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BEGIN:VCALENDAR VERSION:2.0 PRODID:-//wp-events-plugin.com//6.6.4.4//EN TZID:Asia/Jerusalem X-WR-TIMEZONE:Asia/Jerusalem BEGIN:VEVENT UID:1328@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20260629T130000 DTEND;TZID=Asia/Jerusalem:20260629T140000 DTSTAMP:20251029T121516Z URL:https://biology.technion.ac.il/en/seminars/faculty-seminar-prof-avraha m-yaron/ SUMMARY:Faculty Seminar- Prof. Avraham Yaron [No Categories] DESCRIPTION:Location: Faculty Of Biology Auditorium \n Affiliation: Weizma nn Institute of Science\n Host:Dr\, Maya Maor-Nof \n LOCATION:Faculty Of Biology Auditorium END:VEVENT BEGIN:VEVENT UID:1327@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20260615T130000 DTEND;TZID=Asia/Jerusalem:20260615T140000 DTSTAMP:20251029T121400Z URL:https://biology.technion.ac.il/en/seminars/faculty-seminar-dr-eyal-kar zbrun/ SUMMARY:Faculty Seminar- Dr. Eyal Karzbrun [No Categories] DESCRIPTION:Location: Faculty Of Biology Auditorium \n Affiliation: Weizma nn Institute of Science\n Host:Dr\, Maya Maor-Nof \n LOCATION:Faculty Of Biology Auditorium END:VEVENT BEGIN:VEVENT UID:1326@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20260608T130000 DTEND;TZID=Asia/Jerusalem:20260608T140000 DTSTAMP:20251029T121203Z URL:https://biology.technion.ac.il/en/seminars/faculty-seminar-dr-abed-man sour/ SUMMARY:Faculty Seminar- Dr. Abed Mansour [No Categories] DESCRIPTION:Location: Faculty Of Biology Auditorium \n Affiliation: The He brew University of Jerusalem\n Host:Dr\, Maya Maor-Nof \n LOCATION:Faculty Of Biology Auditorium END:VEVENT BEGIN:VEVENT UID:1325@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20260601T130000 DTEND;TZID=Asia/Jerusalem:20260601T140000 DTSTAMP:20251029T121100Z URL:https://biology.technion.ac.il/en/seminars/faculty-seminar-dr-shahar-a lon/ SUMMARY:Faculty Seminar- Dr. Shahar Alon [No Categories] DESCRIPTION:Location: Faculty Of Biology Auditorium \n Affiliation: Bar I lan University\n Host:Dr\, Maya Maor-Nof \n 13 LOCATION:Faculty Of Biology Auditorium END:VEVENT BEGIN:VEVENT UID:1324@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20260518T130000 DTEND;TZID=Asia/Jerusalem:20260518T140000 DTSTAMP:20251029T120923Z URL:https://biology.technion.ac.il/en/seminars/faculty-seminar-dr-inbal-be nhar/ SUMMARY:Faculty Seminar- Dr. Inbal Benhar [No Categories] DESCRIPTION:Location: Faculty Of Biology Auditorium \n Affiliation: The He brew University of Jerusalem\n Host:Dr\, Maya Maor-Nof \n LOCATION:Faculty Of Biology Auditorium END:VEVENT BEGIN:VEVENT UID:1323@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20260511T130000 DTEND;TZID=Asia/Jerusalem:20260511T140000 DTSTAMP:20251029T120819Z URL:https://biology.technion.ac.il/en/seminars/faculty-seminar-dr-aldema-s as-chen/ SUMMARY:Faculty Seminar- Dr. Aldema Sas-Chen [No Categories] DESCRIPTION:Location: Faculty Of Biology Auditorium \n Affiliation: Tel Av iv University\n Host:Dr\, Maya Maor-Nof \n LOCATION:Faculty Of Biology Auditorium END:VEVENT BEGIN:VEVENT UID:1322@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20260504T130000 DTEND;TZID=Asia/Jerusalem:20260504T140000 DTSTAMP:20251029T120703Z URL:https://biology.technion.ac.il/en/seminars/faculty-seminar-prof-ofer-y izhar/ SUMMARY:Faculty Seminar- Prof. Ofer Yizhar [No Categories] DESCRIPTION:Location: Faculty Of Biology Auditorium \n Affiliation: Weizma nn Institute of Science\n Host:Dr\, Maya Maor-Nof \n LOCATION:Faculty Of Biology Auditorium END:VEVENT BEGIN:VEVENT UID:1321@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20260427T130000 DTEND;TZID=Asia/Jerusalem:20260427T140000 DTSTAMP:20251029T120404Z URL:https://biology.technion.ac.il/en/seminars/faculty-seminar-prof-mike-f ainzilber/ SUMMARY:Faculty Seminar-Prof. Mike Fainzilber [No Categories] DESCRIPTION:Location: Faculty Of Biology Auditorium \n Affiliation: Weizma nn Institute of Science\n Host:Dr\, Maya Maor-Nof \n LOCATION:Faculty Of Biology Auditorium END:VEVENT BEGIN:VEVENT UID:1320@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20260420T130000 DTEND;TZID=Asia/Jerusalem:20260420T140000 DTSTAMP:20251029T120038Z URL:https://biology.technion.ac.il/en/seminars/faculty-seminar-prof-eran-m osherer/ SUMMARY:Faculty Seminar-Prof. Eran Mosherer [No Categories] DESCRIPTION:Location: Faculty Of Biology Auditorium \n Affiliation: The He brew University of Jerusalem\n Host:Dr\, Maya Maor-Nof \n 1 LOCATION:Faculty Of Biology Auditorium END:VEVENT BEGIN:VEVENT UID:1319@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20260413T130000 DTEND;TZID=Asia/Jerusalem:20260413T140000 DTSTAMP:20251029T115929Z URL:https://biology.technion.ac.il/en/seminars/faculty-seminar-dr-iris-dro r/ SUMMARY:Faculty Seminar- Dr. Iris Dror [No Categories] DESCRIPTION:Location: Faculty Of Biology Auditorium \n Affiliation: MIGAL - Galilee Research Institute\n Host:Dr\, Maya Maor-Nof \n LOCATION:Faculty Of Biology Auditorium END:VEVENT BEGIN:VEVENT UID:1318@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20260330T130000 DTEND;TZID=Asia/Jerusalem:20260330T140000 DTSTAMP:20251029T115752Z URL:https://biology.technion.ac.il/en/seminars/faculty-seminar-assistant-p rofessor-itay-koren/ SUMMARY:Faculty Seminar-Assistant Prof. Itay Koren [No Categories] DESCRIPTION:Location: Faculty Of Biology Auditorium \n Affiliation: Bar Il an University\n Host:Dr\, Maya Maor-Nof \n LOCATION:Faculty Of Biology Auditorium END:VEVENT BEGIN:VEVENT UID:1317@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20260126T130000 DTEND;TZID=Asia/Jerusalem:20260126T140000 DTSTAMP:20251029T115559Z URL:https://biology.technion.ac.il/en/seminars/faculty-seminar-prof-yakub- hanna/ SUMMARY:Faculty Seminar- Prof. Yakub Hanna [No Categories] DESCRIPTION:Location: Faculty Of Biology Auditorium \n Affiliation: Weizm ann Institute of Science\n Host:Dr\, Maya Maor-Nof \n LOCATION:Faculty Of Biology Auditorium END:VEVENT BEGIN:VEVENT UID:1316@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20251201T130000 DTEND;TZID=Asia/Jerusalem:20251201T140000 DTSTAMP:20251029T115427Z URL:https://biology.technion.ac.il/en/seminars/faculy-seminar-dr-ifat-sher -rosenthal/ SUMMARY:Faculy Seminar-Dr. Ifat Sher-Rosenthal [No Categories] DESCRIPTION:Location: Faculty Of Biology Auditorium \n Affiliation: Shiba Medical Center\n Host:Dr\, Maya Maor-Nof \n LOCATION:Faculty Of Biology Auditorium END:VEVENT BEGIN:VEVENT UID:1315@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20251124T130000 DTEND;TZID=Asia/Jerusalem:20251124T140000 DTSTAMP:20251029T115249Z URL:https://biology.technion.ac.il/en/seminars/faculty-seminar-prof-schrag i-shwartz/ SUMMARY:Faculty Seminar-Prof. Schragi Shwartz [No Categories] DESCRIPTION:Location: Faculty Of Biology Auditorium \n Affiliation: Weizma nn Institute of Science\n Host:Dr\, Maya Maor-Nof \n 1 LOCATION:Faculty Of Biology Auditorium END:VEVENT BEGIN:VEVENT UID:1314@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20251117T130000 DTEND;TZID=Asia/Jerusalem:20251117T140000 DTSTAMP:20251029T115128Z URL:https://biology.technion.ac.il/en/seminars/faculty-seminar-dr-dvir-ara n/ SUMMARY:Faculty Seminar- Dr. Dvir Aran [No Categories] DESCRIPTION:Location: Faculty Of Biology Auditorium \n Affiliation: \n Hos t:Dr\, Maya Maor-Nof \n 1 LOCATION:Faculty Of Biology Auditorium END:VEVENT BEGIN:VEVENT UID:1329@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20251112T130000 DTEND;TZID=Asia/Jerusalem:20251112T140000 DTSTAMP:20251105T082510Z URL:https://biology.technion.ac.il/en/seminars/phd-graduate-seminar-dharan