Genetic Regulation and Protein Expression

Researchers involved in genetic regulation study the cellular and extracellular regulation of protein production and activity.
These processes are regulated at the DNA level, the RNA level, and the individual protein level. The regulatory process mediates between the genotype and phenotype, and developing an understanding of it will help us find new interventions and treatments for the future.
The Faculty of Biology at the Technion uses experimental and computational methodologies to study DNA damage, DNA/RNA modifications, and the relationships between them, as well as signal pathways, endocrinology, and protein expression in sickness and in health across various models (human, plant, and microorganism).

Part of the fascinating research in this field includes:

• DNA damage response, CRISPR-Cas9 genome editing, targeted cancer therapy, genomic instability, carcinogenesis, chromatin post-translational modifications
• Investigating the recognition mechanisms of DNA by regulatory proteins
• Studying fundamental epigenetics processes affecting gene expression and regulation in the C. elegans transcriptome
• Developing novel techniques for single-molecule capturing of protein-mRNA interactions
• Selective Ribosome Profiling – capturing the ribosomes engaged by target proteins, in codon resolution