Admon - פקולטה לביולוגיה Biology Faculty

Education/ Resume:

B.Sc. Agronomy, 1976, Hebrew University, Rehovot, Israel

M.Sc. Plant physiology and biochemistry, 1980, Hebrew University, Rehovot, Israel

Ph.D. Biochemistry, 1984, Weizmann Institute, Rehovot, Israel

Research Summary

My main research interest focuses on molecular immunology, with a special interest HLA-peptidomics; the research field aimed at characterization of the full repertoires of HLA peptides presented by human cells (HLA peptidome) and the implementation of the HLA peptidomics into development of personalized immunotherapy of cancer, autoimmunity, and inflammatory diseases.

Key Publications

Rijensky, N. M., Blondheim Shraga, N. R., Barnea, E., Peled, N., Rosenbaum, E., Popovtzer, A., Stemmer, S. M., Livoff, A., Shlapobersky, M., Moskovits, N., Perry, D., Rubin, E., Haviv, I., and Admon, A. (2020) Identification of tumor antigens in the HLA peptidome of patient-derived xenograft tumors in mouse. Mol. Cell. Proteomics 19, mcp.RA119.001876
Shraibman, B., Barnea, E., Kadosh, D. M., Haimovich, Y., Slobodin, G., Rosner, I., López-Larrea, C., Hilf, N., Kuttruff, S., Song, C., Britten, C., Castle, J., Kreiter, S., Frenzel, K., Tatagiba, M., Tabatabai, G., Dietrich, P.-Y. Y., Dutoit, V., Wick, W., Platten, M., Winkler, F., Von Deimling, A., Kroep, J., Sahuquillo, J., Martinez-Ricarte, F., Rodon, J., Lassen, U., Ottensmeier, C., Van Der Burg, S. H., Straten, P. T., Poulsen, H. S., Ponsati, B., Okada, H., Rammensee, H.-G. G., Sahin, U., Singh, H., Admon, A., Thor Straten, P., Poulsen, H. S., Ponsati, B., Okada, H., Rammensee, H.-G. G., Sahin, U., Singh, H., Admon, A., Straten, P. T., Poulsen, H. S., Ponsati, B., Okada, H., Rammensee, H.-G. G., Sahin, U., Singh, H., and Admon, A. (2019) Identification of Tumor Antigens Among the HLA Peptidomes of Glioblastoma Tumors and Plasma. Mol. Cell. Proteomics 18, 1255–1268

Rijensky, N. M., Blondheim Shraga, N. R., Barnea, E., Peled, N., Rosenbaum, E., Popovtzer, A., Stemmer, S. M., Livoff, A., Shlapobersky, M., Moskovits, N., Perry, D., Rubin, E., Haviv, I., and Admon, A. (2020) Identification of tumor antigens in the HLA peptidome of patient-derived xenograft tumors in mouse. Mol. Cell. Proteomics 19, mcp.RA119.001876
Shraibman, B., Barnea, E., Kadosh, D. M., Haimovich, Y., Slobodin, G., Rosner, I., López-Larrea, C., Hilf, N., Kuttruff, S., Song, C., Britten, C., Castle, J., Kreiter, S., Frenzel, K., Tatagiba, M., Tabatabai, G., Dietrich, P.-Y. Y., Dutoit, V., Wick, W., Platten, M., Winkler, F., Von Deimling, A., Kroep, J., Sahuquillo, J., Martinez-Ricarte, F., Rodon, J., Lassen, U., Ottensmeier, C., Van Der Burg, S. H., Straten, P. T., Poulsen, H. S., Ponsati, B., Okada, H., Rammensee, H.-G. G., Sahin, U., Singh, H., Admon, A., Thor Straten, P., Poulsen, H. S., Ponsati, B., Okada, H., Rammensee, H.-G. G., Sahin, U., Singh, H., Admon, A., Straten, P. T., Poulsen, H. S., Ponsati, B., Okada, H., Rammensee, H.-G. G., Sahin, U., Singh, H., and Admon, A. (2019) Identification of Tumor Antigens Among the HLA Peptidomes of Glioblastoma Tumors and Plasma. Mol. Cell. Proteomics 18, 1255–1268
Komov, L., Kadosh, D. M., Barnea, E., Milner, E., Hendler, A., and Admon, A. (2018) Cell Surface MHC Class I Expression Is Limited by the Availability of Peptide-Receptive “Empty” Molecules Rather than by the Supply of Peptide Ligands. Proteomics 18, e1700248
Kalaora, S., Barnea, E., Merhavi-Shoham, E., Qutob, N., Teer, J. K., Shimony, N., Schachter, J., Rosenberg, S. A., Besser, M. J., Admon, A., and Samuels, Y. (2016) Use of HLA peptidomics and whole exome sequencing to identify human immunogenic neo-antigens. Oncotarget 7, 5110–7
Milner, E., Gutter-Kapon, L., Bassani-Strenberg, M., Barnea, E., Beer, I., and Admon, A. (2013) The effect of proteasome inhibition on the generation of the human leukocyte antigen (HLA) peptidome. Mol. Cell. Proteomics 12, 1853–64
Admon, A., and Bassani-Sternberg, M. (2011) The Human Immunopeptidome Project, a suggestion for yet another postgenome next big thing. Mol. Cell. Proteomics 10, O111.011833
Bassani-Sternberg, M., Barnea, E., Beer, I., Avivi, I., Katz, T., and Admon, A. (2010) Soluble plasma HLA peptidome as a potential source for cancer biomarkers. Proc Natl Acad Sci U S A 107, 18769–18776
Ben Dror, L., Barnea, E., Beer, I., Mann, M., and Admon, A. (2010) The HLA-B*2705 peptidome. Arthritis Rheum. 62, 420–9
Milner, E., Barnea, E., Beer, I., and Admon, A. (2006) The turnover kinetics of major histocompatibility complex peptides of human cancer cells. Mol. Cell. Proteomics 5, 357–65
Admon, A., Barnea, E., and Ziv, T. (2003) Tumor antigens and proteomics from the point of view of the major histocompatibility complex peptides. Mol. Cell. Proteomics 2, 388–98
Buchsbaum, S., Barnea, E., Dassau, L., Beer, I., Milner, E., and Admon, A. (2003) Large-scale analysis of HLA peptides presented by HLA-Cw4. Immunogenetics 55, 172–176
Barnea, E., Beer, I., Patoka, R., Ziv, T., Kessler, O., Tzehoval, E., Eisenbach, L., Zavazava, N., and Admon, A. (2002) Analysis of endogenous peptides bound by soluble MHC class I molecules: a novel approach for identifying tumor-specific antigens. Eur. J. Immunol. 32, 213–22

Recent Publications

Bai, C., Tesker, M., Melamed-Kadosh, D., Engelberg, D., and Admon, A. (2020) Hog1-induced transcription of RTC3 and HSP12 is robust and occurs in cells lacking Msn2, Msn4, Hot1 and Sko1. PLoS One 15, e0237540

Arie Admon