ibalan-kasiviswanathan/ SUMMARY:PhD Graduate Seminar-Dharanibalan Kasiviswanathan [No Categories] DESCRIPTION:Location: Faculty Of Biology Auditorium/ZOOMhttps://technion.zo om.us/j/99692061614 Dharanibalan Kasiviswanathan\n Affiliation: \n Host: Associate Prof. Shenhav Shemer\n  \;\n\nA controlled in vitro model o f disuse atrophy reveals that skeletal muscle drives its own wasting via e xtracellular vesicles \n\nWe established a controlled in vitro model of m uscle disuse using simulated microgravity\, eliminating systemic influence s. This model accurately recapitulates transcriptional and proteomic signa tures of inactive muscles in vivo. We discovered that extracellular vesicl es (EVs) secreted by unloaded myotubes induce catabolic signaling in recip ient muscle cells. Our findings reveal that skeletal muscle can drive its own disuse atrophy through EV-mediated communication. LOCATION:Faculty Of Biology Auditorium/ZOOMhttps://technion.zoom.us/j/99692 061614 END:VEVENT BEGIN:VEVENT UID:1313@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20251110T130000 DTEND;TZID=Asia/Jerusalem:20251110T140000 DTSTAMP:20251103T160826Z URL:https://biology.technion.ac.il/en/seminars/faculty-semninr-professor-g il-ast/ SUMMARY:Faculty Semninr: Professor Gil Ast- 3D Genome Organization Directs Alternative Splicing [No Categories] DESCRIPTION:Location: Faculty Of Biology Auditorium \n Affiliation: Tel Av iv University\n Host:Dr\, Maya Maor-Nof \n I am very happy to open this ye ar’s Faculty Seminar Series at 1:00 p.m. on Monday\, November 10\, with a talk by Prof. Gil Ast of Tel Aviv University. Prof. Ast will present a talk titled “3D Genome Organization Directs Alternative Splicing.”\n\n  \;\n\nYou’re invited to enjoy pizza at 12:30 p.m. on Monday\, Novem ber 10\, at the Biology Auditorium.\n\n \;\n\nTalk Abstract:\nAlternat ive splicing is a major contributor to the creation of human genomic compl exity. However\, this comes at a price: it also contributes dramatically t o higher levels of genetic disorders and cancer. Understanding how alterna tive splicing drives human complexity is one of the major questions we add ress in my lab. We were the first to show that chromatin organization and epigenetic markers regulate alternative splicing. We demonstrated that the y exert this regulation by modulating the elongation rate of RNA polymeras e II. We further discovered that the genome contains two distinct gene arc hitectures—one that primarily resides in the nuclear center and another in the nuclear periphery. Cancer-associated mutations in each of these arc hitectures lead to different outcomes on alternative splicing. Overall\, I will present how 3D genome organization directs alternative splicing.\n\n  \;\n\nSome details about his research and publications can be found a t:\nhttps://www.astlab.sites.tau.ac.il/\n\n \;\n\nLooking forward to s eeing you!\nMaya\n\n \; LOCATION:Faculty Of Biology Auditorium END:VEVENT BEGIN:VEVENT UID:1312@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20251021T130000 DTEND;TZID=Asia/Jerusalem:20251021T140000 DTSTAMP:20251015T082649Z URL:https://biology.technion.ac.il/en/seminars/phd-graduate-seminar-berta- eliad/ SUMMARY:PhD Graduate Seminar-Berta Eliad [No Categories] DESCRIPTION:Location: Hybrid - in the Faculty Auditorium /ZOOM: https://tec hnion.zoom.us/j/99589054205 Berta Eliad\n Affiliation: \n Host : Associate Prof. Ayelet Lamm \n “Game of Edits” - A-to-I RNA Editi ng: Thrones of Regulation\, Gametogenesis and Embryogenesis\n\n \;\n\n Adenosine-to-inosine (A-to-I) RNA editing\, catalyzed by ADARs\, is a wide spread and evolutionarily conserved modification needed to regulate innate immunity. Using C. elegans\, a powerful model for RNA editing research\, we reveal that ADAR subcellular localization affects its substrate prefere nces and function. We show that edited transcripts are maternally\, but no t paternally\, inherited\, and editing levels fluctuate during embryogenes is\, probably to control transcript expression.  LOCATION:Hybrid - in the Faculty Auditorium /ZOOM: https://technion.zoom.us /j/99589054205 END:VEVENT BEGIN:VEVENT UID:1310@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20250918T130000 DTEND;TZID=Asia/Jerusalem:20250918T133000 DTSTAMP:20250914T105138Z URL:https://biology.technion.ac.il/en/seminars/msc-graduate-seminar-barak- gutman/ SUMMARY:MSc Graduate Seminar-Barak Gutman [No Categories] DESCRIPTION:Location: Hybrid - in the Faculty Auditorium /ZOOM: https://tec hnion.zoom.us/j/95647741443 Barak Gutman\n Affiliation: \n Host:Dr. Dvir Aran\n  \;\n\nImmune Profiling in CD59 Deficiency: From Single-Patient scRNA-seq to Therapeutic Insights\n\nCD59 deficiency is a rare disorder i n which cells are vulnerable to uncontrolled complement-mediated immune at tacks. To investigate its mechanisms of action\, we applied single-cell RN A sequencing (scRNA-seq) to peripheral blood mononuclear cells (PBMCs). Be cause only one CD59-deficient patient sample was available\, we developed a pairwise differential expression pipeline that leverages multiple matche d controls and significantly reduces false-positive discoveries. Using thi s approach\, we uncovered a distinct exhausted immune profile marked by do wnregulation of NF-κB signaling and evidence of oxidative stress\, findin gs that illuminate the pathophysiology of CD59 deficiency and also suggest potential avenues for therapeutic intervention LOCATION:Hybrid - in the Faculty Auditorium /ZOOM: https://technion.zoom.us /j/95647741443 END:VEVENT BEGIN:VEVENT UID:1311@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20250916T133000 DTEND;TZID=Asia/Jerusalem:20250916T140000 DTSTAMP:20250914T110634Z URL:https://biology.technion.ac.il/en/seminars/msc-graduate-seminar-valeri a-tsvichenko/ SUMMARY:MSc Graduate Seminar- Valeria Tsvichenko [No Categories] DESCRIPTION:Location: Hybrid - in the Faculty Auditorium /ZOOM: https://tec hnion.zoom.us/j/95522568296 Valeria Tsvichenko\n Affiliation: \n Host:P rof. Debbie Lindell \n Phage Resistance in Synechococcus sp. WH8109 \n\n& nbsp\;\n\nPhage resistance plays a central role in shaping cyanobacterial population dynamics and their interactions with viruses in the ocean. The coexistence of resistant and susceptible cells is likely one of the proces ses enabling hosts and phages to persist together. Yet the patterns and ge netic basis of resistance are only partially resolved. Here\, I examined g enetically distinct populations of Synechococcus sp. WH8109 and found that resistance to the cyanophages Syn9 and S-TIP37 was consistently density-d ependent across host populations. Whole genome sequencing of Syn9-resistan t cyanobacteria revealed mutations in nine genes in the resistant strains. In a complementary approach\, I investigated two porin-like genes previou sly implicated in resistance to phages S-TIP37 and Syn5. However\, heterol ogous binding assays in E. coli did not conclusively establish their role in phage resistance. Together\, these studies integrate ecological and gen etic perspectives to advance understanding of the processes that govern ho st–phage coexistence in marine systems. LOCATION:Hybrid - in the Faculty Auditorium /ZOOM: https://technion.zoom.us /j/95522568296 END:VEVENT BEGIN:VEVENT UID:1308@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20250916T130000 DTEND;TZID=Asia/Jerusalem:20250916T133000 DTSTAMP:20250909T054729Z URL:https://biology.technion.ac.il/en/seminars/msc-graduate-seminar-dolev- shmaltz/ SUMMARY:MSc Graduate Seminar-Dolev