND;TZID=Asia/Jerusalem:20210419T140000 DTSTAMP:20210802T125904Z URL:https://biology.technion.ac.il/en/seminars/prof-danny-ben-zvi-the-facu lty-of-medicine-the-hebrew-university-of-jerusalem-2/ SUMMARY:Prof. Danny Ben-Zvi\, The faculty of medicine\, The Hebrew Universi ty of Jerusalem [No Categories] DESCRIPTION:Location: \n Affiliation: \n Host:\n Title: Weight loss depe ndentand independent effects of weight-loss surgery    Host: Sagi Levy & Ayala ShiberJoin ZoomMeeting https://technion.zoom.us/j/93293373229 Meet ing ID: 932 9337 3229     END:VEVENT BEGIN:VEVENT UID:949@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20210412T130000 DTEND;TZID=Asia/Jerusalem:20210412T140000 DTSTAMP:20210802T125904Z URL:https://biology.technion.ac.il/en/seminars/prof-gidi-gross-migal-head- of-the-immunology-lab-galilee-israel-2/ SUMMARY:Prof. Gidi Gross\, MIGAL\, Head of the Immunology Lab\, Galilee\, I srael [No Categories] DESCRIPTION:Location: \n Affiliation: \n Host:\n Title:“Implementing lo gic gates in cancer immunotherapy    ”Host: OfirLevin-Piaeda& Ayala Sh iberJoin ZoomMeeting https://technion.zoom.us/j/93293373229 Meeting ID: 93 2 9337 3229     END:VEVENT BEGIN:VEVENT UID:948@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20210405T130000 DTEND;TZID=Asia/Jerusalem:20210405T140000 DTSTAMP:20210802T125904Z URL:https://biology.technion.ac.il/en/seminars/prof-dana-reichmann-the-ale xander-silberman-institute-of-life-science-the-hebrew-university-of-jerusa lem-2/ SUMMARY:Prof. Dana Reichmann\, The Alexander Silberman Institute of Life Sc ience\, The Hebrew University of Jerusalem [No Categories] DESCRIPTION:Location: \n Affiliation: \n Host:\n Title:  "The Cys Se nsing: Thiol Redox Switches Mediate Life Cycles of Cellular Proteins" Host: Ayala ShiberJoin ZoomMeeting https://technion.zoom.us/j/93293373229 Meeting ID: 932 9337 3229     END:VEVENT BEGIN:VEVENT UID:947@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20210325T130000 DTEND;TZID=Asia/Jerusalem:20210325T140000 DTSTAMP:20210802T125904Z URL:https://biology.technion.ac.il/en/seminars/assistant-prof-dvir-aran-fa culty-of-biology-technion-2/ SUMMARY:Assistant Prof. Dvir Aran\, Faculty of Biology\, Technion [No Categ ories] DESCRIPTION:Location: \n Affiliation: \n Host:\n Title:“Researchin the data-rich biomedical era to advance precision medicine”Host: Ayala Shibe rJoin ZoomMeeting https://technion.zoom.us/j/93293373229 Meeting ID: 932 9 337 3229     END:VEVENT BEGIN:VEVENT UID:946@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20210303T130000 DTEND;TZID=Asia/Jerusalem:20210303T140000 DTSTAMP:20210802T125904Z URL:https://biology.technion.ac.il/en/seminars/phd-graduate-seminar-dina-a weida-2/ SUMMARY:PhD Graduate Seminar-Dina Aweida [No Categories] DESCRIPTION:Location: \n Affiliation: \n Host:\n An ordered loss ofdesmin filaments precedesand promotes muscle atrophyMyofibril breakdown is a hall markof muscle wasting and an inevitable sequel of aging and disease. The d esmincytoskeleton is critical for skeletal muscle architecture and functio n\, and itsdepolymerization is required for myofibril loss and atrophy. We uncovered thesequence of events leading to desmin loss\, which is activat ed byphosphorylation. We developed a mass spectrometry-based kinase-trap a ssay andidentified glycogen synthase kinase 3-b (GSK3-b) as responsible fo r desmin phosphorylation. GSK3-b inhibition in mouse muscle prevented desm in phosphorylationand depolymerization\, and blocked atrophy upon fasting or denervation. Hence\,GSK3-b represents a novel drug target to prevent my ofibril breakdownand atrophy. Phosphorylation by GSK3-b mediatedthe subseq uent cleavage and depolymerization of desmin filaments by the Ca2+-specifi cprotease\, calpain-1\, when cytosolic Ca2+ levels rose. Consistently\,cal pain-1 downregulation prevented loss of phosphorylated desmin and blockedm yofibril breakdown and atrophy. Intriguingly\, the depolymerization of des minfilament is facilitated by an understudied protein complex\, the AAA-AT Pase\,Atad1. Atad1 bound phosphorylated desmin filaments\, and together wi th its two previouslyunidentified co-factors\, PLAA and Ubxn4\, promoted d esmin filament solubilizationand loss. Our studies uncovered a cooperative role for Atad1 and calpain-1 inpromoting desmin solubilization and loss\, because downregulation of both genesin atrophying muscles had an additive beneficial effect on desmin filaments andoverall proteolysis. In addition \, cleavage of desmin filaments by calpain-1 invitro was more efficient in the presence of Atad1. Therefore\, we propose the“Pull and cut” mecha nism\, in which Atad1 and calpain-1 cooperate to facilitatedesmin loss in atrophy. END:VEVENT BEGIN:VEVENT UID:945@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20210217T130000 DTEND;TZID=Asia/Jerusalem:20210217T140000 DTSTAMP:20210802T125904Z URL:https://biology.technion.ac.il/en/seminars/phd-graduate-seminar-yoav-p izem-2/ SUMMARY:PhD Graduate Seminar- Yoav Pizem [No Categories] DESCRIPTION:Location: \n Affiliation: \n Host:\n BiophysicalProperties th at Influence Optimal Functional Output of TCR Engineered T Cells Theencou nter of the TCR with its cognate peptide-MHC complex (pMHC) is a crucialst ep in T-cell activation. One of the most critical parameters\, among manyf actors that influence antigen specific T-cell activation\, is the biophysi calnature of the TCR-pMHC interaction defined by TCR affinity and avidity and therelationship with antigen density. Current understanding of how the se factorsand the interrelationships between them affect functional avidit y remainsundefined. To answer this question\, we generated an experimental system inwhich all these main parameters of T cell stimulation are contro llable usingTCR engineered T cells with single specificity. This unique sy stem allowedunderstanding the interplay between TCR affinity\, avidity and antigen densityand their effect on T cell functionality (as measured by c ytokine production\, Tcell degranulation and cytotoxicity). We found that TCRs with medium affinityand avidity are more functionality in in-vitro an d in-vivo experiments. We alsofound that affinity is related to high TCR d ownregulation and antigen trogocytosiswhich can affect T-cells functionali ty at high antigen density\, these newfinding can explain the deference in functionality between TCRs. The knowledgeobtained in my research could ha ve significant impact in understanding basicT-cell biology and decision ma king in choose TCR for therapy in response toantigen. END:VEVENT BEGIN:VEVENT UID:944@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20210210T130000 DTEND;TZID=Asia/Jerusalem:20210210T140000 DTSTAMP:20210802T125904Z URL:https://biology.technion.ac.il/en/seminars/msc-gradutae-seminar-sewar- zbidat-2/ SUMMARY:Msc Gradutae seminar-Sewar Zbidat [No Categories] DESCRIPTION:Location: \n Affiliation: \n Host:\n Insulinreceptor turnover in fasting is dependent on b-dystroglycan deglycosylationFasting exertsva rious physiological effects\, most notably\, reduced signaling through the insulin receptor. Insulin receptor activity requires association withDystr ophin Glycoprotein Complex (DGC)\, and fasting induces autophagic clearanc eof this co-assembly. We showed that insulin receptor turnover during fast ingrequires deglycosylation of b-dystroglycan.Removal of N-linked glycans on b-dystroglycanis catalyzed by the lysosomal enzymes HexA and Man2b1 bec ause theirdownregulation in atrophying muscles prevented b-dystroglycandeg lycosylation and insulin receptor-DGC loss. Surprisingly\, the lysosomalen zyme NAGLU\, which cannot process N-linked glycosylation\, also facilitate d b-dystroglycan deglycosylation and insulinreceptor loss. Furthermore\, M an2b1 andHexA were induced in fasting by the transcriptional complex PPAR- g/RXR-a\, but not whenNAGLU or RXR-a were downregulated.By promoting PPAR- g O-GlcNAcylation\,NAGLU facilitates PPAR-g/RXR-a-mediated Man2b1 and HexA induction and b-dystroglycandeglycosylation. Accordingly\, downregulation of NAGLU or RXR-a during fasting blocked b-dystroglycan deglycosylation\, and consequentlyinsulin receptor-DGC co-assemblies accumulated on the mus cle membrane. Thus\,NAGLU mediates physiological adaptation to fasting by promoting b-dystroglycan deglycosylation.https://technion.zoom.us/j/912491 61095The seminarwill be given in English END:VEVENT BEGIN:VEVENT UID:3@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20210202T120000 DTEND;TZID=Asia/Jerusalem:20210202T143000 DTSTAMP:20210113T091408Z URL:https://biology.technion.ac.il/seminars/lorem-ipsum-is-simply-dummy-te xt-of-the-printing/ SUMMARY:Lorem Ipsum is simply dummy text of the printing [No Categories] DESCRIPTION:Location: Agnon Yehuda\n Affiliation: \n Host:\n Lorem Ipsum is simply dummy text of the printing and typesetting industry.\nLorem Ipsu m has been the industry's standard dummy text ever since the 1500s\, when an unknown printer took a galley of type and scrambled it to make a type s pecimen book. It has survived not only five centuries\, but also the leap into electronic typesetting\, remaining essentially unchanged. It was popu larised in the 1960s with the release of Letraset sheets containing Lorem Ipsum passages\, and more recently with desktop publishing software like A ldus PageMaker including versions of Lorem Ipsum.\nLorem Ipsum is simply d ummy text of the printing and typesetting industry.\nLorem Ipsum has been the industry's standard dummy text ever since the 1500s\, when an unknown printer took a galley of type and scrambled it to make a type specimen boo k. It has survived not only five centuries\, but also the leap into electr onic typesetting\, remaining essentially unchanged. It was popularised in the 1960s with the release of Letraset sheets containing Lorem Ipsum passa ges\, and more recently with desktop publishing software like Aldus PageMa ker including versions of Lorem Ipsum. END:VEVENT BEGIN:VEVENT UID:943@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20210127T130000 DTEND;TZID=Asia/Jerusalem:20210127T140000 DTSTAMP:20210802T125903Z URL:https://biology.technion.ac.il/en/seminars/phd-graduate-seminar-elena- matveev-2/ SUMMARY:PhD Graduate Seminar- Elena Matveev [No Categories] DESCRIPTION:Location: \n Affiliation: \n Host:\n Title:Structure-function analysis of EFF-1 mediated cell-cell fusion Cell-cellfusion is a univers al multi-step process essential for organogenesis and sexualreproduction. EFF-1 protein and its paralog AFF-1 are necessary and sufficientfor fusion in the nematode Caenorhabditis elegans and in heterologoussystems. EFF-1 crystal structure showed that it is a homotrimer\, structurallysimilar to viral class II fusion proteins (e.g. from Zika\, Semliki Forest andDengue viruses). However\, the mechanisms of EFF-1 and AFF-1-mediated cell-cellfu sion remain elusive. Therefore\, to achieve better understanding of themec hanism of action\, the focus of my research was EFF-1 and AFF-1oligomeriza tion dynamics on the plasma membrane. My hypothesis was thattrimerization is a step required for the fusogenic activity of the proteins. Totest this hypothesis\, I applied biochemical methods\, such as surfacebiotinylation \, and sucrose gradients as well as infections of AFF-1 andEFF-1-coated ps eudotyped viruses. I found that A. Wild type EFF-1 ismostly trimeric on th e surface of cells. B. The trimerization of EFF-1can be prevented in the p resence of two independent point mutations\, without areduction in protein activity. C. AFF-1 showed different oligomericstates on the plasma membra ne. Based on these results I suggest a new model inwhich the monomer\, and not the trimer\, constitutes the active form of theseeukaryotic fusogens. END:VEVENT BEGIN:VEVENT UID:942@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20210125T130000 DTEND;TZID=Asia/Jerusalem:20210125T140000 DTSTAMP:20210802T125903Z URL:https://biology.technion.ac.il/en/seminars/prof-arie-admon-faculty-of- biology-technion-2/ SUMMARY:Prof. Arie Admon\, Faculty of Biology\, Technion [No Categories] DESCRIPTION:Location: \n Affiliation: \n Host:\n Title: “The HLA peptid ome – its cellular production pipeline andclinical usefulness”Host: Ay ala Shiberhttps://technion.zoom.us/j/96789984896 END:VEVENT BEGIN:VEVENT UID:941@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20210120T130000 DTEND;TZID=Asia/Jerusalem:20210120T140000 DTSTAMP:20210802T125903Z URL:https://biology.technion.ac.il/en/seminars/ph-d-graduate-seminar-sivas ubramanya-mangapuram-2/ SUMMARY:Ph.D. Graduate Seminar- Sivasubramanya Mangapuram [No Categories] DESCRIPTION:Location: \n Affiliation: \n Host:\n Characterizing the auxil iarynucleotide binding sites in RecBCDDNA helicase\, towards deciphering t heir functional roleAbstract:RecBCD is aDNA helicase-nuclease\, powering t he initiation of dsDNA break repair. It is ahighly processive fast helicas e\, with unwinding rates approaching 1\,600 bp/s.Yet\, there is no underly ing biophysical model to understand this fast-unwindingvelocity. To unrave l RecBCD'smechanochemical basis for its robust performance on DNA\, we hav e employedquantitative biophysical studies utilizing rapid kinetics\, ther modynamics\,cross-linking mass spectrometry (CLMS) and in-vivosurvival ass ays. Previous work in our lab had demonstrated the existence ofauxiliary b inding sites in RecBCD\, specifically in the RecCsubunit\, where ATP binds with lower affinity and with distinct chemicalinteractions as compared to the known catalytic sites. According to our model\,at intermediate ATP co ncentrations\, RecBCD achieves its fast-unwinding rate byutilizing the aux iliary binding sites to increase the flux of ATP to itscatalytic sites. Th e number of nucleotide-binding sites determined byequilibrium dialysis has been estimated to be at least four. While RecB and RecD\,each have one kn own structurally and chemically well-defined nucleotide-bindingsite\, the additional two (or more) auxiliary nucleotide-binding sites remainedunknow n. Our current study strongly supports that they are likely to be locatedi n RecC. Inthis work\, we have attempted to abolish the nucleotide-binding sites in RecC byusing a multi-step approach. A list of possible nucleotide -binding sites wasobtained by using a combination of CLMS and molecular do cking studies. Based onthis\, several mutations in RecC were carefully des igned and successfullycloned and purified to produce a variety of RecBCmut Ds. RecBCmutD proteins have an activated DNA ATPaseactivity\, with a highe r KM\,ATP.Furthermore\, equilibrium nucleotide binding\, DNA unwinding\, a nd invivosurvival assays suggest that the RecBCmutDs donot display the sam e biochemical behavior as the WT RecBCD. Inaddition\, despite exhibiting r apid transition\, as suggested by the rate ofunwinding performed by RecBCD \, wecan still observe a stepping mechanism essential to translocate along its DNAtracks. Our work sheds light on a novel and fundamental enzymatic mechanismexhibited by a molecular motor.Beyond the mechanism of RecBCD and how it is evolved for its cellular function\, the question of why such an enzymeto repair dsDNA break in humans did not evolve\, continues to be per tinent. END:VEVENT BEGIN:VEVENT UID:940@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20210118T130000 DTEND;TZID=Asia/Jerusalem:20210118T140000 DTSTAMP:20210802T125903Z URL:https://biology.technion.ac.il/en/seminars/prof-gabriel-frank-departme nt-of-life-science-ben-gurion-university-of-the-negev-2/ SUMMARY:Prof. Gabriel Frank\, Department of Life Science\, Ben-Gurion Unive rsity of the Negev [No Categories] DESCRIPTION:Location: \n Affiliation: \n Host:\n Title: TBAHost: Ayala Sh iberhttps://technion.zoom.us/j/91816487260     END:VEVENT BEGIN:VEVENT UID:939@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20210113T130000 DTEND;TZID=Asia/Jerusalem:20210113T140000 DTSTAMP:20210802T125903Z URL:https://biology.technion.ac.il/en/seminars/ph-d-graduate-seminar-hadee l-khamis-2/ SUMMARY:Ph.D. Graduate Seminar-Hadeel Khamis [No Categories] DESCRIPTION:Location: \n Affiliation: \n Host:\n TitleA single molecule s tudy of protein-DNAinteractionsAbstract Bindingof transcription factors (T Fs) to regulatory regions in the genome is crucialfor the initiation of tr anscription\, and thus one of the most important layersin the regulation o f gene expression. Most TFs regulate multiple genes andinduce responses th at are gene-specific and vary between cell types anddevelopmental stages\, suggesting that the mere binding of the TF to the DNAcannot explain this diversity of outcomes. In our work\, we developed a set ofnovel optical tw eezers assays to study how binding of Egr1\, a TF harboring 3zinc finger m otifs\, is tuned by variations in the binding site sequence\,sequences fla nking the binding site\, DNA methylation and the structure ofchromatin. Ou r results show that Egr1 binds to a “consensus” binding site in avery stable conformation\, but variations in the core-site\, as observed invivo \,weaken the protein-DNA interactions\, resulting in a wide spectrum of st ructuresand binding energies\, that are also sensitive to variations in th e flankingsequences. Moreover\, we found that DNA methylation at the bindi ng sitesignificantly affects the affinity of the protein and the kinetics of binding\,in a sequence- and position-specific manner. Methylation chang es the breathingkinetics of the DNA itself\, suggesting that the methylati on effect on Egr1binding is mediated by local structural changes in the DN A. Finally\, we studiedEgr1 binding in the vicinity of a nucleosome that c overs the binding site. Wefound that incorporation of the histone variant H2A.Z resulted in an increasein nucleosome diffusion\, which increased Egr 1 binding. Together\, our findingsreveal novel regulatory mechanisms to fi ne-tune the expression of genes.  END:VEVENT BEGIN:VEVENT UID:938@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20210111T130000 DTEND;TZID=Asia/Jerusalem:20210111T140000 DTSTAMP:20210802T125903Z URL:https://biology.technion.ac.il/en/seminars/prof-daphna-nachmani-the-al exander-silberman-institute-of-life-sciencethe-hebrew-university-of-jerusa lem-2/ SUMMARY:Prof. Daphna Nachmani\, The Alexander Silberman Institute of Life S cience\,The Hebrew University of Jerusalem [No Categories] DESCRIPTION:Location: \n Affiliation: \n Host:\n Title: “Lost in Transl ation: the Ribosomal Epitranscriptome in Hematopoiesis”\nHost: Ayala Shi ber\nZOOM END:VEVENT BEGIN:VEVENT UID:937@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20210104T130000 DTEND;TZID=Asia/Jerusalem:20210104T140000 DTSTAMP:20210802T125903Z URL:https://biology.technion.ac.il/en/seminars/prof-nick-talbot-the-sainsb ury-laboratory-norwich-research-park-norwich-uk-2/ SUMMARY:Prof. Nick Talbot\, The Sainsbury Laboratory\, Norwich Research Par k\, Norwich\, UK [No Categories] DESCRIPTION:Location: \n Affiliation: \n Host:\n Title: Investigatingthe cell biology of plant infection by the rice blast fungus Magnaportheoryza eHost: Ayala Shiber END:VEVENT BEGIN:VEVENT UID:936@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20201228T130000 DTEND;TZID=Asia/Jerusalem:20201228T140000 DTSTAMP:20210802T125903Z URL:https://biology.technion.ac.il/en/seminars/prof-tamar-avin-wittenberg- the-alexander-silberman-institute-of-life-science-the-hebrew-university-of -jerusalem-2/ SUMMARY:Prof. Tamar Avin-Wittenberg\, The Alexander Silberman Institute of Life Science\, The Hebrew University of Jerusalem [No Categories] DESCRIPTION:Location: \n Affiliation: \n Host:\n Title: Studying the inte rplay between autophagy andmetabolism in plants Host: Ayala ShiberZoom:  https://technion.zoom.us/j/97980014119 END:VEVENT BEGIN:VEVENT UID:935@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20201223T130000 DTEND;TZID=Asia/Jerusalem:20201223T140000 DTSTAMP:20210802T125903Z URL:https://biology.technion.ac.il/en/seminars/phd-graduate-seminar-michal -ackerman-lavert-2/ SUMMARY:PhD. Graduate Seminar-Michal Ackerman-Lavert [No Categories] DESCRIPTION:Location: \n Affiliation: \n Host:\n “A meristematic state depends on atissue specific-incoherent effect of steroid hormones”The en tire plant body can be traced backto the activity meristems\, tiny organiz ed structures   harboring the stem cells niche. Thisactivity enables pla nts to uniquely produce new organs throughout their lifecycle\, thus provi ding a fascinating model system to study fundamentaldevelopmental question s. In this study\, we asked how a meristematic state ismaintained. We unco vered an incoherent effect of the steroid hormones brassinosteroids(BRs) o n auxin\, involving contradicting molecular outcomes\, as a critical means for preventing differentiation of root meristem. By presenting data relyin g ona new “tool-kit” to map BR signaling responses alongside the use o f reporterlines\, mutants\, transcriptome analysis and direct hormone meas urements\, I willdemonstrate a basis for inter-tissue coordination and how a critical ratiobetween BR and auxin determines the meristematic state.    END:VEVENT BEGIN:VEVENT UID:934@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20201221T130000 DTEND;TZID=Asia/Jerusalem:20201221T140000 DTSTAMP:20210802T125903Z URL:https://biology.technion.ac.il/en/seminars/prof-barak-rotblat-departme nt-of-life-science-ben-gurion-university-of-the-negev-2/ SUMMARY:Prof. Barak Rotblat\, Department of Life Science\, Ben-Gurion Unive rsity of the Negev [No Categories] DESCRIPTION:Location: \n Affiliation: \n Host:\n Title: 4EBP is exploited by tumor cells to adapt toglucose starvationHost: Ayala ShiberZoom: http s://technion.zoom.us/j/99516266251 END:VEVENT BEGIN:VEVENT UID:933@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20201216T130000 DTEND;TZID=Asia/Jerusalem:20201216T140000 DTSTAMP:20210802T125903Z URL:https://biology.technion.ac.il/en/seminars/ph-d-graduate-seminar-vered -cohen-from-the-lab-of-doctor-meiri-david-2/ SUMMARY:Ph.D. Graduate Seminar-Vered Cohen From the Lab of Doctor Meiri D avid [No Categories] DESCRIPTION:Location: \n Affiliation: \n Host:\n Breastcanceris not a sin gle disease\, it is comprised of many biologically differentfeatures with distinct pathological and clinicalimplications. Accumulating evidence sugg est breast cancers with different histopathological andbiological features exhibit different behaviors that lead to differenttreatment responses\, a nd should be handled by different therapeutic strategies.In ERa-positivetu mors\, adjustive endocrine therapy\, such as tamoxifen (TAM)\, is the stan dardfor a 5 years course.  However\, almosthalf of the patients that star t tamoxifen therapy do not complete the wholecourse. Poor adherence to tam oxifen has been associated with many reasonsincluding severe side effects such as hot flashes\, pain and bleeding. In cancertreatment\, Cannabisis b eing primarily used as palliative care to alleviate pain\, relieve nauseaa nd stimulate appetite. However\, asidefrom these palliative actions\, exte nsive preclinical research demonstratedthat phytocannabinoids\, theunique active components of the Cannabisplant\, can trigger an antitumor response in different cancer models. Inthis study\, we found a unique Cannabisstra in (CANN14) that has a synergistic effect with TAM on ERa-positivebreast c ancer cells. CANN14 sensitizes the cells to TAM’s effect\, allowing fora lower TAM concentration. Moreover\, we isolated the phytocannabinoidsresp onsible for the effect: THC\, CBN and the novel phytocannabinoid331-18b. I n a xenograft model\, tumor growth was suppressed significantly withthe co mbined synergistic effect of TAM and CANN14. A combination of THC\, CBNand 331-18b  in the same concentrationsas in CANN14 had a similar effect to the whole CANN14 on breast cancer cells.Furthermore\, a higher concentrati on of 331-18b significantly sensitized thecells to lower TAM concentration by itself. The mechanism of breast cancer celldeath following exposure to CANN14 or the three pure cannabinoids involves areduction in ERaexpressio n and translation\, as well as in its activity as a transcriptionfactor. T hese findings will allow\, in thefuture\, to make a compatible match betwe en the Cannabisstrain and specific breast cancer tumor features. As a resu lt\, treatment dosagewill decrease and the patients’ quality of life wil l improve.      END:VEVENT BEGIN:VEVENT UID:932@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20201209T130000 DTEND;TZID=Asia/Jerusalem:20201209T140000 DTSTAMP:20210802T125903Z URL:https://biology.technion.ac.il/en/seminars/phd-graduate-seminar-einas- abu-zhayia-2/ SUMMARY:PhD. Graduate Seminar- Einas Abu Zhayia [No Categories] DESCRIPTION:Location: \n Affiliation: \n Host:\n Identification of a nove l pathway to ensure double strand break-inducedtranscriptional silencing a nd repairDouble-strand break (DSB) are the most cytotoxic form DNA damagea nd defective DSB repair leads to genomic instabilities that may augment ca rcinogenesis.DSBs trigger local transcriptional silencing in an ATM\, DNA- PK\, and PARP1-dependentmanner. During my PhD\, I identified a previously unrecognized dual role ofchromodomain Y-like (CDYL1) protein in fortifying double-strand break (DSB)-inducedtranscriptional silencing and homology-d irected repair. Mechanistically\, CDYL1ensures DSB-induced transcriptional silencing by local stimulation of therepressive methyl mark H3K27me3 and down regulation of histone lysinecrotonylation. Unexpectedly\, while inhib iting the reduction in lysinecrotonylation at DSB sites alleviates transcr iptional silencing\, the integrityof HDR of DSBs remains intact. Our resul ts uncoupled therefore the repair andthe silencing activity of CDYL1 at DS Bs. In a broader context\, our dataaddressed a long-standing question in t he field concerning the functionalrelationship between HDR and DSB-induced transcriptional silencing and suggestthat they may occur independently. END:VEVENT BEGIN:VEVENT UID:931@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20201207T130000 DTEND;TZID=Asia/Jerusalem:20201207T140000 DTSTAMP:20210802T125903Z URL:https://biology.technion.ac.il/en/seminars/prof-dedi-meiri-faculty-of- biology-2/ SUMMARY:Prof. Dedi Meiri\, Faculty of Biology [No Categories] DESCRIPTION:Location: \n Affiliation: \n Host:\n Title: The endocannabin oid system and its therapeutic potentialHost: Ayala ShiberZoom: https://t echnion.zoom.us/j/93644157337 END:VEVENT BEGIN:VEVENT UID:930@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20201202T130000 DTEND;TZID=Asia/Jerusalem:20201202T140000 DTSTAMP:20210802T125902Z URL:https://biology.technion.ac.il/en/seminars/daniel-zaidman-phd-graduate -seminar-2/ SUMMARY:Daniel Zaidman-PhD Graduate Seminar [No Categories] DESCRIPTION:Location: \n Affiliation: \n Host:\n DanielZaidmanFrom the La b ofDr. Nir London  Weizmann Institute of Science  Computational protoc ols for thedesign of next generation chemical tools.Covalent irreversible inhibitors\, andprotein degraders (PROTACs) are two emerging fields that a re growing rapidlyover the past decade. Such molecular modulators have sev eral advantagescompared to traditional drugs. Irreversible inhibitors have a longer residencetime\, time dependent inhibition\, and improved potency . PROTACs are alsoeffective at lower concentrations\, due to their catalyt ic effect\, and theirrecyclable nature. Yet\, both field suffer from lack of computational tools forthe rational design of compounds. We developed c omputational protocols forthese two domains that are built on simple geome trically oriented schemes whichleverage the specific nature of the problem s at hand.        Inthe field of covalent and irreversible inhibitor s\, I will present – Covalentizer\, apipeline for turning reversible no n-covalent inhibitors into covalent ones\,based on a crystal structure of the molecule bound to its target protein. Apublic database with prediction s against the entire protein data bank (PDB)\,including over 1500 covalen tized structureswas made available at https://covalentizer.weizmann.ac.i l/. Wetested the method retrospectively and successfully recapitulated kno wn covalentkinase inhibitors\, given only their reversible recognition ele ments.Furthermore\, selected candidates were synthesized and tested\, and a few novelcovalent kinase inhibitors\, as well as an inhibitor for the SA RS-CoV-2 mainprotease were discovered [1].        Inthe field of PRO TACs\, I shall present the ProsettaC protocol\,which predicts ternary co mplexes between the degradation target\, the E3 ligaseand the PROTAC. This is achieved by alternating between the sampling of theprotein-protein int eraction space\, and the PROTAC molecular conformationalspace. It was used to recapitulate crystal structures with atomic accuracy\, aswell as prosp ectively predict a new ternary complex with high confidence [2].The method is available at https://prosettac.weizmann.ac.il/. Ina second project\, by a group effort\, we created a public database of PROTACs\,which will be based on contributions and reviews from members of the entirePROTAC commu nity. It is available at https://protacdb.weizmann.ac.il/.  Thesetools\ , combined with our efforts to make them publicly available\, should enabl ebroad access to new and improved chemical probes.  Zoomlink:https://weiz mann.zoom.us/j/98162721348  END:VEVENT BEGIN:VEVENT UID:929@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20201130T130000 DTEND;TZID=Asia/Jerusalem:20201130T140000 DTSTAMP:20210802T125902Z URL:https://biology.technion.ac.il/en/seminars/netanel-tzarem-the-alexande r-silberman-institute-of-life-science-the-hebrew-university-of-jerusalem-2 / SUMMARY:Netanel Tzarem\, The Alexander Silberman Institute of Life Science\ , The Hebrew University of Jerusalem [No Categories] DESCRIPTION:Location: \n Affiliation: \n Host:\n Title: Toward HCV vaccin e - Structural studies of HCV E2 envelopglycoprotein that facilitates rati onal design of HCV vaccine.\nHost: Ayala Shiber END:VEVENT BEGIN:VEVENT UID:928@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20201125T130000 DTEND;TZID=Asia/Jerusalem:20201125T140000 DTSTAMP:20210802T125902Z URL:https://biology.technion.ac.il/en/seminars/m-sc-graduate-seminar-roi-s iegelman-2/ SUMMARY:M.Sc. Graduate Seminar-Roi Siegelman [No Categories] DESCRIPTION:Location: \n Affiliation: \n Host:\n A single molecule study of theroles of the RecC subunit in DNA unwinding by RecBCD DNAdouble-stra nd breaks (DSBs) are the most cytotoxic of DNA lesions and theirrepair req uires a comprehensive and rapid cellular response. In EscherichiaColi\,Rec BCDinitiates the homologous recombination pathway for DSB repair by unwind ing theDNA at the damaged site rapidly and processively. Asingle-molecule assay previously developed in our lab\, enabled monitoring theactivity of the individual subunits\, as part of the full complex of RecBCD. Theresult s demonstrated that synergy between its subunits supports unwinding by Rec BCD.However\, how RecCcontributes to RecBCD'sunwinding activity has not ye t been fully understood. In my work\, I combinedsingle-molecule and in viv oassays to probe the activity of RecBCD mutated in their “pin” domain within RecC\,which was suggested to split the duplex DNA before the indivi dual strands arepulled by RecB and RecD.  Our single molecule results rev eal that\,while the velocity is not significantly affected by these mutati ons\, the pindomain is crucial for the processivity of the whole complex a nd its subunits.Moreover\, the in vivoexperiments suggest that the process ivity determines the ability of RecBCD toefficiently initiate the repair r eaction. END:VEVENT BEGIN:VEVENT UID:927@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20201123T130000 DTEND;TZID=Asia/Jerusalem:20201123T140000 DTSTAMP:20210802T125902Z URL:https://biology.technion.ac.il/en/seminars/tom-shemesh-the-faculty-of- biology-technion-2/ SUMMARY:Tom Shemesh\, The Faculty of Biology\, Technion [No Categories] DESCRIPTION:Location: \n Affiliation: \n Host:\n Title: Softmembranes & r igid filaments: a role for endoplasmic reticulum in thecellular distributi on of microtubules \nHost: Ayala Shiber END:VEVENT BEGIN:VEVENT UID:926@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20201116T130000 DTEND;TZID=Asia/Jerusalem:20201116T140000 DTSTAMP:20210802T125902Z URL:https://biology.technion.ac.il/en/seminars/anat-ben-zvi-department-of- life-science-ben-gurion-university-of-the-negev-2/ SUMMARY:Anat Ben-Zvi\, Department of Life Science\, Ben-Gurion University o f the Negev [No Categories] DESCRIPTION:Location: \n Affiliation: \n Host:\n Title: Neuronal regulati on of proteostasis collapse inCaenorhabditis elegans\nHost:Ayala Shiber END:VEVENT BEGIN:VEVENT UID:925@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20201109T130000 DTEND;TZID=Asia/Jerusalem:20201109T140000 DTSTAMP:20210802T125902Z URL:https://biology.technion.ac.il/en/seminars/rina-rosenzweigdepartment-o f-structural-biology-weizmann-institute-of-science-2/ SUMMARY:Rina Rosenzweig\,Department of Structural Biology\, Weizmann Instit ute of Science [No Categories] DESCRIPTION:Location: \n Affiliation: \n Host:\n Title: Molecular Chapero nes in Protein Disaggregation - What wecan learn by NMR \nHost:Michael Glickman and Ayala Shiber END:VEVENT BEGIN:VEVENT UID:924@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20201102T130000 DTEND;TZID=Asia/Jerusalem:20201102T140000 DTSTAMP:20210802T125902Z URL:https://biology.technion.ac.il/en/seminars/smadar-ben-tabou-de-leon-de partment-of-marine-biology-university-of-haifa-2/ SUMMARY:Smadar Ben Tabou de Leon\, Department of Marine Biology\, Universit y of Haifa [No Categories] DESCRIPTION:Location: \n Affiliation: \n Host:\n Title: Sea urchin skelet ogenesis and its resemblance tovertebrates vascularization: From gene regu latory networks to cytoskeletonremodeling and back\nHost: Benkamin Podbile wicz and AyalaShiber END:VEVENT BEGIN:VEVENT UID:923@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20201101T130000 DTEND;TZID=Asia/Jerusalem:20201101T140000 DTSTAMP:20210802T125902Z URL:https://biology.technion.ac.il/en/seminars/m-sc-graduate-seminar-eshel -elishav-2/ SUMMARY:M.Sc. Graduate Seminar-Eshel Elishav [No Categories] DESCRIPTION:Location: \n Affiliation: \n Host:\n Model-to-crop translatio n:interaction between mineral-nutrient availability and steroid hormones  Plants acquire essentialmineral nutrients from inherently heterogeneous so ils\, in which phosphateavailability vary. Consequently\, plants have deve loped adaptive strategies tocope with low phosphate levels\, including alt ernation between root growth enhancementand attenuation. Using the plant m odel Arabidopsis\, it was recently found thatthe steroid hormone signaling enables root growth plasticity in response tolimited availability of this nutrient.  In addition\, the molecularmechanism that operates at the ba se of this interaction was revealed. The aimof this study was to: i) trans late these findings to crop using tomato and ii)establish physiological gr owth conditions outside agar plates that facilitatesthe analysis of the hi dden root system in both plants.  Indeed\, weestablished an inert soil-l ike substance that allowed us to control the mineralcomposition in the med ia and thus\, to compare root responses of both plantspecies. As part of t he translation strategy\, we took a pharmacology approachto perturb hormon al levels in tomato and use the CRISPR/CAS9 method to createloss-of-functi on mutations in select key transcription factors. This revealedthat the ro ot system of tomato is shaped by low phosphate availabilitydepending on th e steroid signaling. However\, this modulation differed from thatoccurring in Arabidopsis\, highlighting the flexibility and adaptive response ofdif ferent plants to their environment. In addition\, we show that the hormone signaling affected the homeostasis of select elements\, but these were not common between tomato and Arabidopsis. Collectively\, these data demonstra tethat the interaction between phosphate availability and steroid hormones hasdifferent outcome in different plants. Thus\, this study highlights th e advantageof using various plant systems towards understanding of how pla nts makedevelopmental decisions in response to heterogeneous soil.  Thek nowledge in crop could be also harnessed for improving agriculture.  END:VEVENT BEGIN:VEVENT UID:922@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20201026T130000 DTEND;TZID=Asia/Jerusalem:20201026T140000 DTSTAMP:20210802T125902Z URL:https://biology.technion.ac.il/en/seminars/benjamin-podbilewicz-facult y-of-biology-technion-2/ SUMMARY:Benjamin Podbilewicz\, Faculty of Biology\, Technion [No Categories ] DESCRIPTION:Location: \n Affiliation: \n Host:\n Title:Fusion\, sex and t he origin ofeukaryotesHost: Ayala ShiberJoin Zoom Meeting https://technio n.zoom.us/j/5746925814 END:VEVENT BEGIN:VEVENT UID:921@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20201024T231500 DTEND;TZID=Asia/Jerusalem:20201025T001500 DTSTAMP:20210802T125902Z URL:https://biology.technion.ac.il/en/seminars/m-sc-graduate-seminar-manis ha-sahoo-2/ SUMMARY:M.Sc. Graduate Seminar-Manisha Sahoo [No Categories] DESCRIPTION:Location: \n Affiliation: \n Host:\n Manisha SahooFrom the La b of Doctor Kleifeld OdedResearch Topic:  Proteomic profiling of active proteasomes and intracellular peptidome The proteasomes are multisubunit\, multicatalytic protein complex in eukaryotic cells which degrade misfolded \,damaged\, or unstructured proteins. Functionally it is divided into a 20 Scatalytic core particle and two 19S regulatory particles at both side of 20Sparticle.  