ערבה - פקולטה לביולוגיה Biology Faculty

Research Summary:

We study the steps of gene expression in eukaryots with emphasis on mRNA localization and translation regulation. We apply diverse methods to understand how the translation of mRNAs is regulated, what are the RNA sequences that are important for regulation and which RNA binding proteins are involved in this process.

Awards:

2020 Technion Safety prize

2008,2012, 2013,2015, 2016, 2018 Technion distinguished lecturer

2012 Yanai prize for excellence in academic education

2009 Mani award for excellence in teaching

2006 Jacob and Rosaline Academic Lectureship

2003- 2005 Horev fellow – Career Development Chair funded by the Taub and Shalom foundations.

Key Publications:

Pseudouridine-mediated translation control by methionine aminoacyl tRNA synthetase, Ofri Levi and Yoav Arava (2020) Nucleic Acids Research, in press
Characterization of factors involved in localized translation near mitochondria by ribosome-proximity labeling. Vardi-Oknin D. and Arava Y. (2019) Frontiers in Cell and Developmental Biology,

mRNA association by aminoacyl tRNA synthetase occurs at a putative anticodon mimic and autoregulates translation in response to tRNA levels. Levy O. and Arava Y. (2019) PLoS Biology, 2019 May 17;17(5):e3000274
Identification and characterization of roles for Puf1 and Puf2 proteins in the yeast response to high calcium. Haramati O, Brodov A, Yelin I, Atir-Lande A, Samra N, Arava Y. (2017) Sci Rep. 2017 Jun 8;7(1):3037
OM14 is a mitochondrial receptor for cytosolic ribosomes that supports co-translational import into mitochondria. Lesnik C, Cohen Y, Atir-Lande A, Schuldiner M and Arava Y. (2014) Nature Communications 2014 Dec 9;5:5711.
Divergent RNA binding specificity of yeast Puf2p. Yosefzon Y, Koh YY, Chritton JJ, Lande A, Leibovich L, Barziv L, Petzold C, Yakhini Z, Mandel-Gutfreund Y, Wickens M, Arava Y. (2011) RNA. 2011 Aug;17(8):1479-88
Tom20 mediates localization of mRNAs to mitochondria in a translation-dependent manner Eliyahu E, Pnueli L, Melamed D, Scherrer T, Gerber AP, Pines O, Rapaport D, Arava Y. (2010) Mol Cell Biol. 2010 Oct 26
The 3′-UTR mediates the cellular localization of an mRNA encoding a short plasma membrane protein. Loya A, Pnueli L, Yosefzon Y, Wexler Y, Ziv-Ukelson M, Arava Y. RNA. 2008 Jul;14(7):1352-65.
Yeast translational response to high salinity: Global analysis reveals regulation at multiple levels. Melamed D, Pnueli L, Arava Y. RNA. 2008 Jul;14(7):1337-51.
Dissecting eukaryotic translation and its control by ribosome density mapping. Arava Y, Boas FE, Brown PO, Herschlag D. Nucleic Acids Res. 2005 Apr 28;33(8):2421-32.
Genome-wide analysis of mRNA translation profiles in Saccharomyces cerevisiae. Arava Y, Wang Y, Storey JD, Liu CL, Brown PO, Herschlag D. Proc Natl Acad Sci U S A. 2003 Apr 1;100(7):3889-94.

קרא עוד

Recent Publications:

Pseudouridine-mediated translation control by methionine aminoacyl tRNA synthetase, Ofri Levi and Yoav Arava (2020) Nucleic Acids Research, in press
Localization and RNA binding of mitochondrial aminoacyl tRNA synthetases, Shahar Garin, Ofri Levi, Bar Cohen, Adi Golani and Yoav Arava (2020) Genes, in press

CytoCensus, mapping cell identity and division in tissues and organs using machine learning. Hailstone M, Waithe D, Samuels TJ, Yang L, Costello I, Arava Y, Robertson E, Parton RM, Davis I (2020) Elife. 2020 May 19;9:e51085. doi: 10.7554/eLife.51085.
Neuronal upregulation of Prospero protein is driven by alternative mRNA polyadenylation and Syncrip-mediated mRNA stabilisation Samuels TJ, Arava Y, Järvelin AI, Robertson F, Lee JY, Yang L, Yang CP, Lee T, Ish-Horowicz D, Davis I. Biol Open. 2020 May 4;9(5):bio049684. doi: 10.1242/bio.049684.
Expanding the CRISPR/Cas9 toolbox for gene engineering in S. cerevisiae. Levi O. and Arava Y. (2020) Current Microbiology Mar;77(3):468-478. doi: 10.1007/s00284-019-01851-0. Epub 2020 Jan 4.
Characterization of factors involved in localized translation near mitochondria by ribosome-proximity labeling. Vardi-Oknin D. and Arava Y. (2019) Frontiers in Cell and Developmental Biology, Front. Cell Dev. Biol., 26 November 2019
RNA mimicry in post-transcriptional regulation by aminoacyl tRNA synthetases Levi O., Garin S. and Arava Y. (2019) WIREs RNA, e1564. https://doi.org/10.1002/wrna.1564
Distinct RNA-binding modules in a single PUF protein cooperate to determine RNA specificity. Chen Qiu, Robert C. Dutcher, Douglas F. Porter, Yoav Arava, Marvin Wickens and Traci M. Tanaka Hall (2019) Nucleic Acids Research, 47(16):8770-8784.
mRNA association by aminoacyl tRNA synthetase occurs at a putative anticodon mimic and autoregulates translation in response to tRNA levels. Levy O. and Arava Y. (2019) PLoS Biology, 2019 May 17;17(5):e3000274

קרא עוד

יואב ערבה