Prof. Nissan Yissachar, The Mina and Everard Goodman Faculty of Life Sciences Bar-Ilan Institute of Nanotechnology and Advanced Materials The Gonda Multidisciplinary Brain Research Center Bar-Ilan University, Israel
20/06/2022 13:00

Title: Thinking outsidethe mouse: ex-vivo dissections of host-microbiome cross-talks

Key points:


·        We developed a novel 3D gut organ culture system, as a uniquetool for studying host-microbiome interactions.

·        Enteric neuro-immune-microbiome cross-talks control regulatoryand effector T-cells development.

·        The gut organ culture system provides insights into thefunctional consequences of microbial dysbiosis in mice and humans.

·        Development of a novel ‘on-chip gut permeability assay’, for trackingreal-time changes in gut permeability.

·        Dysbiotic, chemotherapy-disrupted microbiome alters gutpermeability, suggesting that barrier-modulating microbes may promotechemotherapy-induced gastrointestinal inflammation. 

Host: Sagi Levy