In eukaryotic cells activeproteasomes exist inthree major t ypes:doubly capped proteasomes - 30S (two 19S on both side of 20S)\, singl y cappedproteasomes – 26S (one 19S on 20S) and 20S proteasomes. The19S r ecognizes and binds ubiquitin modified target proteins to be degraded bypr oteasomes. Then after gets unfolded\, the target protein is catalyticallyc leaved inside the 20S core and released as peptide products. Thecompositio n and amount of each of the proteasome active forms are dynamicallycontrol led by the cellular conditions and thought to be directed towardsdifferent types of substrates and to generate different types of products.Unlike th e lysosome\, where proteases shear proteins up into individual aminoacids\ , the proteasome just chops proteins into small peptides\, with an mean av eragesize of 10-12 amino acids length.These peptides can further be proces sedto single amino acids or possibly be used in many cellular signaling pa thways. Thecurrent study is based on to develop a methodology  for profil ing of active proteasome and  the analysis of peptidome generated bydiffe rent types of proteasomes in yeast cellular system. END:VEVENT BEGIN:VEVENT UID:920@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20200915T130000 DTEND;TZID=Asia/Jerusalem:20200915T140000 DTSTAMP:20210802T125902Z URL:https://biology.technion.ac.il/en/seminars/m-sc-graduate-seminar-benja min-eichenbaum-2/ SUMMARY:M.Sc. Graduate Seminar-Benjamin Eichenbaum [No Categories] DESCRIPTION:Location: \n Affiliation: \n Host:\n Photosynthesisis the pro cess by which solar energy is converted into chemical energy in theform of complex carbohydrates and ATP. With growing interest inphotosynthesis a s a potential renewable- energysource\, Bio-photo-electrochemical cells  (BPEC) were designed andfabricated with the purpose of light energy tra nsformation into electricalpower or even hydrogen fuel. InBPEC systems\, one of the factors limiting power outputs and efficiency is themolecular damage caused to the photosynthetic protein machinery due to intenseradiat ion exposure for long time periods (e.g. Photoinhibition). Tocope with ra diation damage and minimize photoinhibition\,certain organisms that dwell in high radiation areas have developed specialrepair mechanisms (e.g. ph otoprotection).One such organism is the unicellular green micro-algae Chl orella ohadii\,which was isolated from soil-crust beds in the Nitzanadese rt\, Israel. Originating from an arid desert area\, C. ohadii isa good candidate for improving our BPEC set-up\, having a robust photoprotection mechanism and fast proliferation rate. C. ohadii cells and isolatedth ylakoid membranes have generated stable photocurrents inthe BPEC sys tem\, with ferricyanide asthe exogenous electron mediator. The majority of current originates fromphotosynthesis\, as it was inhibited upon additio n of DCMU.Inthis study\, we established and evaluated the power-output andperformance of an algal BPEC system with C. ohadii cellsor thylakoid s\, demonstrating its potential for sustainable bio-energyproduction.   END:VEVENT BEGIN:VEVENT UID:919@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20200914T130000 DTEND;TZID=Asia/Jerusalem:20200914T140000 DTSTAMP:20210802T125902Z URL:https://biology.technion.ac.il/en/seminars/m-sc-graduate-seminar-roni- monin-2/ SUMMARY:M.Sc. Graduate Seminar- Roni Monin [No Categories] DESCRIPTION:Location: \n Affiliation: \n Host:\n Roni MoninFrom the Lab o f  Professor Michael GlickmanResearch Topic: 20S Proteasome gain-of-func tionduring stress conditionsThe Proteasome is a large Protein complexrespo nsible for protein degradation in cells. The 26S Proteasome is composed of two main parts – the 19S is the regulatory particle and the 20S which is thecatalytic core particle. Under normal conditions\, proteins are ubiqui tinated andthen recognized as a substrates for degradation by the 19S\, wh ich prepares themfor proteolysis within the 20S subcomplex.However\, durin g stress condition as more proteins are damaged they couldoverload the ubi quitin-proteasome system. Also\, during stress\, the proteasomeitself coul d be modified or damaged. We found preliminary evidence that hypoxiaor oxi dative stress conditions promote separation of the 19S from the 20S.Recent studies have shown the ability of the 20S to degrade non-ubiquitinatedpro teins. We propose a gain-of-function of the 20S during stress conditionsth at could help clearing damaged or partially unfolded proteins. In our work weshow the effect of hypoxia on proteasome composition in the cell and th eability of purified human proteasome to degrade a partially unfolded mode lsubstrate. END:VEVENT BEGIN:VEVENT UID:918@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20200908T130000 DTEND;TZID=Asia/Jerusalem:20200908T140000 DTSTAMP:20210802T125902Z URL:https://biology.technion.ac.il/en/seminars/m-sc-graduate-seminar-maria n-nicola-2/ SUMMARY:M.Sc. Graduate Seminar-Marian Nicola [No Categories] DESCRIPTION:Location: \n Affiliation: \n Host:\n The RNA recognition moti f (RRM) is found approximately in all lifekingdoms and is one of the most abundant protein domains. RRM-containingproteins take part in post transcr iptional events such as: pre-mRNA processing\,splicing\, alternative splic ing\, mRNA stability\, mRNA export\, RNA editing\, andtranslation regulati on. My M.Sc. project focuses on RNA-binding motif 42(RBM42) that contains one RRM motif at its C-terminal region. Unpublished workfrom our lab impli cated RBM42 in RNA splicing and DNA damage response (DDR) bya yet unknown mechanism. In an attempt to shed molecular insights into how RBM42regulate s splicing and DNA repair\, we sought to map RBM42 interactome using ascor bateperoxidase (APEX2)-based proximity labelling approach combined with Ma ssSpectrometry. Toward this end\, we used CRISPR-cas9 methodology to knock -inAPEX2 to the C-terminal of the endogenous RBM42. RBM42 proximal protein s werebiotinylated by APEX2 activation using H2O2 and subjectedto Mass spe ctrometry. Interactome analysis substantiates RBM42 role in mRNA splicing andDNA damage repair and revealed unexpected pathways that are regulated b y RBM42such as protein synthesis. During the seminar\, I will elaborate on how RBM42interactome advances our understanding of RBM42 biological funct ions. END:VEVENT BEGIN:VEVENT UID:917@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20200907T130000 DTEND;TZID=Asia/Jerusalem:20200907T140000 DTSTAMP:20210802T125901Z URL:https://biology.technion.ac.il/en/seminars/phd-graduate-seminar-dzmitr y-mukha-2/ SUMMARY:PhD. Graduate Seminar-Dzmitry Mukha [No Categories] DESCRIPTION:Location: \n Affiliation: \n Host:\n One-carbon(1C) metabolis m is highlydysregulated in cancer. While serine serves as the main donor o ffolate-mediated 1C units\, recent studies reveal the importance of metabo liccontribution by other 1C donors in tumors.Studyingthe contribution of g lycine to 1C metabolism\, we found major increase in theexpression of glyc ine cleavage system (GCS) genes specifically inhepatocellular carcinoma (H CC). We developed a Systems Biology method fordirectly quantifying GCS flu x by integrating 13C and 14Ctracers\, and computational modeling – a hig hly challenging task considering thevariety of pathways oxidizing glycine and serine\, and the rapid interconversionof these two amino acids. We sho w\, for the first time\, that glycine-derived 1Cunits support purine and p yrimidine biosynthesis in tumors (via shuttling ofglycine-derived formate to cytosol) and that this occursspecifically in HCC.Geneticsilencing of gl ycine decarboxylase (P-subunit of GCS) leads to mitochondrialdysfunction a nd halts HCC tumor growth in mouse models. Our work establishesGCS as a no vel target for HCC – the most common and highly malignant type ofprimary liver cancer\, currently without an effective treatment. END:VEVENT BEGIN:VEVENT UID:916@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20200903T130000 DTEND;TZID=Asia/Jerusalem:20200903T143000 DTSTAMP:20210802T125901Z URL:https://biology.technion.ac.il/en/seminars/%d7%90%d7%a8%d7%95%d7%97-%d 7%a4%d7%90%d7%a0%d7%9c-%d7%9e%d7%93%d7%95%d7%a7%d7%98%d7%95%d7%a8%d7%98-%d 7%9c%d7%aa%d7%a2%d7%a9%d7%99%d7%99%d7%94-%d7%94%d7%a4%d7%a7%d7%95%d7%9c%d7 %98%d7%94-%d7%9c%d7%91-2/ SUMMARY:ארוח פאנל מדוקטורט לתעשייה- הפקולטה לביולוגיה [No Categories] DESCRIPTION:Location: \n Affiliation: \n Host:\n  בסיוםהדוקטו רט חלקנו נמשיך במחקר באקדמיה\, וחלקנו נצ א לדרך חדשה בתעשיה- אבל מהןהאפשרויות העו מדות בפנינו? מהם האתגרים הצפויים?כדי לשו חח\, להקשיב\, ובעיקר לפתוח את הראש להזדמנ ויות עבורינו בתום הדוקטורט- אנו מתכבדו ת לארח פאנל מעורר השראה\, של בוגרידוקטו רט שנמצאים כיום בתפקידים מגוונים ומעני ינים בתעשייה. הפאנל יערך בזום ביום חמי שי ה- 3.9.20 בשעות 13:00-14:30   ההרשמהלאירוע :h ttps://technion.zoom.us/meeting/register/tJYpce2vrD4oG9Bsj06OOGCTASSleJe2e rCbבסיוםההרשמה יישלח לינק לזום- מהרו להרש ם! משתתפי הפאנל:Dr. MartinAkerman\, CTO\, Cofounder at Envis agenics\, Inchttps://www.linkedin.com/in/martin-akerman-586b4a1a/ Dr. Dik laMontekio Malter\, Director ofInvestments & Partnerships at The Kitchen Hubhttps://www.linkedin.com/in/dr-dikla-montekio-malter-a282baa2/ Dr. Roi Feingersch\, Foresee Genomics\, CEO& Founderhttps://www.linkedin.com/in/r oi-feingersch-5666b715/ Dr. Jasmin Ravid\, Co-founder ofKinoko-Techhttp s://www.linkedin.com/in/jasmin-ravid/ Dr. Shimon(Shimi) Shteingart\, VP R&D atBioimmunate LTDhttps://www.linkedin.com/in/shimon-shimi-shteingart- 9810311a/ נשוחחעל הנושאים הבאים-·         א יךמחליטים בין המשך מחקר באקדמיהלבין מע בר לתעשייה?·         אילואפשרויות קיימ ות בפני אם אני לא רוצה להמשיך בתפקידי מחק ר?·         אילוכישורים כדאי לרכוש במהל ך הלימודים?·         איךאני מייחד את עצ מי בחיפוש עבודה?·         מהוטווח המשכו רות הצפוי?·         האםכדאי בכל זאת לצא ת לפוסט דוקטורט לפני המעבר לתעשיה?·          האםאוכל להמשיך לעסוק בהוראה? END:VEVENT BEGIN:VEVENT UID:915@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20200901T130000 DTEND;TZID=Asia/Jerusalem:20200901T140000 DTSTAMP:20210802T125901Z URL:https://biology.technion.ac.il/en/seminars/m-sc-graduate-seminar-meshi -sadot-2/ SUMMARY:M.Sc. Graduate Seminar- Meshi Sadot [No Categories] DESCRIPTION:Location: \n Affiliation: \n Host:\n END:VEVENT BEGIN:VEVENT UID:914@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20200831T010000 DTEND;TZID=Asia/Jerusalem:20200831T020000 DTSTAMP:20210802T125901Z URL:https://biology.technion.ac.il/en/seminars/m-sc-graduate-seminar-keren -amsalem-2/ SUMMARY:M.Sc. Graduate Seminar- Keren Amsalem [No Categories] DESCRIPTION:Location: \n Affiliation: \n Host:\n END:VEVENT BEGIN:VEVENT UID:913@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20200825T130000 DTEND;TZID=Asia/Jerusalem:20200825T140000 DTSTAMP:20210802T125901Z URL:https://biology.technion.ac.il/en/seminars/phd-graduate-seminar-nataly -rijensky-2/ SUMMARY:PhD. Graduate Seminar- Nataly Rijensky [No Categories] DESCRIPTION:Location: \n Affiliation: \n Host:\n END:VEVENT BEGIN:VEVENT UID:912@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20200824T130000 DTEND;TZID=Asia/Jerusalem:20200824T140000 DTSTAMP:20210802T125901Z URL:https://biology.technion.ac.il/en/seminars/m-sc-graduate-seminar-shaha r-garin-2/ SUMMARY:M.Sc.. Graduate Seminar-Shahar Garin [No Categories] DESCRIPTION:Location: \n Affiliation: \n Host:\n END:VEVENT BEGIN:VEVENT UID:911@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20200818T130000 DTEND;TZID=Asia/Jerusalem:20200818T140000 DTSTAMP:20210802T125901Z URL:https://biology.technion.ac.il/en/seminars/phd-graduate-seminar-nir-sa linas-2/ SUMMARY:PhD. Graduate Seminar-Nir Salinas [No Categories] DESCRIPTION:Location: \n Affiliation: \n Host:\n END:VEVENT BEGIN:VEVENT UID:910@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20200817T130000 DTEND;TZID=Asia/Jerusalem:20200817T140000 DTSTAMP:20210802T125901Z URL:https://biology.technion.ac.il/en/seminars/phd-graduate-semniar-einat- tamar-2/ SUMMARY:PhD Graduate Semniar-Einat Tamar [No Categories] DESCRIPTION:Location: \n Affiliation: \n Host:\n END:VEVENT BEGIN:VEVENT UID:909@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20200811T011500 DTEND;TZID=Asia/Jerusalem:20200811T021500 DTSTAMP:20210802T125901Z URL:https://biology.technion.ac.il/en/seminars/phd-graduate-seminar-liran- komov-2/ SUMMARY:PhD. Graduate Seminar-Liran Komov [No Categories] DESCRIPTION:Location: \n Affiliation: \n Host:\n END:VEVENT BEGIN:VEVENT UID:908@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20200804T130000 DTEND;TZID=Asia/Jerusalem:20200804T140000 DTSTAMP:20210802T125901Z URL:https://biology.technion.ac.il/en/seminars/m-sc-graduate-seminar-yarde n-nave-2/ SUMMARY:M.Sc. Graduate Seminar-Yarden Nave [No Categories] DESCRIPTION:Location: \n Affiliation: \n Host:\n Zoom link :https://techn ion.zoom.us/j/97455022198Meeting ID: 974 5502 2198 END:VEVENT BEGIN:VEVENT UID:907@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20200728T130000 DTEND;TZID=Asia/Jerusalem:20200728T140000 DTSTAMP:20210802T125901Z URL:https://biology.technion.ac.il/en/seminars/phd-graduate-seminar-noa-be n-asher-2/ SUMMARY:PhD Graduate Seminar- Noa Ben-Asher [No Categories] DESCRIPTION:Location: \n Affiliation: \n Host:\n Zoom link :https://techn ion.zoom.us/j/96370240342?pwd=RUdMWnBraFFOMnZ3MHdVUUJFVTIrdz09Meeting ID: 963 7024 0342Passcode: 878332 END:VEVENT BEGIN:VEVENT UID:906@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20200629T130000 DTEND;TZID=Asia/Jerusalem:20200629T140000 DTSTAMP:20210802T125901Z URL:https://biology.technion.ac.il/en/seminars/prof-nabieh-ayoub-faculty-o f-biology-technion-2/ SUMMARY:Prof. Nabieh Ayoub\, Faculty of Biology\, Technion [No Categories] DESCRIPTION:Location: \n Affiliation: \n Host:\n Title: Exploitingthe nov el role of RBM6 splicing factor in DNA repair for targeted cancertherapyZo om:https://technion.zoom.us/j/92737656162    Host: Debbie Lindell END:VEVENT BEGIN:VEVENT UID:905@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20200622T130000 DTEND;TZID=Asia/Jerusalem:20200622T140000 DTSTAMP:20210802T125901Z URL:https://biology.technion.ac.il/en/seminars/prof-adi-stern-school-of-mo lecular-cell-biology-and-biotechnology-tel-aviv-university-2/ SUMMARY:Prof. Adi Stern\, School of Molecular Cell Biology and Biotechnolog y\, Tel Aviv University [No Categories] DESCRIPTION:Location: \n Affiliation: \n Host:\n Title:Sequencing SARS-CO V-2: Deducing spread into and within Israel\, and incidence rates Zoom:htt ps://technion.zoom.us/j/92724814449Host: Debbie Lindell END:VEVENT BEGIN:VEVENT UID:904@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20200615T130000 DTEND;TZID=Asia/Jerusalem:20200615T140000 DTSTAMP:20210802T125901Z URL:https://biology.technion.ac.il/en/seminars/yotam-bar-on-faculty-of-med icine-technion-2/ SUMMARY:Yotam Bar-On\, Faculty of Medicine. Technion [No Categories] DESCRIPTION:Location: \n Affiliation: \n Host:\n Title: Mappingthe landsc ape of viral immune evasion and diversityZoom:https://technion.zoom.us/j/9 5391957314Host: Ayala Shiber and Debbie Lindell END:VEVENT BEGIN:VEVENT UID:903@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20200608T130000 DTEND;TZID=Asia/Jerusalem:20200608T140000 DTSTAMP:20210802T125900Z URL:https://biology.technion.ac.il/en/seminars/prof-adi-kimchi-dept-molecu lar-genetics-weizmann-institute-of-science-2/ SUMMARY:Prof. Adi Kimchi\, Dept. Molecular Genetics\, Weizmann Institute of Science [No Categories] DESCRIPTION:Location: \n Affiliation: \n Host:\n Title: Controlling embr yonic stem cell fate decisions by aunique mechanism of mRNA translationZoo m:https://technion.zoom.us/j/91893421605    Host: Debbie Lindell END:VEVENT BEGIN:VEVENT UID:902@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20200601T130000 DTEND;TZID=Asia/Jerusalem:20200601T140000 DTSTAMP:20210802T125900Z URL:https://biology.technion.ac.il/en/seminars/prof-yuko-ulrich-university -of-lausanne-switzerland-2/ SUMMARY:Prof. Yuko Ulrich\, University of Lausanne\, Switzerland [No Catego ries] DESCRIPTION:Location: \n Affiliation: \n Host:\n Title: Division of labo r and disease dynamics in clonal ant societies    Zoom: https://techni on.zoom.us/j/95504628686Host: Shay Stern and Debbie Lindell END:VEVENT BEGIN:VEVENT UID:901@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20200525T130000 DTEND;TZID=Asia/Jerusalem:20200525T140000 DTSTAMP:20210802T125900Z URL:https://biology.technion.ac.il/en/seminars/prof-alessio-ciulli-univers ity-of-dundee-uk-2/ SUMMARY:Prof. Alessio Ciulli\, University of Dundee\, UK [No Categories] DESCRIPTION:Location: \n Affiliation: \n Host:\n Title:Targeted protein d egradationwith small-molecules: How PROTACs workZoom: https://technion.zo om.us/j/93090655153    Host: Michael Glickman and Debbie Lindell END:VEVENT BEGIN:VEVENT UID:900@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20200518T130000 DTEND;TZID=Asia/Jerusalem:20200518T140000 DTSTAMP:20210802T125900Z URL:https://biology.technion.ac.il/en/seminars/prof-folma-buss-university- of-cambridge-uk-2/ SUMMARY:Prof. Folma Buss\, University of Cambridge\, UK [No Categories] DESCRIPTION:Location: \n Affiliation: \n Host:\n Title: Cellular functio ns of myosin motor proteins in health and disease    Zoom: https://tec hnion.zoom.us/j/96840114760    Host: Arnon Henn and Debbie Lindell END:VEVENT BEGIN:VEVENT UID:899@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20200511T130000 DTEND;TZID=Asia/Jerusalem:20200511T140000 DTSTAMP:20210802T125900Z URL:https://biology.technion.ac.il/en/seminars/prof-alga-zuccaro-universit y-of-koeln-germany-2/ SUMMARY:Prof. Alga Zuccaro\, University of Koeln\, Germany [No Categories] DESCRIPTION:Location: \n Affiliation: \n Host:\n Title:“TBA”Zoom: ht tps://technion.zoom.us/j/91264505233Host: Benjamin Horwitz and Debbie Lind ell  END:VEVENT BEGIN:VEVENT UID:898@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20200504T130000 DTEND;TZID=Asia/Jerusalem:20200504T140000 DTSTAMP:20210802T125900Z URL:https://biology.technion.ac.il/en/seminars/prof-sebastian-geibel-insti tute-for-molecular-infection-biologyuniversity-of-wurzburg-germany-2/ SUMMARY:Prof. Sebastian Geibel\, Institute for Molecular Infection Biology University of Würzburg\, Germany [No Categories] DESCRIPTION:Location: \n Affiliation: \n Host:\n Title: “Structural and mechanistic insights intothe mycobacterial type VII secretion system”\n Zoom: https://technion.zoom.us/j/91264505233\nHost: Ayala Shiber and Debbi e Lindell END:VEVENT BEGIN:VEVENT UID:897@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20200330T130000 DTEND;TZID=Asia/Jerusalem:20200330T140000 DTSTAMP:20210802T125900Z URL:https://biology.technion.ac.il/en/seminars/prof-dedi-meiri-faculty-of- biology-technion-2/ SUMMARY:Prof. Dedi Meiri\, Faculty of Biology\, Technion [No Categories] DESCRIPTION:Location: \n Affiliation: \n Host:\n Title: Theendocannabinoi d system and its therapeutic potential \nHost: Debbie Lindell END:VEVENT BEGIN:VEVENT UID:896@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20200323T130000 DTEND;TZID=Asia/Jerusalem:20200323T140000 DTSTAMP:20210802T125900Z URL:https://biology.technion.ac.il/en/seminars/prof-rina-rosernzweig-depar tment-of-structural-biology-weizmann-institute-of-science-2/ SUMMARY:Prof. Rina Rosernzweig\, Department of Structural Biology\, Weizman n Institute of Science [No Categories] DESCRIPTION:Location: \n Affiliation: \n Host:\n Title: “Top of their c lass: Class B Hsp40chaperones in amyloid disaggregation”\nHost: Michael Glickman and Debbie Lindell END:VEVENT BEGIN:VEVENT UID:895@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20200316T130000 DTEND;TZID=Asia/Jerusalem:20200316T140000 DTSTAMP:20210802T125900Z URL:https://biology.technion.ac.il/en/seminars/prof-ronit-ilouz-faculty-of -medicine-bar-ilan-university-2/ SUMMARY:Prof. Ronit Ilouz\, FAculty of Medicine\, Bar Ilan University [No C ategories] DESCRIPTION:Location: \n Affiliation: \n Host:\n Title: ProteinKinase A ( PKA) Isoform Specificity: From Single Molecules to the Brain \nHost: Da n Zilberstein and Debbie Lindell END:VEVENT BEGIN:VEVENT UID:894@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20200309T130000 DTEND;TZID=Asia/Jerusalem:20200309T140000 DTSTAMP:20210802T125900Z URL:https://biology.technion.ac.il/en/seminars/prof-yehuda-chowers-directo r-of-the-research-division-and-gastroenterology-institute-at-rambam-hospit al-2/ SUMMARY:Prof. Yehuda Chowers\, Director of the Research Division and Gastr oenterology Institute at Rambam Hospital [No Categories] DESCRIPTION:Location: \n Affiliation: \n Host:\n Title: Personalize thera py of inflammatory bowel diseases\nHost: Roy Kishony END:VEVENT BEGIN:VEVENT UID:893@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20200226T130000 DTEND;TZID=Asia/Jerusalem:20200226T140000 DTSTAMP:20210802T125900Z URL:https://biology.technion.ac.il/en/seminars/ph-d-graduate-seminar-rinat -zaid-2/ SUMMARY:Ph.D. Graduate Seminar-Rinat Zaid [No Categories] DESCRIPTION:Location: \n Affiliation: \n Host:\n END:VEVENT BEGIN:VEVENT UID:892@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20200213T130000 DTEND;TZID=Asia/Jerusalem:20200213T140000 DTSTAMP:20210802T125900Z URL:https://biology.technion.ac.il/en/seminars/ph-d-graduate-seminar-louie -said-2/ SUMMARY:Ph.D. Graduate Seminar-Louie Said [No Categories] DESCRIPTION:Location: \n Affiliation: \n Host:\n END:VEVENT BEGIN:VEVENT UID:891@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20200210T130000 DTEND;TZID=Asia/Jerusalem:20200210T140000 DTSTAMP:20210802T125900Z URL:https://biology.technion.ac.il/en/seminars/shai-pilosof-department-of- life-sciences-ben-gurion-university-2/ SUMMARY:Shai Pilosof\, Department of Life Sciences\, Ben Gurion University [No Categories] DESCRIPTION:Location: \n Affiliation: \n Host:\n Title: The interplay bet ween immunity\, structure and dynamics inhost-pathogen systems \nHost: Debbie Lindell END:VEVENT BEGIN:VEVENT UID:890@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20200205T130000 DTEND;TZID=Asia/Jerusalem:20200205T140000 DTSTAMP:20210802T125900Z URL:https://biology.technion.ac.il/en/seminars/m-sc-graduate-seminar-mahas en-sarji-2/ SUMMARY:M.Sc. Graduate Seminar-Mahasen Sarji [No Categories] DESCRIPTION:Location: \n Affiliation: \n Host:\n END:VEVENT BEGIN:VEVENT UID:889@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20200203T130000 DTEND;TZID=Asia/Jerusalem:20200203T133000 DTSTAMP:20210802T125859Z URL:https://biology.technion.ac.il/en/seminars/david-zeevi-center-for-stud ies-in-physics-and-biology-rockefeller-university-ny-usa-2/ SUMMARY:David Zeevi\, Center for Studies in Physics and Biology\, Rockefell er University\, NY\, USA [No Categories] DESCRIPTION:Location: \n Affiliation: \n Host:\n Title:Towards mining the marine microbiome for remediation targets: lessons fromthe humanmicrobiom eHost: Yael Mandel Gutreund END:VEVENT BEGIN:VEVENT UID:888@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20200130T130000 DTEND;TZID=Asia/Jerusalem:20200130T140000 DTSTAMP:20210802T125859Z URL:https://biology.technion.ac.il/en/seminars/m-sc-graduate-seminar-idan- berlad-2/ SUMMARY:M.Sc. Graduate Seminar- Idan Berlad [No Categories] DESCRIPTION:Location: \n Affiliation: \n Host:\n END:VEVENT BEGIN:VEVENT UID:887@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20200129T130000 DTEND;TZID=Asia/Jerusalem:20200129T140000 DTSTAMP:20210802T125859Z URL:https://biology.technion.ac.il/en/seminars/m-sc-graduate-seminar-benja min-david-euhus-2/ SUMMARY:M.Sc. Graduate Seminar-Benjamin David Euhus [No Categories] DESCRIPTION:Location: \n Affiliation: \n Host:\n END:VEVENT BEGIN:VEVENT UID:885@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20200122T130000 DTEND;TZID=Asia/Jerusalem:20200122T140000 DTSTAMP:20210802T125859Z URL:https://biology.technion.ac.il/en/seminars/prof-guangshuo-ou-school-of -life-sciences-tsinghua-university-china-2/ SUMMARY:Prof. Guangshuo Ou School of Life Sciences\, Tsinghua University\, China [No Categories] DESCRIPTION:Location: \n Affiliation: \n Host:\n Title: "Regulation of Fu sogen Recruitment during Cell-CellFusion in C. elegans"\nHost: Benny Podbi lewicz END:VEVENT BEGIN:VEVENT UID:886@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20200122T130000 DTEND;TZID=Asia/Jerusalem:20200122T140000 DTSTAMP:20210802T125859Z URL:https://biology.technion.ac.il/en/seminars/msc-graduate-seminar-alaa-j bara-2/ SUMMARY:MSC Graduate Seminar-Alaa Jbara [No Categories] DESCRIPTION:Location: \n Affiliation: \n Host:\n END:VEVENT BEGIN:VEVENT UID:884@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20200120T130000 DTEND;TZID=Asia/Jerusalem:20200120T140000 DTSTAMP:20210802T125859Z URL:https://biology.technion.ac.il/en/seminars/sagi-levi-laboratory-of-neu ral-circuits-and-behavior-rockefeller-university-ny-usa-2/ SUMMARY:Sagi Levi\, Laboratory of Neural Circuits and Behavior\, Rockefelle r University\, NY\, USA [No Categories] DESCRIPTION:Location: \n Affiliation: \n Host:\n Title: An adaptive-thre shold mechanism for odor sensation and animal navigationHost: Yael Mandel- Gutfreund END:VEVENT BEGIN:VEVENT UID:883@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20200113T130000 DTEND;TZID=Asia/Jerusalem:20200113T140000 DTSTAMP:20210802T125859Z URL:https://biology.technion.ac.il/en/seminars/livnat-jerby-arnonthe-broad -institute-of-mit-and-harvard-usa-2/ SUMMARY:Livnat Jerby-Arnon\,The Broad Institute of MIT and Harvard\, USA [N o Categories] DESCRIPTION:Location: \n Affiliation: \n Host:\n Title: Dissecting immun e evasion mechanisms in cancer using single-celltechnologiesHost: Yael Man del-Gutfreund END:VEVENT BEGIN:VEVENT UID:882@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20200108T130000 DTEND;TZID=Asia/Jerusalem:20200108T140000 DTSTAMP:20210802T125859Z URL:https://biology.technion.ac.il/en/seminars/phd-graduate-seminar-elazar -besser-2/ SUMMARY:PhD. Graduate Seminar-Elazar Besser [No Categories] DESCRIPTION:Location: \n Affiliation: \n Host:\n END:VEVENT BEGIN:VEVENT UID:881@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20200106T130000 DTEND;TZID=Asia/Jerusalem:20200106T140000 DTSTAMP:20210802T125859Z URL:https://biology.technion.ac.il/en/seminars/aeid-igbariachemistry-oncog enesis-stress-signaling-coss-universite-de-rennes-france-2/ SUMMARY:Aeid Igbaria\,Chemistry\, Oncogenesis\, stress\, Signaling (COSS)\, Universite de Rennes\, France [No Categories] DESCRIPTION:Location: \n Affiliation: \n Host:\n Title: Endoplasmic Reti culum to CYtosol Signaling (ERCYS)\, A FunctionalER SurveillanceMechanism in Health and DiseaseHost: Yael Mandel-Gutfreund END:VEVENT BEGIN:VEVENT UID:880@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20191230T130000 DTEND;TZID=Asia/Jerusalem:20191230T140000 DTSTAMP:20210802T125859Z URL:https://biology.technion.ac.il/en/seminars/sahar-melamed-national-inst itute-of-child-health-and-human-development-nih-maryland-usa-2/ SUMMARY:Sahar Melamed\, National Institute of Child Health and Human Develo pment\, NIH\, Maryland\, USA [No Categories] DESCRIPTION:Location: \n Affiliation: \n Host:\n Title: IntricateNetworks of Small RNA-Mediated Regulation Revealed by RIL-seq\nHost: Yael Mandel G utfreund END:VEVENT BEGIN:VEVENT UID:879@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20191223T130000 DTEND;TZID=Asia/Jerusalem:20191223T140000 DTSTAMP:20210802T125859Z URL:https://biology.technion.ac.il/en/seminars/nadav-sharon-harvard-depart ment-of-stem-cell-and-regenerative-biology-harvard-usa-2/ SUMMARY:Nadav Sharon\, Harvard department of stem cell and regenerative Bio logy\, Harvard\, USA [No Categories] DESCRIPTION:Location: \n Affiliation: \n Host:\n Title:“The pancreatic islet – an organ frombeginning to end “\nHost: Yael Mandel-Gutfreund END:VEVENT BEGIN:VEVENT UID:878@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20191216T130000 DTEND;TZID=Asia/Jerusalem:20191216T140000 DTSTAMP:20210802T125859Z URL:https://biology.technion.ac.il/en/seminars/orly-laufman-department-of- microbiology-and-immunology-university-of-california-san-francisco-usa-2/ SUMMARY:Orly Laufman\, Department of Microbiology and Immunology\, Universi ty of California San Francisco\, USA [No Categories] DESCRIPTION:Location: \n Affiliation: \n Host:\n Title: “Deconstructing the replication program ofenteroviruses in human cells “\nHost: Yael Ma ndel Gutfreund END:VEVENT BEGIN:VEVENT UID:877@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20191202T130000 DTEND;TZID=Asia/Jerusalem:20191202T140000 DTSTAMP:20210802T125859Z URL:https://biology.technion.ac.il/en/seminars/mor-nitzanpaulson-school-of -engineering-and-applied-sciences-harvard-university-usa-2/ SUMMARY:Mor\, Nitzan\,Paulson School of Engineering and Applied Sciences\, Harvard University\, USA [No Categories] DESCRIPTION:Location: \n Affiliation: \n Host:\n Title:Representation\, i nference anddesign of multicellular systemsHost: Yael Mandel-Gutfreund END:VEVENT BEGIN:VEVENT UID:876@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20191128T093000 DTEND;TZID=Asia/Jerusalem:20191201T103000 DTSTAMP:20210802T125858Z URL:https://biology.technion.ac.il/en/seminars/m-sc-graduate-seminar-hoday a-farber-4/ SUMMARY:M.Sc. Graduate Seminar-Hodaya Farber [No Categories] DESCRIPTION:Location: \n Affiliation: \n Host:\n Research Topic:Identifin gMetabolic Alterations and VulnerabilitesinSenescentandCancer Cellsזיה וינקודות התורפה המטבוליות בתאי סרטן אשר הפעילו את מנגנון ה- Senescence END:VEVENT BEGIN:VEVENT UID:875@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20191125T130000 DTEND;TZID=Asia/Jerusalem:20191125T140000 DTSTAMP:20210802T125858Z URL:https://biology.technion.ac.il/en/seminars/prof-yaron-fuchs-faculty-of -biology-technion-2/ SUMMARY:Prof. Yaron Fuchs\, Faculty of Biology\, Technion [No Categories] DESCRIPTION:Location: \n Affiliation: \n Host:\n Title: “Stem cells and apoptosis: A matter oflife and death\nHost: Debbie Lindell END:VEVENT BEGIN:VEVENT UID:874@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20191118T130000 DTEND;TZID=Asia/Jerusalem:20191118T140000 DTSTAMP:20210802T125858Z URL:https://biology.technion.ac.il/en/seminars/prof-aladar-szalay-cancer-t herapy-research-center-university-of-wuerzburg-germany-and-department-of-r adiation-oncology-ucsd-cancer-center-san-diego-usa-2/ SUMMARY:Prof. Aladar Szalay\, Cancer Therapy Research Center\, University o f Wuerzburg\, Germany and Department of Radiation Oncology\, UCSD Cancer C enter\, San Diego USA [No Categories] DESCRIPTION:Location: \n Affiliation: \n Host:\n Title: Autologous stem c ells as oncolyticsmall pox vaccine carriers for immunotherapy of cancer in human patients.”\nHost: Debbie Lindell END:VEVENT BEGIN:VEVENT UID:873@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20191106T130000 DTEND;TZID=Asia/Jerusalem:20191106T140000 DTSTAMP:20210802T125858Z URL:https://biology.technion.ac.il/en/seminars/msc-graduate-seminar-polina -raif-singher-2/ SUMMARY:MSC Graduate Seminar-Polina Raif Singher [No Categories] DESCRIPTION:Location: \n Affiliation: \n Host:\n END:VEVENT BEGIN:VEVENT UID:872@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20191104T090000 DTEND;TZID=Asia/Jerusalem:20191104T100000 DTSTAMP:20210802T125858Z URL:https://biology.technion.ac.il/en/seminars/harvey-prize-laureates-symp osium-2019-2/ SUMMARY:Harvey Prize Laureates Symposium 2019 [No Categories] DESCRIPTION:Location: \n Affiliation: \n Host:\n Title: CRISPR Breakthrou gh - From Bacteria to Bedside\nKeynote Lecture: Feng Zhang\, MIT\, Broad I nstitute\nKeynote Lecture: Emmanuelle Charpentier\, Max Planck Institute END:VEVENT BEGIN:VEVENT UID:870@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20191030T130000 DTEND;TZID=Asia/Jerusalem:20191030T140000 DTSTAMP:20210802T125858Z URL:https://biology.technion.ac.il/en/seminars/msc-graduate-seminar-yuval- ginosar-2/ SUMMARY:MSC Graduate Seminar-Yuval Ginosar [No Categories] DESCRIPTION:Location: \n Affiliation: \n Host:\n END:VEVENT BEGIN:VEVENT UID:869@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20191028T130000 DTEND;TZID=Asia/Jerusalem:20191028T140000 DTSTAMP:20210802T125858Z URL:https://biology.technion.ac.il/en/seminars/prof-debbie-lindell-faculty -of-biology-technion-2/ SUMMARY:Prof. Debbie Lindell\, Faculty of Biology\, Technion [No Categories ] DESCRIPTION:Location: \n Affiliation: \n Host:\n Title: “Resistance and coexistance among cyanobacteria and their phages in the ocean” END:VEVENT BEGIN:VEVENT UID:868@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20191027T130000 DTEND;TZID=Asia/Jerusalem:20191027T140000 DTSTAMP:20210802T125858Z URL:https://biology.technion.ac.il/en/seminars/prof-alberto-kornblihtt-uni versity-of-buenos-aires-argentina-2/ SUMMARY:Prof. Alberto Kornblihtt\, University of Buenos Aires\, Argentina [ No Categories] DESCRIPTION:Location: \n Affiliation: \n Host:\n Lokey Distinguished Semi nar\n\nTitle:\n“Coupling of transcription and alternative splicing”\n\ nHost and Opening remarks: Ariel Kaplan END:VEVENT BEGIN:VEVENT UID:867@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20191003T100000 DTEND;TZID=Asia/Jerusalem:20191003T110000 DTSTAMP:20210802T125858Z URL:https://biology.technion.ac.il/en/seminars/msc-graduate-seminar-ariel- chazan-2/ SUMMARY:MSC Graduate Seminar-Ariel Chazan [No Categories] DESCRIPTION:Location: \n Affiliation: \n Host:\n END:VEVENT BEGIN:VEVENT UID:866@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20191002T130000 DTEND;TZID=Asia/Jerusalem:20191002T140000 DTSTAMP:20210802T125858Z URL:https://biology.technion.ac.il/en/seminars/phd-graduate-seminar-neta-c haim-2/ SUMMARY:PhD Graduate Seminar-Neta Chaim [No Categories] DESCRIPTION:Location: \n Affiliation: \n Host:\n END:VEVENT BEGIN:VEVENT UID:865@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20190924T130000 DTEND;TZID=Asia/Jerusalem:20190924T140000 DTSTAMP:20210802T125858Z URL:https://biology.technion.ac.il/en/seminars/phd-graduate-seminar-alona- feldman-2/ SUMMARY:PhD Graduate Seminar- Alona Feldman [No Categories] DESCRIPTION:Location: \n Affiliation: \n Host:\n END:VEVENT BEGIN:VEVENT UID:864@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20190909T130000 DTEND;TZID=Asia/Jerusalem:20190909T140000 DTSTAMP:20210802T125858Z URL:https://biology.technion.ac.il/en/seminars/phd-graduate-seminar-dror-s hitrit-september-9-9-9-19-2/ SUMMARY:PhD Graduate Seminar-Dror Shitrit-September 9 (9/9/19) [No Categori es] DESCRIPTION:Location: \n Affiliation: \n Host:\n END:VEVENT BEGIN:VEVENT UID:863@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20190903T130000 DTEND;TZID=Asia/Jerusalem:20190903T140000 DTSTAMP:20210802T125858Z URL:https://biology.technion.ac.il/en/seminars/msc-graduate-seminar-looz-m ilay-2/ SUMMARY:MSC Graduate Seminar-Looz Milay [No Categories] DESCRIPTION:Location: \n Affiliation: \n Host:\n END:VEVENT BEGIN:VEVENT UID:862@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20190902T130000 DTEND;TZID=Asia/Jerusalem:20190902T140000 DTSTAMP:20210802T125857Z URL:https://biology.technion.ac.il/en/seminars/msc-graduate-seminar-yael-i osilevskii-2/ SUMMARY:MSC Graduate Seminar-Yael Iosilevskii [No Categories] DESCRIPTION:Location: \n Affiliation: \n Host:\n Research Topic:Functions for git-1in dendritic maintenance and behavior in Caenorhabditis elegansT he protein GIT1 (G-protein-coupled receptorkinase interacting ArfGAP 1) is a GTPase activating protein (GAP) for the Arfsmall GTP-binding proteins\, and a focal-adhesion-based scaffold\, with over 100associated proteins. G IT1 has been linked to dendritic spine formation andsynaptic changes in ro dent hippocampus\, as well as impairment in fear responseand learning. It has also been implicated in Huntington’s disease\,Schizophrenia\, and AD HD (reviewed in 1). Inorder to study the effects of GIT1 on dendritic morp hology\, we use C.elegansand its stereotypically-arborized polymodal neuro n PVD (2) and follow its dendritic arborizationpattern and associated beha vioral outputs. We found that while git-1mutantsdisplay relatively normal PVD neuron morphology in L4 stage\, this is followedby a significant and a symmetric increase in tertiary and quaternary ectopicbranches during early adulthood. Thus\, git-1 isnecessary for dendritic maintenance\, but not m orphogenesis. To reveal thesignaling pathway mediating this effect\, we te sted mutants of the GIT-1 primarybinding partner PIX (p21-activated kinase [PAK]-interacting exchange factor)and its downstream kinase PAK. We found that pix-1mutants have a similar\, yet milder\, phenotype in adult PVD mo rphology\, but pak-1 andhomologue max-2 mutants are wild-type-like\, sugge stingthat git-1 acts partly through its binding partner pix-1 as anegative regulator of branch arborization in adulthood. The behavioralphenotypes a ssociated with git-1 weretested by movement analysis and a harsh touch res ponse assay\, where we showthat two git-1 mutant alleles have no apparentm echanosensory defects but display increased speed and body wavelength. The seresults open a possibility for a novel dendritic maintenance pathway\, w hich mayinfluence proprioceptive faculties in the worm. END:VEVENT BEGIN:VEVENT UID:861@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20190820T130000 DTEND;TZID=Asia/Jerusalem:20190820T140000 DTSTAMP:20210802T125857Z URL:https://biology.technion.ac.il/en/seminars/msc-graduate-seminar-anna-y unaev-2/ SUMMARY:MSC Graduate Seminar-Anna Yunaev [No Categories] DESCRIPTION:Location: \n Affiliation: \n Host:\n MSC Graduate SeminarTues day\, August20(20/08/19) Facultyof Biology Auditorium\, 13:00 PMAnna Yunae vFrom the Lab ofProfessorYehuda AssarafResearchTopic:Molecular characteriz ation ofdrug-induced lysosomal biogenesis END:VEVENT BEGIN:VEVENT UID:860@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20190813T130000 DTEND;TZID=Asia/Jerusalem:20190813T140000 DTSTAMP:20210802T125857Z URL:https://biology.technion.ac.il/en/seminars/msc-graduate-seminar-dean-l ight-2/ SUMMARY:MSC Graduate Seminar-Dean Light [No Categories] DESCRIPTION:Location: \n Affiliation: \n Host:\n END:VEVENT BEGIN:VEVENT UID:859@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20190806T130000 DTEND;TZID=Asia/Jerusalem:20190806T140000 DTSTAMP:20210802T125857Z URL:https://biology.technion.ac.il/en/seminars/msc-graduate-seminar-adrian -lehvy-2/ SUMMARY:MSC Graduate Seminar-Adrian Lehvy [No Categories] DESCRIPTION:Location: \n Affiliation: \n Host:\n END:VEVENT BEGIN:VEVENT UID:858@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20190723T130000 DTEND;TZID=Asia/Jerusalem:20190723T140000 DTSTAMP:20210802T125857Z URL:https://biology.technion.ac.il/en/seminars/phd-graduate-seminar-lana-k ostic-2/ SUMMARY:PhD Graduate Seminar-Lana Kostic [No Categories] DESCRIPTION:Location: \n Affiliation: \n Host:\n END:VEVENT BEGIN:VEVENT UID:857@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20190716T130000 DTEND;TZID=Asia/Jerusalem:20190716T140000 DTSTAMP:20210802T125857Z URL:https://biology.technion.ac.il/en/seminars/phd-graduate-seminar-shlomi -dvir-2/ SUMMARY:PhD. Graduate Seminar-Shlomi Dvir [No Categories] DESCRIPTION:Location: \n Affiliation: \n Host:\n ResearchTopic:Decipherin g theRNA-bound proteome of human embryonic stem cellsRNA-binding proteins( RBPs) are essential regulators of post-transcriptional gene expression\,co ntrolling numerous aspects in the life of an RNA molecule. While remarkabl eprogress has been made in unveiling the transcriptional regulatory princi plesunderlying pluripotency\, relatively little is known about the role of post-transcriptional regulation in embryonic stem cells (ESCs). Here\, we