Shuster

Gadi Shuster

Education/ Resume:

PhD, 1987, Hebrew University of Jerusalem

B Sc, 1982, Hebrew University of Jerusalem

Research Summary

We study the molecular mechanisms of how plants and algae protect the photosynthetic machinery from photoinhibition, the damages caused by extreme high light (photoinhibition).

We also study the molecular mechanism of RNA polyadenylation and degradation in different organisms including prokaryotes, archaea, chloroplast, human mitochondria and nuclear encoded RNA; the mechanism of post-transcriptional regulation of mRNA stability; RNA maturation and interaction on mRNA with proteins; control of gene expression in the chloroplast and human mitochondria.

We also study the control of gene expression in the chloroplast. Mainly at the level of RNA metabolism, how the RNA half-life is determined and the molecular mechanisms of polyadenylation and degradation.

Awards:

Henry Goldberg Academic Chair.

Hershel Rich Innovation Prize

Distinguished Lecturer Award at the Technion.

Key Publications
  • Lisitsky, I., Klaff, P. and Schuster, G. (1996) Addition of destabilizing poly(A)-rich sequences to endonuclease cleavage sites during the degradation of chloroplast mRNA. Natl. Acad. Sci. USA 93: 13398-13403.
  • Portnoy, V., Evguenieva-Hackenberg, E., Klein, F., Walter, P., Lorentzen, E., Klug, G. and Schuster, G. (2005) RNA polyadenylation in Archaea: Not observed in Haloferax while the exosome polyadenylates RNA in Sulfolobus. EMBO Rep. 6: 1188-1193.
  • Slomovic, S., Laufer, D., Geiger, D. and Schuster, G. (2006) Polyadenylation of ribosomal RNA in human cells. Nucl. Acid. Res. 34: 2966-2975.
  • Slomovic S., Fremder E., Staals R., Pruijn G. and Schuster G. (2010) Addition of poly(A) and poly(A)-rich tails during RNA degradation in the cytoplasm of human cells. Proc. Natl. Acad. Sci. USA 107: 7407-12.
  • Larum, S., Faris, S., Schuster, G. and Adir, N (2010) Engineering of an alternative electron transfer path in Photosystem II. Proc. Natl. Acad. Sci. (USA),  107: 9650-5
  • Levy, S., Allerston, CK., Liveanu, V., Haviv, MR., Gileadi. O. and Schuster, G. (2016) Identification of LACTB2, a metallo-b-lactamase protein, as a human mitochondrial endoribonuclease. Nucl. Acid Res. 44:1813-32.
  • Saper, G., Kallmann, D., Conzuelo, F., Zhao, F., Toth, T., Liveanu, V., .Meir, M., Szymanski, J., Aharoni, A., Schuhmann, W., Rothschild, A., Schuster, G.,* and Adir, N* (2018) Live cyanobacteria produce photocurrent and hydrogen using both the respiratory and photosynthetic
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Recent Publications:
  • Larom, S., Kallmann, D., Saper, G., Pinhassi, R.I., Rothschild, A., Dotan, H., Ankonina, G., Schuster*, , and Adir*, N. (2015) The Photosystem II D1-K238E mutation enhances electrical current production using cyanobacterial thylakoid membranes in a bio-photoelectrochemical cell. Photosynth. Res. 126:161–169. (*corresponding authors).
  • Pinhassi, R.I., Kallmann, D., Saper, G., Larom, S., Linkov, A., Boulouis, A., Schöttler, M-A., Bock, R., Rothschild, A., Adir* and Schuster* G. (2015) Photosynthetic membranes of Synechocystis or plants convert sunlight to photocurrent through different pathways due to different architectures. PLoS One 10(4):e0122616. (*corresponding authors).
  • Levy, S., Allerston, CK., Liveanu, V., Haviv, MR., Gileadi. O. and Schuster, G. (2016) Identification of LACTB2, a metallo-b-lactamase protein, as a human mitochondrial endoribonuclease. Acid Res. 44:1813-32.
  • Pinhassi, R.I, Kallmann, D., Saper, G., Dotan, H., Linkov, , Liveanu, V., Schuster, G., Adir, N., and Rothschild,, A. (2016) Hybrid Bio-Photo-Electro-Chemical Cells for Solar Water Splitting. Nature Comm. 7:12552-12562.
  • Saper, G., Kallmann, D., Conzuelo, F., Zhao, F., Toth, T., Liveanu, V., .Meir, M., Szymanski, , Aharoni, A., Schuhmann, W., Rothschild, A., Schuster, G.,* and Adir, N* (2018) Live cyanobacteria produce photocurrent and hydrogen using both the respiratory and photosynthetic systems. Nature Comm. 9:2168 (*corresponding authors)
  • Halpert, M., Liveanu, V., Glaser, F., Schuster,G. (2019) The Arabidopsis chloroplast RNase J displays both exo- and robust endonucleolytic activities. Plant Mol. Biol. 99: 17-29.
  • Shlosberg, Y., Eichenbaum, B., Tóth, T., Levin, G., Liveanu, V., Schuster, G.,* and Adir, N* (2020) NADPH performs mediated electron transfer in cyanobacterial-driven bio-photoelectrochemical cells. iScience 24: 101892. (*corresponding authors)
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Open Positions

We are looking and have open positions for highly motivated students and Post Docs. For details, please contact gadis@technion.ac.il

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