Mandel-Gutfreund - פקולטה לביולוגיה Biology Faculty

Education/ Resume:

Professor, Technion-Israel Institute of Technology, Haifa

Betty Ann and Raymond J. Rosen chair in Life Sciences

Professor of Biology, Secondary affiliation in Computer Sciences

Dean, Faculty of Biology, Technion

Director of the Bioinformatics Knowledge Unit at the Technion

PhD, 1999, Hebrew University of Jerusalem, Faculty of Medicine (Bioinformatics)

M.Sc. 1992 The Hebrew University of Jerusalem, Faculty of Medicine (Human Genetics)

BS.C, 1990, The Hebrew University of Jerusalem, Cum Laude (Biology, minor Chemistry)

Research Summary

In our laboratory, we conduct interdisciplinary research to study gene expression regulation in human cells, during normal development, and in disease states. Specifically, we employ a variety of computational, genomics, transcriptomic, and proteomics based approaches to study the cross-talk between transcriptional and post-transcriptional regulation and its role in dictating pluripotency and cell fate decisions in human embryonic stem cells. In addition, we develop computational models and novel single-cell genomics technologies for predicting the effect of viral infections on the host cells and study changes in gene expression in placenta and embryo cells subjected to viral infections during pregnancy.

Awards:

2016 Cell Circuit Research Award- Klaman cell observatory

2010 Taub Prize for excellence in science

Recent Publications:

Paz I, Kosti I, Ares M. Jr., Cline M and Mandel-Gutfreund Y.RBPmap: a web server for mapping binding sites of RNA-binding proteins. Nucleic Acids Res. W361-7 (2014). DOIi: 10.1093/nar/gku406 PMID: 24829458

Enav H, Mandel-Gutfreund Y, Béjà O. Comparative metagenomic analyses reveal viral-induced shifts of host metabolism towards nucleotide biosynthesis. Microbiome. 2:9 (2014).DOIi: 10.1186/2049-2618-2-9 PMID: 24666644
Singer M, Kosti, I,Pachter L., Mandel-Gutfreund Y. A diverse epigenetic landscape at human exons with implication for expression. Nucleic Acids Res 43:3498-508 (2015).DOIi: 10.1093/nar/gkv153 PMID: 25765649
Dror I, Golan T, Levy C, Rohs R and Mandel-Gutfreund Y. A widespread role of the motif environment on transcription factor binding across diverse protein families. Genome Research25:1268-80 (2015). DOI: 10.1101/gr.184671.114 PMID: 26160164
Polishchuk M, Paz I, Yakhini Z, Mandel-Gutfreund Y. SMARTIV: combined sequence and structure de-novo motif discovery for in-vivo RNA binding data. Nucleic Acids Res. 46:W221-W228 (2018). DOI: 10.1093/nar/gky453 PMID: 29800452
Budowski-Tal I, Kolodny R, Mandel-Gutfreund Y. A Novel Geometry-Based Approach to Infer Protein Interface Similarity. Sci Rep. 8: 8192 (2018) DOI: 10.1038/s41598-018-26497-z PMID: 29844500
Enav H, Kirzner S, Lindell D, Mandel-Gutfreund Y, Béjà O.Adaptation to sub-optimal hosts is a driver of viral diversification in the ocean. Nat Communion. 8:4698 (2018).DOI: 10.1038/s41467-018-07164-3 PMID: 30409965
Yelin I, Aharony N, Tamar ES, Argoetti A, Messer E, Berenbaum D, Shafran E, Kuzli A, Gandali N, Shkedi O, Hashimshony T, Mandel-Gutfreund Y, Halberthal M, Geffen Y, Szwarcwort-Cohen M, Kishony R. Evaluation of COVID-19 RT-qPCR Test in Multi sample Pools. Clin Infect Dis. 71(16):2073-2078. (2020)
DOI: 10.1093/cid/ciaa531. PMID: 32358960
Dvir S, Argoetti A, Lesnik C, Roytblat M, Shriki K, Amit M, Hashimshony T, Mandel-Gutfreund Y. Uncovering the RNA-binding protein landscape in the pluripotency network of human embryonic stem cells. Cell Rep. 35(9):109198. (2021)
DOI: 10.1016/j.celrep.2021.109198. PMID: 34077720.

Yael Mandel-Gutfreund