זילברשטיין

דן זילברשטיין

מעבדת זילברשטיין
Education/ Resume:

1975   B.Sc. in Biology, Hebrew University of Jerusalem, Israel.

1977   M.Sc. in Environmental Sciences with distinction, Hebrew University of Jerusalem.

1983   Ph.D. in Microbiology and Biochemistry, Hebrew University of Jerusalem, Israel.

Research interest
  • Assessment of the molecular mechanism of Leishmania development inside its host
  • Functional genomics of amino acid transporters: molecular cloning and assessments of their role in virulence
  • Arginine sensing in Leishmania and assessment of its role in virulence
  • Exploiting Leishmania amino acid transporters as drug delivery systems
  • Assessment of the mechanism of Leishmania resistance of heavy metals
Key Publications

Rosenzweig, D., Smith, D., Opperdoes, F.R., Stern, S., Olafson, R.W. and Zilberstein, D. Retooling Leishmania metabolism: from sandfly gut to human macrophage. The FASEB Journal 22, 590-602, (2008).

  • Darlyuk, I., Goldman A., Roberts, S.C., Ullman, B., Rentschm D. and Zilberstein, D. Arginine homeostasis and transport in the human pathogen Leishmania donovani. J. Biol. Chemistry, J. Biol. Chem. 284, 19800-19807, (2009).
  • Lahav, T., Sivam, D, Volpin, H., Holland, N., Anderson-Green, A., Zilberstein, D.*§ and Myler, P.J.§ Multiple levels of gene regulation mediate differentiation of the intracellular pathogen Leishmania donovani. FASEB J. 25, 515-525, (2011).
  • Inbar, E., Schlisselberg, D., Suter Grotemeyer, M., Rentsch, D. and Zilberstein, D. A versatile proline-alanine transporter in the unicellular pathogen Leishmania donovani regulates amino acid homeostasis and osmotic stress responses. Biochem. J. 449, 555-566, (2013).
  • Tsigankov, P., Gherardini, F.P., Helmer-Citterich, M., Späth, G.F., Myler, P.J., Zilberstein, D. Regulation dynamics of Leishmania differentiation: deconvoluting signals and identifying phosphorylation trends. Mol. & Cell. Prot., 13, 1769-1786 (2014).
קרא עוד
Recent Publications

Schlisselberg, D., Mazarib, E., Inbar, E., Rentsch, D., Myler, P. J., Zilberstein, D. Size does matter: 18 amino acids at the N-terminal tip of a neutral amino acid transporter (LdAAP24) in Leishmania determine substrate specificity. Scientific Reports, 5, 16289-16298 (2015).

  • Bachmaier, S., Witztum, R., Tsigankov, P., Koren, R., Boshart, M., Zilberstein, D. Protein kinase A signaling during bidirectional axenic differentiation of Leishmania, Int J Parasitol, 46, 75-82 (2016).
  • Goldman-Pinkovich, A., Balno, C., Strasser, R., Zeituni-Molad, M., Bendelak, K., Rentsch, D.,  Ephros, M., Wiese, M., Jardim, A., Myler, P.J., Zilberstein, D. An arginine deprivation response pathway is induced in Leishmania during macrophage invasion., PLoS Path, 14, e1005494 (2016).
  • Mathieu, C., Macedo, J. P., Hurlimann, D., Wirdnam, C., Haindrich, A. C., Suter Grotemeyer, M., Gonzalez-Salgado, A., Schmidt, R. S., Inbar, E., Maser, P., Butikofer, P., Zilberstein, D., and Rentsch, D. Arginine and Lysine Transporters Are Essential for Trypanosoma brucei. PLoS One, 12, e0168775 (2017).
  • Liburkin-Dan, T., Schlisselberg, D., Fischer-Weinberger, R., Pescher, P., Inbar, E., Rentsch, D., Späth, G.F., Myler, P.J. and Zilberstein, D. Stage-specific expression of the proline-alanine transporter in the human pathogen Leishmania. Mol. Biochem. Parasitol. 222, 1-5 (2018).
  • Pawar, H., Puri, M., Fischer-Weinberger, R., Madhubala, R. and Zilberstein, D. The arginine sensing and transport binding sites are distinct in the human pathogen Leishmania. PLoS NTD, 13: e0007304 (2019).
  • Landfear, S.M. and Zilberstein, D. Sensing What’s Out There – Kinetoplastid Parasites. Trends in Parasitol. Trends Parasitol., 35: 274-277. DOI: 10.1016/j.pt.2018.12.004 (2019).
  • Goldman-Pinkovich, A., Kannan, S., Nitzan-Koren, R., Puri, M., Bar-Avraham, Y., McDonald, J.A., Sur, A., Zhang, W.-W., Matlashewski, G., Madhubala, R., Myler, P.J. and Zilberstein, D. Sensing Host Arginine Is Essential for Leishmania Parasites’ Intracellular Development. MBio 11: e02023-20 (2020)
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