present the first mRNA-binding proteome of human ESCs (hESCs).Using a prot eomic-based approach\, we identified 810 high-confidence RBPs\,including 1 68 candidate dual DNA and RNA binding proteins (DRBPs). We show thatRBPs a re preferentially expressed in hESCs and dynamically regulated during exit from pluripotency. Notably\, we found that many RBPs are bound by the core transcriptional circuitry of ESCs\, consisting of OCT4\, SOX2 and NANOG.Kn ockdown of these three master regulators further indicated that RBPs arek ey players in the pluripotency network. Finally\, we determined the dualnu cleic-acid-binding activity of two pluripotency factors\, ESRP1 and STAT3. Taken together\, our findings reveal that RBPs have a far greater role in theregulation of human pluripotency than previously appreciated. END:VEVENT BEGIN:VEVENT UID:856@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20190709T130000 DTEND;TZID=Asia/Jerusalem:20190709T140000 DTSTAMP:20210802T125857Z URL:https://biology.technion.ac.il/en/seminars/phd-graduate-seminar-yarden -golan-maor-2/ SUMMARY:PhD. Graduate Seminar-Yarden Golan Maor [No Categories] DESCRIPTION:Location: \n Affiliation: \n Host:\n Research Topic:The role of ZnT2 in health anddisease END:VEVENT BEGIN:VEVENT UID:855@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20190625T130000 DTEND;TZID=Asia/Jerusalem:20190625T140000 DTSTAMP:20210802T125857Z URL:https://biology.technion.ac.il/en/seminars/phd-graduate-seminar-sophia -zborowsky-2/ SUMMARY:PhD. Graduate Seminar-Sophia Zborowsky [No Categories] DESCRIPTION:Location: \n Affiliation: \n Host:\n Research Topic:Resistanc e in marinecyanobacteria against infection bygeneralist and specialist cya nophagesCyanobacteria of the genera Synechococcus and Prochloroccocus arei nfected by generalist and specialist phages. Coexistence between thecyanob acteria and the phages is thought to be facilitated by resistance. Whileex tracellular resistance is established\, it not known if intracellularresis tance exists in marine cyanobacteria. In order to investigate whetherintra cellular resistance exists in Prochlorococcus and Synechococcusandif resis tance differs against generalist and specialist cyanophages wechecked if i nfections of resistant strains are halted inside or outside thecell. Resis tance was extracellular in most interactions against specialist cyanophage s. Incontrast\, resistance was intracellular in practically all interactio ns againstgeneralist cyanophages.This unveils a heavy cost of promiscuous entry of generalist phages intonon-host cells that is rarely paid by speci alists. Furthermore\, the stage ofintracellular arrest was interaction-spe cific\, halting at various stages of theinfection cycle. This indicates th e presence of potential differentintracellular mechanismsofresistance. Sea rching the genome of marine Synechococcus and Prochloroccocusstrains for g enes of known defense systems showed that complete systems arerare. Inacti vation of two known systems in SynechococcusWH5701did not result in sensit ivity. Finally\, we found that in SynechococcusWH5701the mechanism of resi stance was loss of transaction of tRNAgenesthat appear to be crucial for t ranslation of phages proteins. TheSeminar will be given in English. END:VEVENT BEGIN:VEVENT UID:854@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20190624T130000 DTEND;TZID=Asia/Jerusalem:20190624T140000 DTSTAMP:20210802T125857Z URL:https://biology.technion.ac.il/en/seminars/prof-rafi-haddad-the-gonda- brain-research-center-bar-ilan-university-2/ SUMMARY:Prof. Rafi Haddad\, The Gonda Brain Research Center\, Bar Ilan Univ ersity [No Categories] DESCRIPTION:Location: \n Affiliation: \n Host:\n Title: Sharing sensory information between the two hemispheres\nHosts: Debbie Lindell and Shenhav Cohen END:VEVENT BEGIN:VEVENT UID:853@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20190611T130000 DTEND;TZID=Asia/Jerusalem:20190611T140000 DTSTAMP:20210802T125857Z URL:https://biology.technion.ac.il/en/seminars/phd-graduate-seminar-inbal- maniv-2/ SUMMARY:PhD. Graduate Seminar-Inbal Maniv [No Categories] DESCRIPTION:Location: \n Affiliation: \n Host:\n ResearchTopic:Mutant Ubi quitin Drives theEmergence And Pathogenesis of Alzheimer’s DiseaseAlzhei mer’sdisease(AD) is characterized by accumulation of hazardous proteins in the brain. Asthe primary signal of protein clearance in the cell is ubi quitin\, defectiveubiquitin signaling could play a pivotal role in the eme rgence of this disease.Although the only reported ubiquitin mutation\, UBB +1\,can be found in brains of all AD patients\, mouse studies have failed insupplying a causal link with AD pathogenesis. By establishing a 3D neuro nalnetwork utilizing human neuronal progenitors\, we demonstrate that UBB+ 1expression alone can initiate the two pathological hallmarks of AD: Abpla ques and neurofibrillary tangles.Specifically\, we show that UBB+1competes with ubiquitin for the binding to the neuroprotective enzyme UCH-L1 leadin g toelevated levels of Amyloid Precursor Protein and amyloid plaque buildu p.Importantly\, silencing UBB+1expressionis sufficient to hinder the emerg ence of AD hallmarks. Taken together\, UBB+1plays a critical role in drivi ng AD development\, serving as a promisingtherapeutic target for the treat ment of AD END:VEVENT BEGIN:VEVENT UID:852@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20190610T130000 DTEND;TZID=Asia/Jerusalem:20190610T140000 DTSTAMP:20210802T125857Z URL:https://biology.technion.ac.il/en/seminars/prof-sigal-ben-yehuda-facul ty-of-medicine-hebrew-university-of-jerusalem-2/ SUMMARY:Prof. Sigal Ben Yehuda\, Faculty of Medicine\, Hebrew University of Jerusalem [No Categories] DESCRIPTION:Location: \n Affiliation: \n Host:\n Title: Bacterial nanotub es: Conduits for intra- and inter-kingdom molecular trafficking\nHost: Deb bie Lindell END:VEVENT BEGIN:VEVENT UID:851@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20190603T130000 DTEND;TZID=Asia/Jerusalem:20190603T140000 DTSTAMP:20210802T125857Z URL:https://biology.technion.ac.il/en/seminars/prof-oded-rechavi-dept-neur obiology-tel-aviv-university-2/ SUMMARY:Prof. Oded Rechavi\, Dept. Neurobiology\, Tel Aviv University [No C ategories] DESCRIPTION:Location: \n Affiliation: \n Host:\n Title: Neuronal RNA tran sgenerational memories in C. elegans\nHosts: Debbie Lindell and Beni Podbi lewicz END:VEVENT BEGIN:VEVENT UID:850@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20190527T130000 DTEND;TZID=Asia/Jerusalem:20190527T140000 DTSTAMP:20210802T125857Z URL:https://biology.technion.ac.il/en/seminars/prof-shenhav-cohen-faculty- of-biology-technion-2/ SUMMARY:Prof. Shenhav Cohen\, Faculty of Biology\, Technion [No Categories] DESCRIPTION:Location: \n Affiliation: \n Host:\n Title: “Molecular mech anisms regulating muscle size – from protein degradation to disease ther apy”\nHost: Debbie Lindell END:VEVENT BEGIN:VEVENT UID:849@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20190523T130000 DTEND;TZID=Asia/Jerusalem:20190523T140000 DTSTAMP:20210802T125857Z URL:https://biology.technion.ac.il/en/seminars/prof-rolf-backofen-chair-fo r-bioinformatics-at-the-university-of-freiburg-institute-of-computer-scien ce-freiburg-germany-2/ SUMMARY:Prof. Rolf Backofen\, Chair for Bioinformatics at the University o f Freiburg\, Institute of Computer Science. Freiburg\, Germany [No Categor ies] DESCRIPTION:Location: \n Affiliation: \n Host:\n Title: Bioinformatics an alysis of complex protocols: CLIP-seq and single-cell RNA-seq *\n\nHost: Y ael Mandel-Gutfreund END:VEVENT BEGIN:VEVENT UID:848@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20190521T130000 DTEND;TZID=Asia/Jerusalem:20190521T140000 DTSTAMP:20210802T125856Z URL:https://biology.technion.ac.il/en/seminars/phd-graduate-seminar-anna-m eledin-2/ SUMMARY:PhD. Graduate Seminar-Anna Meledin [No Categories] DESCRIPTION:Location: \n Affiliation: \n Host:\n END:VEVENT BEGIN:VEVENT UID:847@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20190520T130000 DTEND;TZID=Asia/Jerusalem:20190520T140000 DTSTAMP:20210802T125856Z URL:https://biology.technion.ac.il/en/seminars/prof-kinneret-keren-faculty -of-physics-technion-2/ SUMMARY:Prof. Kinneret Keren\, Faculty of Physics\, Technion [No Categories ] DESCRIPTION:Location: \n Affiliation: \n Host:\n Title:Hydra regeneration : actin dynamics and the influence of mechanical constraints\nHost: Debbie Lindell END:VEVENT BEGIN:VEVENT UID:846@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20190516T103000 DTEND;TZID=Asia/Jerusalem:20190516T113000 DTSTAMP:20210802T125856Z URL:https://biology.technion.ac.il/en/seminars/daniel-shiran-prize-for-exc ellence-in-research-2/ SUMMARY:Daniel Shiran Prize for excellence in research [No Categories] DESCRIPTION:Location: \n Affiliation: \n Host:\n Dear Members of the Facu lty\,\nOn Thursday\, May 16 at 10:30 our colleague Yaron Fuchs will receiv e the Daniel Shiran Prize for excellence in research. See attached invitat ion.\nYaron will give a lecture titled: "Stem Cells and Apoptosis: A Matte r of Life and Death". END:VEVENT BEGIN:VEVENT UID:845@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20190515T123000 DTEND;TZID=Asia/Jerusalem:20190515T140000 DTSTAMP:20210802T125856Z URL:https://biology.technion.ac.il/en/seminars/phd-graduate-seminar-lilach -zattelman-2/ SUMMARY:PhD. Graduate Seminar- Lilach Zattelman [No Categories] DESCRIPTION:Location: \n Affiliation: \n Host:\n END:VEVENT BEGIN:VEVENT UID:844@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20190514T130000 DTEND;TZID=Asia/Jerusalem:20190514T140000 DTSTAMP:20210802T125856Z URL:https://biology.technion.ac.il/en/seminars/phd-graduate-seminar-alona- rabner-2/ SUMMARY:PhD. Graduate Seminar-Alona Rabner [No Categories] DESCRIPTION:Location: \n Affiliation: \n Host:\n END:VEVENT BEGIN:VEVENT UID:843@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20190513T130000 DTEND;TZID=Asia/Jerusalem:20190513T140000 DTSTAMP:20210802T125856Z URL:https://biology.technion.ac.il/en/seminars/prof-joshua-rabinowitz-depa rtment-of-chemistry-princeton-university-usa-2/ SUMMARY:Prof. Joshua Rabinowitz\, Department of Chemistry\, Princeton Unive rsity\, USA [No Categories] DESCRIPTION:Location: \n Affiliation: \n Host:\n Title: Metabolism Revisi ted\nHost: Tomer Shlomi END:VEVENT BEGIN:VEVENT UID:842@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20190507T130000 DTEND;TZID=Asia/Jerusalem:20190507T140000 DTSTAMP:20210802T125856Z URL:https://biology.technion.ac.il/en/seminars/phd-graduate-seminar-won-do ng-lee-2/ SUMMARY:PhD. Graduate Seminar-Won Dong Lee [No Categories] DESCRIPTION:Location: \n Affiliation: \n Host:\n END:VEVENT BEGIN:VEVENT UID:841@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20190430T130000 DTEND;TZID=Asia/Jerusalem:20190430T140000 DTSTAMP:20210802T125856Z URL:https://biology.technion.ac.il/en/seminars/phd-graduate-seminar-gur-he vroni-2/ SUMMARY:PhD. Graduate Seminar-Gur Hevroni [No Categories] DESCRIPTION:Location: \n Affiliation: \n Host:\n END:VEVENT BEGIN:VEVENT UID:840@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20190429T130000 DTEND;TZID=Asia/Jerusalem:20190429T140000 DTSTAMP:20210802T125856Z URL:https://biology.technion.ac.il/en/seminars/prof-shulamit-levenberg-fac ulty-of-biomedical-engineering-2/ SUMMARY:Prof. Shulamit Levenberg\, Faculty of Biomedical Engineering [No Ca tegories] DESCRIPTION:Location: \n Affiliation: \n Host:\n Title: "Vascularization and 3D bioprinting for engineering implantable complex tissue structures"\ nHost: Debbie Lindell END:VEVENT BEGIN:VEVENT UID:839@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20190416T130000 DTEND;TZID=Asia/Jerusalem:20190416T140000 DTSTAMP:20210802T125856Z URL:https://biology.technion.ac.il/en/seminars/m-sc-graduate-seminar-dana- goldbraikh-2/ SUMMARY:M.Sc. Graduate Seminar-Dana Goldbraikh [No Categories] DESCRIPTION:Location: \n Affiliation: \n Host:\n END:VEVENT BEGIN:VEVENT UID:838@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20190415T130000 DTEND;TZID=Asia/Jerusalem:20190415T140000 DTSTAMP:20210802T125856Z URL:https://biology.technion.ac.il/en/seminars/prof-jordon-chill-dept-chem istry-bar-ilan-university-2/ SUMMARY:Prof. Jordon Chill Dept. Chemistry\, Bar Ilan University [No Catego ries] DESCRIPTION:Location: \n Affiliation: \n Host:\n Title: NMR investigation of membrane-associated and membrane-targeting proteins\nHosts: Debbie Lin dell & Arnon Henn END:VEVENT BEGIN:VEVENT UID:837@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20190408T130000 DTEND;TZID=Asia/Jerusalem:20190408T140000 DTSTAMP:20210802T125856Z URL:https://biology.technion.ac.il/en/seminars/prof-nikolay-dokholyan-dept -pharmacology-dept-biochemistry-and-molecular-biology-pennsylvania-state-c ollege-of-medicine-2/ SUMMARY:Prof. Nikolay Dokholyan\, Dept. Pharmacology & Dept. Biochemistry a nd Molecular Biology\, Pennsylvania State College of Medicine [No Categori es] DESCRIPTION:Location: \n Affiliation: \n Host:\n Title: “From etiology to therapeutics of the Lou Gehrig’s disease”\n\nHost: Meytal Landau END:VEVENT BEGIN:VEVENT UID:836@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20190402T130000 DTEND;TZID=Asia/Jerusalem:20190402T140000 DTSTAMP:20210802T125856Z URL:https://biology.technion.ac.il/en/seminars/phd-graduate-seminar-yasmin -leshem-2/ SUMMARY:PhD. Graduate Seminar-Yasmin Leshem [No Categories] DESCRIPTION:Location: \n Affiliation: \n Host:\n END:VEVENT BEGIN:VEVENT UID:835@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20190401T130000 DTEND;TZID=Asia/Jerusalem:20190401T140000 DTSTAMP:20210802T125856Z URL:https://biology.technion.ac.il/en/seminars/prof-andrea-pauli-research- institute-of-molecular-pathology-vienna-biocenter-austria-2/ SUMMARY:Prof. Andrea Pauli\, Research Institute of Molecular Pathology\, Vi enna BioCenter\, Austria [No Categories] DESCRIPTION:Location: \n Affiliation: \n Host:\n “Small proteins with b ig roles – from coordinating cell migration to mediating species-specifi c fertilization”\nHost: Benjamin Podbilewicz podbilew@technion.ac.il END:VEVENT BEGIN:VEVENT UID:834@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20190325T130000 DTEND;TZID=Asia/Jerusalem:20190325T140000 DTSTAMP:20210802T125855Z URL:https://biology.technion.ac.il/en/seminars/prof-michael-glickman-facul ty-of-biology-technion-2/ SUMMARY:Prof. Michael Glickman\, Faculty of Biology\, Technion [No Categori es] DESCRIPTION:Location: \n Affiliation: \n Host:\n “Still struggling with fundamental questions in the Ubiquitin Proteasome System”\n\n\nHost Deb bie Lindell END:VEVENT BEGIN:VEVENT UID:833@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20190319T130000 DTEND;TZID=Asia/Jerusalem:20190319T140000 DTSTAMP:20210802T125855Z URL:https://biology.technion.ac.il/en/seminars/phd-graduate-seminar-nabeel -ganem-2/ SUMMARY:PhD. Graduate Seminar-Nabeel Ganem [No Categories] DESCRIPTION:Location: \n Affiliation: \n Host:\n END:VEVENT BEGIN:VEVENT UID:832@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20190318T130000 DTEND;TZID=Asia/Jerusalem:20190318T140000 DTSTAMP:20210802T125855Z URL:https://biology.technion.ac.il/en/seminars/prof-hannes-e-buelow-depart ments-of-genetics-and-neuroscience-albert-einstein-college-of-medicine-ny- usa-2/ SUMMARY:Prof. Hannes E. Buelow Departments of Genetics and Neuroscience\, A lbert Einstein College of Medicine\, NY\, USA [No Categories] DESCRIPTION:Location: \n Affiliation: \n Host:\n “Shaping dendritic arb ors – non-autonomous control of neural patterning”\n\nHםst: Podbilewi cz Benjamin END:VEVENT BEGIN:VEVENT UID:831@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20190311T130000 DTEND;TZID=Asia/Jerusalem:20190311T140000 DTSTAMP:20210802T125855Z URL:https://biology.technion.ac.il/en/seminars/prof-peleg-hasson-rappaport -faculty-of-medicine-technion-2/ SUMMARY:Prof. Peleg Hasson\, Rappaport Faculty of Medicine\, Technion [No C ategories] DESCRIPTION:Location: \n Affiliation: \n Host:\n “Bridging the gap – the making of seamless junctions in the muscular system”\n\nHost: Debbie Lindell END:VEVENT BEGIN:VEVENT UID:830@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20190306T093000 DTEND;TZID=Asia/Jerusalem:20190306T103000 DTSTAMP:20210802T125855Z URL:https://biology.technion.ac.il/en/seminars/phd-seminar-2/ SUMMARY:PhD Seminar [No Categories] DESCRIPTION:Location: \n Affiliation: \n Host:\n Raanan Greenman\, Facult y of Biology\n“Studying the Biophysical Properties that Shape Functional Output of Engineered Chimeric Antigen Receptor (CAR)-T cells”\n\nUnder the supervision of Yoram Reiter END:VEVENT BEGIN:VEVENT UID:829@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20190304T130000 DTEND;TZID=Asia/Jerusalem:20190304T140000 DTSTAMP:20210802T125855Z URL:https://biology.technion.ac.il/en/seminars/prof-rachel-green-dept-plan t-and-environmental-sciences-hebrew-university-of-jerusalem-2/ SUMMARY:Prof. Rachel Green\, Dept. Plant and Environmental Sciences\, Hebre w University of Jerusalem [No Categories] DESCRIPTION:Location: \n Affiliation: \n Host:\n “In sync with the outs ide – the plant circadian system”\n\nHost: Debbie Lindell END:VEVENT BEGIN:VEVENT UID:828@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20190225T130000 DTEND;TZID=Asia/Jerusalem:20190225T140000 DTSTAMP:20210802T125855Z URL:https://biology.technion.ac.il/en/seminars/prof-marcel-machluf-faculty -of-biotechnology-and-food-engineering-technion-2/ SUMMARY:Prof. Marcel Machluf\, Faculty of Biotechnology and Food Engineeri ng\, Technion [No Categories] DESCRIPTION:Location: \n Affiliation: \n Host:\n “NanoGhost: Harnessing the power of stem cells to modulate the tumor niche”\n\nHost: Debbie Li ndell END:VEVENT BEGIN:VEVENT UID:827@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20190219T090000 DTEND;TZID=Asia/Jerusalem:20190219T100000 DTSTAMP:20210802T125855Z URL:https://biology.technion.ac.il/en/seminars/m-sc-graduate-seminar-ferna ndo-sasso-2/ SUMMARY:M.Sc. Graduate Seminar-Fernando Sasso [No Categories] DESCRIPTION:Location: \n Affiliation: \n Host:\n Fernando Sasso  From t he Lab of       ProfessorBenjaminHorwitzResearch Topic:Germination: the Initial Stages in Trichodermavirens-Plant InteractionThe Seminar will be given inEnglish. END:VEVENT BEGIN:VEVENT UID:826@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20190218T130000 DTEND;TZID=Asia/Jerusalem:20190218T140000 DTSTAMP:20210802T125855Z URL:https://biology.technion.ac.il/en/seminars/dr-yoav-gothilf-the-george- s-wise-faculty-of-life-sciences-tel-aviv-university-2/ SUMMARY:Dr. Yoav Gothilf\, The George S. Wise Faculty of Life Sciences\, T el-Aviv University [No Categories] DESCRIPTION:Location: \n Affiliation: \n Host:\n “The role of hypothala mic agouti-related peptides in appetite regulation and beyond: A study in zebrafish”\n\nHost: Debbie Lindell a\,d Esther Lubzens END:VEVENT BEGIN:VEVENT UID:825@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20190213T093000 DTEND;TZID=Asia/Jerusalem:20190213T103000 DTSTAMP:20210802T125855Z URL:https://biology.technion.ac.il/en/seminars/jennifer-iden-faculty-of-bi ology-2/ SUMMARY:Jennifer Iden\, Faculty of Biology [No Categories] DESCRIPTION:Location: \n Affiliation: \n Host:\n MSc Thesis Lecture title d: The Efficacy of Cannabis on Anylosing Spondylitis\n\nUnder the supervis ion of: Meiri David and Associate Advisor Doctor Yishai Ofran END:VEVENT BEGIN:VEVENT UID:824@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20190211T130000 DTEND;TZID=Asia/Jerusalem:20190211T140000 DTSTAMP:20210802T125855Z URL:https://biology.technion.ac.il/en/seminars/prof-philippa-melamed-facul ty-of-biology-technion-2/ SUMMARY:Prof. Philippa Melamed\, Faculty of Biology\, Technion [No Categori es] DESCRIPTION:Location: \n Affiliation: \n Host:\n “The central control o f reproduction in an epigenetic landscape”\nHost: Debbie Lindell END:VEVENT BEGIN:VEVENT UID:823@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20190210T093000 DTEND;TZID=Asia/Jerusalem:20190210T103000 DTSTAMP:20210802T125855Z URL:https://biology.technion.ac.il/en/seminars/iris-wyrobnik-faculty-of-bi ology-2/ SUMMARY:Iris Wyrobnik\, Faculty of Biology [No Categories] DESCRIPTION:Location: \n Affiliation: \n Host:\n MSc Thesis Lecture title : The effect of Cannabis on the tumor microenvironment\n\nUnder the Superv ision of: Meiri David and Associate Advisor Doctor Yishai Ofran END:VEVENT BEGIN:VEVENT UID:822@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20190206T133000 DTEND;TZID=Asia/Jerusalem:20190206T143000 DTSTAMP:20210802T125855Z URL:https://biology.technion.ac.il/en/seminars/jameela-easa-biology-techni on-2/ SUMMARY:Jameela Easa\, Biology\, Technion [No Categories] DESCRIPTION:Location: \n Affiliation: \n Host:\n MSc Thesis Seminar under the supervision of Benny Horwitz.\nTitle:\nUnderstanding the role of pH i n colonization of plant roots by Trichoderma virens\nבאכלוס שורש י צמחים על ידי טריכודרמה pH תפקיד ה \nWill be given in Hebrew END:VEVENT BEGIN:VEVENT UID:821@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20190204T130000 DTEND;TZID=Asia/Jerusalem:20190204T140000 DTSTAMP:20210802T125855Z URL:https://biology.technion.ac.il/en/seminars/dr-oded-kopper-hubrecht-ins titute-knaw-university-medical-centre-utrecht-the-netherlands-2/ SUMMARY:Dr. Oded Kopper\, Hubrecht Institute-KNAW\, University Medical Ce ntre Utrecht\, The Netherlands [No Categories] DESCRIPTION:Location: \n Affiliation: \n Host:\n “Novel breast and ovar ian cancer organoid platforms for research and personalized medicine”\nH ost: Yael Mandel Gutfruend END:VEVENT BEGIN:VEVENT UID:820@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20190128T130000 DTEND;TZID=Asia/Jerusalem:20190128T140000 DTSTAMP:20210802T125855Z URL:https://biology.technion.ac.il/en/seminars/dr-yosef-maruvka-cancer-cen ter-and-department-of-pathology-massachusetts-general-hospital-2/ SUMMARY:Dr. Yosef Maruvka\, Cancer Center and Department of Pathology\, Massachusetts General Hospital [No Categories] DESCRIPTION:Location: \n Affiliation: \n Host:\n \n“The genomic landsca pe of microsatellite unstable tumors\, how to detect them and how to preve nt them”\nHost: Yael Mandel-Gutfruend yaelmg@technion.ac.il END:VEVENT BEGIN:VEVENT UID:819@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20190123T130000 DTEND;TZID=Asia/Jerusalem:20190123T140000 DTSTAMP:20210802T125854Z URL:https://biology.technion.ac.il/en/seminars/phd-graduate-seminar-yara-e id-mutlak-2/ SUMMARY:PhD. Graduate Seminar-Yara Eid Mutlak [No Categories] DESCRIPTION:Location: \n Affiliation: \n Host:\n Research Topic:Novel sig naling hub of insulin receptor\, dystrophin glycoprotein complex and plako globin regulates muscle sizePlakoglobin החלבון  שומר על גו דל תא שריר ע"י צימוד מטבוליזם תאי לארכיטק טורה של הרקמה. END:VEVENT BEGIN:VEVENT UID:818@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20190121T130000 DTEND;TZID=Asia/Jerusalem:20190121T140000 DTSTAMP:20210802T125854Z URL:https://biology.technion.ac.il/en/seminars/dr-tzachi-reizel-perelman-s chool-of-medicine-university-of-pennsylvania-2/ SUMMARY:Dr. Tzachi Reizel\, Perelman School of Medicine\, University of Pennsylvania [No Categories] DESCRIPTION:Location: \n Affiliation: \n Host:\n “DNA methylation: from mechanism to an application”\nHost: Yael Mandel-Gutfruend yaelmg@techni on.ac.il END:VEVENT BEGIN:VEVENT UID:817@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20190116T093000 DTEND;TZID=Asia/Jerusalem:20190116T100000 DTSTAMP:20210802T125854Z URL:https://biology.technion.ac.il/en/seminars/m-sc-graduate-seminar-omer- nadel-2/ SUMMARY:M.Sc. Graduate Seminar-Omer Nadel [No Categories] DESCRIPTION:Location: \n Affiliation: \n Host:\n Research Topic:Degradati on of MarineCyanobacterial Antennas by Viralencoded Nb1A proteins.הרס אנטנות של ציאנובקטריהימיים על ידי חלבונ ים וירליים. END:VEVENT BEGIN:VEVENT UID:816@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20190114T130000 DTEND;TZID=Asia/Jerusalem:20190114T140000 DTSTAMP:20210802T125854Z URL:https://biology.technion.ac.il/en/seminars/dr-kobi-maman-laboratory-of -genome-integrity-national-cancer-institute-nih-2/ SUMMARY:Dr. Kobi Maman\, Laboratory of Genome Integrity\, National Cance r Institute\, NIH [No Categories] DESCRIPTION:Location: \n Affiliation: \n Host:\n “Give me a break! – the necessary evil of genome instability”\nHost: Yael Mandel-Gutfruend y aelmg@technion.ac.il END:VEVENT BEGIN:VEVENT UID:815@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20190113T143000 DTEND;TZID=Asia/Jerusalem:20190113T153000 DTSTAMP:20210802T125854Z URL:https://biology.technion.ac.il/en/seminars/dr-yftach-gepner-school-of- public-health-tau-2/ SUMMARY:Dr. Yftach Gepner\, School of Public Health\, TAU [No Categories] DESCRIPTION:Location: \n Affiliation: \n Host:\n “Ketogenic diet impact on athletes performance – good or bad?"Host: Shenhav Cohen shenhavc@tec hnion.ac.il END:VEVENT BEGIN:VEVENT UID:814@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20190109T130000 DTEND;TZID=Asia/Jerusalem:20190109T140000 DTSTAMP:20210802T125854Z URL:https://biology.technion.ac.il/en/seminars/phd-graduate-seminar-ilia-m aidanik-2/ SUMMARY:PhD. Graduate Seminar-Ilia Maidanik [No Categories] DESCRIPTION:Location: \n Affiliation: \n Host:\n Populationdynamics of T7 -like cyanophagesand their hosts inthe Gulf of Eilatדינמיקהשל א וכלוסיות  Like CyanophagesT7-והמאכסנים END:VEVENT BEGIN:VEVENT UID:813@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20190107T130000 DTEND;TZID=Asia/Jerusalem:20190107T140000 DTSTAMP:20210802T125854Z URL:https://biology.technion.ac.il/en/seminars/dr-eyal-ben-david-departmen t-of-human-genetics-university-of-california-los-angeles-2/ SUMMARY:Dr. Eyal Ben-David\, Department of Human Genetics\, University of California\, Los Angeles [No Categories] DESCRIPTION:Location: \n Affiliation: \n Host:\n “Studying the biology of genomes through the lens of natural variation”\nHost: Yael Mandel-Gut fruend yaelmg@technion.ac.il END:VEVENT BEGIN:VEVENT UID:812@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20190102T130000 DTEND;TZID=Asia/Jerusalem:20190102T140000 DTSTAMP:20210802T125854Z URL:https://biology.technion.ac.il/en/seminars/dr-dvir-aran-university-of- california-san-francisco-2/ SUMMARY:Dr. Dvir Aran\, University of California\, San Francisco [No Cate gories] DESCRIPTION:Location: \n Affiliation: \n Host:\n “Portraying the Cellul ar Heterogeneity in the Tumor Microenvironment Using Bulk and Single-Cell Transcriptomes”\nHost: Yael Mandel-Gutfruend yaelmg@technion.ac.il END:VEVENT BEGIN:VEVENT UID:811@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20181231T130000 DTEND;TZID=Asia/Jerusalem:20181231T140000 DTSTAMP:20210802T125854Z URL:https://biology.technion.ac.il/en/seminars/dr-abed-alfattah-mansour-sa lk-inst-for-biological-studies-la-jolla-ca-usa-2/ SUMMARY:Dr. Abed AlFattah Mansour\, Salk Inst. For Biological Studies\, La Jolla\, CA\, USA [No Categories] DESCRIPTION:Location: \n Affiliation: \n Host:\n “ Stem cell-based thre e-dimensional platforms to study human brain development and disease"\nHos t: Yael Mandel-Gutfruend yaelmg@technion.ac.il END:VEVENT BEGIN:VEVENT UID:810@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20181224T130000 DTEND;TZID=Asia/Jerusalem:20181224T140000 DTSTAMP:20210802T125854Z URL:https://biology.technion.ac.il/en/seminars/dr-ayala-shiber-the-center- for-molecular-biology-zmbh-the-german-cancer-research-center-dkfz-heidelbe rg-germany-2/ SUMMARY:Dr. Ayala Shiber\, The Center for Molecular Biology (ZMBH) & The G erman Cancer Research Center (DKFZ)\, Heidelberg\, Germany [No Categories] DESCRIPTION:Location: \n Affiliation: \n Host:\n “Co-translational asse mby of protein complexes in eukaryotes revealed by ribosome profiling"\nHo st: Yael Mandel-Gutfruend yaelmg@technion.ac.il END:VEVENT BEGIN:VEVENT UID:809@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20181219T090000 DTEND;TZID=Asia/Jerusalem:20181219T100000 DTSTAMP:20210802T125854Z URL:https://biology.technion.ac.il/en/seminars/phd-graduate-seminar-alina- pushkarev-2/ SUMMARY:PhD. Graduate Seminar-Alina Pushkarev [No Categories] DESCRIPTION:Location: \n Affiliation: \n Host:\n Research Topic:The searc h for new ways to harvest lightusing functionalmetagenomicsהחיפושא חר דרכים חדשות לקצירת אור בעזרת מטגנומיק התפקודית END:VEVENT BEGIN:VEVENT UID:808@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20181218T130000 DTEND;TZID=Asia/Jerusalem:20181218T140000 DTSTAMP:20210802T125854Z URL:https://biology.technion.ac.il/en/seminars/prof-paul-tempst-from-memor ial-sloan-kettering-cancer-center-new-york-usa-2/ SUMMARY:Prof. Paul Tempst from Memorial Sloan Kettering Cancer Center\, New York\, USA [No Categories] DESCRIPTION:Location: \n Affiliation: \n Host:\n Aminopeptidase activitie s as biomarkers for cancer\nThe seminar will be on Tuesday\, Dec 18\, 2018 \, at 1300\, in the Biology Auditorium\nThe host will be Arie Admon END:VEVENT BEGIN:VEVENT UID:807@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20181217T130000 DTEND;TZID=Asia/Jerusalem:20181217T140000 DTSTAMP:20210802T125854Z URL:https://biology.technion.ac.il/en/seminars/dr-kfir-sharabi-dana-farber -cancer-inst-harvard-medical-school-boston-usa-2/ SUMMARY:Dr. Kfir Sharabi\, Dana-Farber Cancer Inst. & Harvard Medical Scho ol\, Boston\, USA [No Categories] DESCRIPTION:Location: \n Affiliation: \n Host:\n TBA\nHost: Yael Mandel G utfruend yaelmg@technion.ac.il END:VEVENT BEGIN:VEVENT UID:806@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20181213T110000 DTEND;TZID=Asia/Jerusalem:20181213T120000 DTSTAMP:20210802T125854Z URL:https://biology.technion.ac.il/en/seminars/prof-luisa-cochella-imp-res earch-institute-of-molecular-pathologycampus-vienna-biocenter-1austria-2/ SUMMARY:Prof. Luisa Cochella\, IMP - Research Institute of Molecular Patho logy Campus-Vienna-Biocenter 1\,Austria [No Categories] DESCRIPTION:Location: \n Affiliation: \n Host:\n “Roles of miRNAs in an imal development” \nHost: Benjamin Podbilewicz podbilew@technion.ac.il END:VEVENT BEGIN:VEVENT UID:805@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20181213T100000 DTEND;TZID=Asia/Jerusalem:20181213T110000 DTSTAMP:20210802T125853Z URL:https://biology.technion.ac.il/en/seminars/prof-massimo-hilliard-nhmrc -senior-research-fellowclem-jones-centre-for-ageing-dementia-researchqueen sland-brain-instituteuniversity-of-queensland-2/ SUMMARY:Prof. Massimo Hilliard\, NHMRC Senior Research Fellow Clem Jones C entre for Ageing Dementia Research Queensland Brain Institute\,University of Queensland [No Categories] DESCRIPTION:Location: \n Affiliation: \n Host:\n “Cell-cell fusion in t he nervous system: challenging the neuron theory”\nHost: Benjamin Podbil ewicz podbilew@technion.ac.il END:VEVENT BEGIN:VEVENT UID:804@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20181212T093000 DTEND;TZID=Asia/Jerusalem:20181212T103000 DTSTAMP:20210802T125853Z URL:https://biology.technion.ac.il/en/seminars/m-sc-graduate-seminar-sharo n-kulikovsky-2/ SUMMARY:M.Sc. Graduate Seminar-Sharon Kulikovsky [No Categories] DESCRIPTION:Location: \n Affiliation: \n Host:\n Research Topic:Photosynt hesis in the dessert:the search for an organism for green energy productio nפוטוסינתזה במדבר: החיפוש אחראורגניזם לי צירת אנרגיה ירוקה END:VEVENT BEGIN:VEVENT UID:803@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20181210T130000 DTEND;TZID=Asia/Jerusalem:20181210T140000 DTSTAMP:20210802T125853Z URL:https://biology.technion.ac.il/en/seminars/dr-tzachi-hagay-wellcome-sa nger-inst-european-bioinformatics-inst-uk-2/ SUMMARY:Dr. Tzachi Hagay\, Wellcome Sanger Inst. & European Bioinformatics Inst. UK [No Categories] DESCRIPTION:Location: \n Affiliation: \n Host:\n “Trapped between patho gens and autoimmunity: The evolution of our immune system"\nHost: Yael Man del-Gutfruend yaelmg@technion.ac.il END:VEVENT BEGIN:VEVENT UID:802@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20181205T090000 DTEND;TZID=Asia/Jerusalem:20181205T100000 DTSTAMP:20210802T125853Z URL:https://biology.technion.ac.il/en/seminars/m-sc-graduate-seminar-micol -melchers-2/ SUMMARY:M.Sc. Graduate Seminar- Micol Melchers [No Categories] DESCRIPTION:Location: \n Affiliation: \n Host:\n Research Topic: The Eff ect of the IDH1R132H Mutation in CancerCells on the Lmmunopeptidome הה שפעה של המוטציה IDH1R132Hעל האימונופפטידוםב תאים סרטנים. END:VEVENT BEGIN:VEVENT UID:801@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20181203T130000 DTEND;TZID=Asia/Jerusalem:20181203T140000 DTSTAMP:20210802T125853Z URL:https://biology.technion.ac.il/en/seminars/phd-graduate-seminar-samah- awwad-2/ SUMMARY:PhD. Graduate Seminar-Samah Awwad [No Categories] DESCRIPTION:Location: \n Affiliation: \n Host:\n Aspotlight on genomic st ability: Characterizing novel regulators of DNA damagerepairמבטעל י ציבות הגנום: אפיון חלבונים חדשים בבקרת ה תגובה התאית לנזקי דנ"א END:VEVENT BEGIN:VEVENT UID:800@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20181128T090000 DTEND;TZID=Asia/Jerusalem:20181128T100000 DTSTAMP:20210802T125853Z URL:https://biology.technion.ac.il/en/seminars/m-sc-graduate-seminar-hoday a-farber-3/ SUMMARY:M.Sc. Graduate Seminar-Hodaya Farber [No Categories] DESCRIPTION:Location: \n Affiliation: \n Host:\n Research Topic:Identifin gMetabolic Alterations and VulnerabilitesinSenescentandCancer Cellsזיה וינקודות התורפה המטבוליות בתאי סרטן אשר הפעילו את מנגנון ה- Senescence END:VEVENT BEGIN:VEVENT UID:799@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20181126T130000 DTEND;TZID=Asia/Jerusalem:20181126T140000 DTSTAMP:20210802T125853Z URL:https://biology.technion.ac.il/en/seminars/prof-ilana-kolodkin-gal-dep artment-of-molecular-geneticsweizmann-institute-of-science-2/ SUMMARY:Prof. Ilana Kolodkin-Gal\, Department of Molecular Genetics Weizma nn Institute of Science [No Categories] DESCRIPTION:Location: \n Affiliation: \n Host:\n “New insights on the b iofilm structure\, function and antibiotic resistance"\nHost: Meytal Landa u END:VEVENT BEGIN:VEVENT UID:798@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20181121T090000 DTEND;TZID=Asia/Jerusalem:20181121T100000 DTSTAMP:20210802T125853Z URL:https://biology.technion.ac.il/en/seminars/phd-graduate-seminar-alexan dra-volodin-2/ SUMMARY:PhD. Graduate Seminar-Alexandra Volodin [No Categories] DESCRIPTION:Location: \n Affiliation: \n Host:\n  Molecularmechanisms of skeletal muscle adaptationtofastingחקרהמנגנונים המולקו לריםהמתווכים אטרופיה של שריר שלד במהלך ה רעבה END:VEVENT BEGIN:VEVENT UID:797@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20181112T130000 DTEND;TZID=Asia/Jerusalem:20181112T140000 DTSTAMP:20210802T125853Z URL:https://biology.technion.ac.il/en/seminars/prof-doris-rentsch-plant-in stitutebern-university-switzerland-2/ SUMMARY:Prof. Doris Rentsch\, Plant Institute\,Bern University\, Switzerla nd [No Categories] DESCRIPTION:Location: \n Affiliation: \n Host:\n “Amino acid and drug t ransport in the human pathogen Trypanosoma brucei\nHost: Dan Zilberstein END:VEVENT BEGIN:VEVENT UID:796@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20181105T130000 DTEND;TZID=Asia/Jerusalem:20181105T140000 DTSTAMP:20210802T125853Z URL:https://biology.technion.ac.il/en/seminars/prof-tomer-hertz-dept-of-mi crobiology-immunology-and-genetics-ben-gurion-university-of-the-negev-2/ SUMMARY:Prof. Tomer Hertz\, Dept. of Microbiology\, Immunology and Genetic s\, Ben-Gurion University of the Negev [No Categories] DESCRIPTION:Location: \n Affiliation: \n Host:\n Influenza antibody lands capes: you are what you were END:VEVENT BEGIN:VEVENT UID:795@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20181031T093000 DTEND;TZID=Asia/Jerusalem:20181031T103000 DTSTAMP:20210802T125853Z URL:https://biology.technion.ac.il/en/seminars/m-sc-graduate-seminar-sagie -dvir-2/ SUMMARY:M.Sc. Graduate Seminar- Sagie Dvir [No Categories] DESCRIPTION:Location: \n Affiliation: \n Host:\n Research Topic:The Effec t of Epigenome Modulationon HLA Peptidomeהשפעתהמודולציה של האפיגנום על הפפטידום שלקומפלקס התאמת רק מות END:VEVENT BEGIN:VEVENT UID:794@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20181029T130000 DTEND;TZID=Asia/Jerusalem:20181029T140000 DTSTAMP:20210802T125853Z URL:https://biology.technion.ac.il/en/seminars/dr-nitzan-gonen-the-francis -crick-institute-london-2/ SUMMARY:Dr. Nitzan Gonen\, The Francis Crick Institute\, London [No Categor ies] DESCRIPTION:Location: \n Affiliation: \n Host:\n Dr. Nitzan Gonen\nAffili ation: The Francis Crick Institute\, London\n\nTitle: How to Enhance Sex?\ n\nHost: Yael Mandel Gutfruend yaelmg @ technion.ac.il END:VEVENT BEGIN:VEVENT UID:793@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20181022T130000 DTEND;TZID=Asia/Jerusalem:20181022T140000 DTSTAMP:20210802T125853Z URL:https://biology.technion.ac.il/en/seminars/yoram-reiter-faculty-of-bio logy-technion-2/ SUMMARY:Yoram Reiter\, Faculty of Biology\, Technion [No Categories] DESCRIPTION:Location: \n Affiliation: \n Host:\n Title:Engineering Immune Effector Cells and Molecules for Immunotherapy of Cancer and Autoimmunity \nHost: Debbie Lindell END:VEVENT BEGIN:VEVENT UID:792@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20181017T093000 DTEND;TZID=Asia/Jerusalem:20181017T103000 DTSTAMP:20210802T125853Z URL:https://biology.technion.ac.il/en/seminars/m-sc-graduate-seminar-yael- bar-avraham-2/ SUMMARY:M.Sc. Graduate Seminar- Yael Bar Avraham [No Categories] DESCRIPTION:Location: \n Affiliation: \n Host:\n Identifying members of t he argininedeprivation response pathway in Leishmaniausing CRISPER/Cas9ז יהוי חלבונים המשתתפים במסלולהתגובה להרע בה לארגנין בלישמניהבאמצעות שימוש במערכת   CRISPER/Cas9 END:VEVENT BEGIN:VEVENT UID:791@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20181015T083000 DTEND;TZID=Asia/Jerusalem:20181015T163000 DTSTAMP:20210802T125853Z URL:https://biology.technion.ac.il/en/seminars/mini-symposium-for-dani-cas sel70-the-63rd-katzir-conference-on-intercellular-trafficking-2/ SUMMARY:Mini Symposium for Dani Cassel@70\, The 63rd Katzir Conference on I ntercellular Trafficking [No Categories] DESCRIPTION:Location: \n Affiliation: \n Host:\n Keynote lecture:Bruno An tonnyInstitut de Pharmacologie Moléculaire et Cellulaire\, Valbonne\, Fra nce Invited speakers:Edna Cukierman Fox Chase Cancer Center\, Philadelphi a\, USAZevi ElazarWeizmann Institute\, Rehovot\, IsraelNatalie Elia Ben Gu rion University\, Beer Sheva\, IsraelBruno Goud Institut Curie\, Paris\, FranceYossi Orly The Hebrew University of Jerusalem\, Jerusalem\, IsraelPe ter Peters Maastricht University\, Maastricht\, NetherlandsElah Pick Unive rsity of Haifa\, Haifa\, IsraelOrganized by:Benjamin Podbilewicz podbilew@ technion.ac.ilSivan Geiser-Edelbaum sivangei@technion.ac.il END:VEVENT BEGIN:VEVENT UID:790@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20181010T093000 DTEND;TZID=Asia/Jerusalem:20181010T103000 DTSTAMP:20210802T125852Z URL:https://biology.technion.ac.il/en/seminars/m-sc-graduate-seminar-hiba- simaan-2/ SUMMARY:M.Sc. Graduate Seminar- Hiba Simaan [No Categories] DESCRIPTION:Location: \n Affiliation: \n Host:\n TheAP-1 like transcripti on factor ChAP-1 balances toleranceand cell death in the response of the m aize pathogen Cochliobolusheterostrophustoa plant phenolic.