Shmaltz-Ayal [No Categories] DESCRIPTION:Location: Hybrid - in the Faculty Auditorium /ZOOM: https://tec hnion.zoom.us/j/95522568296 Dolev Shmaltz\n Affiliation: \n Host:Prof. Yo ram Reiter \n Inside and Out: Antigen Type Shapes T-Cell Engager Performan ce Across Intracellular and Extracellular Targets\n\n \;\n\nBi-specifi c T-cell engagers (BiTEs) are engineered antibodies that redirect a patien t’s own T cells to attack tumors\, providing an “off-the-shelf” immu notherapy option alongside cell-based therapies like CAR T cells. Most BiT Es focus on surface proteins\, yet many of the most clinically relevant tu mor antigens reside inside the cell and are displayed only as peptide–MH C complexes. In this work\, we directly compared BiTEs targeting a convent ional melanoma surface antigen (MCSP) with BiTEs recognizing an intracellu lar peptide presented by HLA. Through analysis of T-cell activation\, cyto kine release\, and tumor cell killing across a range of antigen densities\ , we demonstrate that the route of antigen presentation decisively shapes therapeutic potency and functional outcomes. LOCATION:Hybrid - in the Faculty Auditorium /ZOOM: https://technion.zoom.us /j/95522568296 END:VEVENT BEGIN:VEVENT UID:1309@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20250915T130000 DTEND;TZID=Asia/Jerusalem:20250915T140000 DTSTAMP:20250911T115612Z URL:https://biology.technion.ac.il/en/seminars/phd-graduate-seminar-christ oph-velling/ SUMMARY:PhD Graduate Seminar-Christoph Velling [No Categories] DESCRIPTION:Location: Hybrid - in the Faculty Auditorium /ZOOM: https://tec hnion.zoom.us/j/91646006232?pwd=qONDv5ujifMHOeKsXdQ2W5zByVjAF2.1 Christop h Velling\n Affiliation: \n Host:Prof. Roy Kishony \n Spatio-temporal micr obial evolution dynamics\n\n In natural microbial communities\, antagonis tic interactions among bacterial species\, or between bacteria and phages\ , are important drivers of community evolution and ecological dynamics. Th ese natural environments often involve spatial structure\, which could be a key factor for evolutionary processes as well as for expansion dynamics into new spaces\, yet it is often neglected in microbial community experim entation and simulations. In this project\, we first studied evolution of antibiotic producers in microdroplets\, effectively forming small\, distin ct environments where direct competition with resistant bacteria is exclud ed and\, therefore\, selection for producers can occur. In the second part \, we modeled bacteria-phage interactions in an expanding bacterial wave i n space. We show how phage-resistant bacteria can protect sensitive bacter ia through an indirect slowdown of phage migration in a competition scenar io and how phages could potentially overcome this protection mechanism. To gether\, these studies help shed light on the complex spatio-temporal dyna mics of antagonistically interacting microbial species. LOCATION:Hybrid - in the Faculty Auditorium /ZOOM: https://technion.zoom.us /j/91646006232?pwd=qONDv5ujifMHOeKsXdQ2W5zByVjAF2.1 END:VEVENT BEGIN:VEVENT UID:1305@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20250909T133000 DTEND;TZID=Asia/Jerusalem:20250909T140000 DTSTAMP:20250904T132848Z URL:https://biology.technion.ac.il/en/seminars/msc-graduate-seminar-tylor- brent-de-leon/ SUMMARY:MSc Graduate Seminar-Tylor-Tyler Brent de Leon [No Categories] DESCRIPTION:Location: Hybrid - in the Faculty Auditorium /ZOOM: - https:// technion.zoom.us/j/4885283424 Tylor-Brent De-Leon\n Affiliation: \n Host: Prof. Yoav Arava \n Locally synthesized glycyl aminoacyl tRNA synthetase ( GARS1) is important for  local translation in neurons\n\nRegulation of ge ne expression is essential for neuronal development and function. A promin ent regulatory mechanism involves synthesis of proteins at their activity site. Such local protein synthesis enables neurons to respond rapidly and tightly to stimuli. Key components of the translation machinery\, includin g mRNA and ribosomes\, were identified in subcellular regions of neurons. Yet\, the role of tRNAs and their charging enzymes\, aminoacyl tRNA synthe tases (aaRS)\, in this process remains largely unclear. Here\, we demonstr ate that glycyl tRNA synthetase (GARS1) mRNA is abundant in neurites and u ndergoes local translation\, producing GARS1 protein. Localized GARS1 prot ein is in close proximity to tRNAGly\, and disrupting this interaction imp airs local protein synthesis in neurites. Notably\, in a neuropathy-causin g mutant variant of GARS1\, we observed enhanced proximity to tRNAGly\, in dicating that altered GARS1– tRNAGly interactions may contribute to dise ase pathogenesis. These findings establish the functional importance of GA RS1 and tRNAGly in neuritic translation and suggest a mechanism for periph eral neuropathies due to mutations in GARS1. LOCATION:Hybrid - in the Faculty Auditorium /ZOOM: - https://technion.zoom .us/j/4885283424 END:VEVENT BEGIN:VEVENT UID:1304@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20250909T130000 DTEND;TZID=Asia/Jerusalem:20250909T133000 DTSTAMP:20250904T114048Z URL:https://biology.technion.ac.il/en/seminars/msc-graduate-seminar-dina-a lexandrovich/ SUMMARY:MSc Graduate Seminar-Dina Alexandrovich [No Categories] DESCRIPTION:Location: Hybrid - in the Faculty Auditorium /ZOOM:- https://te chnion.zoom.us/j/4885283424 Dina Alexandrovich\n Affiliation: \n Host:P rof. Yael Mandel-Gutfreund \n Developing computational approaches for pred icting nucleic acid binding proteins and their targets\n\n \;\n\nNucle ic acid binding proteins\, and specifically DNA-binding proteins (DBPs) an d RNA-binding proteins (RBPs)\, play a central role in all steps of the ge ne expression pathway\, from RNA transcription via post-transcriptional re gulation to protein translation. Understanding the complexity of gene expr ession regulation requires the identification of RBPs and DBPs\, which are involved in these processes\, and to define their binding sites. To addre ss these challenges\, we developed BindUP-Alpha\, a machine learning-based algorithm for predicting nucleic acid-binding proteins based on protein s tructure models from AlphaFold.We also developed intRBP\, a deep learning model trained on high-throughput RNA-binding data\, which accurately predi cts the targets of RNA-binding proteins. LOCATION:Hybrid - in the Faculty Auditorium /ZOOM:- https://technion.zoom.u s/j/4885283424 END:VEVENT BEGIN:VEVENT UID:1307@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20250908T133000 DTEND;TZID=Asia/Jerusalem:20250908T140000 DTSTAMP:20250907T065924Z URL:https://biology.technion.ac.il/en/seminars/msc-graduate-seminar-netane l-amiel/ SUMMARY:MSc Graduate Seminar-Netanel Amiel [No Categories] DESCRIPTION:Location: Hybrid - in the Faculty Auditorium /ZOOM: https://tec hnion.zoom.us/j/95534105252 Netanel Amiel\n Affiliation: \n Host:Associat e Prof. David Meiri \n The cumulative effect of cannabinoids on the immun e system in IBD mouse models\n\n \;\n\nInflammatory bowel disease (IBD ) is a chronic\, relapsing inflammatory disorder of the gastrointestinal t ract\, and current therapies often rely on immunosuppression with limited long-term success. To explore alternative strategies\, we examined the pot ential of cannabinoids to modulate both adaptive and innate immune pathway s relevant to IBD. Previous work in our lab showed that cannabidiolic acid (CBDA) affected the adaptive immune system by reducing pro-inflammatory T cell responses\, while a combination of cannabidiol (CBD) and