Title: Spatial transcriptomics ofmammalian tissues
Abstract: Mammaliantissues are composed of repeating anatomical units that are polarized bymorphogens or directional blood flow. As a result, cells at different tissuecoordinates sub-specialize in distinct physiological functions, a phenomenontermed ‘zonation’. I will describe approaches based on single cell RNAsequencing, single molecule transcript imaging and spatial transcriptomics tocharacterize zonation in the key metabolic organs – the liver and intestine. Iwill discuss emerging design principles that facilitate optimal organ functionthrough spatial division of labor. I will also describe the impact of zonationon diverse pathological states.
Host: Sagi Levy