Manor

Haim Manor

Short CV

1937- Born in 1937 in Petah Tikva, Israel

1961- B.Sc. in Agriculture, Hebrew University, Jerusalem.

1966- Ph.D. in Biophysics, University of Chicago, Chicago, Ill.

1966-1968-postdoctoral fellow, University of California, Berkeley, Helen Hay Whitney fellowship

1968-1970- postdoctoral fellow, Weizmann Institute, Helen Hay Whitney fellowship

1970-1972- Research Associate, Weizmann Institute.

1972-1980- Senior Lecturer, Department of Biology, Technion-Israel Institute of Technology

1980-1991- Associate Professor, Department of Biology, Technion-Israel Institute of Technology

1992-2005- Professor, Department of Biology, Technion-Israel Institute of Technology

1994-2005- The women’s division American Technion Society Chair in Biology

2005- Professor Emeritus, Technion-Israel Institute of Technology

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Research Summary

Throughout my scientific career I have been interested in the molecular biology of nucleic acids.

As a Ph.D. student and a postdoctoral fellow I studied fundamental aspects of RNA and DNA metabolism in the bacterium E. coli.

As a research associate at the Weizmann Institute, I began my research on the molecular biology of DNA tumor viruses. Together with my students, I continued these studies at the Technion. Later, this research led to our studies of DNA triplexes and quadruplexes, in which field we made several significant discoveries.

In the final phase of my scientific career at the Technion, my students and I studied the enzyme telomerase. This enzyme catalyzes the synthesis of telomeres, which contain DNA repeats that form triplexes and quadruplexes. In parallel, we discovered and studied a protein (named translin by others who discovered it independently) that selectively binds such repeats.

The various phases of our research are described in our scientific articles, of which a list of selected publications is provided herewith.

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Selected publications
  • Haim Manor and Robert Haselkorn (1967) Size fractionation of exponentially growing Escherichia coli. Nature 14:983-986.
  • Haim Manor, David Goodman and Gunter S. Stent (1969) RNA chain growth rates in Escherichia coli. Journal of Molecular Biology 39:1-26*.
  • Haim Manor, Murray P. Deutscher and Uriel Z. Littauer (1971) Rates of DNA chain growth in Escherichia coli. Journal of Molecular Biology 61:503-521.
  • Ada Neer, Nava Baran and Haim Manor (1977) In situ hybridization analysis of polyoma DNA replication in an inducible line of polyoma transformed cells. Cell 11:65-71.
  • Ella Mendelsohn, Nava Baran, Ada Neer and Haim Manor (1982) The integration site of polyoma virus DNA in the inducible LPT line of polyoma transformed rat cells. Journal of Virology 41:192-209
  • Nava Baran, Ada Neer and Haim Manor (1983) “Onion skin” replication of integrated polyoma virus DNA and flanking sequences in polyoma-transformed rat cells: Termination within a specific cellular DNA segment. Proceedings of the National Academy of Sciences of the USA 80:105-109.
  • Nava Baran, Aviva Lapidot and Haim Manor (1987) Unusual sequence element found at the end of an amplicon. Molecular and Cellular Biology 7:2636-2640.
  • Moshe Baru, Meir Shlissel and Haim Manor (1991) The yeast GAL4 protein transactivates the polyomavirus origin of DNA replication in mouse cells. Journal of Virology 65:3496-3503.
  • Nava Baran, Aviva Lapidot and Haim Manor (1991) Formation of DNA triplexes accounts for arrests of DNA synthesis at d(TC)n and d(GA)n tracts.  Proceedings of the National Academy of Sciences of the USA 88:507-511**.
  • Anat Aharoni, Nava Baran and Haim Manor (1993) Characterization of a multisubunit human protein which selectively binds single stranded d(GA)n and d(GT)n sequence repeats in DNA. Nucleic Acids Research 21:5221-5228.
  • Nava Baran, Lev Pucshansky, Yonit Marco, Sima Benjamin and Haim Manor (1997) The SV40 large T-antigen helicase can unwind four stranded DNA structures linked by G-quartets. Nucleic Acids Research 25:297-303**
  • Erez Romi, Nava Baran, Marina Gantman, Michael Shmoish, Bosun Min, Kathleen Collins and Haim Manor (2007) High-resolution physical and functional mapping of the template adjacent DNA binding site in catalytically active telomerase. Proceedings of the National Academy of Sciences of the USA 104: 8791-8796.
  • Elad Eliahoo, Ron Ben Yosef, Laura Pérez-Cano, Juan Fernández-Recio, Fabian Glaser and Haim Manor (2010) Mapping of interaction sites of the Schizosaccharomyces pombe protein Translin with nucleic acids and proteins: A combined molecular genetics and bioinformatics study. Nucleic Acids Research, 38, 2975-2989.
  • Svetlana Goldin, Karin Kertesz Rosenfeld, and Haim Manor (2012) Tracing the path of DNA substrates in active Tetrahymena telomerase holoenzyme complexes: Mapping of the DNA contact sites in the RNA subunit. Nucleic Acids Research, 40, 7430-7441
  • Elad Eliahoo, Phyana Litovco, Ron Ben Yosef, Keren Bendalak, Tamar Ziv and  Haim Manor (2014) Identification of proteins that form specific complexes with the highly conserved protein Translin in Schizosaccharomyces pombe. BBA Proteins and Proteomics 1844, 767-777.
  • *Throughout the years since its publication in 1969 this paper has been cited by 152 articles in major scientific journals. Most recently, it was cited in 2020, namely 51 years after its publication.
  • **Throughout the years since their publication in 1991 and 1997 these papers have been cited by 131 and 64 articles, respectively, in major scientific journals. Most recently, both papers were cited in 2020, namely 29 and 23 years after their publication.

 

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