cannabidiva rin (CBDV) acted on innate immunity by limiting CXCR4-dependent recruitmen t of inflammatory cells to the gut. We hypothesized that combining these c ompounds might provide additive or synergistic benefits by targeting compl ementary arms of the immune system. Using both acute and chronic DSS-induc ed colitis models in mice\, we assessed disease severity under separate an d combined treatments. While each treatment effectively reduced disease se verity\, the combination did not yield additive effects\, pointing the nee d for further exploration of cannabinoids in gut inflammation LOCATION:Hybrid - in the Faculty Auditorium /ZOOM: https://technion.zoom.us /j/95534105252 END:VEVENT BEGIN:VEVENT UID:1306@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20250908T130000 DTEND;TZID=Asia/Jerusalem:20250908T133000 DTSTAMP:20250904T115224Z URL:https://biology.technion.ac.il/en/seminars/msc-graduate-seminar-hannah -eda-rand/ SUMMARY:MSc Graduate Seminar-Hannah Eda Rand [No Categories] DESCRIPTION:Location: Hybrid - in the Faculty Auditorium /ZOOM: https://tec hnion.zoom.us/j/95534105252 Hannah Eda Rand\n Affiliation: \n Host:Dr. Na dav Sharon \n Investigating MMP12⁺ Macrophages as Potential Modulators o f Islet Vulnerability in Type 1 Diabetes\n\nType 1 diabetes is an autoimmu ne disease that leads to the selective destruction of insulin-producing pa ncreatic beta cells in the islets of Langerhans. Notably\, MMP12-expressin g macrophages appear predominantly in non-attacked islets. In line with th eir reported anti-inflammatory function in cancer\, we hypothesize that MM P12⁺ macrophages may play a protective role in T1D. To test this\, I use RNAscope to validate the scRNAseq findings in Non-Obese Diabetic (NOD) mi ce\, spatial transcriptomics to confirm their presence in human tissue\, a nd am working to create a transgenic mouse model to manipulate the cells. LOCATION:Hybrid - in the Faculty Auditorium /ZOOM: https://technion.zoom.us /j/95534105252 END:VEVENT BEGIN:VEVENT UID:1303@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20250826T130000 DTEND;TZID=Asia/Jerusalem:20250826T140000 DTSTAMP:20250724T080246Z URL:https://biology.technion.ac.il/en/seminars/phd-graduate-seminar-jonath an-ram/ SUMMARY:PhD Graduate Seminar-Jonathan Ram [No Categories] DESCRIPTION:Location: Hybrid - in the Faculty Auditorium /ZOOM: https://tec hnion.zoom.us/j/93938772814 Jonathan Ram\n Affiliation: \n Host:Prof. Mic hael Glickman\n  \;\n\nNew players in mitochondrial protein import qua lity control13\n\nMitochondria import most of their proteins from the cyto sol via dedicated channels in the outer membrane. This process is complex\ , and import can occasionally stall when proteins get stuck in transit. Wh ile the role of the ubiquitin–proteasome system (UPS) in this context is well established in yeast\, it remains poorly understood in mammalian cel ls. We performed a proximity-based screen to identify UPS components near the mitochondrial import channel and uncovered novel interactors. Among th em\, we identified UBXD8 and investigated its role in the quality control of mitochondrial protein import. These findings not only expand our unders tanding of mitochondrial proteostasis in mammals\, but also reveal UBXD8 a s a potential regulator of import channel homeostasis. LOCATION:Hybrid - in the Faculty Auditorium /ZOOM: https://technion.zoom.us /j/93938772814 END:VEVENT BEGIN:VEVENT UID:1302@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20250819T130000 DTEND;TZID=Asia/Jerusalem:20250819T140000 DTSTAMP:20250722T113934Z URL:https://biology.technion.ac.il/en/seminars/phd-graduate-seminar-sunu-j oseph/ SUMMARY:PhD Graduate Seminar-Sunu Joseph [No Categories] DESCRIPTION:Location: Sunu Joseph\n Affiliation: \n Host:Associate Prof. Shenhav Shemer\n 13\n\nThe ubiquitin-proteasome system plays a crucial ro le in excessive muscle proteolysis during atrophy\, a condition triggered by inactivity\, starvation\, aging\, cancer\, and muscular dystrophies. Wh ile ubiquitin ligases (E3s) have been extensively studied in this process\ , the functions of E2 conjugating enzymes\, which facilitate ubiquitin tra nsfer with E3s\, remain poorly understood. Ube2h is an E2 ubiquitin-conjug ating enzyme with less understood cellular functions compared to E3 ligase s. Ube2h is distinct in lacking a typical ubiquitin-binding surface and ha ving a unique disordered C-terminal region. Our data suggest that Ube2h pr omotes fasting-induced muscle atrophy by impairing insulin signaling via i ts C-terminal region. In addition\, Ube2h reduces desmin integrity by targ eting the heat shock protein Hspb1 for degradation\, facilitating desmin d epolymerization and the resulting loss of the contractile machinery.0:0011 END:VEVENT BEGIN:VEVENT UID:1301@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20250812T130000 DTEND;TZID=Asia/Jerusalem:20250812T133000 DTSTAMP:20250715T071927Z URL:https://biology.technion.ac.il/en/seminars/msc-graduate-seminar-shahar -lavid/ SUMMARY:MSc Graduate Seminar-Shahar Lavid [No Categories] DESCRIPTION:Location: Hybrid - in the Faculty Auditorium /ZOOM: https://tec hnion.zoom.us/j/96544365611 Shahar Lavid\n Affiliation: \n Host:Prof. Ben jamin Podbilewicz \n  Title: Structure Prediction and Sequence Phylogeny of Fusion Family (FF) Proteins Indicate a Common Ancestor in Nematodes and Horizontal Gene Transfer Origin in Non-Nematodes13\n\nThe fusexin superfa mily comprises proteins that mediate cell-cell fusion during viral infecti ons\, somatic development and sexual reproduction\, and have also been ide ntified in Archaea. Among them\, a subfamily of FF proteins\, first identi fied in the nematode C. elegans\, exhibits a striking structural similarit y to Class II viral fusogens. This similarity\, however\, is absent at the sequence level\, making their evolutionary origin difficult to pinpoint. By analyzing the phylogenetic relationships and structural predictions of FF candidate ectodomains\, we present a phylogenetic inquiry of FF protein s in both nematode and non-nematode species. Results show that nematodes h arbor two distinct FF subgroups\, which correspond to the C. elegans fusog ens EFF-1 and AFF-1 and align with nematode phylogeny. In contrast\, the g eneral phylogeny of FF in non-nematode species diverges from broader inver tebrate evolution. The results reveal the variable origins of FF proteins and suggest divergence in their structural properties as well\n\n \; LOCATION:Hybrid - in the Faculty Auditorium /ZOOM: https://technion.zoom.us /j/96544365611 END:VEVENT BEGIN:VEVENT UID:1299@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20250722T130000 DTEND;TZID=Asia/Jerusalem:20250722T140000 DTSTAMP:20250702T150957Z URL:https://biology.technion.ac.il/en/seminars/phd-graduate-seminar-joshua -hazan/ SUMMARY:PhD Graduate Seminar-Joshua Hazan [No Categories] DESCRIPTION:Location: Hybrid - in the Faculty Auditorium /ZOOM: https://tec hnion.zoom.us/j/94162344686 Joshua Hazan \n Affiliation: \n Host:Dr. Assa f Bester \n  \;\n\nA toolkit to decipher mechanistic insights of long non-coding RNAs based on guided CRISPR screens\n\nLong non-coding RNAs (ln cRNAs) are a large and diverse group of non-protein-coding genes whose fun ctions span a wide range of cellular processes in healthy cells and in the progression of various diseases. Despite their potential roles in many ma jor cellular processes\, the molecular function of the majority of lncRNAs remains unknown. To improve the strategy for lncRNA identification\, we