פקטורהש עתוק ChAP-1מאזןבין מוות תאי וסבילות של הפטר ייה Cochliobolusheterostrophusהפתוגניתלתירס בגובה ל פנול צמחי END:VEVENT BEGIN:VEVENT UID:789@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20181003T093000 DTEND;TZID=Asia/Jerusalem:20181003T103000 DTSTAMP:20210802T125852Z URL:https://biology.technion.ac.il/en/seminars/m-sc-graduate-seminar-layla -saied-2/ SUMMARY:M.Sc. Graduate Seminar-Layla Saied [No Categories] DESCRIPTION:Location: \n Affiliation: \n Host:\n Newinsights on Sef impa ct in breast cancerתובנותחדשות לגבי השפעת הSefעלס רטן השד END:VEVENT BEGIN:VEVENT UID:788@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20180828T093000 DTEND;TZID=Asia/Jerusalem:20180828T103000 DTSTAMP:20210802T125852Z URL:https://biology.technion.ac.il/en/seminars/m-sc-graduate-seminar-may-a lmog-2/ SUMMARY:M.Sc. Graduate Seminar- May Almog [No Categories] DESCRIPTION:Location: \n Affiliation: \n Host:\n Research Topic:Platelet- Activating ReceptorCLEC-2: Characterization andmodulation of protein-ligan d interactionspromoting cancer metastases.רצפטור משפעל על ג בי טסיות דם Clec-2:איפיוןועיכובאינטרקציותח לבון-ליגנדהמקדמות את התהליךהגרורתיהסרט ן END:VEVENT BEGIN:VEVENT UID:787@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20180717T093000 DTEND;TZID=Asia/Jerusalem:20180717T103000 DTSTAMP:20210802T125852Z URL:https://biology.technion.ac.il/en/seminars/m-sc-graduate-seminar-anna- zivan-2/ SUMMARY:M.Sc. Graduate Seminar- Anna Zivan [No Categories] DESCRIPTION:Location: \n Affiliation: \n Host:\n Research Topic:The Impac t of DNA structure andFlexibility of p53 ResponseElements with Long Spacer s on p53 Binding Affinityand Cooperativityהשפעת מבנה וגמישו ת הדנ"אבמרווח ארוך בין אתרי המטרה שלפ 53 ע ל אפיניותהקישור והקואופרטיביות של חלבון ה-פ 53 END:VEVENT BEGIN:VEVENT UID:786@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20180703T093000 DTEND;TZID=Asia/Jerusalem:20180703T103000 DTSTAMP:20210802T125852Z URL:https://biology.technion.ac.il/en/seminars/m-sc-graduate-seminar-liat- iancovici-2/ SUMMARY:M.Sc. Graduate Seminar- Liat Iancovici [No Categories] DESCRIPTION:Location: \n Affiliation: \n Host:\n Research Topic:The hydro philic N-Terminus of theProline-AlanineTransporter in the Human pathogen l eishmaniaRegulates Substrate Specificity.הקצה ה- Nטרמינאלי ה הידארופילי של הנשא לפורין-אלאנין בפתוגן האנושי לישמניה מבקר ספציפיות מגיע בנשא. END:VEVENT BEGIN:VEVENT UID:785@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20180702T130000 DTEND;TZID=Asia/Jerusalem:20180702T140000 DTSTAMP:20210802T125852Z URL:https://biology.technion.ac.il/en/seminars/prof-nir-gov-weizmann-insti tute-of-science-2/ SUMMARY:Prof. Nir Gov Weizmann Institute of Science [No Categories] DESCRIPTION:Location: \n Affiliation: \n Host:\n \nTitle:”Theoretical M odels for Traffic Jams of Molecular Motors along Actin-Filled Cellular Pro trusions”\n\nHost: Arnon Henn END:VEVENT BEGIN:VEVENT UID:784@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20180626T093000 DTEND;TZID=Asia/Jerusalem:20180626T103000 DTSTAMP:20210802T125852Z URL:https://biology.technion.ac.il/en/seminars/phd-graduate-seminar-bracha -shraibman-2/ SUMMARY:PhD. Graduate Seminar-Bracha Shraibman [No Categories] DESCRIPTION:Location: \n Affiliation: \n Host:\n Research Topic:Toward de velopment of personalizedimmunotherapy andearly detection for Glioblastoma פיתוח חיסון מותאם אישית וגילוימוקדם לגל יובלסטומה END:VEVENT BEGIN:VEVENT UID:783@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20180625T130000 DTEND;TZID=Asia/Jerusalem:20180625T140000 DTSTAMP:20210802T125852Z URL:https://biology.technion.ac.il/en/seminars/yaniv-fox-department-of-gen eral-history-bar-ilan-university-2/ SUMMARY:Yaniv Fox Department of General History\, Bar-Ilan University. [No Categories] DESCRIPTION:Location: \n Affiliation: \n Host:\n Yaniv Fox\nDepartment of General History\, Bar-Ilan University.\nTitle: ’The East’ and western imagination in Late Antiquity. ״׳המזרח׳ בדמיון המערבי בשלהי העת העתיקה.״\nThe lecture will be in Hebrew\nHost: Y aron Fuchs END:VEVENT BEGIN:VEVENT UID:782@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20180619T093000 DTEND;TZID=Asia/Jerusalem:20180619T103000 DTSTAMP:20210802T125852Z URL:https://biology.technion.ac.il/en/seminars/dr-itay-koren-harvard-medic al-school-2/ SUMMARY:Dr. Itay Koren\, Harvard Medical School [No Categories] DESCRIPTION:Location: \n Affiliation: \n Host:\n The End of The End: C-te rminal Degrons Discovery Using Synthetic Peptide Libraries END:VEVENT BEGIN:VEVENT UID:781@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20180618T130000 DTEND;TZID=Asia/Jerusalem:20180618T140000 DTSTAMP:20210802T125852Z URL:https://biology.technion.ac.il/en/seminars/oren-parnas-the-hebrew-univ ersity-hadassah-school-of-medicine-2/ SUMMARY:Oren Parnas The Hebrew University\, Hadassah School of Medicine [No Categories] DESCRIPTION:Location: \n Affiliation: \n Host:\n Oren Parnas\nThe Hebrew University\, Hadassah School of Medicine\nCRISPR screens and Perturb-Seq t o find new targets for immunotherapy\nHost: Ayoub Nabieh END:VEVENT BEGIN:VEVENT UID:780@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20180613T140000 DTEND;TZID=Asia/Jerusalem:20180613T150000 DTSTAMP:20210802T125852Z URL:https://biology.technion.ac.il/en/seminars/nobel-2006-chemistry-laurea te-prof-roger-kornberg-stanford-university-school-of-medicine-california-u sa-2/ SUMMARY:Nobel 2006 Chemistry Laureate - Prof. Roger Kornberg Stanford Unive rsity School of Medicine\, California\, USA [No Categories] DESCRIPTION:Location: \n Affiliation: \n Host:\n END:VEVENT BEGIN:VEVENT UID:779@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20180611T130000 DTEND;TZID=Asia/Jerusalem:20180611T140000 DTSTAMP:20210802T125852Z URL:https://biology.technion.ac.il/en/seminars/prof-carla-j-shatz-sapp-fam ily-provostial-professor-professor-of-biology-and-neurobiology-david-starr -jordan-director-standford-bio-x-stanford-university-usa-2/ SUMMARY:Prof. Carla J. Shatz Sapp Family Provostial Professor\, Professor o f Biology and Neurobiology\, David Starr Jordan Director\, Standford Bio-X \, Stanford University\, USA [No Categories] DESCRIPTION:Location: \n Affiliation: \n Host:\n Synapses lost and found: developmental critical periods and Alzheimer’s Disease END:VEVENT BEGIN:VEVENT UID:778@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20180605T093000 DTEND;TZID=Asia/Jerusalem:20180605T103000 DTSTAMP:20210802T125852Z URL:https://biology.technion.ac.il/en/seminars/phd-graduate-seminar-renana -fischer-weinberger-2/ SUMMARY:PhD. Graduate Seminar-Renana Fischer-Weinberger [No Categories] DESCRIPTION:Location: \n Affiliation: \n Host:\n ResearchTopic:Adivergent regulatory subunit of PKA has a role in Leishmaniadevelopmentתתיחיד ה רגולטורית\,מסועפתאבולוציונית\, של פרוט אין קינאזמשתתפתבהתפתחות הפתוגןלישמניהA END:VEVENT BEGIN:VEVENT UID:777@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20180604T130000 DTEND;TZID=Asia/Jerusalem:20180604T140000 DTSTAMP:20210802T125852Z URL:https://biology.technion.ac.il/en/seminars/prof-alon-zaslaver-the-hebr ew-university-2/ SUMMARY:Prof. Alon Zaslaver\, The Hebrew University [No Categories] DESCRIPTION:Location: \n Affiliation: \n Host:\n Alon Zaslaver\, The Hebr ew University\nTitle: A mechanism for efficient navigation in chemical gra dients\nHost: Benjamin Podbilewicz END:VEVENT BEGIN:VEVENT UID:776@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20180528T130000 DTEND;TZID=Asia/Jerusalem:20180528T140000 DTSTAMP:20210802T125851Z URL:https://biology.technion.ac.il/en/seminars/prof-tommer-ravid-dept-of-b iological-chemistry-the-alexander-silberman-institute-of-life-sciences-the -hebrew-university-of-jerusalem-2/ SUMMARY:Prof. Tommer Ravid Dept. of Biological Chemistry\, The Alexander Si lberman Institute of Life Sciences\, The Hebrew University of Jerusalem [ No Categories] DESCRIPTION:Location: \n Affiliation: \n Host:\n Title: ”Principles of misfolded protein clearance by the ubiquitin-proteasome system”.\nHost: Shenhav Cohen END:VEVENT BEGIN:VEVENT UID:775@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20180514T130000 DTEND;TZID=Asia/Jerusalem:20180514T140000 DTSTAMP:20210802T125851Z URL:https://biology.technion.ac.il/en/seminars/dr-sheera-adar-department-o f-microbiology-and-molecular-genetics-the-institute-for-medical-research-i srael-canada-the-hebrew-university-hadassah-medical-school-2/ SUMMARY:Dr. Sheera Adar Department of Microbiology and Molecular Genetics T he Institute for Medical Research Israel-Canada The Hebrew University-Hada ssah Medical School [No Categories] DESCRIPTION:Location: \n Affiliation: \n Host:\n Title: “Interrogating DNA repair in chromatin using high-resolution genomics"\nHost: Nabieh Ayou b END:VEVENT BEGIN:VEVENT UID:774@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20180507T130000 DTEND;TZID=Asia/Jerusalem:20180507T140000 DTSTAMP:20210802T125851Z URL:https://biology.technion.ac.il/en/seminars/prof-eitan-okun-the-paul-fe der-alzheimers-disease-research-laboratory-the-leslie-and-susan-gonda-mult idisciplinary-brain-research-center-the-mina-and-everard-goodman-faculty-o f-life-sciences-bar-i-2/ SUMMARY:Prof. Eitan Okun The Paul Feder Alzheimer's Disease Research Labora tory The Leslie and Susan Gonda Multidisciplinary Brain Research Center. T he Mina and Everard Goodman Faculty of Life sciences. Bar Ilan University [No Categories] DESCRIPTION:Location: \n Affiliation: \n Host:\n \n\nTitle: “Targeting cognitive decline and neuropathology in Down Syndrome using an anti Amyloi d-beta vaccine"\nHost: Meytal Landau END:VEVENT BEGIN:VEVENT UID:773@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20180430T130000 DTEND;TZID=Asia/Jerusalem:20180430T140000 DTSTAMP:20210802T125851Z URL:https://biology.technion.ac.il/en/seminars/prof-ohad-mazor-israel-inst itute-for-biological-research-ness-ziona-2/ SUMMARY:Prof. Ohad Mazor\, Israel Institute for Biological Research\, Ness Ziona [No Categories] DESCRIPTION:Location: \n Affiliation: \n Host:\n Novel recombinant antibo dies as countermeasures for biothreat agentsHost: Meytal Landau END:VEVENT BEGIN:VEVENT UID:772@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20180416T130000 DTEND;TZID=Asia/Jerusalem:20180416T140000 DTSTAMP:20210802T125851Z URL:https://biology.technion.ac.il/en/seminars/prof-ron-diskin-weizmann-in stitute-of-science-2/ SUMMARY:Prof. Ron Diskin Weizmann Institute of Science [No Categories] DESCRIPTION:Location: \n Affiliation: \n Host:\n “Hemorrhagicfever viru ses: from molecular mechanisms of pathogenicity to noveltherapeutics.”Ho st: Meytal Landau END:VEVENT BEGIN:VEVENT UID:771@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20180411T130000 DTEND;TZID=Asia/Jerusalem:20180411T140000 DTSTAMP:20210802T125851Z URL:https://biology.technion.ac.il/en/seminars/yoram-haimi-2/ SUMMARY:Yoram Haimi [No Categories] DESCRIPTION:Location: \n Affiliation: \n Host:\n “ArchaeologicExcavatio ns in Sobibor Extermination Camp”Host: Dafna Dressler END:VEVENT BEGIN:VEVENT UID:770@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20180410T093000 DTEND;TZID=Asia/Jerusalem:20180410T103000 DTSTAMP:20210802T125851Z URL:https://biology.technion.ac.il/en/seminars/sergei-rudnizky-faculty-of- biology-technion-2/ SUMMARY:Sergei Rudnizky\, Faculty of Biology\, Technion [No Categories] DESCRIPTION:Location: \n Affiliation: \n Host:\n PhD. Seminar titled:Sing le-moleculestudies of transcription regulation: insights from the LH genes Under the supervision of: Ariel Kaplan and Phillipa Melamed END:VEVENT BEGIN:VEVENT UID:769@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20180409T130000 DTEND;TZID=Asia/Jerusalem:20180409T140000 DTSTAMP:20210802T125851Z URL:https://biology.technion.ac.il/en/seminars/prof-emmanuel-levy-weizmann -institute-of-science-2/ SUMMARY:Prof. Emmanuel Levy\, Weizmann Institute of Science [No Categories ] DESCRIPTION:Location: \n Affiliation: \n Host:\n “Self-assembling\,prot ein-based biomaterials in living cells”Host: Meytal Landau END:VEVENT BEGIN:VEVENT UID:768@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20180327T130000 DTEND;TZID=Asia/Jerusalem:20180327T140000 DTSTAMP:20210802T125851Z URL:https://biology.technion.ac.il/en/seminars/assistant-prof-gad-getz-dir ector-cancer-genome-computational-analysis-and-institute-member-broad-inst itute-director-bioinformatics-program-mgh-cancer-center-and-department-of- pathology-associat-2/ SUMMARY:Assistant Prof. Gad Getz\, Director\, Cancer Genome Computational A nalysis and Institute Member\, Broad Institute Director\, Bioinformatics P rogram\, MGH Cancer Center and Department of Pathology\, Associate Profess or of Pathology\, Harvard Medical School Paul C. Zamecnik Chair in Oncolog y\, MGH Cancer Center [No Categories] DESCRIPTION:Location: \n Affiliation: \n Host:\n The Lokey Distinguished Lecture Series:\nTitle:\n"Coding and Non-Coding Drivers Based on a Pan-Can cer Analysis of Whole Genomes"\n\n\nHost: Prof. Roy Kishony END:VEVENT BEGIN:VEVENT UID:767@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20180320T093000 DTEND;TZID=Asia/Jerusalem:20180320T103000 DTSTAMP:20210802T125851Z URL:https://biology.technion.ac.il/en/seminars/graduate-seminer-roman-krei serman-2/ SUMMARY:Graduate seminer- Roman Kreiserman [No Categories] DESCRIPTION:Location: \n Affiliation: \n Host:\n New method to measure cl ose rangeforces and membrane fusion using dual trap optical tweezers שי טה חדשה למדידה של כוחות קצרי טווחואיחוי ממברנות בעזרת מלקחיים אופטיים END:VEVENT BEGIN:VEVENT UID:766@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20180318T130000 DTEND;TZID=Asia/Jerusalem:20180318T140000 DTSTAMP:20210802T125851Z URL:https://biology.technion.ac.il/en/seminars/professor-tamir-gonen-inves tigator-howard-hughes-medical-institute-professor-physiology-and-biologica l-chemistry-david-geffen-school-of-medicineuniversity-of-california-los-an geles-2/ SUMMARY:Professor Tamir Gonen Investigator\, Howard Hughes Medical Institut e\, Professor\, Physiology and Biological Chemistry\, David Geffen School of Medicine\,University of California\, Los Angeles [No Categories] DESCRIPTION:Location: \n Affiliation: \n Host:\n “MicroED opens a new e ra in cryoEMforbiological structure determination” END:VEVENT BEGIN:VEVENT UID:765@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20180315T130000 DTEND;TZID=Asia/Jerusalem:20180315T140000 DTSTAMP:20210802T125851Z URL:https://biology.technion.ac.il/en/seminars/prof-malini-raghavan-depart ment-of-microbiology-and-immunology-university-of-michigan-medical-school- ann-arbor-2/ SUMMARY:Prof. Malini Raghavan\, Department of Microbiology and Immunology\ , University of Michigan Medical School\, Ann Arbor [No Categories] DESCRIPTION:Location: \n Affiliation: \n Host:\n “To TAP or not: Assemb lyVariations among HLA-B allotypes”Host: Arie Admon END:VEVENT BEGIN:VEVENT UID:764@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20180314T130000 DTEND;TZID=Asia/Jerusalem:20180314T140000 DTSTAMP:20210802T125851Z URL:https://biology.technion.ac.il/en/seminars/dr-nitzan-shabek-department -of-pharmacology-university-of-washington-2/ SUMMARY:Dr. Nitzan Shabek\, Department of Pharmacology\, University of Was hington [No Categories] DESCRIPTION:Location: \n Affiliation: \n Host:\n “Hormone Perception th roughDestruction: Lesson from Plants” END:VEVENT BEGIN:VEVENT UID:763@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20180313T093000 DTEND;TZID=Asia/Jerusalem:20180313T103000 DTSTAMP:20210802T125851Z URL:https://biology.technion.ac.il/en/seminars/phd-graduate-seminar-jose-f lores-uribe-2/ SUMMARY:PhD. Graduate Seminar-Jose Flores-Uribe [No Categories] DESCRIPTION:Location: \n Affiliation: \n Host:\n Characterization of the oceanmetagenomes: from phages to proteinsאפיון המטאגנומיםש ל האוקיינוס: מפאג'יםועד חלבונים END:VEVENT BEGIN:VEVENT UID:762@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20180312T130000 DTEND;TZID=Asia/Jerusalem:20180312T140000 DTSTAMP:20210802T125851Z URL:https://biology.technion.ac.il/en/seminars/dr-konstantin-feinberg-hosp ital-for-sick-children-university-of-toronto-2/ SUMMARY:Dr. Konstantin Feinberg\, Hospital for Sick Children\, University o f Toronto [No Categories] DESCRIPTION:Location: \n Affiliation: \n Host:\n “Regulationof axonal d egeneration and neuronal death during development and underpathological co nditions” END:VEVENT BEGIN:VEVENT UID:761@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20180304T093000 DTEND;TZID=Asia/Jerusalem:20180304T103000 DTSTAMP:20210802T125850Z URL:https://biology.technion.ac.il/en/seminars/phd-graduate-seminar-rani-z ananiri-2/ SUMMARY:PhD Graduate Seminar- Rani Zananiri [No Categories] DESCRIPTION:Location: \n Affiliation: \n Host:\n Ensemble and Single mole cule Studies of DNA Unwinding byRecBCDחקר פרימת דנ"א על יד י Recbcdברמת הצבר וברמת המולקולההבודדת. END:VEVENT BEGIN:VEVENT UID:760@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20180219T130000 DTEND;TZID=Asia/Jerusalem:20180219T140000 DTSTAMP:20210802T125850Z URL:https://biology.technion.ac.il/en/seminars/dr-boris-slobodin-netherlan ds-cancer-institute-weizmann-institute-2/ SUMMARY:Dr. Boris Slobodin\, Netherlands Cancer Institute/Weizmann Institut e [No Categories] DESCRIPTION:Location: \n Affiliation: \n Host:\n Dr. Boris SlobodinNether lands CancerInstitute/Weizmann InstituteTitle: Epigenetics in action: howt ranscription of mRNAs regulates their translation and stabilityHost: Yael Mandel Gutfruend END:VEVENT BEGIN:VEVENT UID:759@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20180214T093000 DTEND;TZID=Asia/Jerusalem:20180214T103000 DTSTAMP:20210802T125850Z URL:https://biology.technion.ac.il/en/seminars/phd-graduate-seminar-binyam in-zhitomirsky-2/ SUMMARY:PhD. Graduate Seminar- Binyamin Zhitomirsky [No Categories] DESCRIPTION:Location: \n Affiliation: \n Host:\n The role of lysosomes in cancer multidrug resistance \n \n תפקידם של ליזוזומים ב עמידות רב-תרופתית בסרטן\n END:VEVENT BEGIN:VEVENT UID:758@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20180212T130000 DTEND;TZID=Asia/Jerusalem:20180212T140000 DTSTAMP:20210802T125850Z URL:https://biology.technion.ac.il/en/seminars/dr-hagai-shpigler-universit y-of-illinois-urbana-champaign-2/ SUMMARY:Dr. Hagai Shpigler\, University of Illinois Urbana-Champaign [No Ca tegories] DESCRIPTION:Location: \n Affiliation: \n Host:\n Dr. Hagai ShpiglerUniver sity ofIllinois Urbana-ChampaignTitle: The molecular basis ofsocial behavi or in beesHost: Yael Mandel Gutfreund END:VEVENT BEGIN:VEVENT UID:757@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20180207T093000 DTEND;TZID=Asia/Jerusalem:20180207T103000 DTSTAMP:20210802T125850Z URL:https://biology.technion.ac.il/en/seminars/dr-gal-haimovich-albert-ein stein-college-of-medicine-weizmann-institute-2/ SUMMARY:Dr. Gal Haimovich\, Albert Einstein College of Medicine/Weizmann I nstitute [No Categories] DESCRIPTION:Location: \n Affiliation: \n Host:\n Dr. Gal HaimovichAlbert Einstein College of Medicine/Weizmann InstituteTitle: Membranenanotubes an d gene expression: a new intercellular pathway for communicatingthe messag e Host: Yael Mandel Gutfreund END:VEVENT BEGIN:VEVENT UID:756@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20180205T130000 DTEND;TZID=Asia/Jerusalem:20180205T140000 DTSTAMP:20210802T125850Z URL:https://biology.technion.ac.il/en/seminars/dr-shai-bel-university-of-t exas-southwestern-2/ SUMMARY:Dr. Shai Bel\, University of Texas\, Southwestern [No Categories] DESCRIPTION:Location: \n Affiliation: \n Host:\n Dr. Shai BelUniversity of Texas\, SouthwesternTitle: Secretory autophagy is a noveldefence mechan ism in the intestineHost: Yael Mandel Gutfruend END:VEVENT BEGIN:VEVENT UID:755@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20180131T093000 DTEND;TZID=Asia/Jerusalem:20180131T103000 DTSTAMP:20210802T125850Z URL:https://biology.technion.ac.il/en/seminars/m-sc-graduate-seminar-nitza n-shamir-2/ SUMMARY:M.Sc. Graduate Seminar- Nitzan Shamir [No Categories] DESCRIPTION:Location: \n Affiliation: \n Host:\n \n\n Research Topic:\n P opulation dynamics of T7-like cyanophages during the spring bloom in the G ulf of Aqaba.\n \n דינמיקות האוכלוסיה של וירוסים דמוי-\nT7\n שמדביקים ציאנובקטריה במהלך פרי חת האביב במפרץ עקבה END:VEVENT BEGIN:VEVENT UID:754@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20180129T130000 DTEND;TZID=Asia/Jerusalem:20180129T140000 DTSTAMP:20210802T125850Z URL:https://biology.technion.ac.il/en/seminars/dr-rafael-alhadeff-universi ty-of-southern-california-2/ SUMMARY:Dr. Rafael Alhadeff\, University of Southern California [No Catego ries] DESCRIPTION:Location: \n Affiliation: \n Host:\n Title: Generating energy landscapes andusing them to study complex biological systemsHost: Yael Ma ndel Gutfreund END:VEVENT BEGIN:VEVENT UID:753@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20180128T093000 DTEND;TZID=Asia/Jerusalem:20180128T103000 DTSTAMP:20210802T125850Z URL:https://biology.technion.ac.il/en/seminars/m-sc-graduate-seminar-rony- chanoch-2/ SUMMARY:M.Sc. Graduate Seminar- Rony Chanoch [No Categories] DESCRIPTION:Location: \n Affiliation: \n Host:\n \nEffect of Cannabis on Microglial Cell Functions\n\nהשפעת הקנביס על תפקוד תא י מיקרוגליה.\n END:VEVENT BEGIN:VEVENT UID:752@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20180124T093000 DTEND;TZID=Asia/Jerusalem:20180124T103000 DTSTAMP:20210802T125850Z URL:https://biology.technion.ac.il/en/seminars/dr-shai-stern-rockefeller-u niversity-2/ SUMMARY:Dr. Shai Stern\, Rockefeller University [No Categories] DESCRIPTION:Location: \n Affiliation: \n Host:\n Title: Regulation of lon g-term behaviorand individuality across developmentHost: Yael Mandel Gutfr eund END:VEVENT BEGIN:VEVENT UID:751@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20180122T130000 DTEND;TZID=Asia/Jerusalem:20180122T140000 DTSTAMP:20210802T125850Z URL:https://biology.technion.ac.il/en/seminars/dr-yaron-antebi-california- institute-of-technology-2/ SUMMARY:Dr. Yaron Antebi\, California Institute of Technology [No Categori es] DESCRIPTION:Location: \n Affiliation: \n Host:\n Title: Perception and co mputation incellular signaling pathwaysHost: Yael Mandel Gutfreund END:VEVENT BEGIN:VEVENT UID:750@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20180117T093000 DTEND;TZID=Asia/Jerusalem:20180117T110000 DTSTAMP:20210802T125850Z URL:https://biology.technion.ac.il/en/seminars/michal-mayer-m-sc-graduate- seminar-2/ SUMMARY:Michal Mayer- M.Sc. Graduate Seminar [No Categories] DESCRIPTION:Location: \n Affiliation: \n Host:\n Structure-function Chara cterization of Bacterial Tyrosine Kinases as Antibacterial Drug.\n \nאפ יון קשר מבנה-תפקוד של טירוזין קינאזות ממ קור חיידקי כמטרות לתרופות אנטיבקטריאליו ת\n END:VEVENT BEGIN:VEVENT UID:749@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20180115T130000 DTEND;TZID=Asia/Jerusalem:20180115T140000 DTSTAMP:20210802T125850Z URL:https://biology.technion.ac.il/en/seminars/dr-shai-sabbach-brown-unive rsity-2/ SUMMARY:Dr. Shai Sabbach\, Brown University [No Categories] DESCRIPTION:Location: \n Affiliation: \n Host:\n Title: Dissecting retina l circuitsencoding light intensity and visual motionHost: Yael Mandel Gutf reund END:VEVENT BEGIN:VEVENT UID:748@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20180108T130000 DTEND;TZID=Asia/Jerusalem:20180108T140000 DTSTAMP:20210802T125850Z URL:https://biology.technion.ac.il/en/seminars/dr-eitan-hoch-broad-institu te-2/ SUMMARY:Dr. Eitan Hoch\, Broad Institute [No Categories] DESCRIPTION:Location: \n Affiliation: \n Host:\n Title: From human geneti cs to a new mechanism underlyingtype 2 diabetesHost: Yael Mandel Gutfruend END:VEVENT BEGIN:VEVENT UID:747@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20180103T093000 DTEND;TZID=Asia/Jerusalem:20180103T103000 DTSTAMP:20210802T125850Z URL:https://biology.technion.ac.il/en/seminars/einav-tayeb-fligelman-facul ty-of-biology-technion-2/ SUMMARY:Einav Tayeb-Fligelman\, Faculty of Biology\, Technion [No Categorie s] DESCRIPTION:Location: \n Affiliation: \n Host:\n \nResearch Topic:\n \nNe w structure-Activity Paradigms for Amyloids form Pathogenic Microbes\n \n פרדיגמות חדשות ביחסי מבנה פעילות של עמיל ואידים \nהמופרשים ע״י מיקרובים פתוגניים\n \n END:VEVENT BEGIN:VEVENT UID:746@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20180101T130000 DTEND;TZID=Asia/Jerusalem:20180101T140000 DTSTAMP:20210802T125849Z URL:https://biology.technion.ac.il/en/seminars/dr-oren-kolodny-stanford-un iversity-2/ SUMMARY:Dr. Oren Kolodny\, Stanford University [No Categories] DESCRIPTION:Location: \n Affiliation: \n Host:\n Title: Modeling eco-evo dynamics inmulti-agent systems: tiger genetics\, fly microbiomes\, and hum an toolsHost: Yael Mandel Gutfreund  END:VEVENT BEGIN:VEVENT UID:745@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20171227T093000 DTEND;TZID=Asia/Jerusalem:20171227T103000 DTSTAMP:20210802T125849Z URL:https://biology.technion.ac.il/en/seminars/dr-michal-rabani-dept-of-mo lecular-and-cellular-biology-harvard-university-2/ SUMMARY:Dr. Michal Rabani\, Dept. of Molecular and Cellular Biology\, Harva rd University [No Categories] DESCRIPTION:Location: \n Affiliation: \n Host:\n Systematic dissection of dynamic post-transcriptional RNA regulation\nHost: Yael Mandel Gutfruend yaelmg@technion.ac.il END:VEVENT BEGIN:VEVENT UID:744@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20171225T130000 DTEND;TZID=Asia/Jerusalem:20171225T140000 DTSTAMP:20210802T125849Z URL:https://biology.technion.ac.il/en/seminars/dr-asaf-levi-us-doe-joint-g enome-institute-jgi-2/ SUMMARY:Dr. Asaf Levi\, US DOE Joint Genome Institute (JGI) [No Categories] DESCRIPTION:Location: \n Affiliation: \n Host:\n Genomic features of bact erial adaptation to plants\nHost: Yael Mandel Gutfruend - yaelmg@technion. ac.il END:VEVENT BEGIN:VEVENT UID:743@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20171220T093000 DTEND;TZID=Asia/Jerusalem:20171220T103000 DTSTAMP:20210802T125849Z URL:https://biology.technion.ac.il/en/seminars/shira-yair-sabag-faculty-of -biologe-technion-2/ SUMMARY:Shira Yair-Sabag\, Faculty of Biologe\, Technion [No Categories] DESCRIPTION:Location: \n Affiliation: \n Host:\n Involvement of HLA-B27 i n Ankylosing Spondylitis\nמעורבות HLA-B27 בדלקת חוליות מקשחת. \n END:VEVENT BEGIN:VEVENT UID:742@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20171218T130000 DTEND;TZID=Asia/Jerusalem:20171218T140000 DTSTAMP:20210802T125849Z URL:https://biology.technion.ac.il/en/seminars/jon-yewdell-head-of-the-cel lular-biology-and-viral-immunology-section-at-the-niaid-nih-2/ SUMMARY:Jon Yewdell\, Head of the Cellular Biology and Viral Immunology Se ction at the NIAID\, NIH. [No Categories] DESCRIPTION:Location: \n Affiliation: \n Host:\n TranslatingImmunosurveil lance: Literally \nHost: Yoram Reiter reter@technion.ac.il END:VEVENT BEGIN:VEVENT UID:741@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20171213T093000 DTEND;TZID=Asia/Jerusalem:20171213T103000 DTSTAMP:20210802T125849Z URL:https://biology.technion.ac.il/en/seminars/alon-senitski-faculty-of-bi ology-technion-2/ SUMMARY:Alon Senitski\, Faculty of Biology\, Technion [No Categories] DESCRIPTION:Location: \n Affiliation: \n Host:\n \n\nDNA structural flexi bility and the mechanism of p53 binding to its target sites\n\nגמישו ת מבנית של DNA והשפעתה על מנגנון הקישור של P53 לאתרי המטרה שלו.\n\nUnder the Supervision of Tali Haran END:VEVENT BEGIN:VEVENT UID:740@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20171211T130000 DTEND;TZID=Asia/Jerusalem:20171211T140000 DTSTAMP:20210802T125849Z URL:https://biology.technion.ac.il/en/seminars/dr-jennifer-resnik-harvard- medical-school-2/ SUMMARY:Dr. Jennifer Resnik\, Harvard Medical School [No Categories] DESCRIPTION:Location: \n Affiliation: \n Host:\n Tracking cortical excita tory and inhibitory dynamics after sensory loss\n\nHost: Yael Mandel Gutfr uend yaelmg@technion.ac.il END:VEVENT BEGIN:VEVENT UID:739@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20171206T093000 DTEND;TZID=Asia/Jerusalem:20171206T103000 DTSTAMP:20210802T125849Z URL:https://biology.technion.ac.il/en/seminars/jessy-safieh-faculty-of-bio logy-2/ SUMMARY:Jessy Safieh\, Faculty of Biology [No Categories] DESCRIPTION:Location: \n Affiliation: \n Host:\n Is the functional outcom e of p53​ dependent genes encoded in the flexibility of p53 response ele ments?\n\nAs Part of Her MSc Thesis under the Supervision of Tali Haran END:VEVENT BEGIN:VEVENT UID:738@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20171204T130000 DTEND;TZID=Asia/Jerusalem:20171204T140000 DTSTAMP:20210802T125849Z URL:https://biology.technion.ac.il/en/seminars/dr-naama-kanarek-whitehead- institute-for-biomedical-research-2/ SUMMARY:Dr. Naama Kanarek\, Whitehead Institute for Biomedical Research [No Categories] DESCRIPTION:Location: \n Affiliation: \n Host:\n New Findings in folate h omeostasis and their implications in cancer therapy\nHost: Yael Mandel Gut fruend yaelmg@technion.ac.il END:VEVENT BEGIN:VEVENT UID:737@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20171129T093000 DTEND;TZID=Asia/Jerusalem:20171129T103000 DTSTAMP:20210802T125849Z URL:https://biology.technion.ac.il/en/seminars/aya-khwaja-faculty-of-biolo gy-technion-2/ SUMMARY:Aya Khwaja\, Faculty of Biology\, Technion [No Categories] DESCRIPTION:Location: \n Affiliation: \n Host:\n Molecular basis for Vif chaperoning In the E3-ligase mediated degradation of APOBEC3.\n\nThe Lectu re will be given in English\nPart of her PhD. These under the supervision of Prof Alian Akram END:VEVENT BEGIN:VEVENT UID:736@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20171127T130000 DTEND;TZID=Asia/Jerusalem:20171127T140000 DTSTAMP:20210802T125849Z URL:https://biology.technion.ac.il/en/seminars/prof-dr-saverio-bellusci-ph d-professor-of-experimental-medicine-chair-for-lung-matrix-remodelling-exc ellence-cluster-cardio-pulmonary-system-university-justus-liebig-giessen-2 / SUMMARY:Prof. Dr. Saverio Bellusci\, PhD Professor of Experimental Medicine \, Chair for Lung Matrix Remodelling Excellence Cluster Cardio Pulmonary S ystem\, University Justus Liebig Giessen [No Categories] DESCRIPTION:Location: \n Affiliation: \n Host:\n Title: Origin\, function and fate of Fibroblast growth factor 10-producing cells during lung devel opment\, homeostasis and repair after injury.\nHost: Prof Dina Ron END:VEVENT BEGIN:VEVENT UID:735@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20171120T130000 DTEND;TZID=Asia/Jerusalem:20171120T140000 DTSTAMP:20210802T125849Z URL:https://biology.technion.ac.il/en/seminars/dr-yotam-drier-massachusett s-general-hospital-2/ SUMMARY:Dr. Yotam Drier\, Massachusetts General Hospital [No Categories] DESCRIPTION:Location: \n Affiliation: \n Host:\n Title: When enhancers dr ive the wrong genes: Mechanisms and role in tumorigenesis\nHost: Prof. Yae l Mandel-Gutfruend END:VEVENT BEGIN:VEVENT UID:734@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20171115T093000 DTEND;TZID=Asia/Jerusalem:20171115T103000 DTSTAMP:20210802T125849Z URL:https://biology.technion.ac.il/en/seminars/dor-ross-faculty-of-biology -technion-2/ SUMMARY:Dor Ross\, Faculty of Biology\, Technion [No Categories] DESCRIPTION:Location: \n Affiliation: \n Host:\n Bacterial response to Mu ltitude of Effectors in Nature and in the Lab\n\nPhD. Thesis under the sup ervision of Prof Roy Kishony END:VEVENT BEGIN:VEVENT UID:733@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20171113T130000 DTEND;TZID=Asia/Jerusalem:20171113T140000 DTSTAMP:20210802T125849Z URL:https://biology.technion.ac.il/en/seminars/dr-limor-friedfeld-the-synt hetic-neurobiology-group-media-lab-mit-2/ SUMMARY:Dr. Limor Friedfeld\, The Synthetic Neurobiology group Media lab\, MIT [No Categories] DESCRIPTION:Location: \n Affiliation: \n Host:\n Title: Expansion Microsc opy of Zebrafish\nHost: Prof Yael Mandel-Gutfruend END:VEVENT BEGIN:VEVENT UID:732@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20171108T093000 DTEND;TZID=Asia/Jerusalem:20171108T103000 DTSTAMP:20210802T125849Z URL:https://biology.technion.ac.il/en/seminars/dr-avraham-ashkenazi-cambri dge-institute-for-medical-research-university-of-cambridge-2/ SUMMARY:Dr. Avraham Ashkenazi\, Cambridge Institute for Medical Research\, University of Cambridge [No Categories] DESCRIPTION:Location: \n Affiliation: \n Host:\n Title : Glutamine repeat s (polyQ) shape autophagy in health and neurodegeneration\nHost: Prof Yael Mandel-Gutruend END:VEVENT BEGIN:VEVENT UID:731@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20171106T130000 DTEND;TZID=Asia/Jerusalem:20171106T140000 DTSTAMP:20210802T125848Z URL:https://biology.technion.ac.il/en/seminars/assist-prof-hagen-hofmannde partment-of-structural-biology-weizmann-institute-of-science-2/ SUMMARY:Assist. Prof. Hagen Hofmann\,Department of Structural Biology Weizm ann Institute of Science [No Categories] DESCRIPTION:Location: \n Affiliation: \n Host:\n Mapping an IDP-network w ith single-molecule spectroscopy\nHost: Prof Ariel Kaplan END:VEVENT BEGIN:VEVENT UID:730@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20171101T093000 DTEND;TZID=Asia/Jerusalem:20171101T103000 DTSTAMP:20210802T125848Z URL:https://biology.technion.ac.il/en/seminars/aya-saleh-faculty-of-biolog y-technion-2/ SUMMARY:Aya Saleh\, Faculty of Biology\, Technion [No Categories] DESCRIPTION:Location: \n Affiliation: \n Host:\n Hyperglycemia and Altera tions in the Epigenome and Transcriptome of the Pituitary Gonadotropes and the Mammary Gland.\n\nThe lecture will be in Hebrew.\n\nמנחה אחרא ית: פרופ'/ח פיליפה מלמד\n\nבמסגרת עבודת מחק ר לתואר מגיסטר\n\nההרצאה תתקיים בעברית\, ב אודיטוריום\, בבניין ביולוגיה END:VEVENT BEGIN:VEVENT UID:729@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20171030T130000 DTEND;TZID=Asia/Jerusalem:20171030T140000 DTSTAMP:20210802T125848Z URL:https://biology.technion.ac.il/en/seminars/prof-ronen-zaidel-bar-dept- of-cell-and-developmental-biology-sackler-faculty-of-medicine-tel-aviv-uni versity-2/ SUMMARY:Prof. Ronen Zaidel-Bar\, Dept. of Cell and Developmental Biology\, Sackler Faculty of Medicine\, Tel Aviv University [No Categories] DESCRIPTION:Location: \n Affiliation: \n Host:\n Title: “Regulation of actomyosin contractility in C. elegans”\nHost: Benny Podbilewicz\n END:VEVENT BEGIN:VEVENT UID:728@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20171023T130000 DTEND;TZID=Asia/Jerusalem:20171023T140000 DTSTAMP:20210802T125848Z URL:https://biology.technion.ac.il/en/seminars/assist-prof-tami-geiger-dep artment-of-human-molecular-genetics-and-biochemistry-sackler-faculty-of-me dicine-tel-aviv-university-2/ SUMMARY:Assist. Prof. Tami Geiger \,Department of Human Molecular Genetics and Biochemistry Sackler Faculty of Medicine Tel Aviv University [No Categ ories] DESCRIPTION:Location: \n Affiliation: \n Host:\n Title:\nClinical Proteom ics of Response to Anti-Cancer Treatment END:VEVENT BEGIN:VEVENT UID:727@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20170926T093000 DTEND;TZID=Asia/Jerusalem:20170926T103000 DTSTAMP:20210802T125848Z URL:https://biology.technion.ac.il/en/seminars/liad-cohen-faculty-of-biolo gy-technion-2/ SUMMARY:Liad Cohen\, Faculty of Biology\, Technion [No Categories] DESCRIPTION:Location: \n Affiliation: \n Host:\n A Geometric Based Approa ch to Identify Interface Similarities DNA and RNA Binding Proteins\nגיש ה חישובית לזיהוי דמיון בין ממשקים של חלב ונים\nקושרי DNAו-RNA.\n\nAs prt of her MSc Thesis requirments u nder the supervision of Associate Prof. Yael Mendel-Gutfruend\nThe lecture will be given in Hebrew\n END:VEVENT BEGIN:VEVENT UID:726@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20170924T093000 DTEND;TZID=Asia/Jerusalem:20170924T103000 DTSTAMP:20210802T125848Z URL:https://biology.technion.ac.il/en/seminars/ella-peled-faculty-of-biolo gy-technion-2/ SUMMARY:Ella Peled\, Faculty of Biology\, Technion [No Categories] DESCRIPTION:Location: \n Affiliation: \n Host:\n Title:\nThe Role of Cann abinoid Receptors in the Antitumor Effect of Cannabis\nמעורבות הר צפטורים הקנבינואידים בתגובה האנטי-סרטני ת של\nקנאביס\n\nAs part of her MSc Thesis requirements under the supervision of Assistant Professor David Meiri.\nThe Lecture will be given in Hebrew END:VEVENT BEGIN:VEVENT UID:725@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20170918T130000 DTEND;TZID=Asia/Jerusalem:20170918T140000 DTSTAMP:20210802T125848Z URL:https://biology.technion.ac.il/en/seminars/prof-ehud-ahissar-weizmann- institute-of-science-2/ SUMMARY:Prof. Ehud Ahissar\, Weizmann Institute of Science\, [No Categories ] DESCRIPTION:Location: \n Affiliation: \n Host:\n Title:\n"Is Perception a Computation”\nHost: Prof. Podbilewicz END:VEVENT BEGIN:VEVENT UID:724@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20170912T093000 DTEND;TZID=Asia/Jerusalem:20170912T103000 DTSTAMP:20210802T125848Z URL:https://biology.technion.ac.il/en/seminars/artyom-linkov-faculty-of-bi ology-2/ SUMMARY:Artyom Linkov\, Faculty of Biology [No Categories] DESCRIPTION:Location: \n Affiliation: \n Host:\n הבנת תהליכי ה התחדשות של מערכת המעי באמצעות תאי גזע וה חלבון\n(Cd90)Thy1.\nUnderstanding intestinal regeneration mechanisms through\nstem cells and the Thy1 (CD90) protein. \n\nUnder the supervision of Assistant Prof Yaron Fuchs\nThe lecture will be given in English END:VEVENT BEGIN:VEVENT UID:723@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20170911T130000 DTEND;TZID=Asia/Jerusalem:20170911T140000 DTSTAMP:20210802T125848Z URL:https://biology.technion.ac.il/en/seminars/prof-david-prangishvili-dep artment-of-microbiology-institut-pasteur-paris-france-2/ SUMMARY:Prof. DAvid Prangishvili\, Department of Microbiology\, Institut Pa steur\, Paris\, France [No Categories] DESCRIPTION:Location: \n Affiliation: \n Host:\n The Wonderful World of A rchaeal Viruses\n\nHost: Prof. Debbie Lindell END:VEVENT BEGIN:VEVENT UID:722@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20170907T093000 DTEND;TZID=Asia/Jerusalem:20170907T103000 DTSTAMP:20210802T125848Z URL:https://biology.technion.ac.il/en/seminars/rotem-sinreich-faculty-of-b iology-2/ SUMMARY:Rotem Sinreich\, Faculty of Biology [No Categories] DESCRIPTION:Location: \n Affiliation: \n Host:\n MSC Thesis Seminar\nTitl e:\nCaspase-3 regulates skin cancer progression via yap signaling pathway\ n\nUnder the supervision of Assistant Prof Yaron Fuchs\nThe lecture will b e given in English END:VEVENT BEGIN:VEVENT UID:721@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20170905T093000 DTEND;TZID=Asia/Jerusalem:20170905T103000 DTSTAMP:20210802T125848Z URL:https://biology.technion.ac.il/en/seminars/boris-shneyer-faculty-of-bi ology-technion-2/ SUMMARY:Boris Shneyer\, Faculty of Biology\, Technion [No Categories] DESCRIPTION:Location: \n Affiliation: \n Host:\n PhD Thesis lecture\nTitl e: \nNew Function for the actin-based molecular motor Myo19 in mitochondri al motlity and filopodia formation.