חן - פקולטה לביולוגיה Biology Faculty

Education/ Resume:

Post Doctorate: Molecular Biophysics & Biochemistry, Yale University
Ph.D: Structural Biology, Weizmann Institute of Science

Research Summary

Current research is focused to understand the molecular cell biology and the biophysics of ATP driven molecular motors in human cells by combining microscopy, cell biology, structural biology, kinetics and thermodynamics. We combined array of research disciplines in our research and hence we strive for a diverse group of researchers.

Awards:

1998 The J. Barney and Pauline Goldhar Foundation Scholarship Award

2000 The Lillian Baker Scholarship Award

2001 Aharon Katzir Scholarship Award

2001 Young Investigator Award FASEB Summer Research Conference

2002 Summa cum laude Ph.D. Thesis committee

2003 American Heart Association Postdoctoral Fellowship Award

2009 EMBO “best poster” at Helicase & NTP-Driven Nucleic Acids Motors

2010 Awarded “must read paper” ranking by Faculty 1000 for the publication Henn A. et al., 2010 PNAS.

2016 Awarded as “New Finding” by F1000Prime, Shneyer BI et al., 2016 J Cell Sci.

קרא עוד

Key Publications

Henn, A., W. Cao, D. D. Hackney and E. M. De La Cruz The ATPase cycle mechanism of the DEAD-box rRNA helicase, DbpA. J Mol Biol 377(1): 193-205, 2008.

Henn, A., W. Cao, N. Licciardello, S. E. Heitkamp, D. D. Hackney and E. M. De La Cruz Pathway of ATP utilization and duplex rRNA unwinding by the DEAD-box helicase, DbpA. Proc Natl Acad Sci U S A 107(9): 4046-4050, 2010.
Shneyer, B. I., M. Usaj and A. Henn Myo19 is an outer mitochondrial membrane motor and effector of starvation-induced filopodia. J Cell Sci 129(3): 543-556, 2016.
Zananiri, R., Malik, O., Rudnizky, S., Gaydar, V., and Henn A. & A. Kaplan, Synergy between RecBCD subunits is essential for efficient DNA unwinding. eLife, 2019 Jan 2;8. pii: e40836. doi: 10.7554/eLife.40836.
Ušaj , Zattelman, L. Regev R., Shneyer, B.I., Wiesel-Motiuk, N, & A. Henn, Overexpression and purification of human myosins from transiently and stably transfected suspension adapted HEK293SF-3F6 cells, Analytical Biochemistry, Elsevier, 558: 19-27, 2018.
Barber-Zucker, S., Hall, , M.V. Sivasubramanyan, Kolusheva, S., MacMillan*, F., Zarivach*, R., and A. Henn*, Metal binding to the cation diffusion facilitator protein MamM dynamic cytoplasmic domain induces ‘locked in’ configuration. FEBS, J. 2019 Feb 27 doi: 10.1111/febs.14795.

קרא עוד

Recent Publications:

Shneyer, B. I., M. Usaj and A. Henn Myo19 is an outer mitochondrial membrane motor and effector of starvation-induced filopodia. J Cell Sci 129(3): 543-556, 2016.

Zattelman, L., R. Regev, M. Usaj, Y. A. Reinke, S. Giese, A. O. Samson, M. H. Taft, D. J. Manstein and A. Henn N-terminal splicing extensions of the human MYO1C gene fine-tune the kinetics of the three full-length myosin IC isoforms. J Biol Chem 292(43):17804-17818, 2017.
Ušaj, M. and A. Henn Kinetic adaptation of human Myo19 for active mitochondrial transport to growing filopodia tips. Scientific Reports 7(1): 11596, 2017.
Shneyer, B. I., M. Ušaj, N. Wiesel-Motiuk, R. Regev and A. Henn. ROS induced distribution of mitochondria to filopodia by Myo19 depends on a class specific tryptophan in the motor domain. Scientific Reports 7(1): 11577, 2017.
Zananiri, R., Malik, O., Rudnizky, S., Gaydar, V., and Henn A. & A. Kaplan, Synergy between RecBCD subunits is essential for efficient DNA
Giese S., Reindl T., Reinke Y.A.P., Zattelman L., Fedorov R., Henn A., Taft H M., and D. J. Manstein. Mechanochemical properties of human myosin 1C are modulated by isoform-specific differences in the N-terminal extension. JBC, 2020 In press

קרא עוד

Open Positions

We have currently new funding for a PhD position in cell biology investigating human Myosin 19 functions in different cell lines.

ארנון חן