d eveloped two strategies to discover novel functional lncRNAs and character ize their molecular mechanisms of action. First\, we developed a machine l earning called INFLAMeR to predict functional lncRNAs in a cell type-speci fic manner. INFLAMeR showed high predictive accuracy\, and we saw that the lncRNA SNHG6 affected haematopoiesis in leukaemia cells.Second\, we desig ned a compact CRISPRi-based screening strategy called SPPARCL to identify new lncRNAs that function in diverse cellular stresses. Through this\, we saw that LINC00680 affects tRNA expression and ribosome assembly. Together \, these tools offer important new ways to identify lncRNAs that function in health and disease. LOCATION:Hybrid - in the Faculty Auditorium /ZOOM: https://technion.zoom.us /j/94162344686 END:VEVENT BEGIN:VEVENT UID:1298@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20250721T130000 DTEND;TZID=Asia/Jerusalem:20250721T140000 DTSTAMP:20250702T145905Z URL:https://biology.technion.ac.il/en/seminars/phd-graduate-seminar-peleg- ragonis-bachar/ SUMMARY:PhD Graduate Seminar-Peleg Ragonis-Bachar [No Categories] DESCRIPTION:Location: Hybrid - in the Faculty Auditorium /ZOOM: https://tec hnion.zoom.us/j/98805522689 Peleg Ragonis-Bachar\n Affiliation: \n Host:A ssociate Prof. Meytal Landau\n Towards the Design of Targeted Therapeutics based on Microbial and Antimicrobial \n\n \;\n\nAmyloids\, long thou ght to be defined by their classic cross-β fibril structure\, have recent ly revealed a surprising new form: the cross-α architecture built from α -helices—shifting our fundamental understanding of protein self-assembly . Harnessing cutting-edge computational tools that combine secondary struc ture prediction with AI-driven biochemical analysis\, I discovered dozens of novel amyloid-forming peptides\, including unique structural variants w ith distinct antimicrobial functions. These findings expose the astonishin g structural and functional diversity hidden within amyloids\, challenging the traditional dogma that structure dictates pathology. Additionally\, u sing sequence-based AI model we were able to correlate between various bio chemical property of a sequence to the amyloid structure and function. Ult imately\, this work opens new frontiers for precisely targeting pathologic al amyloids or designing next-generation antimicrobial agents. LOCATION:Hybrid - in the Faculty Auditorium /ZOOM: https://technion.zoom.us /j/98805522689 END:VEVENT BEGIN:VEVENT UID:1297@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20250715T130000 DTEND;TZID=Asia/Jerusalem:20250715T133000 DTSTAMP:20250701T085506Z URL:https://biology.technion.ac.il/en/seminars/7604/ SUMMARY:Msc Graduate Seminar-Tamar Gil [No Categories] DESCRIPTION:Location: Place: Hybrid - in the Faculty Auditorium /ZOOM: http s://technion.zoom.us/j/97752400169 \n Affiliation: \n Host:Prof. Roy Kish ony\n High-throughput mapping of transposon-driven genomic rearrangements under antibiotic stress\n\n \;\n\nTransposons and insertion sequence ( IS elements) facilitate bacterial adaptation to antibiotics through two ma in mechanisms. In regular transposition (insertion)\, an IS is excised fro m the genome and inserted at a target site. In replicative transposition\, each side of the IS attaches to another genomic locus\, joining them toge ther as it duplicates. These transpositions generate genomic rearrangement s and repeats\, which cannot be resolved by short reads. To overcome this challenge\, we couple inverse PCR with paired-end sequencing\, to jointly capture both IS flanks. Joint sequencing is achieved by fragmenting genomi c DNA\, self-ligating the fragments\, and PCR with outward-facing primers to target the now-fused flanks of the IS. We apply this method to IS1 in E . coli populations exposed to antibiotics\, and identify over 100 insertio n sites\, and a variety of locus-joining events. Comparison with control p opulations suggest adaptive amplification events via homologous recombinat ion between ISs\, as well as replicative transpositions. LOCATION:Place: Hybrid - in the Faculty Auditorium /ZOOM: https://technion. zoom.us/j/97752400169 END:VEVENT BEGIN:VEVENT UID:1300@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20250708T130000 DTEND;TZID=Asia/Jerusalem:20250708T140000 DTSTAMP:20250707T065050Z URL:https://biology.technion.ac.il/en/seminars/special-seminar-prof-ting-c hen/ SUMMARY:Special Seminar - Prof. Ting Chen [No Categories] DESCRIPTION:Location: Biology auditorium Prof. Ting Chen \n Affiliation: T singua University\n Host:Dr. Dvir Aran\n Dear all\,\n\n \;\n\nOn Tuesd ay\, July 8th\, we are delighted to host Prof. Ting Chen of Tsingua Unive rsity for a special research seminar. Prof. Chen is a leading figure in co mputational biology and medical informatics.  After earning his Ph.D. at SUNY Stony Brook\, he lectured at Harvard and then spent sixteen years on the faculty of the University of Southern California\, before joining Tsin ghua University in 2016\, where he now directs the Center for Big Data Res earch in Medicine and Health. His work spans genome analysis\, machine-lea rning algorithms for biomedical data\, and large-scale health-data platfor ms\, and it has garnered more than 40\,000 citations.\n0:0013:00\nPlease m ake an effort to attend and pass this notice to others at the Technion who may be interested.\n\nPlace and time: Biology auditorium\, Tuesday July 8 th at 13:00.\n\nTitle: AI Models for Rare Disease Diagnosis\, Treatment\, and Intelligent Medical Inquiry\n\nSpeaker webpage: https://www.cs.tsinghu a.edu.cn/csen/info/1312/4385.htm\n\nGoogle scholar: https://scholar.google .com/citations?user=yE6LvhMAAAAJ\n\n \;\n\nLooking forward to seeing y ou all\,\n\nDvir\n\n \;\n\nDvir Aran\, PhD\nAssistant Professor\n\nFac ulty of Biology \\ Taub Faculty of Computer Science\n\nTechnion - Israel I nstitute of Technology\n\nhttps://aran-lab.com13:00 LOCATION:Biology auditorium END:VEVENT BEGIN:VEVENT UID:1286@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20250708T130000 DTEND;TZID=Asia/Jerusalem:20250708T140000 DTSTAMP:20250521T101431Z URL:https://biology.technion.ac.il/en/seminars/special-seminar-prof-ting-c hen-ai-models-for-rare-disease-diagnosis-treatment-and-intelligent-medical -inquiry/ SUMMARY:Special Seminar - Prof. Ting Chen-AI Models for Rare Disease Diagno sis\, Treatment\, and Intelligent Medical Inquiry [No Categories] DESCRIPTION:Location: Biology auditorium Prof. Ting Chen \n Affiliation: T singua University \n Host:Dr. Dvir Aran\n On Tuesday\, July 8th\, we are d elighted to host Prof. Ting Chen of Tsingua University for a special rese arch seminar. Prof. Chen is a leading figure in computational biology and medical informatics.  After earning his Ph.D. at SUNY Stony Brook\, he le ctured at Harvard and then spent sixteen years on the faculty of the Unive rsity of Southern California\, before joining Tsinghua University in 2016\ , where he now directs the Center for Big Data Research in Medicine and He alth. His work spans genome analysis\, machine-learning algorithms for bio medical data\, and large-scale health-data platforms\, and it has garnered more than 40\,000 citations.\n\nPlease make an effort to attend and pass this notice to others at the Technion who may be interested.\n\nPlace and time: Biology auditorium\, Tuesday July 8th at 13:00.