“Computational approach to identifynew roles for long non-coding RNAs involved in pluripotency anddifferentiation”
ecently long non coding RNAs (lncRNAs) have emerged asregulators of pluripotency and differentiation, however their contribution tospecific lineage commitment is yet largely unknown. We generated RNA-seq data,in human induced Pluripotent Stem cells (iPSc) and applied a network approach tohelp assign lncRNAs with unknown functions to these processes. We found manydifferentially expressed lncRNAs highly co-expressed with known markers ofdifferentiation. These results were validated with ChiP-seq data suggesting apossible regulatory relationship between the TFs and the lncRNAs.