\nUnder the supervision of Assostant Pr of. Arnon Henn\nThe lecture will be given in English END:VEVENT BEGIN:VEVENT UID:720@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20170815T093000 DTEND;TZID=Asia/Jerusalem:20170815T103000 DTSTAMP:20210802T125848Z URL:https://biology.technion.ac.il/en/seminars/%d7%99%d7%a7%d7%98%d7%a8%d7 %99%d7%a0%d7%94-%d7%a4%d7%95%d7%98%d7%95%d7%a8%d7%99%d7%99%d7%9f-%d7%94%d7 %a4%d7%a7%d7%95%d7%9c%d7%98%d7%94-%d7%9c%d7%91%d7%99%d7%95%d7%9c%d7%95%d7% 92%d7%99%d7%94-2/ SUMMARY:יקטרינה פוטוריין\, הפקולטה לביולוגיה [No Categories] DESCRIPTION:Location: \n Affiliation: \n Host:\n Comprehensive mass-spect rometry based characterization of clinically used Cannabis strains in Isra el\n\nMSc. Thesis under the supervision of Prof David Meiri. END:VEVENT BEGIN:VEVENT UID:719@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20170725T093000 DTEND;TZID=Asia/Jerusalem:20170725T103000 DTSTAMP:20210802T125848Z URL:https://biology.technion.ac.il/en/seminars/harel-zalts-faculty-of-biol ogy-technion-2/ SUMMARY:Harel Zalts\, Faculty of Biology\, Technion [No Categories] DESCRIPTION:Location: \n Affiliation: \n Host:\n Title: Developmental con straints and the evolution of embryonic development \nas part of his PhD T hesis under the supervision of:\nProf. Roi Kishony\nProf. Itai Yanai END:VEVENT BEGIN:VEVENT UID:718@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20170703T130000 DTEND;TZID=Asia/Jerusalem:20170703T140000 DTSTAMP:20210802T125848Z URL:https://biology.technion.ac.il/en/seminars/prof-amnon-buxboim-institut e-of-life-sciences-hebrew-university-of-jerusalem-2/ SUMMARY:Prof. Amnon Buxboim\, Institute of Life Sciences\, Hebrew Universit y of Jerusalem [No Categories] DESCRIPTION:Location: \n Affiliation: \n Host:\n Nuclear lamins are regul ators of cellular mechanosensitivity and homeostasis\n\nHost: Shenhav Cohe n END:VEVENT BEGIN:VEVENT UID:717@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20170626T130000 DTEND;TZID=Asia/Jerusalem:20170626T140000 DTSTAMP:20210802T125848Z URL:https://biology.technion.ac.il/en/seminars/prof-ygal-haupt-peter-macca llum-cancer-centre-melbourne-australia-2/ SUMMARY:Prof. Ygal Haupt\, Peter MacCallum Cancer Centre\, Melbourne\, Aust ralia [No Categories] DESCRIPTION:Location: \n Affiliation: \n Host:\n Restoration of tumor sup pression in hormone related cancers\n\nHost: Oded Kleifeld END:VEVENT BEGIN:VEVENT UID:716@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20170620T093000 DTEND;TZID=Asia/Jerusalem:20170620T103000 DTSTAMP:20210802T125847Z URL:https://biology.technion.ac.il/en/seminars/dan-kol-kalman-faculty-of-b iology-technion-2/ SUMMARY:Dan Kol-Kalman \, Faculty of Biology\, Technion [No Categories] DESCRIPTION:Location: \n Affiliation: \n Host:\n Electron extraction from photosynthetic systems in Bio-Photo-Electro-Chemical cells\nAs part of hi s Ph.D requirements under the Supervision of:\n- Prof. Gadi Shuster\n- Pro f. Noam Adir\n- Prof.Avner Rotschild END:VEVENT BEGIN:VEVENT UID:715@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20170612T130000 DTEND;TZID=Asia/Jerusalem:20170612T140000 DTSTAMP:20210802T125847Z URL:https://biology.technion.ac.il/en/seminars/harvey-prize-lecture-prof-p eter-hegemann-institute-of-biology-experimental-biophysics-humboldt-univer sity-berlin-2/ SUMMARY:HARVEY PRIZE LECTURE\, Prof. Peter Hegemann\, Institute of Biology\ , Experimental Biophysics\, Humboldt University\, Berlin [No Categories] DESCRIPTION:Location: \n Affiliation: \n Host:\n Sensory photoreceptors o f green algae\, biophysics and biological function END:VEVENT BEGIN:VEVENT UID:714@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20170611T090000 DTEND;TZID=Asia/Jerusalem:20170611T100000 DTSTAMP:20210802T125847Z URL:https://biology.technion.ac.il/en/seminars/harvey-prize-lecture-prof-k arl-deisseroth-department-of-bioengineering-stanford-university-and-howard -hughes-medical-institute-2/ SUMMARY:HARVEY PRIZE LECTURE\, Prof. Karl Deisseroth\, Department of Bioeng ineering\, Stanford University and Howard Hughes Medical Institute [No Cat egories] DESCRIPTION:Location: \n Affiliation: \n Host:\n Building new structures and functions within intact biological tissues\n END:VEVENT BEGIN:VEVENT UID:713@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20170606T093000 DTEND;TZID=Asia/Jerusalem:20170606T103000 DTSTAMP:20210802T125847Z URL:https://biology.technion.ac.il/en/seminars/meytal-galilee-faculty-of-b iology-technion-2/ SUMMARY:Meytal Galilee\, Faculty of Biology\, Technion [No Categories] DESCRIPTION:Location: \n Affiliation: \n Host:\n Cross-Species Comparison Identifies Novel Anti- HIV Targets\nPart of her PhD These under the Super vision of Assistant Professor Akram Alian END:VEVENT BEGIN:VEVENT UID:712@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20170605T130000 DTEND;TZID=Asia/Jerusalem:20170605T140000 DTSTAMP:20210802T125847Z URL:https://biology.technion.ac.il/en/seminars/prof-oren-schuldiner-depart ment-of-molecular-cell-biology-weizmann-institute-of-science-2/ SUMMARY:Prof. Oren Schuldiner\, Department of Molecular Cell Biology\, Weiz mann Institute of Science [No Categories] DESCRIPTION:Location: \n Affiliation: \n Host:\n “From genetics to syst em\, and back: A systematic exploration of neuronal remodeling reveals a t ranscription factor hierarchy”\n\n\nHost: Benjamin Podbilewicz podbilew@ technion.ac.il END:VEVENT BEGIN:VEVENT UID:711@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20170529T130000 DTEND;TZID=Asia/Jerusalem:20170529T140000 DTSTAMP:20210802T125847Z URL:https://biology.technion.ac.il/en/seminars/prof-noam-shomron-sackler-f aculty-of-medicine-tel-aviv-university-2/ SUMMARY:Prof. Noam Shomron\, Sackler Faculty of Medicine\, Tel-Aviv Univers ity [No Categories] DESCRIPTION:Location: \n Affiliation: \n Host:\n “Big Data and genomics : stopping the spread of breast cancer”\n\nHost: Yoav Arava arava@techni on.ac.il END:VEVENT BEGIN:VEVENT UID:710@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20170523T093000 DTEND;TZID=Asia/Jerusalem:20170523T103000 DTSTAMP:20210802T125847Z URL:https://biology.technion.ac.il/en/seminars/sergei-perov-faculty-of-bio logy-technion-2/ SUMMARY:Sergei Perov\, Faculty of Biology\, Technion [No Categories] DESCRIPTION:Location: \n Affiliation: \n Host:\n Structural-function Rela tionship and Modulation of Microbial Functional Amyloids from E. coli and Candida albicans \nיחסי מבנה פעולה ועיכוב של עמיל ואידים מיקרוביאלים פונקציונלים מא. קולי וקנדידה אלביקנס\n\n the lecture will be in English and is pa rt of the PhD Thesis inder the supervisoin of Prof Meytal Landau END:VEVENT BEGIN:VEVENT UID:709@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20170516T093000 DTEND;TZID=Asia/Jerusalem:20170516T103000 DTSTAMP:20210802T125847Z URL:https://biology.technion.ac.il/en/seminars/pratik-vyas-faculty-of-biol ogy-technion-2/ SUMMARY:Pratik Vyas\, Faculty of Biology\, Technion [No Categories] DESCRIPTION:Location: \n Affiliation: \n Host:\n ההתקשרות של ה חלבון פ53 מזן הבר עם אתרי המטרה שלו: התפקי ד של רצפים מגשרים בהתקשרות פ53דנ"א\n"The intera ctions of wild-type p53 with its response elements: the role of sequence s pacers in p53/DNA interactions"\n\nThe lecture will be in English.\n\n\nמ נחה: פרופ'/ח טלי הרן\nבמסגרת עבודת מחקר לת ואר דוקטור\n END:VEVENT BEGIN:VEVENT UID:708@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20170515T133000 DTEND;TZID=Asia/Jerusalem:20170515T143000 DTSTAMP:20210802T125847Z URL:https://biology.technion.ac.il/en/seminars/the-lokey-center-distinguis hed-lecture-series-prof-gary-karpen-biological-systems-and-engineering-div ision-lawrence-berkeley-national-laboratory-department-of-molecular-and-ce ll-biology-univers-2/ SUMMARY:The Lokey Center Distinguished Lecture Series - Prof. Gary Karpen\, Biological Systems and Engineering Division\, Lawrence Berkeley National Laboratory\, Department of Molecular and Cell Biology\, University of Cali fornia\, Berkeley [No Categories] DESCRIPTION:Location: \n Affiliation: \n Host:\n Subject:\n"Biophysics me ets chromatin: Is heterochromatin just a phase?”\n\nPart of: The Lokey D istinguished Lecture Series END:VEVENT BEGIN:VEVENT UID:707@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20170515T120000 DTEND;TZID=Asia/Jerusalem:20170515T130000 DTSTAMP:20210802T125847Z URL:https://biology.technion.ac.il/en/seminars/the-lokey-center-distinguis hed-lecture-series-prof-abby-dernburg-hhmi-investigator-department-of-mole cular-and-cell-biology-university-of-california-berkeley-2/ SUMMARY:The Lokey Center Distinguished Lecture Series - Prof. Abby Dernburg \, HHMI Investigator\, Department of Molecular and Cell Biology\, Universi ty of California\, Berkeley [No Categories] DESCRIPTION:Location: \n Affiliation: \n Host:\n "A liquid crystalline co mpartment between meiotic chromosomes regulates genetic recombination.”\ n\nPart of the The Lokey Center Distinguished Lecture Series\n END:VEVENT BEGIN:VEVENT UID:706@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20170510T130000 DTEND;TZID=Asia/Jerusalem:20170510T140000 DTSTAMP:20210802T125847Z URL:https://biology.technion.ac.il/en/seminars/prof-james-l-manley-departm ent-of-biological-sciences-columbia-university-nyc-usa-2/ SUMMARY:Prof. James L. Manley\, Department of Biological Sciences\, Columb ia University\, NYC\, USA [No Categories] DESCRIPTION:Location: \n Affiliation: \n Host:\n “Dysregulation of mRNA splicing in cancer and neurodegenerative disease”\n\nHost: Prof Tali Ha ran END:VEVENT BEGIN:VEVENT UID:705@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20170509T140000 DTEND;TZID=Asia/Jerusalem:20170509T150000 DTSTAMP:20210802T125847Z URL:https://biology.technion.ac.il/en/seminars/the-israel-pollak-distingui shed-lecture-series-prof-carol-l-prives-department-of-biological-sciences- columbia-university-new-york-usa-4/ SUMMARY:The Israel Pollak Distinguished Lecture Series\, Prof. Carol L. Pri ves Department of Biological Sciences\, Columbia University\, New York\, U SA [No Categories] DESCRIPTION:Location: \n Affiliation: \n Host:\n “The Mdm32 E3 ubiquiti n ligase has p53-dependent and independent roles in cancer and aging”\nH ost: Prof. Tali Haran END:VEVENT BEGIN:VEVENT UID:704@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20170509T133000 DTEND;TZID=Asia/Jerusalem:20170509T143000 DTSTAMP:20210802T125847Z URL:https://biology.technion.ac.il/en/seminars/prof-jane-cullis-nyu-school -of-medicine-nyc-usa-2/ SUMMARY:Prof. Jane Cullis\, NYU School of Medicine\, NYC\, USA [No Categori es] DESCRIPTION:Location: \n Affiliation: \n Host:\n Title: Harnessing Macrop hage Macropinocytosis as a Therapeutic Strategy in Pancreatic Cancer\n\nAb stract: \nPancreatic cancer is a devastating disease that is largely refra ctory to currently available treatment strategies. Therapeutic resistance is partially attributed to the dense stromal reaction of pancreatic ductal adenocarcinoma tumors that includes a pervasive infiltration of immunosup pressive (M2) macrophages. Nab-paclitaxel (trade name Abraxane) is a nanop article albumin-bound formulation of paclitaxel that\, in combination with gemcitabine\, is currently the first-line treatment for pancreatic cancer . We show that macrophages internalize high levels of nab-paclitaxel via m acropinocytosis. The macropinocytic uptake of nab-paclitaxel induces macro phage immunostimulatory (M1) activation in vitro and in an orthotopic mode l of pancreatic cancer. These data reveal an unanticipated role for nab-pa clitaxel in macrophage activation and rationalize the development of album in-coupled immunostimulatory agents to effectively target and re-polarize macrophages in pancreatic cancer.\nHost: David Meiri END:VEVENT BEGIN:VEVENT UID:703@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20170508T130000 DTEND;TZID=Asia/Jerusalem:20170508T140000 DTSTAMP:20210802T125847Z URL:https://biology.technion.ac.il/en/seminars/the-israel-pollak-distingui shed-lecture-series-prof-carol-l-prives-department-of-biological-sciences- columbia-university-new-york-usa-3/ SUMMARY:The Israel Pollak Distinguished Lecture Series\, Prof. Carol L. Pri ves Department of Biological Sciences\, Columbia University\, New York\, U SA [No Categories] DESCRIPTION:Location: \n Affiliation: \n Host:\n “The two faces of p53: tumor suppressor and ocgene”\nHost: Prof Tali Haran END:VEVENT BEGIN:VEVENT UID:702@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20170426T130000 DTEND;TZID=Asia/Jerusalem:20170426T140000 DTSTAMP:20210802T125847Z URL:https://biology.technion.ac.il/en/seminars/dr-dina-lipkind-hunter-coll ege-of-the-city-university-of-new-york-2/ SUMMARY:Dr. Dina Lipkind Hunter College of the City University of New York [No Categories] DESCRIPTION:Location: \n Affiliation: \n Host:\n “Vocal development\, f rom songbirds to humans”\n\nHost: Yael Mandel-Gutfreund END:VEVENT BEGIN:VEVENT UID:701@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20170425T093000 DTEND;TZID=Asia/Jerusalem:20170425T103000 DTSTAMP:20210802T125846Z URL:https://biology.technion.ac.il/en/seminars/daniel-neufeld-faculty-of-b iology-technion-2/ SUMMARY:Daniel Neufeld\, Faculty of Biology\, Technion [No Categories] DESCRIPTION:Location: \n Affiliation: \n Host:\n The Deubiquitinating Enz yme\, USP1\, Promotes Muscle Atrophy by Inhibiting Pl3k-Akt-FoxO Signaling \n\nThe lecture will be given in Hebrew\nThe lecture is part of the M.Sc T hesis under the supervision of Assistant Prof. Shenhav Cohen END:VEVENT BEGIN:VEVENT UID:700@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20170424T130000 DTEND;TZID=Asia/Jerusalem:20170424T140000 DTSTAMP:20210802T125846Z URL:https://biology.technion.ac.il/en/seminars/dr-ofer-ashkenazi-departmen t-of-history-the-hebrew-university-of-jerusalem-2/ SUMMARY:Dr. Ofer Ashkenazi\, Department of History\, The Hebrew University of Jerusalem [No Categories] DESCRIPTION:Location: \n Affiliation: \n Host:\n Jewish Photography in Na zi Germany\nHost: Yoav Arava END:VEVENT BEGIN:VEVENT UID:699@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20170418T093000 DTEND;TZID=Asia/Jerusalem:20170418T103000 DTSTAMP:20210802T125846Z URL:https://biology.technion.ac.il/en/seminars/gal-avital-faculty-of-biolo gy-technion-2/ SUMMARY:Gal Avital\, Faculty of Biology\, Technion [No Categories] DESCRIPTION:Location: \n Affiliation: \n Host:\n Title\nהבנת מסלו לי בקרה גנטיים בתהליכים דינמיים הכוללים\ nטרנסקריפטים חסרי פולי-a\nUnderstanding gene regulatory programs involving non\npoly-A transcripts in dynamic processes\n\nThe le cture will be in English.\n\n\nמנחה: פרופ'/ח איתי ינאי\n במסגרת עבודת מחקר לתואר דוקטור.\nההרצאה ת תקיים באנגלית\, באודיטוריום\, בבניין ביול וגיה.\n END:VEVENT BEGIN:VEVENT UID:698@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20170403T130000 DTEND;TZID=Asia/Jerusalem:20170403T140000 DTSTAMP:20210802T125846Z URL:https://biology.technion.ac.il/en/seminars/dr-ramon-birnbaum-faculty-o f-life-sciences-ben-gurion-university-2/ SUMMARY:Dr. Ramon Birnbaum \, Faculty of Life Sciences\, Ben Gurion Univers ity [No Categories] DESCRIPTION:Location: \n Affiliation: \n Host:\n “Transcriptional enhan cers regulate inhibitory interneuron differentiation ”\nHost: Yoav Arava END:VEVENT BEGIN:VEVENT UID:697@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20170327T130000 DTEND;TZID=Asia/Jerusalem:20170327T140000 DTSTAMP:20210802T125846Z URL:https://biology.technion.ac.il/en/seminars/prof-yuval-garini-departmen t-of-physics-and-nanotechnology-institute-bar-ilan-university-2/ SUMMARY:Prof. Yuval Garini\, Department of Physics and Nanotechnology Insti tute Bar Ilan University [No Categories] DESCRIPTION:Location: \n Affiliation: \n Host:\n The Genome in the nucleu s: Snaky\, soft and well organized\nHost: Yoav Arava END:VEVENT BEGIN:VEVENT UID:696@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20170320T130000 DTEND;TZID=Asia/Jerusalem:20170320T140000 DTSTAMP:20210802T125846Z URL:https://biology.technion.ac.il/en/seminars/dr-shilo-rosenwasser-the-ro bert-h-smith-institute-of-plant-sciences-and-genetics-in-agriculture-the-h ebrew-university-of-jerusalem-2/ SUMMARY:Dr. Shilo Rosenwasser\, The Robert H. Smith Institute of Plant Scie nces and Genetics in Agriculture\, The Hebrew University of Jerusalem [No Categories] DESCRIPTION:Location: \n Affiliation: \n Host:\n "Remodeling  of cellula r metabolism during viral infection and under oxidative stress” \nHost: Hagat Enav END:VEVENT BEGIN:VEVENT UID:695@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20170313T130000 DTEND;TZID=Asia/Jerusalem:20170313T140000 DTSTAMP:20210802T125846Z URL:https://biology.technion.ac.il/en/seminars/prof-yoav-shechtman-departm ent-of-biomedical-engineering-technion-2/ SUMMARY:Prof. Yoav Shechtman\, Department of Biomedical Engineering\, Techn ion [No Categories] DESCRIPTION:Location: \n Affiliation: \n Host:\n “Optimal and multicolo r 3D localization microscopy”\nHost: Yoav Arava END:VEVENT BEGIN:VEVENT UID:694@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20170308T093000 DTEND;TZID=Asia/Jerusalem:20170308T103000 DTSTAMP:20210802T125846Z URL:https://biology.technion.ac.il/en/seminars/%d7%a1%d7%98%d7%9c%d7%94-%d 7%91%d7%95%d7%a8%d7%a7%d7%95-%d7%94%d7%a4%d7%a7%d7%95%d7%9c%d7%98%d7%94-%d 7%9c%d7%91%d7%99%d7%95%d7%9c%d7%95%d7%92%d7%99%d7%94-2/ SUMMARY:סטלה בורקו\, הפקולטה לביולוגיה [No Categor ies] DESCRIPTION:Location: \n Affiliation: \n Host:\n בנושא:\n\nאפיו ן תפקיד הליזין דה-מתילאז Phf2 בתגובה התאית לנזקי דנ"א\n\nCharacterizing the Role of PHF2 Lysine Demethylase i n DNA\nDamage Response\n\nThe lecture will be in English.\n\n\nמנחה: פרופ'/ח נביה איוב\nבמסגרת עבודת מחקר לתוא ר מגיסטר.\n END:VEVENT BEGIN:VEVENT UID:693@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20170306T130000 DTEND;TZID=Asia/Jerusalem:20170306T140000 DTSTAMP:20210802T125846Z URL:https://biology.technion.ac.il/en/seminars/prof-rachel-klevit-departme nt-of-biochemistry-washington-university-2/ SUMMARY:Prof. Rachel Klevit\, Department of Biochemistry\, Washington Unive rsity [No Categories] DESCRIPTION:Location: \n Affiliation: \n Host:\n "The same but different: RING and RING-Between-RING (RBR) Ubiquitin E3 ligases.” \nJoint Seminar from the Faculties of Biology and Chemistry:\nMichael Glickman\nAshraf Br ik END:VEVENT BEGIN:VEVENT UID:692@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20170213T130000 DTEND;TZID=Asia/Jerusalem:20170213T140000 DTSTAMP:20210802T125846Z URL:https://biology.technion.ac.il/en/seminars/prof-moshe-dessau-faculty-o f-medicine-in-the-galilee-bar-ilan-university-2/ SUMMARY:Prof. Moshe Dessau\, Faculty of Medicine in the Galilee\, Bar-Ilan University [No Categories] DESCRIPTION:Location: \n Affiliation: \n Host:\n ’Structural Insights I nto Hantavirus Entry`\nHost: Benjamin Podbilewicz podbilew@technion.ac.il END:VEVENT BEGIN:VEVENT UID:691@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20170206T130000 DTEND;TZID=Asia/Jerusalem:20170206T140000 DTSTAMP:20210802T125846Z URL:https://biology.technion.ac.il/en/seminars/dr-boris-brumshtein-ucla-do e-institute-for-genomics-and-proteomics-university-of-california-los-angel es-2/ SUMMARY:Dr. Boris Brumshtein\, UCLA-DOE Institute for Genomics and Proteomi cs University of California\, Los Angeles [No Categories] DESCRIPTION:Location: \n Affiliation: \n Host:\n Discovery and Developmen t of Novel Pharmacophores for the Treatment of Systemic Amyloidosis\n\nHos t: Meytal Landau mlandau@technion.ac.il END:VEVENT BEGIN:VEVENT UID:690@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20170131T130000 DTEND;TZID=Asia/Jerusalem:20170131T140000 DTSTAMP:20210802T125846Z URL:https://biology.technion.ac.il/en/seminars/dr-ella-preger-ben-noon-how ard-hughes-medical-institute-janelia-research-campus-ashburnva-2/ SUMMARY:Dr. Ella Preger-Ben Noon Howard Hughes Medical Institute\, Janelia Research Campus\, Ashburn\,VA [No Categories] DESCRIPTION:Location: \n Affiliation: \n Host:\n Decoding the regulatory information in genomes: lessons from enhancer evolution\n\nHost: Yael Mand el-Gutfruend END:VEVENT BEGIN:VEVENT UID:689@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20170123T130000 DTEND;TZID=Asia/Jerusalem:20170123T140000 DTSTAMP:20210802T125846Z URL:https://biology.technion.ac.il/en/seminars/prof-nathalie-balaban-racah -institute-of-physics-the-hebrew-university-2/ SUMMARY:Prof. Nathalie Balaban Racah Institute of Physics\, The Hebrew Uni versity [No Categories] DESCRIPTION:Location: \n Affiliation: \n Host:\n Phenotypic variability a nd the evolution of antibiotic tolerance\n\nHost: Yoav Arava END:VEVENT BEGIN:VEVENT UID:688@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20170116T130000 DTEND;TZID=Asia/Jerusalem:20170116T140000 DTSTAMP:20210802T125846Z URL:https://biology.technion.ac.il/en/seminars/dr-naomi-habib-mcgovern-ins titute-of-brain-research-mit-and-broad-institute-of-harvard-and-mit-cambri dge-ma-2/ SUMMARY:Dr. Naomi Habib McGovern Institute of Brain Research\, MIT  and B road Institute of Harvard and MIT\, Cambridge\, MA [No Categories] DESCRIPTION:Location: \n Affiliation: \n Host:\n From Single Nuclei RNA-S equencing to Dynamics of Neuronal Regeneration\n\nHost: Yael Mandel-Gutfru end END:VEVENT BEGIN:VEVENT UID:687@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20170111T093000 DTEND;TZID=Asia/Jerusalem:20170111T103000 DTSTAMP:20210802T125846Z URL:https://biology.technion.ac.il/en/seminars/noor-mruwat-faculty-of-biol ogy-technion-2/ SUMMARY:Noor Mruwat\, Faculty of Biology\, TEchnion [No Categories] DESCRIPTION:Location: \n Affiliation: \n Host:\n כימות היקף הה דבקה של ציאנובקטריה על ידי ציאנווירוסים ברמת התא הבודד באמצעות שיטה המבוססת על PC R במצע חצי מוצק\nQuantitative determination of the extent of cy anobacterial infection by cyanophages at the single-cell level using a sol id-phase PCR method\n\nההרצאה תינתן בעיברית\nבמסגר ת הדרישות לעבודת דוקטורט בהנחיית פרופ דב י לינדל END:VEVENT BEGIN:VEVENT UID:686@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20170109T130000 DTEND;TZID=Asia/Jerusalem:20170109T140000 DTSTAMP:20210802T125845Z URL:https://biology.technion.ac.il/en/seminars/dr-shaul-yogev-department-o f-biology-stanford-university-ca-2/ SUMMARY:Dr. Shaul Yogev Department of Biology\, Stanford University\, CA [N o Categories] DESCRIPTION:Location: \n Affiliation: \n Host:\n Microtubule organization patterns determine axonal transport dynamics\nHost: Yael Mandel-Gutfreund yaelmg@technion.ac.il\n END:VEVENT BEGIN:VEVENT UID:685@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20170104T130000 DTEND;TZID=Asia/Jerusalem:20170104T140000 DTSTAMP:20210802T125845Z URL:https://biology.technion.ac.il/en/seminars/dr-moran-yassour-laboratori es-of-ramnik-xavier-eric-lander-the-broad-institute-of-mit-and-harvard-2/ SUMMARY:Dr. Moran Yassour\,  Laboratories of Ramnik Xavier & Eric Lander   The Broad Institute of MIT and Harvard [No Categories] DESCRIPTION:Location: \n Affiliation: \n Host:\n "The natural history of the infant gut microbiome in health and disease"\n\nHost: Roy Kishony END:VEVENT BEGIN:VEVENT UID:684@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20170104T093000 DTEND;TZID=Asia/Jerusalem:20170104T103000 DTSTAMP:20210802T125845Z URL:https://biology.technion.ac.il/en/seminars/tal-naor-faculty-of-biology -technion-2/ SUMMARY:Tal Naor\, Faculty of Biology\, Technion [No Categories] DESCRIPTION:Location: \n Affiliation: \n Host:\n Subject: "Synthetic micr obial communities with antibiotic-mediated interactions"\n\nas part of his MSc Thesis under the supervision of Prof. Roy Kishony END:VEVENT BEGIN:VEVENT UID:683@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20170102T130000 DTEND;TZID=Asia/Jerusalem:20170102T140000 DTSTAMP:20210802T125845Z URL:https://biology.technion.ac.il/en/seminars/dr-noga-ron-harel-departmen t-of-cell-biology-harvard-medical-school-cambridge-ma-2/ SUMMARY:Dr. Noga Ron-Harel Department of Cell Biology Harvard Medical Scho ol\, Cambridge\, MA [No Categories] DESCRIPTION:Location: \n Affiliation: \n Host:\n Mitochondrial biogenesis and proteome remodeling promote one carbon metabolism for naïve T cell a ctivation \nHost: Yael Mandel-Gutfreund yaelmg@technion.ac.il\n END:VEVENT BEGIN:VEVENT UID:682@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20161229T130000 DTEND;TZID=Asia/Jerusalem:20161229T140000 DTSTAMP:20210802T125845Z URL:https://biology.technion.ac.il/en/seminars/prof-itamar-harel-departmen t-of-genetics-university-school-of-medicine-ca-2/ SUMMARY:Prof. Itamar Harel Department of Genetics\, University School of Me dicine\, CA [No Categories] DESCRIPTION:Location: \n Affiliation: \n Host:\n “Exploring the genetic s of aging using a naturally short-lived vertebrate”\nHost: Yael Mandel- Gutfreund yaelmg@technion.ac.il\n END:VEVENT BEGIN:VEVENT UID:681@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20161228T093000 DTEND;TZID=Asia/Jerusalem:20161228T103000 DTSTAMP:20210802T125845Z URL:https://biology.technion.ac.il/en/seminars/omer-yuval-faculty-of-biolo gy-technion-2/ SUMMARY:Omer Yuval\, Faculty of Biology\, TEchnion [No Categories] DESCRIPTION:Location: \n Affiliation: \n Host:\n בנושא:\nMenorah Ana lyzer: A Computational Analysis of the PVD Neuron in C. elegans.\n\nמנח ים: בנימין פודבילביץ' ותום שמש\nבמסגרת עב ודת מגיסטר\nThe lecture will be English\n END:VEVENT BEGIN:VEVENT UID:680@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20161226T130000 DTEND;TZID=Asia/Jerusalem:20161226T140000 DTSTAMP:20210802T125845Z URL:https://biology.technion.ac.il/en/seminars/prof-omri-wurtzel-whitehead -institute-for-biomedical-research-cambridge-ma-2/ SUMMARY:Prof. Omri Wurtzel Whitehead Institute for Biomedical Research\, C ambridge\, MA [No Categories] DESCRIPTION:Location: \n Affiliation: \n Host:\n “An in vivo system for studying stem cell dynamics and injury response”\nHost: Yael Mandel-Gut freund yaelmg@technion.ac.il\n END:VEVENT BEGIN:VEVENT UID:679@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20161221T130000 DTEND;TZID=Asia/Jerusalem:20161221T140000 DTSTAMP:20210802T125845Z URL:https://biology.technion.ac.il/en/seminars/prof-david-burstein-departm ent-of-earth-and-planetary-sciences-university-of-california-berkeley-2/ SUMMARY:Prof. David Burstein\, Department of Earth And Planetary Sciences\ , University of California\, Berkeley [No Categories] DESCRIPTION:Location: \n Affiliation: \n Host:\n New CRISPR-Cas systems f rom uncultivated microbes\nHost: Yael Mandel-Gutfreund yaelmg@technion.ac. il\n END:VEVENT BEGIN:VEVENT UID:678@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20161219T130000 DTEND;TZID=Asia/Jerusalem:20161219T140000 DTSTAMP:20210802T125845Z URL:https://biology.technion.ac.il/en/seminars/prof-dianne-newman-gordon-m -binder-amgen-professor-of-biology-and-geobiology-hhmi-investigator-caltec h-university-2/ SUMMARY:Prof. Dianne Newman Gordon M.Binder/Amgen Professor of Biology and Geobiology\, HHMI Investigator\, Caltech University [No Categories] DESCRIPTION:Location: \n Affiliation: \n Host:\n Dear all\,\n\nProf. Dian ne Newman from California Institute of Technology will visit the Technion as a Lokey Distinguished Lecturer and will give a seminar on\n \nMonday\, December 19th\, 2016 @ 13:00 PM\nSeminar at Faculty of Biology auditorium\ n"The importance of growing slowly: roles for redox-active ‘antibiotics' in microbial survival and development”\n\nDr. Dianne Newman's research focuses on microbial stress responses\, with an emphasis on mechanisms of energy generation and survival when oxygen is scarce. The contexts that mo tivate her research span ancient sedimentary deposits to chronic infection s yet are linked by similar physiological questions. Dr. Newman earned he r PhD in Environmental Engineering at MIT with Francois Morel\, a geochemi st\, and trained as a postdoc at Harvard Medical School with Roberto Kolte r\, a bacterial geneticist. She joined the Caltech faculty in 2000 as the Clare Boothe Luce Assistant Professor of Geobiology and Environmental Sci ence. She was named a 2002 Packard Fellow and a Howard Hughes Medical Inst itute Investigator in 2005 and 2008. From 2007-2010 she was the Wilson Pro fessor of Biology and Geobiology at MIT. Her honors include the 2008 Eli L illy and Company-Elanco Research Award from the American Society of Microb iology\, and just this past year\, the National Academy of Science’s Awa rd in Molecular Biology for her "discovery of microbial mechanisms underly ing geologic processes" and a MacArthur Fellowship. Dr. Newman is the Gord on M. Binder/Amgen Professor of Biology and Geobiology at Caltech and a Fe llow of the American Academy of Microbiology.\n \nDr. Dianne Newman is an absolutely inspiring speaker\, she bridge across disciplines from geo-sice nces to molecular biology and microbial physiology. I most highly recomme nd meeting her and hearing her seminar. \n\nHost: Roy Kishony END:VEVENT BEGIN:VEVENT UID:677@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20161214T130000 DTEND;TZID=Asia/Jerusalem:20161214T140000 DTSTAMP:20210802T125845Z URL:https://biology.technion.ac.il/en/seminars/prof-efrat-shema-massachuse tts-general-hospital-and-harvard-medical-school-cambridge-ma-2/ SUMMARY:Prof. Efrat Shema\, Massachusetts General Hospital and Harvard Medi cal School\, Cambridge\, MA [No Categories] DESCRIPTION:Location: \n Affiliation: \n Host:\n Unlocking the Combinator ial Epigenetic Code at a Single-Molecule Level\nHost: Yael Mandel-Gutfreun d yaelmg@technion.ac.il\n END:VEVENT BEGIN:VEVENT UID:676@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20161212T130000 DTEND;TZID=Asia/Jerusalem:20161212T140000 DTSTAMP:20210802T125845Z URL:https://biology.technion.ac.il/en/seminars/prof-amit-ziesel-molecular- neurobiology-mbb-karolinska-institute-stockholm-sweden-2/ SUMMARY:Prof. Amit Ziesel Molecular Neurobiology\, MBB\, Karolinska Institu te\, Stockholm\, Sweden [No Categories] DESCRIPTION:Location: \n Affiliation: \n Host:\n Molecular classification of cells in the mouse brain using single-cell RNA-seq \nHost: Yael Mandel -Gutfreund yaelmg@technion.ac.il\n END:VEVENT BEGIN:VEVENT UID:675@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20161207T133000 DTEND;TZID=Asia/Jerusalem:20161207T143000 DTSTAMP:20210802T125845Z URL:https://biology.technion.ac.il/en/seminars/dr-adam-johnston-bruce-good es-lab-brandeis-university-2/ SUMMARY:Dr. Adam Johnston\, Bruce Goode’s lab Brandeis University [No Ca tegories] DESCRIPTION:Location: \n Affiliation: \n Host:\n Regulation of the actin cytoskeleton by control of filament end dynamics\n\nHosted by: Kinneret Ke ren\, Physics Department\n Arnon Henn\, Faculty of Biology\n\n END:VEVENT BEGIN:VEVENT UID:674@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20161207T093000 DTEND;TZID=Asia/Jerusalem:20161207T103000 DTSTAMP:20210802T125845Z URL:https://biology.technion.ac.il/en/seminars/idan-yelin-faculty-of-biolo gy-technion-2/ SUMMARY:Idan Yelin\, Faculty of Biology\, Technion [No Categories] DESCRIPTION:Location: \n Affiliation: \n Host:\n אבולוציה של ח יידקים בזמן אמת\nMicrobial Evolution in Real Time – identif ication of selective agents and of evolvability determinants\nAs part of h is Ph.D \,\nUnder the Supervision of Prof Roy Kishony END:VEVENT BEGIN:VEVENT UID:673@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20161205T130000 DTEND;TZID=Asia/Jerusalem:20161205T140000 DTSTAMP:20210802T125845Z URL:https://biology.technion.ac.il/en/seminars/prof-yoav-gothilf-departmen t-of-neurobiology-tel-aviv-university-2/ SUMMARY:Prof. yoav Gothilf\, Department of Neurobiology\, Tel Aviv Universi ty [No Categories] DESCRIPTION:Location: \n Affiliation: \n Host:\n The Circadian clock syst em in zebrafish: New findings and debates on the role of the pineal gland. \nHost: Yoav Arava END:VEVENT BEGIN:VEVENT UID:672@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20161130T093000 DTEND;TZID=Asia/Jerusalem:20161130T103000 DTSTAMP:20210802T125845Z URL:https://biology.technion.ac.il/en/seminars/lina-kursrnsky-faculty-of-b iology-technion-2/ SUMMARY:Lina Kursrnsky\, Faculty of Biology\, Technion [No Categories] DESCRIPTION:Location: \n Affiliation: \n Host:\n רגולציה של יצ יבות ופעילות החלבון sef\nRegulation of Sef protein levels and activity\n\nמנחה: פרופ' דינה רון\nבמסגרת עבו דת דוקטורט\nThe lecture will be English\n END:VEVENT BEGIN:VEVENT UID:671@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20161128T130000 DTEND;TZID=Asia/Jerusalem:20161128T140000 DTSTAMP:20210802T125844Z URL:https://biology.technion.ac.il/en/seminars/prof-daniel-kaganovich-the- alexander-silberman-institute-of-life-scienceshebrew-university-of-jerusal em-2/ SUMMARY:Prof. Daniel Kaganovich The Alexander Silberman Institute of Life S ciences\,Hebrew University of Jerusalem [No Categories] DESCRIPTION:Location: \n Affiliation: \n Host:\n "Eisosomes mediate stres s response by coordinating cytoskeletal rearrangement and stress granule f ormation”\nHost: Michael Glickman END:VEVENT BEGIN:VEVENT UID:670@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20161114T130000 DTEND;TZID=Asia/Jerusalem:20161114T140000 DTSTAMP:20210802T125844Z URL:https://biology.technion.ac.il/en/seminars/prof-michel-labouesse-direc tor-ibps-institut-de-biologie-paris-seine-2/ SUMMARY:Prof. Michel Labouesse Director IBPS\, Institut de Biologie Paris -Seine [No Categories] DESCRIPTION:Location: \n Affiliation: \n Host:\n "Setting tissue polarity through mechanical cues”\n\nHost: Benjamin Podbilewicz END:VEVENT BEGIN:VEVENT UID:669@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20161107T130000 DTEND;TZID=Asia/Jerusalem:20161107T140000 DTSTAMP:20210802T125844Z URL:https://biology.technion.ac.il/en/seminars/professor-dan-zilberstein-f aculty-of-biology-technion-2/ SUMMARY:Professor Dan Zilberstein Faculty of Biology\, Technion [No Categor ies] DESCRIPTION:Location: \n Affiliation: \n Host:\n “Arginine Sensing in t he human pathogen Leishmania and its role in virulence" \n\nHost: Yoav Ar ava END:VEVENT BEGIN:VEVENT UID:668@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20161102T133000 DTEND;TZID=Asia/Jerusalem:20161102T143000 DTSTAMP:20210802T125844Z URL:https://biology.technion.ac.il/en/seminars/dr-silvia-jansen-brandeis-u niversity-2/ SUMMARY:Dr. Silvia Jansen\, Brandeis University [No Categories] DESCRIPTION:Location: \n Affiliation: \n Host:\n Effects of actin network architecture and Tropomyosin decoration on disassembly induced by Cofilin \, Coronin\, AIP1\, and GMF\n\nCo-Hosted by:\nKinneret Keren\, Physics Dep artment\nArnon Henn\, Faculty of Biology\n END:VEVENT BEGIN:VEVENT UID:667@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20161031T130000 DTEND;TZID=Asia/Jerusalem:20161031T140000 DTSTAMP:20210802T125844Z URL:https://biology.technion.ac.il/en/seminars/prof-eran-perlson-dept-of-p hysiology-and-pharmacology-tel-aviv-university-2/ SUMMARY:Prof. Eran Perlson Dept. of Physiology and Pharmacology Tel Aviv University [No Categories] DESCRIPTION:Location: \n Affiliation: \n Host:\n "Molecular communication mechanisms essential for synapse maintenance and motor neuron survival"\n Host: Yoav Arava END:VEVENT BEGIN:VEVENT UID:666@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20161027T130000 DTEND;TZID=Asia/Jerusalem:20161027T140000 DTSTAMP:20210802T125844Z URL:https://biology.technion.ac.il/en/seminars/dr-martin-akerman-evisageni cs-cto-co-founder-2/ SUMMARY:Dr. Martin Akerman\, Evisagenics\, CTO\, Co-Founder [No Categories] DESCRIPTION:Location: \n Affiliation: \n Host:\n “Bioinformatics Tools to Accelerate RNA Therapeutics Discovery”\nHost: Yael - Mandel-Gutfreund END:VEVENT BEGIN:VEVENT UID:665@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20160929T130000 DTEND;TZID=Asia/Jerusalem:20160929T140000 DTSTAMP:20210802T125844Z URL:https://biology.technion.ac.il/en/seminars/romina-heller-faculty-of-bi ology-2/ SUMMARY:Romina Heller\, Faculty of Biology [No Categories] DESCRIPTION:Location: \n Affiliation: \n Host:\n Establishing CRISPR-Cas9 technology as a tool for studying\nendogenous Sef functions.