\n\nTitle: AI Models for Rare Disease Diagnosis\, Treatment\, and Intelligent Medical Inquiry\n \nSpeaker webpage: https://www.cs.tsinghua.edu.cn/csen/info/1312/4385.htm\ n\nGoogle scholar: https://scholar.google.com/citations?user=yE6LvhMAAAAJ\ n\n \;\n\nLooking forward to seeing you all\, LOCATION:Biology auditorium END:VEVENT BEGIN:VEVENT UID:1295@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20250701T130000 DTEND;TZID=Asia/Jerusalem:20250701T133000 DTSTAMP:20250701T073443Z URL:https://biology.technion.ac.il/en/seminars/msc-graduate-seminar-ekatar ins-petrenko/ SUMMARY:MSc Graduate Seminar-Ekaterina Petrenko [No Categories] DESCRIPTION:Location: Hybrid- in the Faculty Auditorium/ZOOM:https://techni on.zoom.us/j/97497946716 Ekatarins Petrenko\n Affiliation: \n Host:Dr. Dv ir Aran\n  Age-dependent differences in neuroblastoma microenvironment: i ntegrative analysis of human and mouse single-cell RNA sequencing data\n\n  \;\n\nThis research investigates the molecular basis of age-dependent outcome disparities in neuroblastoma\, the most common extracranial solid tumor in children\, where patients under 18 months show dramatically bett er survival rates than older children. We developed CellMentor\, a novel s upervised non-negative matrix factorization method that leverages labeled reference datasets to learn biologically meaningful latent spaces for sing le-cell RNA sequencing analysis. Using both mouse models and human patient data\, we discovered age-specific differences in the tumor microenvironme nt\, particularly in neutrophil populations that may contribute to better outcomes in younger patients. This work provides new computational tools a nd biological insights that could inform age-tailored therapeutic approach es for pediatric neuroblastoma. LOCATION:Hybrid- in the Faculty Auditorium/ZOOM:https://technion.zoom.us/j/ 97497946716 END:VEVENT BEGIN:VEVENT UID:1296@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20250630T130000 DTEND;TZID=Asia/Jerusalem:20250630T140000 DTSTAMP:20250629T054551Z URL:https://biology.technion.ac.il/en/seminars/faculty-seminar-dr-ayala-sh iber-30-6-2025/ SUMMARY:Faculty seminar - Dr. Ayala Shiber 30.6.2025 [No Categories] DESCRIPTION:Location: Dr. Ayala Shiber\n Affiliation: \n Host:Dr. Shainer Inbal\n Dear all\,\n\n \;\n\nOur next seminar will be given by Dr. Ay ala Shiber from the Technion Faculty of Biology\n\n \;\n\nPlace and ti me: Biology auditorium\, Monday 30/6 at 13:00.\n\n \;\n\nTitle: Co-tra nslational protein folding\, assembly and quality control\, in health and disease\n\n \;\n\nDr. Shiber’s website: https://shiberlab.wixsite.c om/shiber\n\n \;\n\nLooking forward to seeing you all\,\n\nInbal\n\n&n bsp\;\n\nThe full list of this semester’s speakers can be found here: Fa culty Seminars Spring 2025\n\n \;\n\nFor inquiries regarding the cours e or to receive a Zoom link\, please contact Prof. Dedi Meiri <\;dmeir i@technion.ac.il>\; END:VEVENT BEGIN:VEVENT UID:1294@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20250625T130000 DTEND;TZID=Asia/Jerusalem:20250625T140000 DTSTAMP:20250624T061542Z URL:https://biology.technion.ac.il/en/seminars/phd-graduate-seminar-raz-be n-david/ SUMMARY:PhD Graduate Seminar- Raz Ben-David [No Categories] DESCRIPTION:Location: ZOOM: https://technion.zoom.us/j/95719561465 Raz Be n-David\n Affiliation: \n Host:Associate Prof. Shenhav Shemer\n Intermitte nt Fasting to Attenuate Age-Related Muscle Atrophy In Aging C57BL/6 Mice:\ n\nStudy of the Underlying Molecular Mechanisms\n\n \;\n\nSarcopenia\, the age-related loss of muscle mass and strength\, contributes to frailty \, impaired mobility\, and metabolic dysfunction. Traditional intervention s\, such as resistance training and increased protein intake\, are not alw ays feasible\, leading to investigation into alternative strategies. This study investigated whether intermittent fasting can attenuate age-related atrophy\, with particular focus on the preservation of the dystrophin-glyc oprotein complex (DGC) and its associated signaling hub involving plakoglo bin and the insulin receptor. Young (3-6 months)\, middle-aged (12-15 and 15-18 months)\, and old (18-21 months) male C57BL/6 mice underwent 12-week regimens of either time-restricted feeding (TRF\; 8-hour feeding/16-hour fasting)\, alternate-day fasting (ADF\; fasting every other day)\, or ad l ibitum (AL) feeding. Outcomes measured included body composition\, muscle mass and function\, glucose metabolism\, anabolic signaling\, muscle histo logy\, and fiber-type distribution. LOCATION:ZOOM: https://technion.zoom.us/j/95719561465 END:VEVENT BEGIN:VEVENT UID:1293@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20250624T130000 DTEND;TZID=Asia/Jerusalem:20250624T133000 DTSTAMP:20250622T110930Z URL:https://biology.technion.ac.il/en/seminars/msc-graduate-seminar-adva-k fir/ SUMMARY:MSc Graduate Seminar-Adva Kfir [No Categories] DESCRIPTION:Location: ZOOM: https://technion.zoom.us/j/98815143098 Adva Kf ir\n Affiliation: \n Host:Dr. Ayala Shiber\n  \;\n\n \;\n\nSplit-A DAR System to Detect in vivo Co-translational Cooperativity in Single-Mole cule Resolution\n\n \;\n\nProtein biogenesis is challenging in the cro wded cellular environment\, where off-pathway interactions can lead to pro tein aggregation - a hallmark of neurodegenerative diseases. To maintain p rotein homeostasis\, cells employ an intricate network of ribosome-associa ted factors that regulate folding\, localization\, and complex assembly co -translationally. Yet\, how these factors coordinate their dynamic binding to translating ribosomes remains poorly understood. Here\, we developed a single-molecule approach that combines Nanopore sequencing of full-length transcripts with mRNA proximity labelling using a split-ADAR system. We h ave provided a proof of concept for the robustness of this approach in det ecting even transient co-translational interactions at the ribosome. Using this system\, we have demonstrated evidence for co-translational cooperat ivity between the highly conserved ribosome-associated factors Map1 and Na tA along single transcripts. LOCATION:ZOOM: https://technion.zoom.us/j/98815143098 END:VEVENT BEGIN:VEVENT UID:1292@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20250617T130000 DTEND;TZID=Asia/Jerusalem:20250617T140000 DTSTAMP:20250615T064500Z URL:https://biology.technion.ac.il/en/seminars/phd-graduate-seminar-hanna- saleem/ SUMMARY:PhD Graduate Seminar-Hanna Saleem [No Categories] DESCRIPTION:Location: Hybrid - in the Faculty Auditorium /ZOOM: https://tec hnion.zoom.us/j/93897432505 \n Affiliation: \n Host:Prof. Emeritus Dina R on and Associate Professor Shenhav Shemer\n Unveiling a new human SEF (IL- 17RD) function in breast cancer prevention LOCATION:Hybrid - in the Faculty Auditorium /ZOOM: https://technion.zoom.us /j/93897432505 END:VEVENT BEGIN:VEVENT UID:1291@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20250616T130000 DTEND;TZID=Asia/Jerusalem:20250616T140000 DTSTAMP:20250612T060840Z URL:https://biology.technion.ac.il/en/seminars/faculty-seminar-dr-ifat-she r-16-6-2025/ SUMMARY:Faculty seminar - Dr. Ifat Sher 16.6.2025 [No Categories] DESCRIPTION:Location: Biology auditorium Dr. Ifat Sher\n Affiliation: She ba Medical Center and Tel-Aviv University\n Host:Dr. Shainer Inbal\n Dear all\,\n\n \;\n\nOur next seminar will be given by Dr. Ifat Sher from the Sheba Medical Center and Tel-Aviv University\n\n \;\n\nPlace and t ime: Biology auditorium\, Monday 16/6 at 13:00.