כהן

שנהב כהן

מעבדת כהן
Education/ Resume:

2020-2022     Visiting scholar, School of Engineering and Applied Sciences, Harvard, USA
2019-              Associate Professor, Faculty of Biology, Technion, Israel
2013-2019     Assistant Professor, Faculty of Biology, Technion, Israel

2011-2013      Research Fellow, Cell Biology Department, Harvard, USA
2006-2011      Postdoctoral Fellow, Cell Biology Department, Harvard, USA
2002-2006      Senior researcher, Biotech, Weizmann Science Park, Israel
1996-2002      Ph.D. (Direct track), Bar-Ilan University, Israel
1992-1995      B.Sc., Biology, Bar-Ilan University, Israel

קרא עוד
Research Summary

Muscle wasting is an inevitable sequel of aging and disease, and often correlates with patient demise. It results from the accelerated breakdown of the contractile myofibrillar apparatus by the proteasome, which is preceded by the loss of desmin intermediate filaments. We strive to uncover the underlyingmechanismsof muscle loss inorder to identify rational therapies to combat wasting. Our research encompasses different fields from physiology and mechanisms of muscle atrophy, through biochemistry and cell biology. Our goal is to advance foundational understanding of diverse types of wasting, highlighting how cells retain and adapt their size to a changing physiological environment.

Awards:

2020           Cooper Award for Excellence in Research
2020           Norman and Helen Asher Research Award
2020           ICA research award for an outstanding researcher
2015           Dr. Bernard and Bobbie Lublin Cancer Research award

2014            Malat family award
2014            Robin award for biomedical research
2006-2011  Edmond J. Safra Fellowship, New York, USA
1995-2000  Ph.D. fellowship from Bar Ilan University, Israel

קרא עוד
Key Publications
קרא עוד
Recent Publications:

Gilda JE and Cohen S. Molecular mechanisms of skeletal muscle wasting in cancer. Invited book chapter, Springer Nature. In press. 2021.

Agnetti G., Herrmann H. and Cohen S. New roles for desmin in the maintenance of muscle homeostasis. 2021. Review. FEBS J. In press.

Aweida D. and Cohen S. Breakdown of Filamentous Myofibrils by the UPS–Step by Step. 2021. Review. Biomolecules.11(1):110.

Cohen S. Role of calpain-1 in promoting desmin depolymerization in muscle wasting and aging. BBA-Molecular Cell Research. 1867(10):118788. 2020.

Goldbraikh D, Neufeld D, Eid-Mutlak Y, Lasry I, Gilda JE, Parnis A and Cohen S. USP1 deubiquitinates Akt to inhibit PI3K-Akt-FoxO signaling in muscle atrophy during prolonged starvation. EMBO reports. 21(4):e48791. 2020.

Yatsenko AS, Kucherenko MM, Xie Y, Aweida D, Urlaub H, Scheibe RJ, Cohen S, Shcherbata HR. Profiling of the muscle-specific dystroglycan interactome reveals the role of Hippo signaling in muscular dystrophy and age-dependent muscle atrophy. BMC Medicine. 18(1):8. 2020.

Shiloh R, Gilad Y, Ber Y, Eisenstein M, Aweida D, Bialik S, Cohen S, Kimchi A. Non-canonical activation of DAPK2 by AMPK constitutes a new pathway linking metabolic stress to autophagy. Nature Communications. 9(1):1759. 2018.

Bassat E, Mutlak YE, Genzelinakh A, Shadrin IY, Baruch Umansky K, Yifa O, Kain D, Rajchman D, Leach J, Riabov Bassat D, Udi Y, Sarig R, Sagi I, Martin JF, Bursac N, Cohen S, Tzahor E. The extracellular matrix protein agrin promotes heart regeneration in mice. Nature. 547(7662):179-184. 2017.

Piterman R, Braunstein I, Isakov E, Ziv T, Navon A, Cohen S, Stanhill A. VWA domain of S5a restricts the ability to bind ubiquitin and Ubl to the 26S proteasome. Mol Biol Cell. 25(25):3988-98. 2014.

 

 

קרא עוד
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