ארן - פקולטה לביולוגיה Biology Faculty

Education/ Resume:

ai, 2019-2020, Palo Alto. Senior Data Scientist
Postdoctoral Fellow, 2014-2019, Stanford University and University of California, San Francisco
PhD, 2014, Hebrew University
MSc, 2010, Hebrew University
BSc, 2009 Hebrew University

Research Summary

We integrate multidimensional biomedical data — including genomics and clinical data — to advance precision medicine and improve therapeutic strategies. Using computational biology and data science methodologies, we aim to develop computational methods to understand cellular heterogeneity in complex tissues and incorporate cutting-edge technologies to study cellular dynamics in the tumor-microenvironment affecting response to therapies. We also investigate real-world clinical data and develop machine-learning models to improve clinical decision-making. The lab branches to both basic and clinical research, and collaborates with computer scientists, bioengineers, basic experimental researchers and clinicians.

Awards

Azrieli Faculty Fellowship, 2020
Gruss-Lipper Postdoctoral Fellowship, 2015

Key Publications

Reference-based analysis of lung single-cell sequencing reveals a transitional profibrotic macrophage. Aran et al. Nature Immunology, 2019
xCell: digitally portraying the tissue cellular heterogeneity landscape. Aran et al. Genom Biology, 2017

Comprehensive analysis of normal adjacent to tumor transcriptomes. Aran et al. Nature Communications, 2017
Systematic pan-cancer analysis of tumour purity. Aran et al. Nature Communications, 2015
DNA methylation of distal regulatory sites characterizes dysregulation of cancer genes. Aran et al. Genome Biology, 2013

קרא עוד

Recent Publications:

Prior presumed coronavirus infection reduces COVID-19 risk: A cohort study. Aran et al. Journal of Infection, 2020

Development and validation of a machine‐learning model for prediction of shoulder dystocia. Tsur et al. Ultrasound in Obstetrics & Gynecology, 2020
Reference-based analysis of lung single-cell sequencing reveals a transitional profibrotic macrophage. Aran et al. Nature Immunology, 2019
EpiSort: Enumeration of cell types using targeted bisulfite sequencing. Aran et al. Biorxiv, 2019
xCell: digitally portraying the tissue cellular heterogeneity landscape. Aran et al. Genom Biology, 2017
Comprehensive analysis of normal adjacent to tumor transcriptomes. Aran et al. Nature Communications, 2017

קרא עוד

Open Positions

Open positions for MSc, PhD and postdoctoral fellows. We are seeking highly motivated students to develop and study novel approaches in bioinformatics, or the application of analytic and interpretive methods to optimize the clinical-decision making.

דביר ארן