\n\n \;\n\nTitle: From Bedside to Bench and Back: Personalized Drug Discovery for Retinal Degener ation Diseases\n\n \;\n\nDr. Sher’s website: https://ifaat3.wixsite .com/restorative-retinal\n\n \;\n\nLooking forward to seeing you all\, \n\nInbal\n\n \;\n\nThe full list of this semester’s speakers can be found here: Faculty Seminars Spring 2025\n\n \;\n\nFor inquiries rega rding the course or to receive a Zoom link\, please contact Prof. Dedi Me iri <\;dmeiri@technion.ac.il>\; LOCATION:Biology auditorium END:VEVENT BEGIN:VEVENT UID:1290@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20250609T130000 DTEND;TZID=Asia/Jerusalem:20250609T140000 DTSTAMP:20250603T102723Z URL:https://biology.technion.ac.il/en/seminars/faculty-seminar-dr-shay-ste rn-9-6-2025/ SUMMARY:Faculty seminar - Dr. Shay Stern 9.6.2025 [No Categories] DESCRIPTION:Location: Biology auditorium Dr. Shay Stern \n Affiliation: \n Host:Dr. Shainer Inbal\n Dear all\,\n\n \;\n\nOur next seminar will b e given by Dr. Shay Stern from the Technion’s Faculty of Biology.\n\n&nb sp\;\n\nPlace and time: Biology auditorium\, Monday 9/6 at 13:00.\n\n  \;\n\nTitle: Organization and regulation of developmental patterns of beha vior and individuality\n\n \;\n\nDr. Stern’s website: https://www.ss ternlab.com/\n\n \;\n\nLooking forward to seeing you all\,\n\nInbal\n\ n \;\n\nThe full list of this semester’s speakers can be found here: Faculty Seminars Spring 2025\n\n \;\n\nFor inquiries regarding the co urse or to receive a Zoom link\, please contact Prof. Dedi Meiri <\;dm eiri@technion.ac.il>\; LOCATION:Biology auditorium END:VEVENT BEGIN:VEVENT UID:1289@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20250603T130000 DTEND;TZID=Asia/Jerusalem:20250603T140000 DTSTAMP:20250528T134458Z URL:https://biology.technion.ac.il/en/seminars/msc-graduate-seminar-yahav- festinger/ SUMMARY:MSc Graduate Seminar-Yahav Festinger [No Categories] DESCRIPTION:Location: Hybrid - in the Faculty Auditorium /ZOOM: https://tec hnion.zoom.us/j/8522459764?omn=91894620721 \n Affiliation: \n Host:Associ ate Professor Ayelet Lamm\n  Identification of false discoveries in seque ncing data\n\n \;\n\nSequencing techniques are fundamental in almost a ll genetic research\, either by sequencing the entire genome or transcript ome\, by high-throughput sequencing\, or by sequencing a small segment of DNA using Sanger sequencing. The biggest challenge in all techniques is id entifying noise and false discovery versus real biological changes. There are not many tools available that can be used for data exploration and the identification of false discoveries. Here\, we developed an algorithm on RNA-seq data to track discrepancies between the data and the statistical m odel design that enables optimal data analysis. In addition\, we developed a Sanger sequencing analyzer that quantifies and determines if a SNP is s equencing noise. LOCATION:Hybrid - in the Faculty Auditorium /ZOOM: https://technion.zoom.us /j/8522459764?omn=91894620721 END:VEVENT BEGIN:VEVENT UID:1287@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20250527T130000 DTEND;TZID=Asia/Jerusalem:20250527T140000 DTSTAMP:20250521T103016Z URL:https://biology.technion.ac.il/en/seminars/phd-graduate-seminar-eshkar -nir/ SUMMARY:PhD Graduate Seminar-Eshkar Nir [No Categories] DESCRIPTION:Location: Hybrid- in the Faculty Auditorium/ZOOM:https://techni on.zoom.us/j/95717334601 Eshkar Nir\n Affiliation: \n Host:Dr. Stern Shay \n Studying developmental patterns of social interactions in C. elegans an d their effects on individuality\n\nIndividuals within the same population dynamically change their social interactions across development. Understa nding how these long-term inter-individual behavioral interactions are mod ified across different stages of development and the neuronal pathways inv olved remains unclear. We developed and utilized a novel imaging setup to study behavioral interactions of multiple pairs of C. elegans across devel opmental timescales. We found that wild-type animals show dynamic patterns of social interactions that increase in frequency and change in duration in a stage-specific manner. We further revealed that these long-term socia l patterns are shaped by specific sensory modalities\, in particular\, mec hanosensation and chemosensation. Moreover\, we found that the social cont ext also affected consistent individuality within the pairs during early d evelopmental stages. Our results highlight an active role for sensory path ways in organizing the developmental dynamics of social behavior and their effects on individual variation. LOCATION:Hybrid- in the Faculty Auditorium/ZOOM:https://technion.zoom.us/j/ 95717334601 END:VEVENT BEGIN:VEVENT UID:1288@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20250526T130000 DTEND;TZID=Asia/Jerusalem:20250526T140000 DTSTAMP:20250525T080931Z URL:https://biology.technion.ac.il/en/seminars/aculty-seminar-prof-amit-ze isel-26-5-2025-single-cell-approaches-to-studying-connectivity-and-neurona l-states-during-fear-learning/ SUMMARY:aculty seminar - Prof. Amit Zeisel  26.5.2025-Single-cell approac hes to studying connectivity and neuronal states during fear learning [No Categories] DESCRIPTION:Location: Biology auditorium Prof. Amit Zeisel \n Affiliation: Technion’s Faculty of Biotechnology and Food Engineering \n Host:Dr. Sh ainer Inbal\n Dear all\,\n\n \;\n\nOur next seminar will be given by P rof. Amit Zeisel from the Technion’s Faculty of Biotechnology and Food E ngineering\n\n \;\n\nPlace and time: Biology auditorium\, Monday 26/5 at 13:00.\n\n \;\n\nTitle: Single-cell approaches to studying connecti vity and neuronal states during fear learning\n\n \;\n\nProf. Zeisel ’s website: https://zeisellab.org/\n\n \;\n\n \;\n\nLooking forw ard to seeing you all\,\n\nInbal\n\n \;\n\nThe full list of this semes ter’s speakers can be found here: Faculty Seminars Spring 2025 LOCATION:Biology auditorium END:VEVENT BEGIN:VEVENT UID:1285@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20250519T130000 DTEND;TZID=Asia/Jerusalem:20250519T140000 DTSTAMP:20250514T101940Z URL:https://biology.technion.ac.il/en/seminars/faculty-seminar-dr-einat-se gev-19-5-2025-in-person-bacterial-physiology-in-an-environmental-context/ SUMMARY:Faculty seminar - Dr. Einat Segev 19.5.2025 [In-person]-Bacterial Physiology in an Environmental Context [No Categories] DESCRIPTION:Location: Biology auditorium Dr. Einat Segev \n Affiliation: Weizmann Institute of Science \n Host:\n Dear all\,\n\n \;\n\nOur nex t seminar will be given by Dr. Einat Segev from the Weizmann Institute of Science\n\n \;\n\nPlace and time: Biology auditorium\, Monday 19/5 at 13:00.\n\n \;\n\nTitle: Bacterial Physiology in an Environmental Cont ext\n\n \;\n\nAbstract:\n\nMicroorganisms have evolved in the cold\, n utrient-poor oceans for millions of years\, yet laboratory studies often u se conditions that differ greatly from their natural habitats. To better u nderstand the physiology of marine bacteria\, our group investigates model systems that closely mimic real-world environments. This approach allows us to reveal novel behaviors of marine microbes.\n\nBeyond basic environme ntal factors like temperature and nutrient availability\, marine bacteria are also shaped by interactions with algal hosts. These interactions range from competition to cooperation\, and significantly influence bacteria\, algae\, and ecosystem processes such as nutrient cycling and food web stab ility.\n\nIn my talk\, I will present our recent findings on bacterial phy siology in the context of algal interactions\, with a focus on how bacteri a transition from starvation to active growth. I will highlight how algal cues can shorten the bacterial lag phase and trigger specific physiologica l responses\, illustrating how microbial interactions shape bacterial beha vior\, and ultimately\, marine ecosystems.