Savaldi-Goldstein

Sigal Savaldi-Goldstein

Education

2008 – Postdoc, Salk Institute (mentor: Prof. Joanne Chory)
2003 – PhD, Weizmann Institute of Science (mentor: Prof. Robert Fluhr)

Research Summary

Our lab investigates fundamental aspects that regulate plant growth and development. Using both classical and state-of-art tools, we study the role of hormonal signaling, tissue identity, and mechanical constraints, that together dictate a developmental output. In parallel, we investigate how these processes are tuned by distinct environmental conditions.

Awards
  • The Cooper Prize for Academic Excellence
  • Landau Fellow in the Technion program “Leaders in Science and Technology”
  • Yigal Alon Fellowship for outstanding starting investigators awarded by the Israeli Council for Higher Education
  • NSF travel award
  • BARD Postdoctoral Fellowship
Key Publications

Ackerman-Lavert, M., Fridman, Y., Matosevich, R., Khandal, H., Friedlander-Shani, L., Vragovic, K., Ben El, R., Horev, G., Tarkowska, D., Efroni, I., and Savaldi-Goldstein, S. Auxin requirements for a meristematic state in roots depend on a dual brassinosteroid function. Curr Biol. (2021).

Singh, A.P., Fridman, Y. , Holland N., Ackerman-Lavert, M.; Zananiri R., Jaillais, Y, Henn A. and Savaldi-Goldstein, S. Interdependent nutrient availability and steroid hormone signals facilitate root growth plasticity, Dev Cell, 46, 59-72 (2018).

Vragović, K.*, Sela, A.*, Friedlander-Shani, L., Fridman, Y., Hacham, Y., Holland, N., Bartom, E., Mockler, T.C. and Savaldi-Goldstein, S. Translatome analyses capture of opposing tissue-specific brassinosteroid signals orchestrating root meristem differentiation. Proc Natl Acad Sci U S A 112, 923-928 (2015).

Fridman, Y., Elkouby, L., Holland, N., Vragovic, K., Elbaum, R., and Savaldi-Goldstein. S. Root growth is modulated by differential hormonal sensitivity in neighboring cells. Genes & Dev 28, 912-920 (2014).

Hacham, Y., Holland, N., Butterfield, C., Ubeda-Tomas, S., Bennett, M.J., Chory, J.  and Savaldi-Goldstein, S. Brassinosteroid perception in the epidermis controls root meristem size. Development 138, 839-48 (2011).

Savaldi-Goldstein, S., Peto, C. and Chory, J. The epidermis both drives and restricts plant shoot growth. Nature 446, 199-202 (2007).

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Recent Publications

Ackerman-Lavert, M., Fridman, Y., Matosevich, R., Khandal, H., Friedlander-Shani, L., Vragovic, K., Ben El, R., Horev, G., Tarkowska, D., Efroni, I., and Savaldi-Goldstein, S. Auxin requirements for a meristematic state in roots depend on a dual brassinosteroid function. Curr Biol. (2021).

Ackerman-Lavert and Savaldi-Goldstein S. Growth models from a brassinosteroid perspective. COPB, 53:90-97 (2020).

Singh, A.P., Fridman, Y. , Holland N., Ackerman-Lavert, M.; Zananiri R., Jaillais, Y, Henn A. and Savaldi-Goldstein, S. Interdependent nutrient availability and steroid hormone signals facilitate root growth plasticity, Dev Cell, 46, 59-72 (2018).

Vragovic, K., Bartom, E., and Savaldi-Goldstein, S. Quantitation of Cell Type-Specific Responses to Brassinosteroid by Deep Sequencing of Polysome-Associated Polyadenylated RNA. Methods MolBiol 1564, 81-102 (2017).

Fridman, Y., Holland, N., Elbaum, R., Savaldi-Goldstein, S. High Resolution Quantification of Crystalline Cellulose Accumulation in Arabidopsis Roots to Monitor Tissue-specific Cell Wall Modifications. Vis. Exp. (111), e53707, doi:10.3791/53707 (2016).

Vragović, K.*, Sela, A.*, Friedlander-Shani, L., Fridman, Y., Hacham, Y., Holland, N., Bartom, E., Mockler, T.C. and Savaldi-Goldstein, S. Translatome analyses capture of opposing tissue-specific brassinosteroid signals orchestrating root meristem differentiation. Proc Natl Acad Sci U S A 112, 923-928 (2015).

Singh, A.P. and Savaldi-Goldstein S.Growth control: Brassinosteroid activity gets context. Journal of Experimental Botany. 66, 1123-1132 (2015).

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Open Positions

We are looking for a Lab Manager/ Research assistant! For more details, please see: https://hr.technion.ac.il/positions/?jobid=23414012
Motivated students are always welcome to join us!

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