Amino acid transport
Shaked-Mishan, P., Suter-Grotemeyer, M., Yoel-Almagor, T., Holland, N., Zilberstein, D. and Rentsch, D. Novel high affinity arginine transporter from the human parasitic protozoan Leishmania donovani. Molecular Microbiology 60, 30-38, (2006).
Inbar, E., Schlisselberg, D., Suter Grotemeyer, M., Rentsch, D. and Zilberstein, D. A versatile proline-alanine transporter in the unicellular pathogen Leishmania donovani regulates amino acid homeostasis and osmotic stress responses. Biochem. J. 449, 555-566, (2013).
Schlisselberg, D., Mazarib, E., Inbar, E., Rentsch, D., Myler, P. J., Zilberstein, D. Size does matter: 18 amino acids at the N-terminal tip of a neutral amino acid transporter (LdAAP24) in Leishmania determine substrate specificity. Scientific Reports, 5, 16289-16298 (2015).
Leishmania development
Barak, E., Amin-Spector, S., Gerliak, E., Goyard, S., Holland, N. and Zilberstein, D. Differentiation of Leishmania donovani in host-free system: analysis of signal perception and response. Mol. Biochem. Parasitol. 141, 99-108, (2005).
Rosenzweig, D., Smith, D., Opperdoes, F.R., Stern, S., Olafson, R.W. and Zilberstein, D. Retooling Leishmania metabolism: from sandfly gut to human macrophage. The FASEB Journal 22, 590-602, (2008).
Lahav, T., Sivam, D, Volpin, H., Holland, N., Anderson-Green, A., Zilberstein, D. and Myler, P.J.§ Multiple levels of gene regulation mediate differentiation of the intracellular pathogen Leishmania donovani. FASEB J. 25, 515-525, (2011).
Tsigankov, P., Gherardini, F.P., Helmer-Citterich, M., Späth, G.F., Myler, P.J., Zilberstein, D. Regulation dynamics of Leishmania differentiation: deconvoluting signals and identifying phosphorylation trends. Mol. & Cell. Prot., 13, 1769-1786 (2014).
Bachmaier, S., Witztum, R., Tsigankov, P., Koren, R., Boshart, M., Zilberstein, D. Protein kinase A signaling during bidirectional axenic differentiation of Leishmania, Int J Parasitol, 46, 75-82 (2016).
The arginine sensing pathway in Leishmania
Darlyuk, I., Goldman A., Roberts, S.C., Ullman, B., Rentschm D. and Zilberstein, D. Arginine homeostasis and transport in the human pathogen Leishmania donovani. J. Biol. Chemistry, J. Biol. Chem. 284, 19800-19807, (2009).
Goldman-Pinkovich, A., Balno, C., Strasser, R., Zeituni-Molad, M., Bendelak, K., Rentsch, D., Ephros, M., Wiese, M., Jardim, A., Myler, P.J., Zilberstein, D. An arginine deprivation response pathway is induced in Leishmania during macrophage invasion., PLoS Path, 14, e1005494 (2016).
Pawar, H., Puri, M., Fischer-Weinberger, R., Madhubala, R. and Zilberstein, D. The arginine sensing and transport binding sites are distinct in the human pathogen Leishmania. PLoS NTD, 13: e0007304 (2019).
Goldman-Pinkovich, A., Kannan, S., Nitzan-Koren, R., Puri, M., Bar-Avraham, Y., McDonald, J.A., Sur, A., Zhang, W.-W., Matlashewski, G., Madhubala, R., Myler, P.J. and Zilberstein, D. Sensing Host Arginine Is Essential for Leishmania Parasites’ Intracellular Development. mBio 11: e02023-20 (2020).