Seminars

“Identification and characterization of DNA damage response lncRNA by spatial-temporal analysis”
Long non-coding RNAs (lncRNAs) are emerging as key regulators of cellular function, with their spatial and temporal expression playing a crucial role in maintaining homeostasis. Among them, LINC00944 stands out for its dynamic response to DNA damage, showing a striking increase in nuclear expression following the DNA damage response (DDR). This lncRNA actively shapes cellular fate by regulating the cell cycle through p21 and driving apoptosis via BCL2 and γ-H2AX. Beyond its role in DDR, our findings reveal an unexpected and significant influence of LINC00944 on inflammation and immune response pathways. This dual functionality suggests that LINC00944 is not just a participant in DNA repair but also a key player in broader stress response networks. Unraveling its mechanisms could open new avenues for understanding how cells balance survival, repair, and immune activation in response to damage