In the latest Globes article, exciting developments in the medical field are revealed, including a groundbreaking discovery from the lab of Professor Michael Glickman, Dean of the Faculty of Biology at the Technion.
In the lab, they developed a 3D tissue model of human neurons and demonstrated that disrupting the protein control system leads to the formation of amyloid deposits and tau tangles—the two key pathologies of Alzheimer’s disease—without the need for a genetic mutation.
“Our lab studies the ubiquitin system, which is responsible for degrading misfolded proteins. The idea that this system might malfunction with age, potentially leading to disease, is not new, but until recently, this connection has not been proven. We made a breakthrough by modeling Alzheimer’s in human cells. We developed a 3D tissue of human neurons and showed that when we disrupt the protein control system, the tissue develops both amyloid deposits and tau tangles—typical of the disease. This is the first time anyone has succeeded in creating both pathologies without using a genetic mutation,’ explains Professor Glickman.
‘In the meantime, what I can say is that maintaining metabolic health (a healthy lifestyle) could be significant in preventing or delaying the disease,’ adds Professor Glickman.
Read the full article: Globes Article“
