“Game of Edits” – A-to-I RNA Editing: Thrones of Regulation, Gametogenesis and Embryogenesis
Adenosine-to-inosine (A-to-I) RNA editing, catalyzed by ADARs, is a widespread and evolutionarily conserved modification needed to regulate innate immunity. Using C. elegans, a powerful model for RNA editing research, we reveal that ADAR subcellular localization affects its substrate preferences and function. We show that edited transcripts are maternally, but not paternally, inherited, and editing levels fluctuate during embryogenesis, probably to control transcript expression.