\nM.Sc Thesis lecture under the supervision of Prof. Dina Ron\nThe Lecture will be give n in Hebrew END:VEVENT BEGIN:VEVENT UID:664@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20160928T130000 DTEND;TZID=Asia/Jerusalem:20160928T140000 DTSTAMP:20210802T125844Z URL:https://biology.technion.ac.il/en/seminars/assistant-adjunct-professor -vicki-plaks-orofacial-sciences-anatomy-university-of-california-san-franc isco-2/ SUMMARY:Assistant Adjunct Professor Vicki Plaks\, Orofacial Sciences & Anat omy\, University of California\, San Francisco [No Categories] DESCRIPTION:Location: \n Affiliation: \n Host:\n Enhancing Immunotherapy by Targeting the Cancer Stem Cell Niche\n\nHost: Philippa Melamed END:VEVENT BEGIN:VEVENT UID:663@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20160926T130000 DTEND;TZID=Asia/Jerusalem:20160926T140000 DTSTAMP:20210802T125844Z URL:https://biology.technion.ac.il/en/seminars/dr-claus-scheidereit-mdc-be rlin-2/ SUMMARY:Dr. Claus Scheidereit\, MDC Berlin [No Categories] DESCRIPTION:Location: \n Affiliation: \n Host:\n “With or without you\, epistatic and divergent inflammatory gene expression control by IκB kina ses and NF-κB”\n\nHost: Michael Glickman glickman@technion.ac.il END:VEVENT BEGIN:VEVENT UID:662@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20160922T130000 DTEND;TZID=Asia/Jerusalem:20160922T140000 DTSTAMP:20210802T125844Z URL:https://biology.technion.ac.il/en/seminars/ofir-haramati-faculty-of-bi ology-2/ SUMMARY:Ofir Haramati\, Faculty of Biology [No Categories] DESCRIPTION:Location: \n Affiliation: \n Host:\n \nRole of Puf proteins i n the yeast response to high calcium. \n\nPhD Thesis Lecture under the Sup ervision of Prof Yoav Arava\nThe lecture will be given in Hebrew END:VEVENT BEGIN:VEVENT UID:661@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20160919T130000 DTEND;TZID=Asia/Jerusalem:20160919T140000 DTSTAMP:20210802T125844Z URL:https://biology.technion.ac.il/en/seminars/dr-omer-moav-university-of- warwick-uk-and-the-interdisciplinary-center-herzliya-2/ SUMMARY:Dr. Omer Moav\, University of Warwick\, UK and the Interdisciplinar y  Center Herzliya [No Categories] DESCRIPTION:Location: \n Affiliation: \n Host:\n “Cereals as a civilizi ng force: How governments emerged in some regions of the world and not in others”\n\nHost: Yoav Arava arava@technion.ac.il END:VEVENT BEGIN:VEVENT UID:660@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20160915T130000 DTEND;TZID=Asia/Jerusalem:20160915T140000 DTSTAMP:20210802T125844Z URL:https://biology.technion.ac.il/en/seminars/kristina-vragovic-faculty-o f-biology-technion-2/ SUMMARY:Kristina Vragovic\, Faculty of Biology\, Technion [No Categories] DESCRIPTION:Location: \n Affiliation: \n Host:\n Translatome Profiling C aptures Tissue-Specific Steroid Signals Controlling Root Growth. \nPhD The sis Lecture\nUnder the supervision of Prof. Sigal Svaldi-Goldstein END:VEVENT BEGIN:VEVENT UID:659@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20160912T130000 DTEND;TZID=Asia/Jerusalem:20160912T140000 DTSTAMP:20210802T125844Z URL:https://biology.technion.ac.il/en/seminars/dr-ehud-lamm-the-cohn-insti tute-for-the-history-and-philosophy-of-science-and-ideas-faculty-of-humani ties-tel-aviv-university-2/ SUMMARY:Dr. Ehud Lamm\,  The Cohn Institute for the History and Philosophy of Science and Ideas\, Faculty of Humanities\, Tel-Aviv University [No Ca tegories] DESCRIPTION:Location: \n Affiliation: \n Host:\n The Role of Learning in Evolution\nHost: Yoav Arava arava@technion.ac.il END:VEVENT BEGIN:VEVENT UID:658@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20160908T130000 DTEND;TZID=Asia/Jerusalem:20160908T140000 DTSTAMP:20210802T125844Z URL:https://biology.technion.ac.il/en/seminars/ortal-hayat-faculty-of-biol ogy-technion-2/ SUMMARY:Ortal Hayat\, Faculty of Biology\, Technion [No Categories] DESCRIPTION:Location: \n Affiliation: \n Host:\n \nבנושא:\nהבנת הסינגל התאי המיוצג על ידי שרשראות פולי-י וביקוויטין\nהמחוברות דרך ליזין 11-.\n\nDefining the cellular context of Lys11-linked polyubiquitin\nsignals.\n \nThe lectu re will be in English.\nמנחה: פרופ' מיכאל גליקמן.\nבמ סגרת עבודת מחקר לתואר מגיסטר. END:VEVENT BEGIN:VEVENT UID:657@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20160804T130000 DTEND;TZID=Asia/Jerusalem:20160804T140000 DTSTAMP:20210802T125844Z URL:https://biology.technion.ac.il/en/seminars/rinat-terno-faculty-of-biol ogy-technion-2/ SUMMARY:Rinat Terno\, Faculty of Biology\, Technion [No Categories] DESCRIPTION:Location: \n Affiliation: \n Host:\n Identifying the factors responsible for RRF-3 recruitment.\nM.SC Thesis Lecture\nUnder the Supervi sion of Assistant Prof Ayelet Lamm END:VEVENT BEGIN:VEVENT UID:656@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20160712T130000 DTEND;TZID=Asia/Jerusalem:20160712T140000 DTSTAMP:20210802T125843Z URL:https://biology.technion.ac.il/en/seminars/dr-roni-dahan-rockefeller-u niversity-2/ SUMMARY:Dr. Roni Dahan\, Rockefeller University [No Categories] DESCRIPTION:Location: \n Affiliation: \n Host:\n "Requirement of FcγR pa thways for the anti-tumor activity of immunomodulatory antibodies”\n\nHo st: Prof Philippa Melamed END:VEVENT BEGIN:VEVENT UID:655@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20160627T130000 DTEND;TZID=Asia/Jerusalem:20160627T140000 DTSTAMP:20210802T125843Z URL:https://biology.technion.ac.il/en/seminars/prof-thilbaut-mayor-departm ent-of-biochemistry-and-molecular-biology-university-of-british-columbia-c anada-2/ SUMMARY:Prof. Thilbaut Mayor\, Department of Biochemistry and Molecular Bi ology\, University of British Columbia\, Canada [No Categories] DESCRIPTION:Location: \n Affiliation: \n Host:\n "Ubiquitin and the Kiss of Death for Misfolded Proteins "\nHost: Michael Glickman END:VEVENT BEGIN:VEVENT UID:654@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20160623T130000 DTEND;TZID=Asia/Jerusalem:20160623T140000 DTSTAMP:20210802T125843Z URL:https://biology.technion.ac.il/en/seminars/nissan-yomiran-faculty-of-b iology-technion-2/ SUMMARY:Nissan Yomiran\, Faculty of Biology\, Technion [No Categories] DESCRIPTION:Location: \n Affiliation: \n Host:\n Studying C-to-U RNA deam ination in the Nematode\nCaenorhabditis elegans.\nMSc Thesis Lecture\nUnde r the Supervision of Assistance Prof Ayelet Lamm END:VEVENT BEGIN:VEVENT UID:653@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20160620T130000 DTEND;TZID=Asia/Jerusalem:20160620T140000 DTSTAMP:20210802T125843Z URL:https://biology.technion.ac.il/en/seminars/dr-ori-avinoam-the-european -molecular-biology-laboratory-embl-heidelberg-germany-2/ SUMMARY:Dr. Ori Avinoam\, The European Molecular Biology Laboratory (EMBL) Heidelberg\, Germany [No Categories] DESCRIPTION:Location: \n Affiliation: \n Host:\n Endocytic site maturatio n revealed by correlated light and 3D electron microscopy\n\nHost: Philipp a Melamed\, philippa@technion.ac.il END:VEVENT BEGIN:VEVENT UID:652@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20160616T130000 DTEND;TZID=Asia/Jerusalem:20160616T140000 DTSTAMP:20210802T125843Z URL:https://biology.technion.ac.il/en/seminars/scott-tucker-faculty-of-bio logy-technion-2/ SUMMARY:Scott Tucker\, Faculty of Biology\, Technion [No Categories] DESCRIPTION:Location: \n Affiliation: \n Host:\n High throughput studies on the mechanistic origin of p53/DNA interactions.\nMSc Thesis Lecture\nUn der the Supervision of Associate Prof Tali Haran END:VEVENT BEGIN:VEVENT UID:651@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20160613T130000 DTEND;TZID=Asia/Jerusalem:20160613T140000 DTSTAMP:20210802T125843Z URL:https://biology.technion.ac.il/en/seminars/dr-nir-qvit-department-of-c hemical-and-systems-biology-stanford-university-2/ SUMMARY:Dr. Nir Qvit\, Department of Chemical and Systems Biology\, Stanfor d University [No Categories] DESCRIPTION:Location: \n Affiliation: \n Host:\n “Selective phosphoryla tion inhibitor of δPKC-PDK protein-protein interactions\; application for myocardial injury in vivo”\n\nHost: Dan Zilberstein danz@technion.ac.il END:VEVENT BEGIN:VEVENT UID:650@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20160609T130000 DTEND;TZID=Asia/Jerusalem:20160609T140000 DTSTAMP:20210802T125843Z URL:https://biology.technion.ac.il/en/seminars/sylvia-zareth-faculty-of-bi ology-technion-2/ SUMMARY:Sylvia Zareth\, FAculty of Biology\, Technion [No Categories] DESCRIPTION:Location: \n Affiliation: \n Host:\n Rub1\, a ubiquitin-like modifier\, is also a ubiquitin modifier\nPhD. Thesis Lecture\nUnder the Su pervision of Prof. Michael Glickman END:VEVENT BEGIN:VEVENT UID:649@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20160606T130000 DTEND;TZID=Asia/Jerusalem:20160606T140000 DTSTAMP:20210802T125843Z URL:https://biology.technion.ac.il/en/seminars/prof-marc-kirschner-harvard -medical-school-boston-usa-2/ SUMMARY:Prof. Marc Kirschner\, Harvard Medical School\, Boston\, USA [No Ca tegories] DESCRIPTION:Location: \n Affiliation: \n Host:\n Special Harvey Laureate Lecture\n"Control of Cell Size in Somatic Cells"\n\nHost: Roy Kishony END:VEVENT BEGIN:VEVENT UID:648@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20160523T130000 DTEND;TZID=Asia/Jerusalem:20160523T140000 DTSTAMP:20210802T125843Z URL:https://biology.technion.ac.il/en/seminars/prof-eli-pikarsky-the-laute nberg-center-for-immunology-and-cancer-research-hebrew-university-hadassah -medical-school-2/ SUMMARY:Prof. Eli Pikarsky\, The Lautenberg Center for immunology and cance r research\, Hebrew University-Hadassah Medical School [No Categories] DESCRIPTION:Location: \n Affiliation: \n Host:\n “Connecting liver infl ammation\, adaptive immunity and cancer”\n\nHost: Prof. Yoav Arava END:VEVENT BEGIN:VEVENT UID:647@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20160519T130000 DTEND;TZID=Asia/Jerusalem:20160519T140000 DTSTAMP:20210802T125843Z URL:https://biology.technion.ac.il/en/seminars/anna-fridman-faculty-of-bio logy-technion-2/ SUMMARY:Anna Fridman\, Faculty of Biology\, Technion [No Categories] DESCRIPTION:Location: \n Affiliation: \n Host:\n “Study of MHC class II epitope presentation with antibodiesthat mimic TCR specificity” \n\nPh D Thesis Seminar - will be given in Hebrew\nUnder the Supervision of Prof. Yoram Reiter END:VEVENT BEGIN:VEVENT UID:646@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20160516T130000 DTEND;TZID=Asia/Jerusalem:20160516T140000 DTSTAMP:20210802T125843Z URL:https://biology.technion.ac.il/en/seminars/prof-benny-shilo-department -of-molecular-genetics-weizmann-institute-of-science-2/ SUMMARY:Prof. Benny Shilo\, Department of Molecular Genetics Weizmann Insti tute of Science [No Categories] DESCRIPTION:Location: \n Affiliation: \n Host:\n The roles of actomyosin in secretion\nHost: Prof. Yoav Arava END:VEVENT BEGIN:VEVENT UID:645@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20160509T130000 DTEND;TZID=Asia/Jerusalem:20160509T140000 DTSTAMP:20210802T125843Z URL:https://biology.technion.ac.il/en/seminars/dr-adi-livnat-department-of -evolutionary-and-environmental-biology-and-institute-of-evolution-univers ity-of-haifa-2/ SUMMARY:Dr. Adi Livnat\, Department of Evolutionary and Environmental Biolo gy and Institute of Evolution University of Haifa [No Categories] DESCRIPTION:Location: \n Affiliation: \n Host:\n “Interaction-based evo lution: how natural selection and non-random mutation work together”\n\n Host: Prof Yoav Arava END:VEVENT BEGIN:VEVENT UID:644@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20160505T130000 DTEND;TZID=Asia/Jerusalem:20160505T140000 DTSTAMP:20210802T125843Z URL:https://biology.technion.ac.il/en/seminars/dr-meital-oren-suissa-depar tment-of-biochemistry-and-molecular-biophysics-columbia-university-new-yor k-ny-2/ SUMMARY:Dr. Meital Oren-Suissa\, Department of Biochemistry and Molecular Biophysics\, Columbia University\, New York\, NY [No Categories] DESCRIPTION:Location: \n Affiliation: \n Host:\n Her Brain\, His Behavior : Dimorphic synaptic connectivity established by sex-specific\nsynapse pru ning in C. elegans \n\nHost: Philippa Melamed END:VEVENT BEGIN:VEVENT UID:643@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20160502T130000 DTEND;TZID=Asia/Jerusalem:20160502T140000 DTSTAMP:20210802T125843Z URL:https://biology.technion.ac.il/en/seminars/dr-yonatan-savir-dept-of-ph ysiology-biophysics-and-systems-biology-rappaport-faculty-of-medicine-tech nion-2/ SUMMARY:Dr. Yonatan Savir\, Dept. of Physiology\, Biophysics and Systems Bi ology Rappaport Faculty of Medicine\, Technion [No Categories] DESCRIPTION:Location: \n Affiliation: \n Host:\n “Yeast response to mul tiple carbon sources: a case study of combinatorial signal integration”\ n\nHost: Prof. Yoav Arava END:VEVENT BEGIN:VEVENT UID:642@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20160414T130000 DTEND;TZID=Asia/Jerusalem:20160414T140000 DTSTAMP:20210802T125843Z URL:https://biology.technion.ac.il/en/seminars/daniel-schwartz-faculty-of- biology-technion-2/ SUMMARY:Daniel Schwartz\, Faculty of Biology\, Technion [No Categories] DESCRIPTION:Location: \n Affiliation: \n Host:\n Genetic hurdles limit th e arms race between Prochlorococcus and the podoviruses infecting them\n\n PhD Thesis lecture under the supervision of Prof. Debbie Lindell END:VEVENT BEGIN:VEVENT UID:641@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20160411T130000 DTEND;TZID=Asia/Jerusalem:20160411T140000 DTSTAMP:20210802T125842Z URL:https://biology.technion.ac.il/en/seminars/prof-michael-feldbrugge-ins titute-for-microbiology-center-for-excellence-on-plant-sciences-department -of-biology-heinrich-heine-university-dusseldorf-2/ SUMMARY:Prof. Michael Feldbrugge Institute for Microbiology\, Center for Ex cellence on Plant Sciences\, Department of Biology\, Heinrich-Heine Univer sity Düsseldorf [No Categories] DESCRIPTION:Location: \n Affiliation: \n Host:\n mRNA transport meets mem brane trafficking\n\nHost: Yoav Arava END:VEVENT BEGIN:VEVENT UID:640@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20160407T130000 DTEND;TZID=Asia/Jerusalem:20160407T140000 DTSTAMP:20210802T125842Z URL:https://biology.technion.ac.il/en/seminars/naftalie-senderovich-facult y-of-biology-technion-2/ SUMMARY:Naftalie Senderovich\, Faculty of Biology\, Technion [No Categories ] DESCRIPTION:Location: \n Affiliation: \n Host:\n Studying tumor heterogen eity using single-cell RNA-seq\nMSc Theses under the supervision of Prof. Itai Yanai END:VEVENT BEGIN:VEVENT UID:639@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20160404T130000 DTEND;TZID=Asia/Jerusalem:20160404T140000 DTSTAMP:20210802T125842Z URL:https://biology.technion.ac.il/en/seminars/asya-rolls-assistant-profes sor-dept-of-immunology-center-for-neuroscience-rapapport-institute-of-medi cal-research-technion-2/ SUMMARY:Asya Rolls\, Assistant Professor Dept. of Immunology\, Center for Neuroscience Rapapport Institute of Medical Research\, Technion [No Categ ories] DESCRIPTION:Location: \n Affiliation: \n Host:\n "It takes a nerve to con trol immunity"\nHost: Yoav Arava END:VEVENT BEGIN:VEVENT UID:638@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20160331T130000 DTEND;TZID=Asia/Jerusalem:20160331T140000 DTSTAMP:20210802T125842Z URL:https://biology.technion.ac.il/en/seminars/tamar-hashimshony-ph-d-facu lty-of-biology-technion-2/ SUMMARY:Tamar Hashimshony\, Ph. D Faculty of Biology\, Technion [No Categor ies] DESCRIPTION:Location: \n Affiliation: \n Host:\n “Deciphering embryonic development through comparative transcriptomics”\n\nHost Philippa Melam ed END:VEVENT BEGIN:VEVENT UID:637@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20160328T130000 DTEND;TZID=Asia/Jerusalem:20160328T140000 DTSTAMP:20210802T125842Z URL:https://biology.technion.ac.il/en/seminars/shimyn-slomovic-ph-d-postdo ctoral-fellow-at-the-massachusetts-institute-of-technology-usa-2/ SUMMARY:Shimyn Slomovic\, Ph. D Postdoctoral Fellow at the Massachusetts Institute of Technology\, USA [No Categories] DESCRIPTION:Location: \n Affiliation: \n Host:\n “DNA Sense-and-Respond \; Linking pathogen detection to a modular transcriptional output"\n\nHost : Philippa Melamed END:VEVENT BEGIN:VEVENT UID:636@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20160321T130000 DTEND;TZID=Asia/Jerusalem:20160321T140000 DTSTAMP:20210802T125842Z URL:https://biology.technion.ac.il/en/seminars/liza-barki-harrington-ph-d- department-of-human-biology-university-of-haifa-2/ SUMMARY:Liza Barki-Harrington\, Ph. D Department of Human Biology\, Univ ersity of Haifa [No Categories] DESCRIPTION:Location: \n Affiliation: \n Host:\n Title: Mechanisms of COX -2 proteolysis and their pathological and therapeutic implications\nHost: Yoav Arava END:VEVENT BEGIN:VEVENT UID:635@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20160314T130000 DTEND;TZID=Asia/Jerusalem:20160314T140000 DTSTAMP:20210802T125842Z URL:https://biology.technion.ac.il/en/seminars/magdalena-ivanova-ph-d-rese arch-assistant-professor-department-of-neurology-adjunct-assistant-profess or-program-of-biophysics-university-of-michigan-ann-arbor-usa-2/ SUMMARY:Magdalena Ivanova\, Ph. D Research Assistant Professor\, Departme nt of Neurology Adjunct Assistant Professor\, Program of Biophysics Univer sity of Michigan\, Ann Arbor\, USA [No Categories] DESCRIPTION:Location: \n Affiliation: \n Host:\n Bio-Molecular Aspects of Neurodegeneration: alpha-synuclein and ubiquilin2 fibril formation\n\nHos t: Meytal Landau END:VEVENT BEGIN:VEVENT UID:634@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20160308T130000 DTEND;TZID=Asia/Jerusalem:20160308T140000 DTSTAMP:20210802T125842Z URL:https://biology.technion.ac.il/en/seminars/asher-moshe-faculty-of-biol ogy-technion-2/ SUMMARY:Asher Moshe\,  Faculty of Biology\, Technion [No Categories] DESCRIPTION:Location: \n Affiliation: \n Host:\n “Atomic structures of Amyloid Peptides and Spine Segments of Staphylococcus aureus Phenol Solubl e Modulins (PSMs) involved in Biofilm Structuring and Cytotoxicity”\n\nM .Sc Thesis under the supervision of Prof Meytal Landau END:VEVENT BEGIN:VEVENT UID:633@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20160307T130000 DTEND;TZID=Asia/Jerusalem:20160307T140000 DTSTAMP:20210802T125842Z URL:https://biology.technion.ac.il/en/seminars/joseph-rosenbluh-the-broad- institute-of-harvard-and-mit-and-dana-farber-cancer-institute-2/ SUMMARY:Joseph Rosenbluh\, The Broad Institute of Harvard and MIT and Dana- Farber Cancer Institute [No Categories] DESCRIPTION:Location: \n Affiliation: \n Host:\n Functional genomic appro aches identify new targets and mechanisms of beta-catenin driven cancers\n Host: Philippa Melamed END:VEVENT BEGIN:VEVENT UID:632@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20160301T130000 DTEND;TZID=Asia/Jerusalem:20160301T140000 DTSTAMP:20210802T125842Z URL:https://biology.technion.ac.il/en/seminars/nadar-ponniah-prathamesh-fa culty-of-biology-technion-2/ SUMMARY:Nadar Ponniah Prathamesh  Faculty of Biology\, Technion [No Categ ories] DESCRIPTION:Location: \n Affiliation: \n Host:\n “Linking histone demet hylation with non coding RNA: Studying the biological functions of KDM4D-R NA interactions” \n\nPh.D Thesis under the supervision of Assoc. Prof N abieh Ayoub END:VEVENT BEGIN:VEVENT UID:631@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20160229T130000 DTEND;TZID=Asia/Jerusalem:20160229T140000 DTSTAMP:20210802T125842Z URL:https://biology.technion.ac.il/en/seminars/ido-bachelet-founder-scient ific-director-augmanity-inc-2/ SUMMARY:Ido Bachelet\, Founder & Scientific Director\, Augmanity Inc [No Ca tegories] DESCRIPTION:Location: \n Affiliation: \n Host:\n “Biologically augmente d reality”\n\nHost: Shenhav Cohen END:VEVENT BEGIN:VEVENT UID:630@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20160216T130000 DTEND;TZID=Asia/Jerusalem:20160216T140000 DTSTAMP:20210802T125842Z URL:https://biology.technion.ac.il/en/seminars/mouna-h-rohana-faculty-of-b iology-technion-2/ SUMMARY:Mouna H Rohana\, Faculty of Biology\, Technion [No Categories] DESCRIPTION:Location: \n Affiliation: \n Host:\n Identification and chara cterization of the ribonucleolytic activity of P53.\n\nמנחה: פרופ' גדי שוסטר.\n\nבמסגרת עבודת מחקר לתואר דוק טור.\n END:VEVENT BEGIN:VEVENT UID:629@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20160215T130000 DTEND;TZID=Asia/Jerusalem:20160215T140000 DTSTAMP:20210802T125842Z URL:https://biology.technion.ac.il/en/seminars/associate-prof-ornit-chiba- falk-department-of-neurology-bryan-alzheimers-disease-research-center-duke -university-medical-center-2/ SUMMARY:Associate Prof. Ornit Chiba Falk \, Department of Neurology\, Bryan Alzheimer's Disease Research Center\, Duke University Medical Center [No Categories] DESCRIPTION:Location: \n Affiliation: \n Host:\n “Structural variants a nd neurodegenerative diseases in aging: regulatory and causality consequen ces”\nHost: Efrat Barak END:VEVENT BEGIN:VEVENT UID:628@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20160209T130000 DTEND;TZID=Asia/Jerusalem:20160209T140000 DTSTAMP:20210802T125842Z URL:https://biology.technion.ac.il/en/seminars/moran-hod-marko-faculty-of- biology-technion-2/ SUMMARY:Moran Hod-Marko\, Faculty of Biology\, Technion [No Categories] DESCRIPTION:Location: \n Affiliation: \n Host:\n בנושא:\nאנליז ה מערכתית של הגורל התפקודי של לימפוציטים חודרי גידול.\n\nSystem analysis of the functional fate of tumor infiltrating lymphocytes.\n\nמנחה: פרופ' יורם רייטר\nמ נחה שותפה: ד"ר מיכל בסר\n\nבמסגרת עבודת מחק ר לתואר דוקטור\n\nההרצאה תתקיים באנגלית\, \ n END:VEVENT BEGIN:VEVENT UID:627@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20160208T130000 DTEND;TZID=Asia/Jerusalem:20160208T140000 DTSTAMP:20210802T125842Z URL:https://biology.technion.ac.il/en/seminars/prof-nathalie-elia-departme nt-of-life-sciences-ben-gurion-university-of-the-negev-2/ SUMMARY:Prof. Nathalie Elia \, Department of Life Sciences\, Ben Gurion Uni versity of the Negev [No Categories] DESCRIPTION:Location: \n Affiliation: \n Host:\n ESCRT mediated mammalian cell abscission: New tools\, new players and new concepts”\n\nHost: Yoa v Arava END:VEVENT BEGIN:VEVENT UID:626@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20160204T130000 DTEND;TZID=Asia/Jerusalem:20160204T140000 DTSTAMP:20210802T125841Z URL:https://biology.technion.ac.il/en/seminars/prof-ira-krull-department-o f-chemistry-and-chemical-biology-northeastern-university-boston-ma-2/ SUMMARY:Prof. Ira Krull\, Department of Chemistry and Chemical Biology\, No rtheastern University\, Boston\, MA [No Categories] DESCRIPTION:Location: \n Affiliation: \n Host:\n “Top-Down Protein Sequ encing by Mass Spectrometry\, Quo Vadis?”\n\n\nHost: Prof. Arie Admon END:VEVENT BEGIN:VEVENT UID:625@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20160203T130000 DTEND;TZID=Asia/Jerusalem:20160203T140000 DTSTAMP:20210802T125841Z URL:https://biology.technion.ac.il/en/seminars/dr-iftach-shaked-neurophysi cs-lab-physics-department-ucsd-2/ SUMMARY:Dr. Iftach Shaked\, Neurophysics Lab\, Physics Department\, UCSD [N o Categories] DESCRIPTION:Location: \n Affiliation: \n Host:\n “The Sympathetic side of Autoimmunity\nHost: Philippa Melamed END:VEVENT BEGIN:VEVENT UID:624@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20160201T130000 DTEND;TZID=Asia/Jerusalem:20160201T140000 DTSTAMP:20210802T125841Z URL:https://biology.technion.ac.il/en/seminars/prof-dan-mishmar-department -of-life-sciences-ben-gurion-university-of-the-negev-2/ SUMMARY:Prof. Dan Mishmar\, Department of Life Sciences\, Ben Gurion Univer sity of the Negev [No Categories] DESCRIPTION:Location: \n Affiliation: \n Host:\n “Evolutionary alternat ive solutions for 16S rRNA function: 947M1A RNA modification and mtDNA mut ations”\n\nHost: Yoav Arava END:VEVENT BEGIN:VEVENT UID:623@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20160126T130000 DTEND;TZID=Asia/Jerusalem:20160126T140000 DTSTAMP:20210802T125841Z URL:https://biology.technion.ac.il/en/seminars/vera-gayder-faculty-of-biol ogy-2/ SUMMARY:Vera Gayder\, Faculty of Biology [No Categories] DESCRIPTION:Location: \n Affiliation: \n Host:\n Unique enzymatic adaptat ion for the super fast RecBCD DNA helicase.\n\nPhD. Thesis Lecture under the supervision of Associate Prof. Arnon Henn END:VEVENT BEGIN:VEVENT UID:622@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20160125T130000 DTEND;TZID=Asia/Jerusalem:20160125T140000 DTSTAMP:20210802T125841Z URL:https://biology.technion.ac.il/en/seminars/prof-ofer-fienerman-departm ent-of-physics-of-complex-systems-weizmann-institute-of-science-2/ SUMMARY:Prof. Ofer Fienerman Department of Physics of Complex Systems\, Wei zmann Institute of Science [No Categories] DESCRIPTION:Location: \n Affiliation: \n Host:\n “Cooperative transport and the role of the individual within a group of ants”\n\nHost: Yoav Ar ava END:VEVENT BEGIN:VEVENT UID:621@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20160118T130000 DTEND;TZID=Asia/Jerusalem:20160118T140000 DTSTAMP:20210802T125841Z URL:https://biology.technion.ac.il/en/seminars/prof-sebastian-kadener-silb erman-institute-of-sciences-the-hebrew-university-of-jerusalem-2/ SUMMARY:Prof. Sebastian Kadener Silberman Institute of Sciences\, The Hebre w University of Jerusalem [No Categories] DESCRIPTION:Location: \n Affiliation: \n Host:\n “Rounding the circle: molecular and physiological functions of circRNAs”\nHost : Yoav Arava END:VEVENT BEGIN:VEVENT UID:620@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20160117T130000 DTEND;TZID=Asia/Jerusalem:20160117T140000 DTSTAMP:20210802T125841Z URL:https://biology.technion.ac.il/en/seminars/ithai-rabinowitch-phd-fred- hutchinson-cancer-research-center-seattle-usa-2/ SUMMARY:Ithai Rabinowitch\, PhD \, Fred Hutchinson Cancer Research Center\, Seattle USA [No Categories] DESCRIPTION:Location: \n Affiliation: \n Host:\n Reprogramming in vivo ne ural circuits by engineering new synaptic connections\n\nHost: Prof Roy Ki shony END:VEVENT BEGIN:VEVENT UID:619@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20160111T130000 DTEND;TZID=Asia/Jerusalem:20160111T140000 DTSTAMP:20210802T125841Z URL:https://biology.technion.ac.il/en/seminars/prof-orr-speigal-university -of-california-at-davis-2/ SUMMARY:Prof. Orr Speigal \, University of California at Davis [No Categor ies] DESCRIPTION:Location: \n Affiliation: \n Host:\n “What’s your move? M ovement as a link between personality\, spatial dynamics and social networ k in animal populations”\n\nHost: Zeev Arad END:VEVENT BEGIN:VEVENT UID:618@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20160107T130000 DTEND;TZID=Asia/Jerusalem:20160107T140000 DTSTAMP:20210802T125841Z URL:https://biology.technion.ac.il/en/seminars/dr-raz-palty-department-of- molecular-and-cell-biology-university-of-california-berkeley-2/ SUMMARY:Dr. Raz Palty Department of Molecular and Cell Biology\, University of California Berkeley [No Categories] DESCRIPTION:Location: \n Affiliation: \n Host:\n “Closing CRACs: regula tion of intracellular calcium signals around organelles ”\n\n\nHost: Phi llipa Melamed END:VEVENT BEGIN:VEVENT UID:617@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20160105T130000 DTEND;TZID=Asia/Jerusalem:20160105T140000 DTSTAMP:20210802T125841Z URL:https://biology.technion.ac.il/en/seminars/muhammad-zoabi-faculty-of-b iology-technion-2/ SUMMARY:Muhammad Zoabi Faculty of Biology\, Technion [No Categories] DESCRIPTION:Location: \n Affiliation: \n Host:\n “High Troughput Mappin g of the Non-Histone Substrates and the RNA Interacting Molecules of KDM4A -C Lysine Demethylases"\n\nPh.D Thesis under the supervision of Prof Ayoub Nabieh END:VEVENT BEGIN:VEVENT UID:616@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20160104T130000 DTEND;TZID=Asia/Jerusalem:20160104T140000 DTSTAMP:20210802T125841Z URL:https://biology.technion.ac.il/en/seminars/prof-michael-elowitz-bren-s cholar-investigator-howard-hughes-medical-institute-california-institute-o f-technology-division-of-biology-2/ SUMMARY:Prof. Michael Elowitz Bren Scholar\; Investigator\, Howard Hughes M edical Institute\, California Institute of Technology - Division of Biolog y [No Categories] DESCRIPTION:Location: \n Affiliation: \n Host:\n A Lokey Distinguished Le cture:\n\nTitle: "An operational view of mammalian signaling\, memory\, an d cell state transition circuits"\n\nOpening remarks:\nProf. Roy Kishony END:VEVENT BEGIN:VEVENT UID:615@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20151228T130000 DTEND;TZID=Asia/Jerusalem:20151228T140000 DTSTAMP:20210802T125841Z URL:https://biology.technion.ac.il/en/seminars/prof-limor-broday-departmen t-of-cell-and-developmental-biology-sackler-school-of-medicine-tel-aviv-un iversity-2/ SUMMARY:Prof. Limor Broday Department of Cell and Developmental Biology\, S ackler School of Medicine\, Tel Aviv University [No Categories] DESCRIPTION:Location: \n Affiliation: \n Host:\n “SUMO and desumoylatio n in cell-cell adhesion ”\n\nHost:: Benjamin Podbilewicz podbilew@techni on.ac.il\n\n END:VEVENT BEGIN:VEVENT UID:614@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20151222T130000 DTEND;TZID=Asia/Jerusalem:20151222T140000 DTSTAMP:20210802T125841Z URL:https://biology.technion.ac.il/en/seminars/haddad-jumana-faculty-of-bi ology-2/ SUMMARY:Haddad Jumana\, Faculty of Biology [No Categories] DESCRIPTION:Location: \n Affiliation: \n Host:\n The role of the tumor su ppressor\, Sef\, in human epidermis development and epidermal neoplasia. \ n\nPh.D Thesis Lecture \nUnder the supervision of Prof. Dina Ron\nThe lect ure will be given in Hebrew END:VEVENT BEGIN:VEVENT UID:613@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20151221T130000 DTEND;TZID=Asia/Jerusalem:20151221T140000 DTSTAMP:20210802T125841Z URL:https://biology.technion.ac.il/en/seminars/prof-benny-geiger-departmen t-of-molecular-cell-biology-weizmann-institute-of-science-2/ SUMMARY:Prof. Benny Geiger Department of Molecular Cell Biology\, Weizmann Institute of Science [No Categories] DESCRIPTION:Location: \n Affiliation: \n Host:\n “The mechanobiology of invasive adhesion”\n\nHost: Yoav Arava arava@technion.ac.il END:VEVENT BEGIN:VEVENT UID:612@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20151215T130000 DTEND;TZID=Asia/Jerusalem:20151215T140000 DTSTAMP:20210802T125841Z URL:https://biology.technion.ac.il/en/seminars/mohammed-kaiss-faculty-of-b iology-technion-2/ SUMMARY:Mohammed Kaiss\, Faculty of Biology\, Technion [No Categories] DESCRIPTION:Location: \n Affiliation: \n Host:\n כותרת:\n\nstudying the role of NAC and OM14 in protein import to mitochondria\n\n \n\nAbstrac t:\n\nPrevious studies showed that there are cytosolic ribosomes located n ear the mitochondria outer membrane\, and these ribosomes translate protei ns that are destined to the mitochondria. Purified mitochondria that were treated with proteases showed significantly lower amount of ribosomes\, in dicating the need for a protein receptor for ribosomes that interacts thro ugh the NAC complex. Recent work identified interaction between OM14\, an outer membrane protein\, and NAC this interaction support co-translational import into the mitochondria. My project is to determine which domains of OM14 are support this interaction and which additional proteins are invol ved.\n\n מנחה: \nפרופ יואב ערבה END:VEVENT BEGIN:VEVENT UID:611@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20151214T130000 DTEND;TZID=Asia/Jerusalem:20151214T140000 DTSTAMP:20210802T125840Z URL:https://biology.technion.ac.il/en/seminars/prof-nava-dekel-department- of-biological-regulation-weizmann-institute-of-science-2/ SUMMARY:Prof. Nava Dekel Department of Biological Regulation\, Weizmann Ins titute of Science [No Categories] DESCRIPTION:Location: \n Affiliation: \n Host:\n Inflammatory events part ake in successful embryo  implantation\nHost: Dina Ron dinar@technion.ac. il END:VEVENT BEGIN:VEVENT UID:610@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20151208T130000 DTEND;TZID=Asia/Jerusalem:20151208T140000 DTSTAMP:20210802T125840Z URL:https://biology.technion.ac.il/en/seminars/noa-ben-asher-faculty-of-bi ology-2/ SUMMARY:Noa Ben-Asher\, Faculty of Biology [No Categories] DESCRIPTION:Location: \n Affiliation: \n Host:\n בנושא:\n\nמודי פיקציות לאחר התרגום בחלבוני gaps-arf\nPost transla tional modifications in Arf-GAPs\n\n\nמנחה: פרופ' דן קסל\n\n במסגרת עבודת מחקר לתואר מגיסטר\n END:VEVENT BEGIN:VEVENT UID:609@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20151201T130000 DTEND;TZID=Asia/Jerusalem:20151201T140000 DTSTAMP:20210802T125840Z URL:https://biology.technion.ac.il/en/seminars/inbar-duek-faculty-of-biolo gy-technion-2/ SUMMARY:Inbar Duek\, Faculty of Biology\, Technion [No Categories] DESCRIPTION:Location: \n Affiliation: \n Host:\n Title: Characterization of the mitochondrial proteome ubiquitination pattern\nAbstract: The mitoch ondrion is an important organelle in eukaryote cells. It is responsible fo r energy production through oxidative phosphorylation\, and also takes par t in other biological process. Ubiquitination is a cytosolic posttranslati onal modification that generally signals for protein degradation by the pr oteasome\, but also signals for lysosomal degradation and cellular localiz ation. \nRecent landmark studies have established that mitochondrial prote ins can be ubiquitinated by several polyUbiquitin linkage types. This lect ure will focus on the mitochondrial proteome ubiquitination pattern\, and will address both the ubiquitination targets and linkage types at mitochon dria. The effects of proteolytic degradation pathways\, proteasomal and ly sosomal\, on the mitochondrial ubiquitinome and proteome will be discussed .\n\nמנחה: פרופ' מיכאל גליקמן במסגרת עבודת מגיסטר END:VEVENT BEGIN:VEVENT UID:608@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20151130T130000 DTEND;TZID=Asia/Jerusalem:20151130T140000 DTSTAMP:20210802T125840Z URL:https://biology.technion.ac.il/en/seminars/dr-eran-levin-department-of -entomology-university-of-arizona-2/ SUMMARY:Dr. Eran Levin\, Department of Entomology\, University of Arizona [ No Categories] DESCRIPTION:Location: \n Affiliation: \n Host:\n " Metabolic fuel use in real time: is it time to refresh our thinking? "\n\nHost: Prof Zeev Arad END:VEVENT BEGIN:VEVENT UID:607@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20151124T130000 DTEND;TZID=Asia/Jerusalem:20151124T140000 DTSTAMP:20210802T125840Z URL:https://biology.technion.ac.il/en/seminars/hagai-cohen-faculty-of-biol ogy-technion-2/ SUMMARY:Hagai Cohen\, Faculty of Biology\, Technion [No Categories] DESCRIPTION:Location: \n Affiliation: \n Host:\n "Elucidation of the regu latory metabolic networks involved in methionine biosynthesis in Arabidops is thaliana seeds"\n\nמנחים: פרופ' רחל אמיר ופרופ' ג די שוסטר\nבמסגרת עבודת מחקר לתואר דוקטור END:VEVENT BEGIN:VEVENT UID:606@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20151123T130000 DTEND;TZID=Asia/Jerusalem:20151123T140000 DTSTAMP:20210802T125840Z URL:https://biology.technion.ac.il/en/seminars/professor-doris-rentsch-ins titute-of-plant-science-bern-university-bern-switzerland-2/ SUMMARY:Professor Doris Rentsch Institute of Plant Science\, Bern Universi ty Bern\, Switzerland [No Categories] DESCRIPTION:Location: \n Affiliation: \n Host:\n "Peptide transporters in Arabidopsis: Role in intra- and intercellular transport of organic nitrog en"\n\nHost: Prof Dan Zilberstein danz@technion.ac.il END:VEVENT BEGIN:VEVENT UID:605@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20151116T130000 DTEND;TZID=Asia/Jerusalem:20151116T140000 DTSTAMP:20210802T125840Z URL:https://biology.technion.ac.il/en/seminars/dr-roey-tzezana-research-fe llow-in-blavatnik-interdisciplinary-cyber-research-center-2/ SUMMARY:Dr. Roey Tzezana Research Fellow in Blavatnik Interdisciplinary Cyb er Research Center [No Categories] DESCRIPTION:Location: \n Affiliation: \n Host:\n Title\nExponential Medic ine and Biological Research: Heading towards Human Immortality\n\nAbstract \nThe capabilities of medicine and biological research are developing in a n exponential rate\, similar to the rapid pace of progress we've observed in computers and information sciences over the last century. In computer s ciences\, this exponential growth has brought super-computers (in terms of 1980s) to every hand\, an abundance of information available to billions at any moment\, and a society that's rapidly moving towards a Sharing Econ omy.\n\nHow will the exponential growth in biological research and medical capabilities change our human body?\n\nIn the lecture\, I'll go over the principles of exponential growth\, and explain why certain fields are deve loping in leaps and jumps why others lag behind. We'll see why medicine ha s been having a hard time going into an exponential rate until recent time s\, and why the pace is picking up in the present. We'll go over some of t he technologies and techniques in biotech that enable and promote exponent ial growth\, and deal with the most important question: will exponential g rowth in biotech lead to human immortality - and if so\, will that occur i n our lifetime?\n END:VEVENT BEGIN:VEVENT UID:604@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20151110T130000 DTEND;TZID=Asia/Jerusalem:20151110T140000 DTSTAMP:20210802T125840Z URL:https://biology.technion.ac.il/en/seminars/svetlana-fridman-faculty-of -biology-technion-2/ SUMMARY:Svetlana Fridman Faculty of Biology\, Technion [No Categories] DESCRIPTION:Location: \n Affiliation: \n Host:\n Isolation and Characteri zation of a Cyanophage Carrying PSI Genes\n\nמנחים: פרופ' עוד ד בז'ה ופרופ' דבי לינדל\n\nבמסגרת עבודת המח קר לתואר דוקטור\n\n END:VEVENT BEGIN:VEVENT UID:603@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20151109T130000 DTEND;TZID=Asia/Jerusalem:20151109T140000 DTSTAMP:20210802T125840Z URL:https://biology.technion.ac.il/en/seminars/prof-eran-bacharach-faculty -of-life-sciences-tel-aviv-university-2/ SUMMARY:Prof. Eran Bacharach Faculty of Life Sciences\, Tel Aviv Univers ity [No Categories] DESCRIPTION:Location: \n Affiliation: \n Host:\n “Viral and cellular fa ctors that dictate the high tropism of the murine leukemia virus for mitot ic cells"\nHost: Yoav Arava arava@technion.ac.il\n END:VEVENT BEGIN:VEVENT UID:602@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20151102T130000 DTEND;TZID=Asia/Jerusalem:20151102T140000 DTSTAMP:20210802T125840Z URL:https://biology.technion.ac.il/en/seminars/prof-dani-zamir-faculty-of- agriculture-the-hebrew-university-of-jerusalem-rehovot-israel-2/ SUMMARY:Prof. Dani Zamir Faculty of Agriculture\, The Hebrew University of Jerusalem\, Rehovot\, Israel [No Categories] DESCRIPTION:Location: \n Affiliation: \n Host:\n "Yield canalization in c rop plants"\n\nRecipient of the EMET prize 2015\n\nמארח: פרופ' י ואב ערבה yoav@technion.ac.ilRecipient of the EMET prize 2015\n END:VEVENT BEGIN:VEVENT UID:601@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20151027T130000 DTEND;TZID=Asia/Jerusalem:20151027T140000 DTSTAMP:20210802T125840Z URL:https://biology.technion.ac.il/en/seminars/lilach-friedlander-shani-fa culty-of-biology-technion-2/ SUMMARY:Lilach Friedlander-Shani Faculty of Biology\, Technion [No Categor ies] DESCRIPTION:Location: \n Affiliation: \n Host:\n "Mechanisms underlying p lant steroid hormone control of root meristem size" \n\nמנחה: פרו פ/ח' סיגל סבלדי-גולדשטיין sigal@technion.ac.il\nבמס גרת עבודת המחקר לתואר דוקטור\n END:VEVENT BEGIN:VEVENT UID:600@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20151020T130000 DTEND;TZID=Asia/Jerusalem:20151020T140000 DTSTAMP:20210802T125840Z URL:https://biology.technion.ac.il/en/seminars/louie-said-faculty-of-biolo gy-technion-2/ SUMMARY:Louie Said Faculty of Biology\, Technion [No Categories] DESCRIPTION:Location: \n Affiliation: \n Host:\n CTL Mediated Killing of Melanoma Cancer Cells by Class I MHC-TCR-like Ab \nRecombinant Fusion Mole cule\n\n\nמנחה: פרופ' יורם רייטר reiter@technion.ac.il\n במסגרת עבודת המחקר לתואר מגיסטר\n END:VEVENT BEGIN:VEVENT UID:599@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20151019T130000 DTEND;TZID=Asia/Jerusalem:20151019T140000 DTSTAMP:20210802T125840Z URL:https://biology.technion.ac.il/en/seminars/prof-edan-cukierman-fox-cha se-cancer-center-philadelphia-2/ SUMMARY:Prof Edan Cukierman Fox Chase Cancer Center\, Philadelphia [No Cate gories] DESCRIPTION:Location: \n Affiliation: \n Host:\n “Gauging mechanistic m eans & pathological diagnostic tools to reprogram Desmoplasia”  \n\nמ ארח: פרופ' דן קסל danc@technion.ac.il\n END:VEVENT BEGIN:VEVENT UID:598@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20151015T140000 DTEND;TZID=Asia/Jerusalem:20151015T150000 DTSTAMP:20210802T125840Z URL:https://biology.technion.ac.il/en/seminars/sivan-slobodkin-faculty-of- biology-technion-2/ SUMMARY:Sivan Slobodkin Faculty of Biology\, Technion [No Categories] DESCRIPTION:Location: \n Affiliation: \n Host:\n “Antigen-specific immu nomodulation for Multiple Sclerosis” \n\nמנחה: פרופ' יורם רייטר reiter@technion.ac.il\nבמסגרת עבודת המחקר לת ואר מגיסטר\n END:VEVENT BEGIN:VEVENT UID:597@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20151011T130000 DTEND;TZID=Asia/Jerusalem:20151011T140000 DTSTAMP:20210802T125840Z URL:https://biology.technion.ac.il/en/seminars/dr-johann-elbaz-synthetic-b iology-center-biological-engineering-departmentmassachusetts-institute-of- technologyusa-2/ SUMMARY:Dr. Johann Elbaz\, Synthetic Biology Center\, Biological Engineeri ng Department\,Massachusetts Institute of Technology\,USA [No Categories] DESCRIPTION:Location: \n Affiliation: \n Host:\n נושא ההרצאה:\n \n \n"Synthetic Biology: Technologies towards Production of Nanomaterials in Living Cells".