קפלן - פקולטה לביולוגיה Biology Faculty

Education/ Resume:

2006-2010: Postdoctoral fellow, University of California, Berkeley.

2004-2006: Postdoctoral fellow, Weizmann Institute of Science.

1999-2004: PhD, Weizmann Institute of Science

1991-1993: MSc, Hebrew University of Jerusalem

1987-1990: BSc, Hebrew University of Jerusalem

קרא עוד

Research Summary

We are a single-molecule biophysics lab, using advanced optical tools to study the interactions between proteins and DNA that are at the heart of the regulation of gene expression. In particular, we are interested in the structure and dynamics of chromatin, binding of transcription factors to DNA and the function of polymerases and helicases.

Key Publications

S. Rudnizky*, H. Khamis*, O. Malik, P. Melamed, and A. Kaplan, “The base pair-scale diffusion of nucleosomes modulates binding of transcription factors”, PNAS 116, 12161 (2019).

Zananiri, O. Malik, S. Rudnizky, V. Gaydar, R. Kreiserman, A. Henn and A. Kaplan, “Synergy between RecBCD subunits is essential for efficient DNA unwinding”, eLife 8, e40836 (2019).

Rudnizky*, H. Khamis*, O. Malik, A. Squires, A. Meller, P. Melamed and A. Kaplan, “Single-molecule DNA unzipping reveals asymmetric modulation of a transcription factor by its binding site sequence and context”, Nucleic Acids Research 46, 1513 (2018).

Malik*, H. Khamis*, S. Rudnizky and A. Kaplan, “The mechano-chemistry of a monomeric reverse transcriptase”, Nucleic Acids Research 45, 12954 (2017).

Malik*, H. Khamis*, S. Rudnizky, A. Marx and A. Kaplan, “Pausing kinetics dominates strand-displacement polymerization by Reverse Transcriptase”, Nucleic Acids Research 45, 10190 (2017).

Rudnizky, A. Bavly, O. Malik, L. Pnueli, P. Melamed and A. Kaplan, “H2A.Z controls the stability and mobility of nucleosomes to regulate expression of the LH genes”, Nature Communications 7, 12958 (2016).

קרא עוד

Recent Publications:

S. Rudnizky, H. Khamis, Y. Ginosar, E. Goren, P. Melamed and A. Kaplan, “Extended and dynamic linker histone-DNA interactions control chromatosome compaction”, bioRxiv https://doi.org/10.1101/2020.10.10.334474 (2020)

Multimedia

Open Positions

We are always looking for talented MSc and PhD students to join us. Students with a background in Physics, Biology, Chemistry or Engineering are wellcome to apply.

Postdoctoral applicants must have a PhD degree, a strong publication record and demonstrated ability to work independently. Expertise in single-molecule and/or bulk biophysics, molecular biology or microscopy is an advantage. However, an open mind, good hands, and a record of success in your PhD are the only requirements.

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