Ron-Harel - פקולטה לביולוגיה Biology Faculty

Education/ Resume:

2010-2017 Postdoctoral research fellow, Department of Cell Biology, Harvard Medical School, Boston, USA. Advisor: Prof. Marcia Haigis.

2004-2010 Direct track PhD, Life Sciences, Department of Neurobiology, The Weizmann Institute of Science, Rehovot, Israel. Advisor: Prof. Michal Schwartz

2003-2004 First year M.Sc. studies, Feinberg Graduate School of the Weizmann Institute of Science, Rehovot, Israel.

2000-2003 B.A., Molecular Biochemistry, Faculty of Chemistry, Technion, Israel Institute of Technology, Haifa, Israel. Summa cum laude

Research Summary

Research in the Ron-Harel lab aims at defining new mechanisms by which cellular metabolism regulates adaptive immunity, with the goal to discover new metabolic nodes that can be targeted to both alleviate immune deficiency (i.e aging) and attenuate exacerbated immunity (i.e. autoimmunity).

Awards:

2020 Catalyst award, Healthy Longevity Global Competition, US National Academy of Medicine

2019 Outstanding Early Career Investigator Team Presentation, NYAS Interstellar Initiative.

2018 Sabri Ulker Early Career Award, Translational Immunomatabolism Cell Symposia.

2011 Award of excellence granted by the Israeli “National Postdoctoral Award Program for Advancing Women In Science”

2011 EMBO long-term postdoctoral research fellowship

2010 Dean’s award for academic excellence and scientific accomplishments, Feinberg Graduate School, The Weizmann Institute of Science

2006 The Clore Israel Foundation scholarship for outstanding PhD candidates

Key Publications

“Mitochondrial biogenesis and proteome remodeling promote one-carbon metabolism for T cell activation” Noga Ron-Harel, Daniel Santos, Jonathan Ghergurovich, Peter T. Sage, Anita Reddy, Scott B. Lovitch, Noah Dephoure, F. Kyle Satterstrom, Michal Sheffer, Jessica B. Spinelli, Steven Gygi, Joshua D. Rabinowitz, Arlene H. Sharpe and Marcia C. Haigis. Cell Metabolism, 2016 24(1): 104-117- featured article. Highlighted in the Editor’s Choice section by Science (Science, 2016, 353(6299) pp. 554).

“Defective respiration and one-carbon metabolism contribute to impaired naïve T cell function in aged mice”. Noga Ron-Harel, Giulia Notarangelo, Jonathan Ghergurovich, Joao A. Paulo, Peter T. Sage, Daniel Santos, F. Kyle Satterstrom, Steven Gygi, Joshua D. Rabinowitz, Arlene H. Sharpe and Marcia C. Haigis. (PNAS, 2018, 115(52), 13347-13352).
“T cell activation depends on cellular alanine”. Noga Ron-Harel, Jonathan Ghergurovich, Giulia Notarangelo, Martin W LaFleur, Yoshiki Tsubosaka, Arlene H. Sharpe, Joshua D. Rabinowitz and Marcia C. Haigis. (Cell Reports, 2019, 28(12), 3011-3021.e4).

Recent Publications:

“T cell activation depends on cellular alanine”. Noga Ron-Harel, Jonathan Ghergurovich, Giulia Notarangelo, Martin W LaFleur, Yoshiki Tsubosaka, Arlene H. Sharpe, Joshua D. Rabinowitz and Marcia C. Haigis. (Cell Reports, 2019, 28(12), 3011-3021.e4).

“Adaptation of human iSPC-Derived Cardiomyocytes to Tyrosine Kinase Inhibitors Reduces Acute Cardiotoxicity via Metabolic Reprogramming”. Huam Wang, Robert P Sheehan, Adam C. Palmer, Robert A. Everley, Sarah A. Boswell, Noga Ron-Harel, Alison E. Ringel, Kristina M. Holton, Conor A. Jacobson, Alison R. Erickson, Laura Maliszewski, Marcia C. Haigis and Peter K. Sorger. (Cell Systems, 2019, 8(5), 412-426.e7).
“Defective respiration and one-carbon metabolism contribute to impaired naïve T cell function in aged mice”. Noga Ron-Harel, Giulia Notarangelo, Jonathan Ghergurovich, Joao A. Paulo, Peter T. Sage, Daniel Santos, Kyle Satterstrom, Steven Gygi, Joshua D. Rabinowitz, Arlene H. Sharpe and Marcia C. Haigis. (PNAS, 2018, 115(52), 13347-13352).
“Maintenance of CD4 T Cell Fitness Through Regulation of Foxo1” Ryan H. Newton, Sharad Shresta, Jenna M. Sullivan, Kathleen B. Yates, Ewould B. Compeer, Noga Ron-Harel, Bruce, R. Blazar, Steven J. Besinger, W. Nicholas Haining, Michael L. Dustin, Daniel J. Campbell, Hongbo Chi, Laurence A. Turka. (Nature Immunology, 2018, 19(8): 838-848.

“Mitochondrial biogenesis and proteome remodeling promote one-carbon metabolism for T cell activation” Noga Ron-Harel, Daniel Santos, Jonathan Ghergurovich, Peter T. Sage, Anita Reddy, Scott B. Lovitch, Noah Dephoure, F. Kyle Satterstrom, Michal Sheffer, Jessica B. Spinelli, Steven Gygi, Joshua D. Rabinowitz, Arlene H. Sharpe and Marcia C. Haigis. Cell Metabolism, 2016 24(1): 104-117- featured article. Highlighted in the Editor’s Choice section by Science (Science, 2016, 353(6299) pp. 554).
“Suppression by TFR cells leads to durable and selective inhibition of B cell effector functions” Peter T. Sage, Noga Ron-Harel, Vikram R. Juneja, et. al. Nature Immunology 2016, 17(12), 1436-1446.
“Mitochondrial Metabolism in T cell activation and senescence” Noga Ron-Harel, Arlene H. Sharpe and Marcia C. Haigis. Gerontology, 2015 61(2): 131-8.

Noga Ron-Harel