\n\nהמארח:Prof. Roy Kishony\n Faculty of Biology\n\n END:VEVENT BEGIN:VEVENT UID:596@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20151008T130000 DTEND;TZID=Asia/Jerusalem:20151008T140000 DTSTAMP:20210802T125839Z URL:https://biology.technion.ac.il/en/seminars/noam-chayut-faculty-of-biol ogy-technion-2/ SUMMARY:Noam Chayut Faculty of Biology\, Technion [No Categories] DESCRIPTION:Location: \n Affiliation: \n Host:\n אפיון רשת הבק רה של הגן 'Orange'בצמח המלון למטרת העשרת תוצ רת חקלאית בקרוטנואידים\n\nCharacterization of the ‘O range’ gene regulatory network in Cucumis melo for carotenoid biofortifi cation in food crop\n\n\n\nמנחה: פרופ' שמעון גפשטיין\n מנחים שותפים: ד"ר יעקב תדמור וד"ר יוסף בור גר\n\nבמסגרת עבודת מחקר לתואר דוקטור\n END:VEVENT BEGIN:VEVENT UID:595@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20150921T130000 DTEND;TZID=Asia/Jerusalem:20150921T140000 DTSTAMP:20210802T125839Z URL:https://biology.technion.ac.il/en/seminars/professor-hans-clevers-m-d- ph-d-professor-of-molecular-genetics-hubrecht-institute-utrecht-the-nether lands-2/ SUMMARY:Professor Hans Clevers\, M.D.\, Ph.D. Professor of Molecular Genet ics Hubrecht Institute Utrecht \, The Netherlands [No Categories] DESCRIPTION:Location: \n Affiliation: \n Host:\n "Wnt signaling\, Lgr5 st em cells\, organoids and cancer"\n\nOpening remarks:\nAssistant Prof. Yaro n Fuchs\nFaculty of Biology END:VEVENT BEGIN:VEVENT UID:594@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20150920T130000 DTEND;TZID=Asia/Jerusalem:20150920T140000 DTSTAMP:20210802T125839Z URL:https://biology.technion.ac.il/en/seminars/ofer-katzir-faculty-of-biol ogy-technion-2/ SUMMARY:Ofer Katzir\, Faculty of Biology\, Technion [No Categories] DESCRIPTION:Location: \n Affiliation: \n Host:\n A novel sufficiency test to define cell-cell fusion proteins \n\nAn MSc Thesis Seminar under the s upervision of Prof Podbilewicz\nThe seminar will be in English END:VEVENT BEGIN:VEVENT UID:593@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20150917T130000 DTEND;TZID=Asia/Jerusalem:20150917T140000 DTSTAMP:20210802T125839Z URL:https://biology.technion.ac.il/en/seminars/%d7%90%d7%9c%d7%95%d7%a0%d7 %94-%d7%a4%d7%9c%d7%93%d7%9e%d7%9f-%d7%94%d7%a4%d7%a7%d7%95%d7%9c%d7%98%d7 %94-%d7%9c%d7%91%d7%99%d7%95%d7%9c%d7%95%d7%92%d7%99%d7%94-%d7%94%d7%98%d7 %9b%d7%a0%d7%99%d7%95-2/ SUMMARY:אלונה פלדמן\, הפקולטה לביולוגיה\, הט כניון – חיפה [No Categories] DESCRIPTION:Location: \n Affiliation: \n Host:\n השפעותיה של ה יפרגליקמיה על מערכת הרבייה דרך שינויים\n אפיגנטיים בתאים גונדוטרופיים\n\nEffects of hyper glycemia on reproduction through altering the gonadotrope epigenome\n\n\n מנחה: פרופ' פיליפה מלמד\n\nבמסגרת עבודת מח קר לתואר מגיסטר\n\nההרצאה תתקיים בעברית END:VEVENT BEGIN:VEVENT UID:592@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20150910T130000 DTEND;TZID=Asia/Jerusalem:20150910T140000 DTSTAMP:20210802T125839Z URL:https://biology.technion.ac.il/en/seminars/anna-rabinovich-faculty-of- biology-2/ SUMMARY:Anna Rabinovich\, Faculty of Biology [No Categories] DESCRIPTION:Location: \n Affiliation: \n Host:\n רגולציית הבי טוי של tet1 וtet2- בתאים הגונדוטרופים\n\nRegulation of Tet1 and Tet2 Expression in the Gonadotrope Cells\n\n\n\nמנחה: פ רופ/ח פיליפה מלמד\n\nבמסגרת עבודת מחקר לתו אר מגיסטר\n END:VEVENT BEGIN:VEVENT UID:591@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20150903T130000 DTEND;TZID=Asia/Jerusalem:20150903T140000 DTSTAMP:20210802T125839Z URL:https://biology.technion.ac.il/en/seminars/majd-haj-muhamad-2/ SUMMARY:Majd Haj Muhamad [No Categories] DESCRIPTION:Location: \n Affiliation: \n Host:\n GnRH induces histone mod ifications to regulate expression\nof the gonadotropin α-subunit gene\n\n מנחה: פרופ' פיליפה מלמד\n\nבמסגרת עבודת מח קר לתואר מגיסטר\n\nההרצאה תתקיים בעברית END:VEVENT BEGIN:VEVENT UID:590@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20150902T130000 DTEND;TZID=Asia/Jerusalem:20150902T140000 DTSTAMP:20210802T125839Z URL:https://biology.technion.ac.il/en/seminars/dr-gabriel-a-frank-nih-2/ SUMMARY:Dr. Gabriel A. Frank NIH [No Categories] DESCRIPTION:Location: \n Affiliation: \n Host:\n “Achieving mechanistic understanding in membrane protein systems using Cryo-electron microscopy: case studies of the HIV-1 core formation and human P-glycoprotein” END:VEVENT BEGIN:VEVENT UID:589@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20150827T130000 DTEND;TZID=Asia/Jerusalem:20150827T140000 DTSTAMP:20210802T125839Z URL:https://biology.technion.ac.il/en/seminars/sheila-roitman-faculty-of-b iology-technion-2/ SUMMARY:Sheila Roitman Faculty of Biology\, Technion [No Categories] DESCRIPTION:Location: \n Affiliation: \n Host:\n שונות ביולוג ית של וירוסים ימיים בעלי גנים פוטוסינטטי ים\nBiodiversity of marine viruses carrying photosystem I genes\n\nThe t alk will be given in English\n END:VEVENT BEGIN:VEVENT UID:588@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20150820T130000 DTEND;TZID=Asia/Jerusalem:20150820T140000 DTSTAMP:20210802T125839Z URL:https://biology.technion.ac.il/en/seminars/omer-abraham-faculty-of-bio logy-technion-2/ SUMMARY:Omer Abraham Faculty of Biology\, Technion [No Categories] DESCRIPTION:Location: \n Affiliation: \n Host:\n “A system for regulate d transport of membrane proteins from the plasma membrane to the ER”\nמ ערכת לבקרת טרנספורט תוך-תאי המבוססת על מ יסוך וחשיפה של סיגנלי טרנספורט\n\nThe lecture wi ll be given in Hebrew END:VEVENT BEGIN:VEVENT UID:587@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20150816T100000 DTEND;TZID=Asia/Jerusalem:20150816T110000 DTSTAMP:20210802T125839Z URL:https://biology.technion.ac.il/en/seminars/dr-ori-avinoam-post-doctora l-fellow-embl-heidelberg-2/ SUMMARY:Dr. Ori Avinoam Post Doctoral fellow EMBL\, Heidelberg [No Categori es] DESCRIPTION:Location: \n Affiliation: \n Host:\n Clathrin-coated pits mat ure by continuous bending and remodeling of the coat\n\nAbstract\n\nClathr in mediated endocytosis (CME) is a fundamental eukaryotic process playing essential roles in nutrient uptake\, membrane recycling\, synaptic transmi ssion and viral infection. Clathrin coated pits were among the first cellu lar structures described by electron microscopy over 5 decades ago\, and h ave been intensively studied ever since. Nevertheless\, researchers remain divided between two contradictory models for how clathrin coated vesicles are formed. Clathrin coated vesicles (CCVs) may form either through bendi ng of a pre-assembled flat coat\, or through coat assembly around the emer ging vesicle directly. To elucidate the mechanism of CCV formation\, I hav e applied two imaging approaches – high precision correlative light and electron tomography\, and targeted fluorescence recovery after photobleach ing (FRAP). I found that clathrin assembles into a defined flat lattice ea rly in endocytosis\, predetermining the size of the vesicle\, and then rea rranges through dynamic exchange with the cytosolic pool to wrap around th e forming vesicle. This finding resolves the long-standing conflict about the mechanism of CME\, leading perhaps to a surprising understanding of en docytosis where clathrin’s role in defining the endocytic site is indepe ndent of its characteristic assembly into curved polygonal shells\, and is mediated by dynamic instability rather than stable polymerization. Furthe rmore\, this study provides the first detailed quantitative description of membrane shape changes during endocytosis\, data which will be essential for biophysical modeling. END:VEVENT BEGIN:VEVENT UID:586@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20150810T130000 DTEND;TZID=Asia/Jerusalem:20150810T140000 DTSTAMP:20210802T125839Z URL:https://biology.technion.ac.il/en/seminars/dr-maya-kleiman-post-doctor al-fellow-from-california-university-2/ SUMMARY:Dr. Maya Kleiman Post Doctoral fellow from California University [ No Categories] DESCRIPTION:Location: \n Affiliation: \n Host:\n “The selective advanta ge for sexual reproduction” END:VEVENT BEGIN:VEVENT UID:585@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20150727T130000 DTEND;TZID=Asia/Jerusalem:20150727T140000 DTSTAMP:20210802T125839Z URL:https://biology.technion.ac.il/en/seminars/dr-guy-horev-bioinformatics -knowledge-unit-the-lorry-i-lokey-interdisciplinary-center-for-life-scienc es-and-engineering-technion-israel-institute-of-technology-2/ SUMMARY:Dr. Guy Horev Bioinformatics Knowledge Unit\, The Lorry I. Lokey Interdisciplinary Center for Life Sciences and Engineering. Technion - I srael Institute of Technology [No Categories] DESCRIPTION:Location: \n Affiliation: \n Host:\n Title: "The chromatin re modeler Chd5 regulates behavior\, dendritic arborization and nuclear reten tion in the brain" END:VEVENT BEGIN:VEVENT UID:584@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20150720T130000 DTEND;TZID=Asia/Jerusalem:20150720T140000 DTSTAMP:20210802T125839Z URL:https://biology.technion.ac.il/en/seminars/%d7%92%d7%95%d7%a8%d7%95%d7 %97%d7%95%d7%91%d7%a1%d7%a7%d7%99-%d7%90%d7%95%d7%9c%d7%92%d7%94-2/ SUMMARY:גורוחובסקי אולגה [No Categories] DESCRIPTION:Location: \n Affiliation: \n Host:\n תרצה על השתתפ ותה במשלחת צה"ל בנפאל 2015 END:VEVENT BEGIN:VEVENT UID:583@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20150713T130000 DTEND;TZID=Asia/Jerusalem:20150713T140000 DTSTAMP:20210802T125839Z URL:https://biology.technion.ac.il/en/seminars/dr-ohad-yosefson-department -of-biology-mit-usa-2/ SUMMARY:Dr. Ohad Yosefson Department of Biology\, MIT\, USA [No Categorie s] DESCRIPTION:Location: \n Affiliation: \n Host:\n Title: "Coordinated grip ping of substrate by subunits of a AAA+ proteolytic \nmachine"\n END:VEVENT BEGIN:VEVENT UID:582@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20150629T130000 DTEND;TZID=Asia/Jerusalem:20150629T140000 DTSTAMP:20210802T125838Z URL:https://biology.technion.ac.il/en/seminars/dr-avigdor-eldar-molecular- microbiology-and-biotechnology-dept-faculty-of-life-sciences-tel-aviv-univ ersity-2/ SUMMARY:Dr. Avigdor Eldar Molecular Microbiology and Biotechnology Dept.\, Faculty of Life Sciences\, Tel-Aviv University [No Categories] DESCRIPTION:Location: \n Affiliation: \n Host:\n “Evolution of redundan cy in bacterial signaling” END:VEVENT BEGIN:VEVENT UID:581@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20150624T130000 DTEND;TZID=Asia/Jerusalem:20150624T140000 DTSTAMP:20210802T125838Z URL:https://biology.technion.ac.il/en/seminars/prof-yuval-kluger-departmen t-of-pathology-yale-university-new-haven-usa-2/ SUMMARY:Prof. Yuval Kluger Department of Pathology\, Yale University\, New Haven\, USA [No Categories] DESCRIPTION:Location: \n Affiliation: \n Host:\n “From heterogeneity in cancer to heterogeneity in bioinformatics tools” \n END:VEVENT BEGIN:VEVENT UID:580@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20150618T130000 DTEND;TZID=Asia/Jerusalem:20150618T140000 DTSTAMP:20210802T125838Z URL:https://biology.technion.ac.il/en/seminars/%d7%99%d7%95%d7%aa%d7%9d-%d 7%97%d7%95%d7%9c%d7%aa%d7%90-%d7%94%d7%a4%d7%a7%d7%95%d7%9c%d7%98%d7%94-%d 7%9c%d7%91%d7%99%d7%95%d7%9c%d7%95%d7%92%d7%99%d7%94-%d7%94%d7%98%d7%9b%d7 %a0%d7%99%d7%95%d7%9f-2/ SUMMARY:יותם חולתא הפקולטה לביולוגיה\, הטכני ון- חיפה [No Categories] DESCRIPTION:Location: \n Affiliation: \n Host:\n “Isolation\, Character ization and Annual Patterns of Cyanophages in Lake Kinneret”\nמנחה: פרופ' דבי לינדל\nבמסגרת עבודת מחקר לתואר מגיסטר\n\n END:VEVENT BEGIN:VEVENT UID:579@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20150615T130000 DTEND;TZID=Asia/Jerusalem:20150615T140000 DTSTAMP:20210802T125838Z URL:https://biology.technion.ac.il/en/seminars/prof-zevi-elazar-faculty-of -biology-weizmann-institute-of-science-rehovot-2/ SUMMARY:Prof. Zevi Elazar Faculty of Biology\, Weizmann Institute of Scien ce\, Rehovot  [No Categories] DESCRIPTION:Location: \n Affiliation: \n Host:\n “Complex relationship between fatty acid synthesis\, lipid droplets and autophagy” END:VEVENT BEGIN:VEVENT UID:578@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20150608T130000 DTEND;TZID=Asia/Jerusalem:20150608T140000 DTSTAMP:20210802T125838Z URL:https://biology.technion.ac.il/en/seminars/dr-oded-kleifeld-department -of-biochemistry-molecular-biology-monash-university-clayton-campus-austra lia-2/ SUMMARY:Dr. Oded Kleifeld\, Department of Biochemistry & Molecular Biology Monash University\, Clayton Campus\, Australia  [No Categories] DESCRIPTION:Location: \n Affiliation: \n Host:\n “Proteomic studies of injury induced aggregation and protease specificity” \n END:VEVENT BEGIN:VEVENT UID:577@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20150607T113000 DTEND;TZID=Asia/Jerusalem:20150607T140000 DTSTAMP:20210802T125838Z URL:https://biology.technion.ac.il/en/seminars/mechanisms-of-protein-misfo lding-and-degradation-in-disease-mini-symposium-2/ SUMMARY:Mechanisms of Protein Misfolding and Degradation in Disease" - mini -symposium [No Categories] DESCRIPTION:Location: \n Affiliation: \n Host:\n 11:30 Refreshments\n1 2:00 Prof. Alfred Goldberg\, Cell Biology Dept at Harvard Medical Schoo l\n Title:"New insights into proteasome function: from protein degradation to disease therapy"\n13:00 Prof. Michael Sherman\, Boston U niversity\n Title:"Hsp70 at the crossroad between cancer and st ress response" response". END:VEVENT BEGIN:VEVENT UID:576@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20150603T130000 DTEND;TZID=Asia/Jerusalem:20150603T140000 DTSTAMP:20210802T125838Z URL:https://biology.technion.ac.il/en/seminars/prof-monty-kreiger-whitehea d-professor-biology-department-massachusetts-institute-of-technology-the-b road-institute-of-harvard-and-mit-usa-2/ SUMMARY:Prof. Monty Kreiger Whitehead Professor\, Biology Department\, Mas sachusetts Institute of Technology\, The Broad Institute of Harvard and MI T\, USA [No Categories] DESCRIPTION:Location: \n Affiliation: \n Host:\n “Insights into cardiov ascular and reproductive pathophysiology from studies of the HDL receptor SR-BL and its tissue-specific adaptor PDZK1” END:VEVENT BEGIN:VEVENT UID:575@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20150601T130000 DTEND;TZID=Asia/Jerusalem:20150601T140000 DTSTAMP:20210802T125838Z URL:https://biology.technion.ac.il/en/seminars/prof-joshua-weitz-school-of -biology-georgia-institute-of-technology-atlanta-usa-2/ SUMMARY:Prof. Joshua Weitz School of Biology\, Georgia Institute of Techno logy\, Atlanta\, USA [No Categories] DESCRIPTION:Location: \n Affiliation: \n Host:\n “Principles of Virus-M icrobe Dynamics: From Ecology to Evolution and Back Again” END:VEVENT BEGIN:VEVENT UID:574@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20150525T130000 DTEND;TZID=Asia/Jerusalem:20150525T140000 DTSTAMP:20210802T125838Z URL:https://biology.technion.ac.il/en/seminars/prof-sarit-larisch-chair-de partments-of-biology-and-medical-sciences-head-of-cell-death-and-cancer-re search-laboratory-university-of-haifa-2/ SUMMARY:Prof. Sarit Larisch Chair\, Departments of Biology and Medical Sci ences Head of Cell Death and Cancer Research Laboratory. University of Haifa [No Categories] DESCRIPTION:Location: \n Affiliation: \n Host:\n “The ARTStistic way of Initiating apoptosis and tumor suppression” END:VEVENT BEGIN:VEVENT UID:573@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20150518T130000 DTEND;TZID=Asia/Jerusalem:20150518T140000 DTSTAMP:20210802T125838Z URL:https://biology.technion.ac.il/en/seminars/prof-henriette-van-praag-he ad-neuroplasticity-and-behavioral-unit-laboratory-of-neurosciences-nationa l-institutes-of-health-2/ SUMMARY:Prof. Henriette van Praag Head\, Neuroplasticity and Behavioral Un it Laboratory of Neurosciences National Institutes of Health [No Categor ies] DESCRIPTION:Location: \n Affiliation: \n Host:\n Regulation and function of the circuitry of new neurons in the mouse hippocampus by exercise END:VEVENT BEGIN:VEVENT UID:572@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20150511T130000 DTEND;TZID=Asia/Jerusalem:20150511T140000 DTSTAMP:20210802T125838Z URL:https://biology.technion.ac.il/en/seminars/prof-ashraf-brik-schulich-f aculty-of-chemistry-technion-2/ SUMMARY:Prof. Ashraf Brik\, Schulich Faculty of Chemistry\, Technion [No Ca tegories] DESCRIPTION:Location: \n Affiliation: \n Host:\n " Chemical and Semisynth esis of Posttranslationally Modified Proteins for Biochemical\, Biophysica l and Functional Analyses: The Case of Ubiquitin Signal " END:VEVENT BEGIN:VEVENT UID:571@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20150506T130000 DTEND;TZID=Asia/Jerusalem:20150506T140000 DTSTAMP:20210802T125838Z URL:https://biology.technion.ac.il/en/seminars/prof-hermann-steller-invest igator-howard-hughes-medical-institute-strang-professor-strang-laboratory- of-apoptosis-and-cancer-biology-4/ SUMMARY:Prof. Hermann Steller\, Investigator\, Howard Hughes Medical Instit ute Strang Professor - Strang Laboratory of Apoptosis and Cancer Biology [ No Categories] DESCRIPTION:Location: \n Affiliation: \n Host:\n " Regulation of Proteaso me Activity in Development\, Aging and Disease" END:VEVENT BEGIN:VEVENT UID:570@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20150504T130000 DTEND;TZID=Asia/Jerusalem:20150504T140000 DTSTAMP:20210802T125838Z URL:https://biology.technion.ac.il/en/seminars/prof-hermann-steller-invest igator-howard-hughes-medical-institute-strang-professor-strang-laboratory- of-apoptosis-and-cancer-biology-3/ SUMMARY:Prof. Hermann Steller\, Investigator\, Howard Hughes Medical Insti tute Strang Professor - Strang Laboratory of Apoptosis and Cancer Biology [No Categories] DESCRIPTION:Location: \n Affiliation: \n Host:\n “Death by Design: Prog rammed Cell Death by Apoptosis" END:VEVENT BEGIN:VEVENT UID:569@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20150429T113000 DTEND;TZID=Asia/Jerusalem:20150429T123000 DTSTAMP:20210802T125838Z URL:https://biology.technion.ac.il/en/seminars/harvey-prize-lecture-prof-j ames-p-allison-department-of-immunology-division-of-basic-research-the-uni versity-of-texas-md-anderson-cancer-center-houston-tx-usa-2/ SUMMARY:Harvey Prize Lecture: Prof. James P. Allison Department of Immuno logy\, Division of Basic Research\, The University of Texas\, MD Anderson Cancer Center\, Houston\, TX\, USA [No Categories] DESCRIPTION:Location: \n Affiliation: \n Host:\n “Immune Checkpoint Blo ckade in Cancer Therapy: New insights\, opportunities and hope for cure"  \n END:VEVENT BEGIN:VEVENT UID:568@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20150426T130000 DTEND;TZID=Asia/Jerusalem:20150426T140000 DTSTAMP:20210802T125838Z URL:https://biology.technion.ac.il/en/seminars/dr-david-morgenstern-post-d octoral-fellow-proteomics-resource-center-nyu-langone-medical-center-2/ SUMMARY:Dr. David Morgenstern Post-Doctoral Fellow\, Proteomics Resource Center NYU Langone Medical Center [No Categories] DESCRIPTION:Location: \n Affiliation: \n Host:\n “One sequence\, many p roteins\, bad databases: challenges in mass spectrometry of non-model orga nisms and highly variable proteomes" END:VEVENT BEGIN:VEVENT UID:567@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20150420T130000 DTEND;TZID=Asia/Jerusalem:20150420T140000 DTSTAMP:20210802T125837Z URL:https://biology.technion.ac.il/en/seminars/prof-rivka-dickstein-facult y-of-biology-department-of-biological-chemistry-weizmann-institute-of-scie nce-2/ SUMMARY:Prof. Rivka Dickstein Faculty of Biology Department of Biological Chemistry Weizmann Institute of Science [No Categories] DESCRIPTION:Location: \n Affiliation: \n Host:\n " Precision and connecti vity in gene regulation: from transcription initiation to mRNA translation al " END:VEVENT BEGIN:VEVENT UID:566@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20150413T130000 DTEND;TZID=Asia/Jerusalem:20150413T140000 DTSTAMP:20210802T125837Z URL:https://biology.technion.ac.il/en/seminars/prof-oded-lewinson-departme nt-of-microbiology-faculty-of-medicine-technion-2/ SUMMARY:Prof. Oded Lewinson Department of Microbiology Faculty of Medicin e\, Technion [No Categories] DESCRIPTION:Location: \n Affiliation: \n Host:\n “ Conformational memor y and hysteretic behaviour of an enzyme/transporter” END:VEVENT BEGIN:VEVENT UID:565@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20150330T130000 DTEND;TZID=Asia/Jerusalem:20150330T140000 DTSTAMP:20210802T125837Z URL:https://biology.technion.ac.il/en/seminars/prof-rotem-karni-department -of-biochemistry-and-molecular-biology-institute-for-medical-research-isra el-canada-hebrew-university-hadassah-medical-school-2/ SUMMARY:Prof. Rotem Karni Department of Biochemistry and Molecular Biology\ , Institute for Medical Research Israel-Canada\, Hebrew University-Hadassa h Medical School [No Categories] DESCRIPTION:Location: \n Affiliation: \n Host:\n “The role of splicing factors in deregulation of alternative splicing during oncogenesis and tum or progression”\n END:VEVENT BEGIN:VEVENT UID:564@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20150323T130000 DTEND;TZID=Asia/Jerusalem:20150323T140000 DTSTAMP:20210802T125837Z URL:https://biology.technion.ac.il/en/seminars/prof-rony-seger-department- of-biological-regulation-the-weizmann-institute-of-science-2/ SUMMARY:Prof. Rony Seger Department of Biological Regulation\, The Weizmann Institute of Science [No Categories] DESCRIPTION:Location: \n Affiliation: \n Host:\n “The nuclear transloca tion of MAPK’s: a novel therapeutic target for cancer and inflammation ”\n END:VEVENT BEGIN:VEVENT UID:563@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20150316T130000 DTEND;TZID=Asia/Jerusalem:20150316T140000 DTSTAMP:20210802T125837Z URL:https://biology.technion.ac.il/en/seminars/dr-dan-kaganovich-departmen t-of-cell-and-developmental-biology-hebrew-university-of-jerusalem-2/ SUMMARY:Dr. Dan Kaganovich Department of Cell and Developmental Biology\, H ebrew University of Jerusalem [No Categories] DESCRIPTION:Location: \n Affiliation: \n Host:\n “Imperfect asymmetry: the mechanism governing asymmetric partitioning of damaged cellular compon ents during mitosis”\n END:VEVENT BEGIN:VEVENT UID:562@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20150309T130000 DTEND;TZID=Asia/Jerusalem:20150309T140000 DTSTAMP:20210802T125837Z URL:https://biology.technion.ac.il/en/seminars/prof-richard-lenski-departm ent-of-microbiology-and-molecular-genetics-michigan-state-university-2/ SUMMARY:Prof. Richard Lenski Department of Microbiology and Molecular Genet ics\, Michigan State University [No Categories] DESCRIPTION:Location: \n Affiliation: \n Host:\n “Time Travel in Experi mental Evolution: Phenotypic and Genomin Dynamics Across 60\,000 Generatio ns”\n END:VEVENT BEGIN:VEVENT UID:561@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20150302T130000 DTEND;TZID=Asia/Jerusalem:20150302T140000 DTSTAMP:20210802T125837Z URL:https://biology.technion.ac.il/en/seminars/prof-yehudit-bergman-depart ment-of-developmental-biology-and-cancer-research-hadassah-medical-school- the-hebrew-university-jerusalem-2/ SUMMARY:Prof. Yehudit Bergman Department of Developmental Biology and Cance r Research\, Hadassah Medical School\, The Hebrew University\, Jerusalem [ No Categories] DESCRIPTION:Location: \n Affiliation: \n Host:\n “Epigenetic programmin g links intestinal inflammation to colon cancer”\n END:VEVENT BEGIN:VEVENT UID:560@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20150216T130000 DTEND;TZID=Asia/Jerusalem:20150216T140000 DTSTAMP:20210802T125837Z URL:https://biology.technion.ac.il/en/seminars/prof-ron-dzikowski-the-kuvi n-center-for-the-studiy-of-infecttious-and-tropical-diseases-department-of -microbiology-molecular-genetics-hebrew-university-2/ SUMMARY:Prof. Ron Dzikowski The Kuvin Center for the Studiy of Infecttious and Tropical Diseases\, Department of Microbiology & Molecular Genetics\, Hebrew University [No Categories] DESCRIPTION:Location: \n Affiliation: \n Host:\n “Mechanisms regulating immune evasion by malaria parasites”\n END:VEVENT BEGIN:VEVENT UID:559@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20150209T130000 DTEND;TZID=Asia/Jerusalem:20150209T140000 DTSTAMP:20210802T125837Z URL:https://biology.technion.ac.il/en/seminars/dr-raz-zavirach-department- of-life-sciences-the-ben-gurion-university-of-the-negev-2/ SUMMARY:Dr. Raz Zavirach Department of Life Sciences\, The Ben Gurion Unive rsity of the Negev [No Categories] DESCRIPTION:Location: \n Affiliation: \n Host:\n “Structure-function st udies of manetosome-associated cation diffusion facilitators MamM and MamB ” END:VEVENT BEGIN:VEVENT UID:558@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20150202T130000 DTEND;TZID=Asia/Jerusalem:20150202T140000 DTSTAMP:20210802T125837Z URL:https://biology.technion.ac.il/en/seminars/prof-eli-keshet-department- of-development-biology-and-cancer-research-hadassah-medical-school-hebrew- university-2/ SUMMARY:Prof. Eli Keshet Department of Development Biology and Cancer Resea rch\, Hadassah Medical School\, Hebrew University [No Categories] DESCRIPTION:Location: \n Affiliation: \n Host:\n “VEGF\, blood vessels and stem cell niches”\n END:VEVENT BEGIN:VEVENT UID:557@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20150126T130000 DTEND;TZID=Asia/Jerusalem:20150126T140000 DTSTAMP:20210802T125837Z URL:https://biology.technion.ac.il/en/seminars/dr-carmit-levy-department-o f-human-genetics-and-biochemistry-sackler-school-of-medicine-tel-aviv-univ ersity-2/ SUMMARY:Dr. Carmit Levy Department of Human Genetics and Biochemistry Sackl er School of Medicine Tel Aviv University [No Categories] DESCRIPTION:Location: \n Affiliation: \n Host:\n “MITF the driver behi nd skin tanning and melanoma progression ”\nמארחת: פרופ"ח יע ל מנדל-גוטפרוינד yaelmg@tx.technion.ac.il)) \n ההרצא ה תתקיים באודיטוריום\, בבניין הפקולטה לב יולוגיה.\n END:VEVENT BEGIN:VEVENT UID:556@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20150119T130000 DTEND;TZID=Asia/Jerusalem:20150119T140000 DTSTAMP:20210802T125837Z URL:https://biology.technion.ac.il/en/seminars/dr-deborah-toiber-departmen t-of-life-sciences-ben-gurion-university-at-the-negev-2/ SUMMARY:Dr. Deborah Toiber Department of Life Sciences Ben Gurion Universit y at the Negev [No Categories] DESCRIPTION:Location: \n Affiliation: \n Host:\n “The role of SIRT6 in DNA damage and neurodegeneration”.\nמארח: פרופ"מ נביה אי וב \n ההרצאה תתקיים באודיטוריום\, בבניין הפקולטה לביולוגיה.\n\n\n\n\n\n END:VEVENT BEGIN:VEVENT UID:555@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20150114T123000 DTEND;TZID=Asia/Jerusalem:20150114T133000 DTSTAMP:20210802T125837Z URL:https://biology.technion.ac.il/en/seminars/dr-ronen-zaidel-bar-mechano biology-institute-and-department-of-biomedical-engineering-national-univer sity-of-singapore-singapore-2/ SUMMARY:Dr. Ronen Zaidel Bar Mechanobiology Institute and Department of Bio medical Engineering\, National University of Singapore\, Singapore. [No Ca tegories] DESCRIPTION:Location: \n Affiliation: \n Host:\n "The secret life of E-ca dherin: non-junctional E-cadherin regulates the actomyosin cortex in C. el egans".\nl מארחת: פרופ' פיליפה מלמד \n \n ההרצאה תתקיי ם באודיטוריום\, בבניין הפקולטה לביולוגיה .\n END:VEVENT BEGIN:VEVENT UID:554@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20150112T130000 DTEND;TZID=Asia/Jerusalem:20150112T140000 DTSTAMP:20210802T125837Z URL:https://biology.technion.ac.il/en/seminars/dr-shelly-tzlil-faculty-of- mechanical-engineering-technion-israel-institute-of-technology-2/ SUMMARY:Dr. Shelly Tzlil Faculty of Mechanical Engineering Technion – Isr ael Institute of Technology [No Categories] DESCRIPTION:Location: \n Affiliation: \n Host:\n ‘‘Cell Mechanosensi ng and Mechanical communication’’ \nAbstract: \n Inter actions between cells and their surrounding matrix play defining roles in biological processes. The biological cell can be thought of as a 'living r heometer' continuously probing the mechanical properties of its environmen t by exerting contractile forces through the actomyosin machinery. These t ension forces are transmitted to the extracellular matrix through transmem brane receptors which link the surrounding matrix to the actin cytoskeleto n. It is clear by now that substrate mechanical properties strongly influe nce cell behavior. Furthermore\, recent lines of evidence indicate that ce lls can respond to mechanical deformations generated by neighboring cells. The basis for this phenomenon and the role of mechanical communication be tween cells through the matrix is unknown. In my talk\, I will describe th e progress made in our lab focusing on the role of cell mechanosensing in cardiac cell synchronized beating. In addition I will describe our progres s towards design of protein-engineered biomaterials that promote mechanica l coupling between cells.\n\n מארח: פרופ' יהודה אסרף \n\ nההרצאה תתקיים באודיטוריום\, בבניין הפקו לטה לביולוגיה.\n END:VEVENT BEGIN:VEVENT UID:553@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20150107T130000 DTEND;TZID=Asia/Jerusalem:20150107T140000 DTSTAMP:20210802T125837Z URL:https://biology.technion.ac.il/en/seminars/dr-rina-rosenzweig-departme nts-of-biochemistry-chemistry-and-molecular-genetics-university-of-toronto -toronto-canada-2/ SUMMARY:Dr. Rina Rosenzweig Departments of Biochemistry\, Chemistry\, and M olecular Genetics\, University of Toronto\, Toronto\, Canada [No Categorie s] DESCRIPTION:Location: \n Affiliation: \n Host:\n "Unraveling the Mechanis m of Protein Disaggregation by Methyl-TROSY NMR"\nמארחת: פרופ' פ יליפה מלמד \n ההרצ אה תתקיים באודיטוריום\, בבניין הפקולטה ל ביולוגיה. \n\n\n\n END:VEVENT BEGIN:VEVENT UID:552@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20150106T130000 DTEND;TZID=Asia/Jerusalem:20150106T140000 DTSTAMP:20210802T125837Z URL:https://biology.technion.ac.il/en/seminars/dr-yoav-shaul-whitehead-ins titute-for-biomedical-research-cambridge-ma-usa-2/ SUMMARY:Dr. Yoav Shaul Whitehead Institute for Biomedical Research Cambridg e\, MA USA [No Categories] DESCRIPTION:Location: \n Affiliation: \n Host:\n Dr. Yoav Shaul \nWhitehe ad Institute for Biomedical Research \nCambridge\, MA USA\n"Cancer metabol ism: more than just proliferation"\n\n מארחת: פרופ' פיליפה מלמד \n הרצאה תתקיים באודיטוריום\, בבניין הפקולט ה לביולוגיה.\n\n\n\n\n END:VEVENT BEGIN:VEVENT UID:551@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20150105T130000 DTEND;TZID=Asia/Jerusalem:20150105T140000 DTSTAMP:20210802T125836Z URL:https://biology.technion.ac.il/en/seminars/prof-assaf-vardi-department -of-plant-and-environmental-sciences-weizmann-institute-of-science-2/ SUMMARY:Prof. Assaf Vardi Department of Plant and Environmental Sciences We izmann Institute of Science [No Categories] DESCRIPTION:Location: \n Affiliation: \n Host:\n “Host-Virus interactio ns during algal blooms in the ocean: From metabolic strategies to large sc ale impact.”\n\n מארח: פרופ' בני פודבילביץ \n\n ההרצאה תתקיים באודיטוריום\, בבניין הפקולטה לביו לוגיה.\n END:VEVENT BEGIN:VEVENT UID:550@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20141231T110000 DTEND;TZID=Asia/Jerusalem:20141231T120000 DTSTAMP:20210802T125836Z URL:https://biology.technion.ac.il/en/seminars/dr-schragi-schwartz-the-bro ad-institute-of-mit-and-harvard-2/ SUMMARY:Dr. Schragi Schwartz The Broad Institute of MIT and Harvard [No Cat egories] DESCRIPTION:Location: \n Affiliation: \n Host:\n "Cracking the epitranscr iptome"\n מארחת: פרופ' פיליפה מלמד \nההרצאה תת קיים באודיטוריום\, בבניין הפקולטה לביולו גיה.\n END:VEVENT BEGIN:VEVENT UID:549@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20141229T130000 DTEND;TZID=Asia/Jerusalem:20141229T140000 DTSTAMP:20210802T125836Z URL:https://biology.technion.ac.il/en/seminars/dr-noam-kaplan-program-in-s ystems-biology-university-of-massachusetts-medical-school-worcester-ma-usa -2/ SUMMARY:Dr. Noam Kaplan\, Program in Systems Biology\, University of Mass achusetts Medical School Worcester\, MA\, USA [No Categories] DESCRIPTION:Location: \n Affiliation: \n Host:\n “From 1D to 3D and bac k: Explaining and exploiting genome structure”.\nמארחת: פרופ' פיליפה מלמד \nההרצאה תתקיים באודיטוריום\, בבניין הפקולטה לביולוגיה. END:VEVENT BEGIN:VEVENT UID:548@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20141224T130000 DTEND;TZID=Asia/Jerusalem:20141224T140000 DTSTAMP:20210802T125836Z URL:https://biology.technion.ac.il/en/seminars/dr-nir-london-dept-of-pharm aceutical-chemistry-university-of-california-san-francisco-2/ SUMMARY:Dr. Nir London Dept. of Pharmaceutical Chemistry University of Cali fornia San Francisco [No Categories] DESCRIPTION:Location: \n Affiliation: \n Host:\n "Covalent Docking of Lar ge Libraries for the Discovery of New Inhibitors and Substrates"\nמארח ת: פרופ' פיליפה מלמד \nההרצאה תתקיים באודי טוריום\, בבניין הפקולטה לביולוגיה. END:VEVENT BEGIN:VEVENT UID:547@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20141222T130000 DTEND;TZID=Asia/Jerusalem:20141222T140000 DTSTAMP:20210802T125836Z URL:https://biology.technion.ac.il/en/seminars/prof-lewis-kay-the-departme nt-of-biochemistry-molecular-genetics-and-chemistry-of-the-university-of-t oronto-canada-2/ SUMMARY:Prof. Lewis Kay\, The Department of Biochemistry\, Molecular Geneti cs and Chemistry of the University of Toronto\, Canada [No Categories] DESCRIPTION:Location: \n Affiliation: \n Host:\n "The proteasome as a dyn amic\, allosteric machine"\nההרצאה תתקיים באודיטוריו ם\, בבניין הפקולטה לביולוגיה\nמארח: מרכז ל וקיי\n END:VEVENT BEGIN:VEVENT UID:546@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20141215T130000 DTEND;TZID=Asia/Jerusalem:20141215T140000 DTSTAMP:20210802T125836Z URL:https://biology.technion.ac.il/en/seminars/dr-ruth-scherz-shouval-whit ehead-institute-for-biomedical-research-cambridge-massachusetts-2/ SUMMARY:Dr. Ruth Scherz-Shouval\, Whitehead Institute for Biomedical Resear ch\, Cambridge\, Massachusetts [No Categories] DESCRIPTION:Location: \n Affiliation: \n Host:\n Dr. Ruth Scherz-Shouval\ , Whitehead Institute for Biomedical Research\, Cambridge\, Massachusetts\ n"Master regulators of stress responses reprogram the tumor microenvironme nt - HSF1 as a case study"\nמארחת: פרופ' פיליפה מלמד \n ההרצאה תתקיים באודיטוריום\, בבניין הפקול טה לביולוגיה. END:VEVENT BEGIN:VEVENT UID:545@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20141208T130000 DTEND;TZID=Asia/Jerusalem:20141208T140000 DTSTAMP:20210802T125836Z URL:https://biology.technion.ac.il/en/seminars/prof-michal-shapira-dept-li fe-sciences-ben-gurion-university-at-the-negev-2/ SUMMARY:Prof. Michal Shapira Dept. Life Sciences Ben Gurion University at t he Negev [No Categories] DESCRIPTION:Location: \n Affiliation: \n Host:\n “Light-induced oxidati ve stress and redox regulated chaperones in the green algae Chlamydomonas ”\nמארח: פרופ"ח יואב ערבה\nההרצאה תתקיים ב אודיטוריום\, בבניין הפקולטה לביולוגיה.\n END:VEVENT BEGIN:VEVENT UID:544@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20141203T130000 DTEND;TZID=Asia/Jerusalem:20141203T140000 DTSTAMP:20210802T125836Z URL:https://biology.technion.ac.il/en/seminars/prof-michael-elowitz-howard -hughes-medical-institute-california-institute-of-technology-usa-4/ SUMMARY:Prof. Michael Elowitz Howard Hughes Medical Institute\, California Institute of Technology\, USA [No Categories] DESCRIPTION:Location: \n Affiliation: \n Host:\n “Mammalian signaling circuits at the single-cell level”.\n מארח: פרופ' רועי קישוני \nההרצאה תתקיים באודיטוריום\, בבנ יין הפקולטה לביולוגיה. END:VEVENT BEGIN:VEVENT UID:543@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20141203T090000 DTEND;TZID=Asia/Jerusalem:20141203T100000 DTSTAMP:20210802T125836Z URL:https://biology.technion.ac.il/en/seminars/dr-oded-rechavi-department- of-neurobiology-wise-faculty-of-life-sciences-and-sagol-school-of-neurosci ence-tel-aviv-university-2/ SUMMARY:Dr. Oded Rechavi Department of Neurobiology\, Wise Faculty of Lif e Sciences and Sagol School of Neuroscience\, Tel Aviv University [No Cat egories] DESCRIPTION:Location: \n Affiliation: \n Host:\n "Small RNAs mediate inh eritance of memories in C. elegans"\n(podbilew@techunix.technion.ac.il ) מארח: פרופ' בני פודבילביץ \n ההרצאה תתקיים במקלט\, בבניין הפקולטה לביולוגיה.\ nיוגש כיבוד קל בשעה 08:45\, לפני ההרצאה. \n\n END:VEVENT BEGIN:VEVENT UID:542@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20141201T130000 DTEND;TZID=Asia/Jerusalem:20141201T140000 DTSTAMP:20210802T125836Z URL:https://biology.technion.ac.il/en/seminars/prof-michael-elowitz-howard -hughes-medical-institute-california-institute-of-technology-usa-3/ SUMMARY:Prof. Michael Elowitz Howard Hughes Medical Institute\, California Institute of Technology\, USA [No Categories] DESCRIPTION:Location: \n Affiliation: \n Host:\n “It’s about time: Ti me-based regulation in individual cells”\n מארח: פרופ' רועי קישוני\n ההרצאה תתקיים באודיטוריום\, בבני ין הפקולטה לביולוגיה\n END:VEVENT BEGIN:VEVENT UID:541@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20141127T140000 DTEND;TZID=Asia/Jerusalem:20141127T150000 DTSTAMP:20210802T125836Z URL:https://biology.technion.ac.il/en/seminars/dr-ilona-nudelman-a-postdoc toral-associate-at-the-laboratory-of-cellular-and-structural-biology-at-th e-rockefeller-university-2/ SUMMARY:Dr. Ilona Nudelman A postdoctoral associate at the Laboratory of Ce llular and Structural Biology at the Rockefeller University [No Categories ] DESCRIPTION:Location: \n Affiliation: \n Host:\n "NCDIR – National Cent er for Dynamic Interactome Research - Novel Technologies and Applications for Study of Macromolecular Complexes"\nAbstract: \nThe vision of the Nati onal Center for Dynamic Interactome Research is to develop innovative and dramatically new approaches for the detection\, isolation\, and analysis o f macromolecular complexes that will enable scientists to realize the full potential of the revolution brought about by genomics\, interdisciplinary research\, and proteomics technologies. In my talk I will present a small sample of our already established methodologies arsenal\, which enables u s to immuno-purify large amounts of endogenous macro-molecular complexes o f various complexities from virtually any organism. With these\, we are ab le to perform structural and functional studies using a multitude of techn iques\, including EM\, super-resolution and fluorescence microscopy\, cros s-linking\, MS\, SAXS and many others. These data serve as input into our integrative modeling platform (IMP) which provides us with a functionally informative pseudo-atomic model of the system in question. IMP has been us ed to demonstrate the strength of our integrative approach by application to several challenging systems\, including the Nuclear Pore Complex\, Nup8 4 complex\, 26S Proteasome\, ribosomes etc. Since our methodology has prov ed to be extremely successful\, we are interested in its dissemination amo ng the different scientific fields. One of our center’s main goals is to make our technologies readily available and provide training and support in their use.