studying the role of NAC and OM14 in protein import to mitochondria
Previous studies showed that there are cytosolic ribosomes located near the mitochondria outer membrane, and these ribosomes translate proteins that are destined to the mitochondria. Purified mitochondria that were treated with proteases showed significantly lower amount of ribosomes, indicating the need for a protein receptor for ribosomes that interacts through the NAC complex. Recent work identified interaction between OM14, an outer membrane protein, and NAC this interaction support co-translational import into the mitochondria. My project is to determine which domains of OM14 are support this interaction and which additional proteins are involved.
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