\n\n \;\n\nProf. Segev’s w ebsite: https://www.weizmann.ac.il/plants/segev/\n\n \;\n\nLooking for ward to seeing you all\,\n\nInbal\n\n \;\n\nThe full list of this seme ster’s speakers can be found here: Faculty Seminars Spring 2025\n\n  \;\n\nFor inquiries regarding the course or to receive a Zoom link\, pleas e contact Prof. Dedi Meiri <\;dmeiri@technion.ac.il>\; LOCATION:Biology auditorium END:VEVENT BEGIN:VEVENT UID:1280@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20250513T130000 DTEND;TZID=Asia/Jerusalem:20250513T140000 DTSTAMP:20250427T083743Z URL:https://biology.technion.ac.il/en/seminars/phd-graduate-seminar-laila- bishara/ SUMMARY:PhD Graduate Seminar-Laila Bishara [No Categories] DESCRIPTION:Location: Biology auditorium\, https:https://technion.zoom.us/j /95485558065 Laila Bishara\n Affiliation: \n Host: Prof. Nabieh Ayoub\n C8orf33: A novel regulator of DNA double strand break repair choice\n\nLiv ing organisms are continuously exposed to exogenous and endogenous DNA-dam aging agents that form DNA lesions. One of the most cytotoxic types of DNA lesions is double strand break (DSB) and its defective repair triggers ge nomic instability and carcinogenesis. DSBs are repaired through two main r epair pathways: homologous recombination (HR) and non-homologous end joini ng (NHEJ). While HR ensures accurate repair\, NHEJ is a rapid but mostly m utagenic repair pathway. Maintaining the balance between HR and NHEJ is cr ucial for preserving genomic stability. Consequently\, there is increasing interest in elucidating the molecular mechanisms that govern DSB repair p athway selection. Here\, we identify the uncharacterized C8orf33 protein a s a novel regulator of DSB repair choice. Our data reveal that C8orf33 is a nuclear protein localized predominantly to the nucleolus and accumulates at DSB sites within both nuclear and nucleolar regions. We demonstrate th at C8orf33 promotes NHEJ and suppresses HR repair of DSBs. Mechanistically \, we show that C8orf33 alters the epigenetic mark histone 4 lysine 16 ace tylation (H4K16ac)\, which controls the recruitment of NHEJ and HR factors to DSB sites. Accordingly\, C8orf33 deficiency elevates HR repair which r esults in genomic instability\, as evidenced by the loss of nucleolar DNA content and increased cell lethality. Collectively\, our findings establi sh C8orf33 as a critical regulator of DSB repair pathway choice\, safeguar ding genomic integrity. LOCATION:Biology auditorium\, https:https://technion.zoom.us/j/95485558065 END:VEVENT BEGIN:VEVENT UID:1283@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20250512T130000 DTEND;TZID=Asia/Jerusalem:20250512T140000 DTSTAMP:20250506T055954Z URL:https://biology.technion.ac.il/en/seminars/special-faculty-seminar-pro f-naama-barkai-12-5-2025-in-person/ SUMMARY:Special Faculty seminar - Prof. Naama Barkai 12.5.2025 [In-person] [No Categories] DESCRIPTION:Location: Biology auditorium Prof. Naama Barkai \n Affiliation : Weizmann Institute of Science \n Host:Dr. Shainer Inbal\n  \;\n\nDe ar all\,\n\n \;\n\nOur next seminar will be given by Prof. Naama Barka i from the Weizmann Institute of Science\n\n \;\n\nPlace and time: Bio logy auditorium\, Monday 12/5 at 13:00.\n\n \;\n\nLooking forward to s eeing you all\,\n\nInbal\n\n \;\n\nThe full list of this semester’s speakers can be found here: Faculty Seminars Spring 2025\n\n \;\n\nFor inquiries regarding the course or to receive a Zoom link\, please contact  Prof. Dedi Meiri <\;dmeiri@technion.ac.il>\; LOCATION:Biology auditorium END:VEVENT BEGIN:VEVENT UID:1281@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20250506T130000 DTEND;TZID=Asia/Jerusalem:20250506T140000 DTSTAMP:20250428T060044Z URL:https://biology.technion.ac.il/en/seminars/phd-gradutae-seminar-maya-l inial/ SUMMARY:PhD Gradutae Seminar- Maya Linial [No Categories] DESCRIPTION:Location: Hybrid- in the Faculty Auditorium/ZOOM:https://techni on.zoom.us/j/8510874821 Maya Linial\n Affiliation: \n Host:Prof\, Reiter Yoram \n  \;\n\nExploring How Antigen Type Shapes CAR T Cell Sensitivi ty and Function\n\n \;\n\nCAR T cell therapy has revolutionized cancer treatment\, yet challenges remain in targeting solid tumors.\nThis resear ch directly compares CAR T cells targeting two different types of antigens : a surface protein and a peptide MHC complex\, using a fully controlled s ystem.\nThe study reveals how antigen type influences CAR T cell sensitivi ty and function\, offering new insights for improving next-generation canc er immunotherapies. LOCATION:Hybrid- in the Faculty Auditorium/ZOOM:https://technion.zoom.us/j/ 8510874821 END:VEVENT BEGIN:VEVENT UID:1282@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20250505T130000 DTEND;TZID=Asia/Jerusalem:20250505T140000 DTSTAMP:20250504T070353Z URL:https://biology.technion.ac.il/en/seminars/faculty-seminar-prof-alexan der-bershadsky-5-5-2025-in-person/ SUMMARY:Faculty seminar - Prof. Alexander Bershadsky 5.5.2025 [In-person] [No Categories] DESCRIPTION:Location: Biology auditorium Prof. Alexander Bershadsky \n Af filiation: Weizmann Institute of Science and The Mechanobiology Institute\ , National University of Singapore\n Host:Dr. Shainer Inbal\n Dear all\,\n \n \;\n\nOur next seminar will be given by Prof. Alexander Bershadsky from the Weizmann Institute of Science and The Mechanobiology Institute\, National University of Singapore\n\n \;\n\nPlace and time: Biology aud itorium\, Monday 5/5 at 13:00.\n\n \;\n\nTitle: Integrin-based Adhesio ns in a Crosstalk with Actomyosin Cytoskeleton and Microtubules\n\n \; \n\nLooking forward to seeing you all\,\n\nInbal\n\n \;\n\nThe full li st of this semester’s speakers can be found here: Faculty Seminars Sprin g 2025\n\n \;\n\nFor inquiries regarding the course or to receive a Zo om link\, please contact Prof. Dedi Meiri <\;dmeiri@technion.ac.il>\ ; LOCATION:Biology auditorium END:VEVENT BEGIN:VEVENT UID:1279@biology.technion.ac.il DTSTART;TZID=Asia/Jerusalem:20250428T130000 DTEND;TZID=Asia/Jerusalem:20250428T140000 DTSTAMP:20250427T070343Z URL:https://biology.technion.ac.il/en/seminars/faculty-seminar-prof-gali-p rag-28-4-2025-in-person/ SUMMARY:Faculty seminar - Prof. Gali Prag 28.4.2025 [In-person] [No Categor ies] DESCRIPTION:Location: Biology auditorium Prof. Gali Prag\n Affiliation: th e School of Neurobiology\, Biochemistry & Biophysics\, Tel-Aviv University .\n Host:Prof. Dedi Meiri \n Dear all\,\n\n \;\n\nOur next seminar wil l be given by Prof. Gali Prag from the School of Neurobiology\, Biochemis try &\; Biophysics\, Tel-Aviv University.\n\n \;\n\nPlace and time: Biology auditorium\, Monday 28/4 at 13:00.\n\n \;\n\nTitle: The Art o f Allostery: Inhibiting Pocketless Enzymes.\n\n \;\n\nLooking forward to seeing you all\,\n\nInbal\n\n \;\n\nThe full list of this semester ’s speakers can be found here: Faculty Seminars Spring 2025\n\n \;\n \nFor inquiries regarding the course or to receive a Zoom link\, please co ntact Prof. Dedi Meiri <\;dmeiri@technion.ac.il>\; LOCATION:Biology auditorium END:VEVENT BEGIN:VTIMEZONE TZID:Asia/Jerusalem X-LIC-LOCATION:Asia/Jerusalem BEGIN:DAYLIGHT DTSTART:20250328T030000 TZOFFSETFROM:+0200 TZOFFSETTO:+0300 TZNAME:IDT END:DAYLIGHT BEGIN:STANDARD DTSTART:20251026T010000 TZOFFSETFROM:+0300 TZOFFSETTO:+0200 TZNAME:IST END:STANDARD BEGIN:DAYLIGHT DTSTART:20260327T030000 TZOFFSETFROM:+0200 TZOFFSETTO:+0300 TZNAME:IDT END:DAYLIGHT END:VTIMEZONE END:VCALENDAR