\nמארח: פרופ' אריה אדמון\n admon@tx.technion .ac.il \nההרצאה תתקיים באודיטוריום בבניין הפקולטה לביולוגיה. END:VEVENT BEGIN:VEVENT UID:540@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20141124T130000 DTEND;TZID=Asia/Jerusalem:20141124T140000 DTSTAMP:20210802T125836Z URL:https://biology.technion.ac.il/en/seminars/dr-roy-dar-gladstone-instit ute-of-virology-and-immunology-and-the-center-for-systems-and-synthetic-bi ology-university-of-california-san-francisco-2/ SUMMARY:Dr. Roy Dar Gladstone Institute of Virology and Immunology\, and t he Center for Systems and Synthetic Biology\, University of California\, S an Francisco [No Categories] DESCRIPTION:Location: \n Affiliation: \n Host:\n “Screening for noise i n gene expression\n identifies drug synergies”.\n ( philippa@tx.technion .ac.il) מארחת: פרופ"ח פיליפה מלמד END:VEVENT BEGIN:VEVENT UID:539@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20141117T130000 DTEND;TZID=Asia/Jerusalem:20141117T140000 DTSTAMP:20210802T125836Z URL:https://biology.technion.ac.il/en/seminars/doron-betel-institute-for-c omputational-biomedicine-weill-cornell-medical-college-new-york-usa-2/ SUMMARY:Doron Betel Institute for Computational Biomedicine Weill Cornell Medical College New York\, USA [No Categories] DESCRIPTION:Location: \n Affiliation: \n Host:\n “Analysis of the Human Gastric Microbiome and Other Epigenetic Adventures”.\n מארח: פר ופ"מ נביה איוב \n( ayoubn@tx.technion.ac.il ) END:VEVENT BEGIN:VEVENT UID:538@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20141110T130000 DTEND;TZID=Asia/Jerusalem:20141110T140000 DTSTAMP:20210802T125836Z URL:https://biology.technion.ac.il/en/seminars/dr-adi-stern-department-of- molecular-microbiology-and-biotechnology-tel-aviv-university-2/ SUMMARY:Dr. Adi Stern Department of Molecular Microbiology and Biotechnolog y Tel Aviv University [No Categories] DESCRIPTION:Location: \n Affiliation: \n Host:\n “Real Time Evolution: A window into selection\, mutation and adaptation of RNA viruses”.\n\nAb stract:\nRNA viruses are distinguished by high mutation rates\, huge popul ations sizes\, and short replication times. As a consequence\, RNA viruses replicate as complex and dynamic mutant swarms\, called viral quasispecie s. The extremely high mutation rates of viruses are central drivers of the ir evolution\, and as such make them fascinating both as pathogens and as evolutionary model systems. Here\, I analyze how the live attenuated vacci ne Poliovirus strain can evolve and rapidly adapt to regain virulence\, us ing a combination of evolutionary models\, field samples\, and experimenta l evolution. I will describe a novel highly accurate method for deep seque ncing of populations and inference of a fitness landscape from serial pass aging. This method allows us for the first time to interrogate virus evolu tion in real time\, and to investigate how viral diversity and robustness contribute to adaptation and virulence.\n\nמארחת: פרופ"מ מיט ל לנדאו \n(mlandau@technion.ac.il) \n\n END:VEVENT BEGIN:VEVENT UID:537@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20141103T130000 DTEND;TZID=Asia/Jerusalem:20141103T140000 DTSTAMP:20210802T125836Z URL:https://biology.technion.ac.il/en/seminars/dr-alexey-amunts-mrc-labora tory-of-molecular-biology-cambridge-united-kingdom-2/ SUMMARY:Dr. Alexey Amunts MRC Laboratory of Molecular Biology Cambridge\, U nited Kingdom [No Categories] DESCRIPTION:Location: \n Affiliation: \n Host:\n "Structures of mitochond rial ribosomes determined entirely by cryo-EM."\n\nAbstract:\nDuring 2 bil lion years of separate evolution\, mitochondrial ribosomes (mitoribosomes) have evolved unique features by acquisition of ~50% more proteins and alt eration of their RNA composition.\nWe resolved structures of large ribosom al subunit from yeast and human mitochondria by cryo-EM to the nominal res olution of 3.2 Å and 3.4 Å respectively. The quality of the density maps enabled de novo model building by following amino acid side chains and nu cleic acid bases. Thus methodologically\, this work shows that recent adva nces in cryo-EM can be used to determine structures of a comparable qualit y to X-ray crystallography\, without a priory biochemical knowledge and fr om much smaller amount of more heterogeneous material. \nStructure of larg e ribosomal subunit from human mitochondria reveals highly divergent archi tecture from all other known ribosomes. This includes unique design of the central protuberance\, rearrangement of tRNA binding sites\, new elements of the L7/L12 stalk and adaptation of the polypeptide exit tunnel to the synthesis of highly hydrophobic polypeptides. \n\n\n(mlandau@technion.ac.i l) מארחת: פרופ"מ מיטל לנדאו END:VEVENT BEGIN:VEVENT UID:536@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20141027T130000 DTEND;TZID=Asia/Jerusalem:20141027T140000 DTSTAMP:20210802T125836Z URL:https://biology.technion.ac.il/en/seminars/prof-manny-ares-center-for- molecular-biology-of-rna-sinsheimer-laboratories-university-of-california- santa-cruz-2/ SUMMARY:Prof. Manny Ares Center for Molecular Biology of RNA Sinsheimer Lab oratories University of California\, Santa Cruz [No Categories] DESCRIPTION:Location: \n Affiliation: \n Host:\n "Mechanisms that influen ce splicing decisions"\n\nמארחת: פרופ"ח יעל מנדל-גוטפ רוינד\n END:VEVENT BEGIN:VEVENT UID:535@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20141020T123000 DTEND;TZID=Asia/Jerusalem:20141020T133000 DTSTAMP:20210802T125835Z URL:https://biology.technion.ac.il/en/seminars/%d7%a1%d7%9e%d7%99%d7%a0%d7 %a8-%d7%9e%d7%91%d7%95%d7%98%d7%9c-2/ SUMMARY:סמינר מבוטל [No Categories] DESCRIPTION:Location: \n Affiliation: \n Host:\n END:VEVENT BEGIN:VEVENT UID:534@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20140908T130000 DTEND;TZID=Asia/Jerusalem:20140908T140000 DTSTAMP:20210802T125835Z URL:https://biology.technion.ac.il/en/seminars/dr-leonid-v-chernomordik-ni h-national-institute-of-child-health-and-human-development-bethesda-md-usa -2/ SUMMARY:Dr. Leonid V. Chernomordik NIH National Institute of Child Health and Human Development\, Bethesda MD USA [No Categories] DESCRIPTION:Location: \n Affiliation: \n Host:\n "Fusion mediated by vira l and developmental fusogens"\n END:VEVENT BEGIN:VEVENT UID:533@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20140630T130000 DTEND;TZID=Asia/Jerusalem:20140630T140000 DTSTAMP:20210802T125835Z URL:https://biology.technion.ac.il/en/seminars/prof-bill-degrado-departmen t-of-pharmaceutical-chemistryuniversity-of-california-2/ SUMMARY:Prof. Bill DeGrado Department of Pharmaceutical Chemistry\,Univers ity of California [No Categories] DESCRIPTION:Location: \n Affiliation: \n Host:\n Prof. Bill DeGrado\n D epartment of Pharmaceutical Chemistry \n University of California\n" Analysis and design of proton transporters"\n מארח: פרופ' אר יה אדמון \nההרצאה תתקיים באודיטוריום\, בב ניין הפקולטה לביולוגיה.\n\n END:VEVENT BEGIN:VEVENT UID:532@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20140623T133000 DTEND;TZID=Asia/Jerusalem:20140623T143000 DTSTAMP:20210802T125835Z URL:https://biology.technion.ac.il/en/seminars/dr-boaz-mizrahi-faculty-of- biotechnology-and-food-engineering-technion-2/ SUMMARY:Dr. Boaz Mizrahi Faculty of Biotechnology and Food Engineering Tech nion [No Categories] DESCRIPTION:Location: \n Affiliation: \n Host:\n Dr. Boaz Mizrahi\, Facul ty of Biotechnology and Food Engineering\, Technion\n"Bio-Inspired Materia ls: Fundamentals to Applications"\nמארחת: פרופ"מ שנהב כהן \nההרצאה תתקיים באודיטוריום\, בבניין הפק ולטה לביולוגיה. END:VEVENT BEGIN:VEVENT UID:531@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20140616T130000 DTEND;TZID=Asia/Jerusalem:20140616T140000 DTSTAMP:20210802T125835Z URL:https://biology.technion.ac.il/en/seminars/prof-elizabeth-kutter-everg reen-state-college-olympia-wa-usa-2/ SUMMARY:Prof. Elizabeth Kutter Evergreen State College Olympia\, WA\, USA [ No Categories] DESCRIPTION:Location: \n Affiliation: \n Host:\n Prof. Elizabeth Kutter\, Evergreen State College Olympia\, WA\, USA\n“Characterization and imple mentation of bacteriophages as natural\, self-replicating and self-limitin g antimicrobials”\nמארחת: פרופ"ח דבי לינדל \nההרצ אה תתקיים באודיטוריום\, בבניין הפקולטה ל ביולוגיה.\n\n END:VEVENT BEGIN:VEVENT UID:530@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20140609T130000 DTEND;TZID=Asia/Jerusalem:20140609T140000 DTSTAMP:20210802T125835Z URL:https://biology.technion.ac.il/en/seminars/prof-uri-alon-department-of -molecular-cell-biology-weizmann-institute-of-science-2/ SUMMARY:Prof. Uri Alon Department of Molecular Cell Biology Weizmann Insti tute of Science [No Categories] DESCRIPTION:Location: \n Affiliation: \n Host:\n Prof. Uri Alon\, Departm ent of Molecular Cell Biology\nWeizmann Institute of Science.\n"Paradoxic al cytokines and enzymes and their role in cell circuits”.\nמארחת: פרופ"מ שנהב כהן \nההרצאה תתקיים באודיטור יום\, בבניין הפקולטה לביולוגיה. END:VEVENT BEGIN:VEVENT UID:529@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20140602T130000 DTEND;TZID=Asia/Jerusalem:20140602T140000 DTSTAMP:20210802T125835Z URL:https://biology.technion.ac.il/en/seminars/prof-ravid-straussman-2/ SUMMARY:Prof. Ravid Straussman\, [No Categories] DESCRIPTION:Location: \n Affiliation: \n Host:\n Prof. Ravid Straussman\n Department of Molecular Cell Biology\,\n Weizmann Institute of Science.\n “Tumor microenvironment-mediated chemoresistance"\nמארחת: פרופ" מ שנהב כהן \nההרצאה תתקיים באודיטוריום\, בבניין הפקולטה לביולוגיה.\n\n\n END:VEVENT BEGIN:VEVENT UID:528@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20140526T130000 DTEND;TZID=Asia/Jerusalem:20140526T140000 DTSTAMP:20210802T125835Z URL:https://biology.technion.ac.il/en/seminars/prof-john-yewdell-2/ SUMMARY:Prof. John Yewdell [No Categories] DESCRIPTION:Location: \n Affiliation: \n Host:\n "The Case for Basic Scie nce: Translating DRiPs for Immunosurveillance" \n\n (reiter@ @tx.te chnion.ac.il) מארח: פרופ' יורם רייטר \n\n END:VEVENT BEGIN:VEVENT UID:527@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20140519T103000 DTEND;TZID=Asia/Jerusalem:20140519T130000 DTSTAMP:20210802T125835Z URL:https://biology.technion.ac.il/en/seminars/gevurot-birthday-celebratio n-professor-emeritus-eliezer-lifschitz-2/ SUMMARY:"Gevurot" Birthday Celebration-Professor Emeritus Eliezer Lifschitz [No Categories] DESCRIPTION:Location: \n Affiliation: \n Host:\n הפקולטה לביו לוגיה מזמינה לחגיגת יום ההולדת של פרופ' א מריטוס אליעזר ליפשיץ שהגיע לגבורות\,\n\nבת כנית:\n\n10:30 ברכות.\n\n10:45-11:15 פרופ' א מריטוס אליעזר ליפשיץ- \n "האוד יסאה של הפלוריגן: על פריחה והפרכה"\n\n11:15-12: 00 פרופ' יוסי שילה מאוניברסיטת תל-אביב-\n "A-T: מסע שהחל בצעד אחד\, בקורס של אליעזר".\n\n12:00-13:00 ארוחת צהריים קלה.\n\n\ n END:VEVENT BEGIN:VEVENT UID:526@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20140512T130000 DTEND;TZID=Asia/Jerusalem:20140512T140000 DTSTAMP:20210802T125835Z URL:https://biology.technion.ac.il/en/seminars/prof-opher-giladi-the-struc tural-genomics-consortium-university-of-oxford-2/ SUMMARY:Prof. Opher Giladi The Structural Genomics Consortium University of Oxford [No Categories] DESCRIPTION:Location: \n Affiliation: \n Host:\n "Orphan genes\, gene fam ilies and therapeutic opportunities: the case of human metallo\n β-lacta mases”.\nמארח: פרופ' גדי שוסטר \nההרצאה תתקיי ם באודיטוריום\, בבניין הפקולטה לביולוגיה . END:VEVENT BEGIN:VEVENT UID:525@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20140407T093000 DTEND;TZID=Asia/Jerusalem:20140407T150000 DTSTAMP:20210802T125835Z URL:https://biology.technion.ac.il/en/seminars/%d7%99%d7%95%d7%9d-%d7%a2%d 7%99%d7%95%d7%9f-%d7%9c%d7%9b%d7%91%d7%95%d7%93-%d7%a4%d7%a8%d7%99%d7%a9%d 7%aa%d7%9d-%d7%a9%d7%9c-%d7%94%d7%a4%d7%a8%d7%95%d7%a4%d7%a1%d7%95%d7%a8%d 7%99%d7%9d-%d7%99%d7%95-2/ SUMMARY:יום עיון לכבוד פרישתם של הפרופסורים: יונה קסיר וחיים מנור [No Categories] DESCRIPTION:Location: \n Affiliation: \n Host:\n (starting at 9:30 with coffee and cakes) we will be honoring Prof. Emeriti Haim Manor and Yona Ka ssir upon their retirement with a dedicated seminar day where invited spea kers including Prof. Martin Kupiec fromTAU and Prof. Joseph Shlomai from t he HU as well as Haim and Yona themselves will be presenting talks. END:VEVENT BEGIN:VEVENT UID:524@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20140331T130000 DTEND;TZID=Asia/Jerusalem:20140331T140000 DTSTAMP:20210802T125835Z URL:https://biology.technion.ac.il/en/seminars/dr-anat-ben-zvi-department- of-life-sciences-and-the-nibn-ben-gurion-university-2/ SUMMARY:Dr. Anat Ben-Zvi Department of Life Sciences and the NIBN Ben Gurio n University [No Categories] DESCRIPTION:Location: \n Affiliation: \n Host:\n “Tailoring the proteos tasis network to the cell needs” END:VEVENT BEGIN:VEVENT UID:523@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20140326T150000 DTEND;TZID=Asia/Jerusalem:20140326T160000 DTSTAMP:20210802T125835Z URL:https://biology.technion.ac.il/en/seminars/prof-melissa-rolls-departme nt-of-biochemistry-and-molecular-biology-penn-state-usa-2/ SUMMARY:Prof. Melissa Rolls\, Department of Biochemistry and Molecular Biol ogy\, Penn State\, USA [No Categories] DESCRIPTION:Location: \n Affiliation: \n Host:\n Prof. Melissa Rolls\, De partment of Biochemistry and Molecular Biology\, Penn State\, USA\n“Maki ng one cell point two ways: setting up opposite orientation microtubules i n axons and dendrites”\nמארח: פרופ' בני פודבילביץ\n END:VEVENT BEGIN:VEVENT UID:522@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20140324T130000 DTEND;TZID=Asia/Jerusalem:20140324T140000 DTSTAMP:20210802T125835Z URL:https://biology.technion.ac.il/en/seminars/dr-itay-onn-faculty-of-medi cine-bar-ilan-university-2/ SUMMARY:Dr. Itay Onn Faculty of Medicine Bar-Ilan University [No Categories ] DESCRIPTION:Location: \n Affiliation: \n Host:\n “The mechanism of main taining genome stability by cohesin” END:VEVENT BEGIN:VEVENT UID:521@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20140317T130000 DTEND;TZID=Asia/Jerusalem:20140317T140000 DTSTAMP:20210802T125835Z URL:https://biology.technion.ac.il/en/seminars/dr-deborah-toiber-the-massa chusetts-general-hospital-cancer-center-harvard-medical-school-cambridge-s t-boston-ma-2/ SUMMARY:Dr. Deborah Toiber The Massachusetts General Hospital Cancer Center Harvard Medical School Cambridge St. Boston MA [No Categories] DESCRIPTION:Location: \n Affiliation: \n Host:\n “Chromatin dynamics as critical modulator of DNA repair” END:VEVENT BEGIN:VEVENT UID:520@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20140310T130000 DTEND;TZID=Asia/Jerusalem:20140310T140000 DTSTAMP:20210802T125834Z URL:https://biology.technion.ac.il/en/seminars/dr-amir-sapir-postdoctoral- fellow-paul-sternberg-lab-california-institute-of-technology-2/ SUMMARY:Dr. Amir Sapir\, Postdoctoral Fellow Paul Sternberg Lab\, Californi a Institute of Technology [No Categories] DESCRIPTION:Location: \n Affiliation: \n Host:\n “Novel fungal parasiti sm in the deep sea”\n &\n“Does SUMO regulate cholesterol\, cancer and mitochondria metabolism? ”\nמארח: פרופ' בני פודבילבי ץ \nההרצאה תתקיים באודיטוריום\, בבניי ן הפקולטה לביולוגיה.\n END:VEVENT BEGIN:VEVENT UID:519@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20140303T130000 DTEND;TZID=Asia/Jerusalem:20140303T140000 DTSTAMP:20210802T125834Z URL:https://biology.technion.ac.il/en/seminars/dr-shimon-bershtein-departm ent-of-chemistry-and-chemical-biology-harvard-university-cambridge-ma-2/ SUMMARY:Dr. Shimon Bershtein Department of Chemistry and Chemical Biology H arvard University Cambridge\, MA [No Categories] DESCRIPTION:Location: \n Affiliation: \n Host:\n “Unraveling the Molecu lar Mechanisms Underpinning Genotype-Phenotype Relationship”\n END:VEVENT BEGIN:VEVENT UID:518@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20140217T130000 DTEND;TZID=Asia/Jerusalem:20140217T140000 DTSTAMP:20210802T125834Z URL:https://biology.technion.ac.il/en/seminars/chen-davidovich-howard-hugh es-medical-institute-department-of-chemistry-and-biochemistry-hhmi-univ-of -colorado-2/ SUMMARY:Chen Davidovich Howard Hughes Medical Institute Department of Chemi stry and Biochemistry HHMI Univ of Colorado [No Categories] DESCRIPTION:Location: \n Affiliation: \n Host:\n Chen Davidovich \nHoward Hughes Medical Institute\nDepartment of Chemistry and Biochemistry\nHHMI Univ of Colorado\n"Promiscuous RNA binding by PRC2: a model for scanning through chromatin and maintaining the repressed epigenetic state"\nמארחת: פרופ"ח פי ליפה מלמד END:VEVENT BEGIN:VEVENT UID:517@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20140203T130000 DTEND;TZID=Asia/Jerusalem:20140203T140000 DTSTAMP:20210802T125834Z URL:https://biology.technion.ac.il/en/seminars/prof-eugene-koonin-national -institutes-of-health-nih-bethesda-md-20894-usa-2/ SUMMARY:Prof. Eugene Koonin National Institutes of Health (NIH) Bethesda\, MD 20894\, USA [No Categories] DESCRIPTION:Location: \n Affiliation: \n Host:\n Prof. Eugene Koonin\nNat ional Institutes of Health (NIH)\nBethesda\, MD 20894\, USA \n"What should replace the Tree of Life and the Molecular Clock in the Post-genomic Era? "\nמארח: פרופ' עודד בז'ה END:VEVENT BEGIN:VEVENT UID:516@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20140127T130000 DTEND;TZID=Asia/Jerusalem:20140127T140000 DTSTAMP:20210802T125834Z URL:https://biology.technion.ac.il/en/seminars/dr-noam-shental-department- of-mathematics-and-computer-science-the-open-university-of-israel-2/ SUMMARY:Dr. Noam Shental\, Department of Mathematics and Computer Science\, The Open University of Israel. [No Categories] DESCRIPTION:Location: \n Affiliation: \n Host:\n “High resolution micr obial community reconstruction by integrating short reads from multiple 16 S rRNA regions”\nAbstract:\nThe emergence of massively parallel sequenci ng technology has revolutionized microbial profiling\, allowing the unprec edented comparison of microbial diversity across time and space in a wide range of host-associated and environmental ecosystems. Although the high t hroughput nature of such methods enables the detection of low frequency ba cteria\, these advances come at the cost of sequencing read length\, limit ing the phylogenetic resolution possible by current methods. \nWe present a generic approach for integrating short reads from large genomic regions\ , thus enabling phylogenetic resolution far exceeding current methods. The approach is based on a mapping to a statistical model that is later solve d as a constrained optimization problem. \nWe demonstrate the utility of t his method by analyzing human saliva and Drosophila samples\, using Illumi na single-end sequencing of a 750bp amplicon of the 16S rRNA gene. Phyloge netic resolution is significantly extended while reducing the number of fa lsely detected bacteria\, as compared to standard single-region Roche 454 Pyrosequencing. \nOur approach can be seamlessly applied to simultaneous s equencing of multiple genes providing a higher resolution view of the comp osition and activity of complex microbial communities.\nJoint work with Am non Amir\, Amit Zeisel\, Michael Elgart\, Shay Stern\, Ohad Shamir and Yoa v Soen\, from Weizmann Institute of Science\, Or Zuk from the Hebrew Unive rsity and Peter J. Turnbaugh\, Harvard University.\nמארחת: פרופ" מ מיטל לנדאו\n END:VEVENT BEGIN:VEVENT UID:515@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20140120T130000 DTEND;TZID=Asia/Jerusalem:20140120T140000 DTSTAMP:20210802T125834Z URL:https://biology.technion.ac.il/en/seminars/prof-gil-ast-department-of- human-molecular-genetics-biochemistry-tel-aviv-university-4/ SUMMARY:Prof. Gil Ast\, Department of Human Molecular Genetics & Biochemi stry\, Tel-Aviv University [No Categories] DESCRIPTION:Location: \n Affiliation: \n Host:\n “How DNA methylation a nd chromatin \n organization regulate alternative splicing”\n מארח: פרופ"מ נביה איו ב \n END:VEVENT BEGIN:VEVENT UID:514@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20140115T130000 DTEND;TZID=Asia/Jerusalem:20140115T140000 DTSTAMP:20210802T125834Z URL:https://biology.technion.ac.il/en/seminars/dr-yifat-merbl-department-o f-systems-biology-harvard-medical-school-boston-ma-2/ SUMMARY:Dr. Yifat Merbl\, Department of Systems Biology\, Harvard Medical S chool\, Boston\, MA. [No Categories] DESCRIPTION:Location: \n Affiliation: \n Host:\n \n"Post-Translational Mo dification (PTM) Profiling: From Global Patterns to Mechanistic Insight O f Ubl Regulation in Mitosis and Cancer Progression"\nמארחת: פרופ" ח פיליפה מלמד \n END:VEVENT BEGIN:VEVENT UID:513@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20140113T130000 DTEND;TZID=Asia/Jerusalem:20140113T140000 DTSTAMP:20210802T125834Z URL:https://biology.technion.ac.il/en/seminars/ass-prof-tomer-shlomi-depar tment-of-compute-science-technion-2/ SUMMARY:Ass.Prof. Tomer Shlomi\, Department of Compute Science\, Technion. [No Categories] DESCRIPTION:Location: \n Affiliation: \n Host:\n "A quantitative approach for studying cancer metabolism"\nמארח: פרופ"מ נביה איוב\ n END:VEVENT BEGIN:VEVENT UID:512@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20140106T130000 DTEND;TZID=Asia/Jerusalem:20140106T140000 DTSTAMP:20210802T125834Z URL:https://biology.technion.ac.il/en/seminars/dr-yoni-haitin-department-o f-physiology-and-biophysics-university-of-washington-seattle-2/ SUMMARY:Dr. Yoni Haitin\, Department of Physiology and Biophysics\, Univers ity of Washington\, Seattle. [No Categories] DESCRIPTION:Location: \n Affiliation: \n Host:\n "KCNH Channel Regulation : A Structural Point of View"\nAbstract:\nThe KCNH voltage dependent potas sium channels are key regulators of cellular excitability\, involved in ca rdiac long QT syndrome type 2 (LQTS2)\, epilepsy\, schizophrenia and cance r. The intracellular domains of KCNH channels are structurally distinct fr om other voltage-gated channels\, and include an amino-terminal eag domain \, composed from a Per-Arnt-Sim (PAS) module and a PAS-cap region\, and a carboxy-terminal cyclic nucleotide-binding homology domain (CNBHD)\, conne cted to the pore domain through a C-linker domain. These specialized intra cellular domains are the site of many disease-causing mutations and bestow unique gating and regulation on KCNH channels. Using fluorescence\, x-ray crystallography and electrophysiological approaches\, we determined and v alidated the structure of the intracellular complex of mEAG1 channel. Harb oring many LQTS2 and cancer-associated mutations\, the eag domain-CNBHD in terface involves three important regions: (i) the “intrinsic ligand” m otif\, a unique structural feature of the CNBHD\; (ii) the post-CNBHD regi on\, known to mediate EAG channels regulation by a variety of cellular sig naling events\; and finally\, (iii) the PAS-cap region\, which constitutes the first 25 amino acids of the eag domain\, and forms a highly conserved amphipathic helix (αCAP). Together\, this work provides a detailed physi ological and pathophysiological description of the intracellular domain of the KCNH family.\nמארחת: פרופ"ח פיליפה מלמד\n END:VEVENT BEGIN:VEVENT UID:511@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20140101T130000 DTEND;TZID=Asia/Jerusalem:20140101T140000 DTSTAMP:20210802T125834Z URL:https://biology.technion.ac.il/en/seminars/dr-assaf-zemach-department- of-plant-microbial-biology-university-of-california-berkeley-2/ SUMMARY:Dr Assaf Zemach\, Department of Plant & Microbial Biology\, Univers ity of California\, Berkeley. [No Categories] DESCRIPTION:Location: \n Affiliation: \n Host:\n "Epigenomics of DNA meth ylation and chromatin structure"\nAbstract: \nDNA methylation epigenetical ly regulates genetic elements across eukaryotes. Inside the nucleus the DN A is wrapped by histone proteins and additional factors into a condensed f iber known as chromatin. Besides packaging the DNA\, the chromatin evolved to regulate the accessibility of the DNA. While the genome can be natural ly subdivided into genes and transposable elements\, my results suggest th at all genomic sequences are part of a chromatin continuum that cuts acros s transposon and gene annotations and better explains how DNA methylation machineries reach their target sites.\nמארחת: פרופ"ח פיליפ ה מלמד\n END:VEVENT BEGIN:VEVENT UID:510@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20131230T130000 DTEND;TZID=Asia/Jerusalem:20131230T140000 DTSTAMP:20210802T125834Z URL:https://biology.technion.ac.il/en/seminars/prof-steven-rosenfeld-lerne r-research-institute-the-cleveland-clinic-cleveland-oh-2/ SUMMARY:Prof. Steven Rosenfeld Lerner Research Institute The Cleveland Clin ic Cleveland\, OH [No Categories] DESCRIPTION:Location: \n Affiliation: \n Host:\n "Structure\, Function\, and Biology of a Cancer-Relevant Kinesin"\nמארח: פרופ"מ ארנו ן חן END:VEVENT BEGIN:VEVENT UID:509@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20131225T130000 DTEND;TZID=Asia/Jerusalem:20131225T140000 DTSTAMP:20210802T125834Z URL:https://biology.technion.ac.il/en/seminars/dr-reut-shalgi-department-o f-biology-mit-2/ SUMMARY:Dr. Reut Shalgi\, Department of Biology\, MIT. [No Categories] DESCRIPTION:Location: \n Affiliation: \n Host:\n "Chaperone-mediated regu lation of translation in the mammalian stress response"\nAbstract: \nProte in homeostasis is one of the core principles that living organisms strive to maintain. When protein homeostasis is perturbed\, cells across all king doms unanimously respond by shutting down protein synthesis and upregulati ng molecular chaperones in an effort to cope with misfolding and aggregati on. Investigating translation regulation genome-wide during the heat shock response\, I discovered a novel mode of translational control: translatio n elongation pausing. Elongation pausing appears to be a major part of the translational response to proteotoxic stress in mammalian cells\, affecti ng nearly all mRNAs\, shortly after the encoded nascent peptide emerges fr om the ribosome exit tunnel. Elongation pausing is mediated by Hsp70 chap erones\, and their dynamic association with the ribosome\, which is downre gulated in heat shock. It is therefore emerging that chaperone association with the ribosome serves to regulate translation\, highlighting the impor tance of chaperone-ribosome cross-talk in protecting cells from proteotoxi c stress. \n END:VEVENT BEGIN:VEVENT UID:508@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20131223T130000 DTEND;TZID=Asia/Jerusalem:20131223T140000 DTSTAMP:20210802T125834Z URL:https://biology.technion.ac.il/en/seminars/prof-joel-sussman-the-depar tment-of-structural-biology-the-weizmann-institute-of-science-2/ SUMMARY:Prof. Joel Sussman The Department of Structural Biology The Weizman n Institute of Science [No Categories] DESCRIPTION:Location: \n Affiliation: \n Host:\n "Molecular Basis of How Nerve Agents and \nanti-Alzheimer Drugs Function: 3D Structure \nof Acetyl cholinesterase"\nמארח: פרופ"מ עליאן אכרם END:VEVENT BEGIN:VEVENT UID:507@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20131218T130000 DTEND;TZID=Asia/Jerusalem:20131218T140000 DTSTAMP:20210802T125834Z URL:https://biology.technion.ac.il/en/seminars/dr-oren-ram-molecular-patho logy-massachusetts-general-hospital-broad-institute-of-mit-harvard-univers ity-boston-2/ SUMMARY:Dr. Oren Ram\, Molecular Pathology\, Massachusetts General Hospital \, Broad Institute of MIT & Harvard University\, Boston [No Categories] DESCRIPTION:Location: \n Affiliation: \n Host:\n "CHARTING THE MAMMALIAN CHROMATIN LANDSCAPE: \nFROM MIXED POPULATIONS TO SINGLE CELLS"\n\nAbstract : \nCells of identical genetic background are capable of maintaining drama tically different transcriptional programs that lead to diverse phenotypes . This variety largely depends on the cells’ distinct epigenetic states that are mostly determined by chromatin regulators (CR). Therefore\, inter rogating CR function and their interplay with histone marks is essential f or understanding mechanisms of gene regulation and biological processes su ch as differentiation and cancer. Genome wide maps of chromatin collected by ChIP-seq therefore provide an extraordinary opportunity to dissect the molecular programs that govern cell states. In the first part of my talk I will describe a systematic approach that I developed for profiling a larg e compendium of CRs and discuss some of the underlying biology that revolv es around their modular associations. Typical analysis of chromatin-state is being done on bulk populations and thus reads out an average signal ove r numerous numbers of cells. In some cases\, the cell population of intere st can be heterogeneous (e.g.\, in cancer)\, however this will be missed. In the second part of my talk I will present an innovative single cell ChI P-seq microfluidic technology\, which can be used to infer sub-populations of cells based on their distinct histone modification profiles. Leveragin g our novel technology\, we were able to uncover two main subpopulations o f embryonic stem cells\, mainly\, one group which is enriched for active h istone mark over pluripotent related loci and a second which exhibit chrom atin organization associated with early differentiation. Altogether\, this technology holds a great potential to tease out novel aspects of chromati n based regulation.\n END:VEVENT BEGIN:VEVENT UID:506@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20131216T130000 DTEND;TZID=Asia/Jerusalem:20131216T140000 DTSTAMP:20210802T125834Z URL:https://biology.technion.ac.il/en/seminars/prof-benjamin-podbilewicz-f aculty-of-biology-technion-2/ SUMMARY:Prof. Benjamin Podbilewicz Faculty of Biology Technion [No Categori es] DESCRIPTION:Location: \n Affiliation: \n Host:\n “Searching for the mec hanism of cell-cell fusion: Our journey from a whole organism to a cell-fr ee system"\n (ayoubn@tx.technion.ac.il ) מארח: פרופ"מ נביה איוב END:VEVENT BEGIN:VEVENT UID:505@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20131209T130000 DTEND;TZID=Asia/Jerusalem:20131209T140000 DTSTAMP:20210802T125833Z URL:https://biology.technion.ac.il/en/seminars/prof-gil-ast-department-of- human-molecular-genetics-biochemistry-tel-aviv-university-3/ SUMMARY:Prof. Gil Ast Department of Human Molecular Genetics & Biochemistr y Tel-Aviv University [No Categories] DESCRIPTION:Location: \n Affiliation: \n Host:\n “How DNA methylation a nd chromatin organization regulate alternative splicing" ayoubn@tx.technio n.ac.il ) מארח: פרופ"מ נביה איוב END:VEVENT BEGIN:VEVENT UID:504@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20131202T130000 DTEND;TZID=Asia/Jerusalem:20131202T140000 DTSTAMP:20210802T125833Z URL:https://biology.technion.ac.il/en/seminars/dr-dan-levy-department-of-m icrobiology-immunology-and-genetics-faculty-of-health-sciences-ben-gurion- university-of-the-negev-2/ SUMMARY:Dr. Dan Levy Department of Microbiology\, Immunology and Genetics F aculty of Health Sciences Ben Gurion University of the Negev [No Categorie s] DESCRIPTION:Location: \n Affiliation: \n Host:\n “Lysine methylation in inflammation and cancer"\n (ayoubn@tx.technion.ac.il ) מארח: פרו פ"מ נביה איוב\n\n END:VEVENT BEGIN:VEVENT UID:503@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20131125T103000 DTEND;TZID=Asia/Jerusalem:20131125T113000 DTSTAMP:20210802T125833Z URL:https://biology.technion.ac.il/en/seminars/prof-marvin-p-wickens-depar tment-of-biochemistry-university-of-wisconsin-madison-2/ SUMMARY:Prof. Marvin P Wickens Department of Biochemistry\, University of W isconsin\, Madison [No Categories] DESCRIPTION:Location: \n Affiliation: \n Host:\n Regulating mRNAs: PUFs\, partners and perspective"" END:VEVENT BEGIN:VEVENT UID:502@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20131125T090000 DTEND;TZID=Asia/Jerusalem:20131125T100000 DTSTAMP:20210802T125833Z URL:https://biology.technion.ac.il/en/seminars/prof-judith-kimble-howard-h ughes-medical-institute-department-of-biochemistry-university-of-wisconsin -madison-2/ SUMMARY:Prof. Judith Kimble Howard Hughes Medical Institute\, Department o f Biochemistry\, University of Wisconsin\, Madison [No Categories] DESCRIPTION:Location: \n Affiliation: \n Host:\n "A model stem cell niche and its control of self-renewal and differentiation"\n END:VEVENT BEGIN:VEVENT UID:501@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20131118T130000 DTEND;TZID=Asia/Jerusalem:20131118T140000 DTSTAMP:20210802T125833Z URL:https://biology.technion.ac.il/en/seminars/dr-arren-bar-even-departmen t-of-plant-sciences-weizmann-institute-of-science-ron-milos-lab-2/ SUMMARY:Dr. Arren Bar-Even Department of Plant Sciences Weizmann Institute of Science (Ron Milo's lab) [No Categories] DESCRIPTION:Location: \n Affiliation: \n Host:\n “Engineering efficient growth on C1 compounds by uncovering metabolic design principles"\nמאר חת: פרופ"מ סיגל סבלדי END:VEVENT BEGIN:VEVENT UID:500@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20131111T130000 DTEND;TZID=Asia/Jerusalem:20131111T140000 DTSTAMP:20210802T125833Z URL:https://biology.technion.ac.il/en/seminars/dr-tom-shemesh-department-o f-cell-biology-harvard-medical-school-tom-rapoports-lab-2/ SUMMARY:Dr. Tom Shemesh Department of Cell Biology\, Harvard Medical School (Tom Rapoport's lab) [No Categories] DESCRIPTION:Location: \n Affiliation: \n Host:\n “Membrane proteins tha t sculpt the morphologies of the endoplasmic reticulum"\n(philippa@techuni x.technion.ac.il) מארח: פרופ"ח פיליפה מלמד\n END:VEVENT BEGIN:VEVENT UID:499@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20131104T130000 DTEND;TZID=Asia/Jerusalem:20131104T140000 DTSTAMP:20210802T125833Z URL:https://biology.technion.ac.il/en/seminars/dr-shenhav-cohen-faculty-of -biology-technion-2/ SUMMARY:Dr. Shenhav Cohen Faculty of Biology Technion [No Categories] DESCRIPTION:Location: \n Affiliation: \n Host:\n “Muscle turnover by th e ubiquitin-proteasome system: novel key players"\n\n (ayoubn@tx.technion. ac.il ) מארח: פרופ"מ נביה איוב\n END:VEVENT BEGIN:VEVENT UID:498@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20131028T123000 DTEND;TZID=Asia/Jerusalem:20131028T133000 DTSTAMP:20210802T125833Z URL:https://biology.technion.ac.il/en/seminars/dr-yaron-fuchs-strang-labor atory-of-apoptosis-and-cancer-biology-hhmi-the-rockefeller-university-new- york-2/ SUMMARY:Dr. Yaron Fuchs\, Strang Laboratory of Apoptosis and Cancer Biology \, HHMI/The Rockefeller University\, New York [No Categories] DESCRIPTION:Location: \n Affiliation: \n Host:\n "Stem cells and apoptosi s- A Matter of Life and Death"\n (philippa@tx.technion.ac.il ) מארח ת: פרופ"ח פיליפה מלמד END:VEVENT BEGIN:VEVENT UID:497@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20131021T123000 DTEND;TZID=Asia/Jerusalem:20131021T133000 DTSTAMP:20210802T125833Z URL:https://biology.technion.ac.il/en/seminars/dr-haguy-wolfenson-departme nt-of-biological-sciences-columbia-university-new-york-2/ SUMMARY:Dr. Haguy Wolfenson\, Department of Biological Sciences\, Columbi a University\, New York [No Categories] DESCRIPTION:Location: \n Affiliation: \n Host:\n "Mechanisms of Cellular Sensing of Extracellular Matrix Rigidity: Nanometer- and Millisecond-scale Measurements Show How Rigidity Sensing by Lamellipodial Contractile Units is Regulated"\n (arnon.henn@technion.ac.il ) מארח: פרופ"מ אר נון חן END:VEVENT BEGIN:VEVENT UID:496@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20130708T130000 DTEND;TZID=Asia/Jerusalem:20130708T140000 DTSTAMP:20210802T125833Z URL:https://biology.technion.ac.il/en/seminars/%d7%a1%d7%9e%d7%99%d7%a0%d7 %a8-%d7%90%d7%95%d7%a8%d7%97-8/ SUMMARY:סמינר אורח [No Categories] DESCRIPTION:Location: \n Affiliation: \n Host:\n \nDr. Yael Mutsafi (From Avi Minsky lab)\nDepartment of Organic Chemistry\nThe Weizmann Institute of Science\n \n\nTitle: בנושא:\n"Structural studie s of the assembly of giant viruses"\n\n\nמארחת: פרופ"ח דבי ל ינדל \n\n\nההרצאה תתקיים באודיטוריום\, בבני ין הפקולטה לביולוגיה.\n END:VEVENT BEGIN:VEVENT UID:495@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20130701T130000 DTEND;TZID=Asia/Jerusalem:20130701T140000 DTSTAMP:20210802T125833Z URL:https://biology.technion.ac.il/en/seminars/%d7%a1%d7%9e%d7%99%d7%a0%d7 %a8-%d7%90%d7%95%d7%a8%d7%97-7/ SUMMARY:סמינר אורח [No Categories] DESCRIPTION:Location: \n Affiliation: \n Host:\n Prof. Moran Bercovici\nF aculty of Mechanical Engineering\nHead\, Technion Microfluidic Technologie s Laboratory\nTechnion\, Haifa \n\nTitle: בנושא:\n "10 pL virtual vials for 10\,000-fold ac celerated DNA hybridization"\n\n\n מארח: פרופ"מ נביה איו ב\n\n\nההרצאה תתקיים באודיטוריום\, בבניין ה פקולטה לביולוגיה.\n END:VEVENT BEGIN:VEVENT UID:493@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20130617T130000 DTEND;TZID=Asia/Jerusalem:20130617T140000 DTSTAMP:20210802T132214Z URL:https://biology.technion.ac.il/en/seminars/%d7%a1%d7%9e%d7%99%d7%a0%d7 %a8-%d7%90%d7%95%d7%a8%d7%97-5/ SUMMARY:סמינר אורח [No Categories] DESCRIPTION:Location: \n Affiliation: \n Host:\n Prof. Moshe Inbar\nDepar tment of Evolutionary &\; Environmental Biology\nUniversity of Haifa\n\ nTitle: בנושא:\n“Direct interactions between herbivores: mammalian bad breath is life-saving”\n\n(beja@techunix.technion.ac.il) מארח: פרופ' עודד בז'ה\nההרצאה תתקיים באודיטוריו ם\, בבניין הפקולטה לביולוגיה. 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