Abstract:
UbiquitinE3-ligases regulate most of the cellular pathways and consequently are tightlyregulated themselves. Several allosteric mechanisms for regulation of HECTE3-ligases that were identified and characterized in our lab will be presented.Deep structural insights combined with our unique E. coli-based toolsfacilitated the development of compounds that affect these regulatorymechanisms and opened the door for pharmacological intervention. We willdemonstrate the downstream effect of these regulations with a spectrum ofsoluble to membrane proteins including the proteasomal ubiquitin-receptorRpn10, the endocytic machinery protein Rvs167 (amphiphysin in human), the RTKprotein EGFR1 and the heart/brain potassium channel KCNQ1.
Host: Sagi Levy
